Decreased basal endogenous opioid levels in diabetic rodents: Effects on morphine and delta-9-tetrahydrocannabinoid-induced antinociception
Abstract
We have previously demonstrated synergy between morphine and Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in the expression of antinociception in acute pain models and in arthritic models of chronic pain. Our data has been extended to include acute pain in both diabetic mice and rats. In diabetic mice, Delta(9)-THC p.o. was more active in the tail-flick test in the diabetic mouse than in the non-diabetic mouse. Morphine (s.c.) was less potent in diabetic than in non-diabetic mice [6.1 (5.1-7.2) versus 3.2 (2.4-4.1) mg/kg, respectively], an effect previously extensively documented in pre-clinical and clinical testing. In addition, the combination of Delta(9)-THC with morphine produced a greater-than-additive relief of acute pain in mice. In the rat, the induction of the diabetic state decreased the antinociceptive effect of morphine, an effect temporally related to a decreased release of specific endogenous opioids. Conversely, Delta(9)-THC retained the ability to release endogenous opioids in diabetic rats and maintained significant antinociception. Extrapolation of such studies to the clinical setting may indicate the potential for use of Delta(9)-THC-like drugs in the treatment of diabetic neuropathic pain, alone or in combination with very low doses of opioids.
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THC and WIN55,212-2 produce antinociception in rodent STZ-induced peripheral neuropathy.
“Several studies have demonstrated that THC (Williams et al, 2008) and WIN55,212-2 (Bujalska, 2008;Doğrul et al, 2004;Ikeda et al, 2013;Jahanabadi et al, 2016;Mohammadi-Farani et al, 2010;Ulugol et al, 2004;Vera et al, 2012;Vincenzi et al, 2013) produce antinociception in rodent STZinduced peripheral neuropathy.”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Williams et al, 2008
Δ9-THC exhibited enhanced antinociceptive efficacy in diabetic rats whereas morphine showed reduced antinociceptive efficacy.
“Interestingly, Δ9-THC exhibited enhanced antinociceptive efficacy in diabetic rats whereas morphine showed reduced antinociceptive efficacy.115”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [115]
A non-nociceptive dose of Δ9-THC administered with morphine enhanced the antinociceptive properties of morphine in both diabetic and naive mice.
“Moreover, a non-nociceptive dose of Δ9-THC, administered in conjunction with morphine, enhanced the antinociceptive properties of morphine in both diabetic and naive mice.115”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [115]
Diabetic rats exhibit lower levels of dynorphin and β-endorphins in cerebrospinal fluid relative to non-diabetic rats treated under the same conditions.
“Diabetic rats exhibit lower levels of dynorphin and β-endorphins in cerebrospinal fluid (CSF) relative to non-diabetic rats treated under the same conditions.115”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [115]
Administration of Δ9-THC to diabetic rats restored cerebrospinal fluid levels of endogenous dynorphin and leu-enkephalin to levels observed following morphine administration to non-diabetic rats.
“Administration of Δ9-THC to diabetic rats restored CSF levels of endogenous dynorphin and leu-enkephalin to levels observed following morphine administration to non-diabetic rats.115”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [115]
delta-9-THC significantly enhanced morphine-induced antinociception in both diabetic and non-diabetic mice.
“delta-9-THC significantly enhanced morphine-induced antinociception in both diabetic and non-diabetic mice”
From Opioid-Sparing Effect of Cannabinoids: A Systematic Review and Meta-Analysis (2017) · cites this paper as Williams 2008
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- Authors
- Williams, J., Haller, V. L., Stevens, D. L., & Welch, S. P.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Haller, Victoria L.
- ORCID
- Stevens, David L.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 584
- Issue
- 1
- Pages
- 78-86
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2036908810
- Cited by
- 45
- References
- 79
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Thomas F. and Kate Miller Jeffress Memorial Trust
- National Institute on Drug Abuse (DA 07027, DA 05274, T32DA007027)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- endogenous opioids, diabetes mellitus, morphine, delta-9-tetrahydrocannabinol, antinociception, acute pain, opioid synergy, diabetic neuropathic pain, opioid release, tail-flick test, chronic pain
- MeSH terms
- Administration, Oral, Analgesics, Opioid, Animals, Diabetes Mellitus, Experimental, Diabetic Neuropathies, Dose-Response Relationship, Drug, Drug Synergism, Drug Therapy, Combination, Injections, Intraperitoneal, Injections, Subcutaneous, Male, Mice, Inbred ICR, Morphine, Pain Measurement, Dronabinol, Down-Regulation, Rats, Sprague-Dawley, Pain Threshold, Analgesics, Non-Narcotic, Opioid Peptides, Mice, Rats
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