Cited by 35Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsNeuropeptides and Animal Physiology

The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat

Cox, Melinda L, Welch, Sandra P·2004·European Journal of Pharmacology

Abstract

Our study addressed the hypothesis that spinal release of endogenous opioids underlies Delta9-tetrahydrocannabinol (Delta9-THC)-induced antinociception in Freund's adjuvant-induced arthritic and nonarthritic rats. The paw-pressure test was used to assess the antinociceptive effects of Delta9-THC versus those of morphine, and opioid and cannabinoid receptor-selective antagonists were used to characterize the involved receptors. Cerebrospinal fluid was collected after Delta9-THC injection (i.p.) for the measurement of endogenous opioid peptides. Our results indicate that morphine or Delta9-THC is equally potent and efficacious in both nonarthritic and arthritic rats. Delta9-THC-induced antinociception is attenuated by the kappa opioid receptor antagonist, nor-binaltorphimine, in arthritic rats only. Delta9-THC induces increased immunoreactive dynorphin A (idyn A) levels in nonarthritic rats while decreasing idyn A in arthritic rats. We hypothesize that the elevated idyn A level in arthritic rats contributes to hyperalgesia by interaction with N-methyl-D-aspartate receptors, and that Delta9-THC induces antinociception by decreasing idyn A release.

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Crossref · 10.1016/j.ejphar.2004.04.022

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Authors
Cox, M. L., & Welch, S. P.
Affiliations
Virginia Commonwealth University (US)
Corresponding author
Welch, Sandra P
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2004-06
Volume
493
Issue
1-3
Pages
65-74
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2035976555
Cited by
35
References
39
Citations by year
2025: 1 · 2024: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 3 · 2015: 2 · 2013: 2
FWCI
2.09
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k02da000186-09)
  • National Institute on Drug Abuse (DA 07027, DA 05274, K02 DA-00186, T32DA007027)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
delta-9-tetrahydrocannabinol, antinociception, adjuvant-induced arthritis, endogenous opioids, kappa opioid receptor, nor-binaltorphimine, dynorphin A, NMDA receptor, hyperalgesia, morphine, cerebrospinal fluid
MeSH terms
Rimonabant, Animals, Arthritis, Experimental, Dose-Response Relationship, Drug, Dynorphins, Enkephalin, Leucine, Enkephalin, Methionine, Freund's Adjuvant, Injections, Intradermal, Injections, Intraperitoneal, Male, Morphine, Mycobacterium, Naloxone, Naltrexone, Narcotic Antagonists, Pain, Pain Measurement, Piperidines, Pyrazoles, Receptors, Opioid, Dronabinol, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB1, Rats, Cannabinoid Receptor Antagonists

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