CoChat
Sign Up
Cited by 396Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsInflammatory mediators and NSAID effects

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain

Costa, Barbara, Trovato, Anna Elisa, Comelli, Francesca, Giagnoni, Gabriella, Colleoni, Mariapia·2007·European Journal of Pharmacology
DOI 10.1016/j.ejphar.2006.11.006
Open this paper in CoChat — free account

Abstract

Cannabidiol, the major psycho-inactive component of cannabis, has substantial anti-inflammatory and immunomodulatory effects. This study investigated its therapeutic potential on neuropathic (sciatic nerve chronic constriction) and inflammatory pain (complete Freund's adjuvant intraplantar injection) in rats. In both models, daily oral treatment with cannabidiol (2.5-20 mg/kg to neuropathic and 20 mg/kg to adjuvant-injected rats) from day 7 to day 14 after the injury, or intraplantar injection, reduced hyperalgesia to thermal and mechanical stimuli. In the neuropathic animals, the anti-hyperalgesic effect of cannabidiol (20 mg/kg) was prevented by the vanilloid antagonist capsazepine (10 mg/kg, i.p.), but not by cannabinoid receptor antagonists. Cannabidiol's activity was associated with a reduction in the content of several mediators, such as prostaglandin E(2) (PGE(2)), lipid peroxide and nitric oxide (NO), and in the over-activity of glutathione-related enzymes. Cannabidiol only reduced the over-expression of constitutive endothelial NO synthase (NOS), without significantly affecting the inducible form (iNOS) in inflamed paw tissues. Cannabidiol had no effect on neuronal and iNOS isoforms in injured sciatic nerve. The compound's efficacy on neuropathic pain was not accompanied by any reduction in nuclear factor-kappaB (NF-kappaB) activation and tumor necrosis factor alpha (TNFalpha) content. The results indicate a potential for therapeutic use of cannabidiol in chronic painful states.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.ejphar.2006.11.006

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 46 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Costa, B., Trovato, A. E., Comelli, F., Giagnoni, G., & Colleoni, M.
Affiliations
  • University of Milano-Bicocca (IT)
  • University of Milan (IT)
Corresponding author
Costa, Barbara
ORCID
Costa, Barbara
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2007-02
Volume
556
Issue
1-3
Pages
75-83
ISSN
0014-2999 (ISSN-L)
DOI
10.1016/j.ejphar.2006.11.006
OpenAlex
W1967303451
Cited by
395
References
46
Citations by year
2026: 22 · 2025: 28 · 2024: 37 · 2023: 42 · 2022: 37 · 2021: 43 · 2020: 35 · 2019: 20 · 2018: 17 · 2017: 16 · 2016: 14 · 2015: 8 · 2014: 9 · 2013: 11 · 2012: 14
FWCI
4.80
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
Funders
Ministero dell’Istruzione, dell’Università e della Ricerca
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords
cannabidiol, neuropathic pain, inflammatory pain, chronic constriction injury, complete Freund's adjuvant, hyperalgesia, capsazepine, vanilloid receptor, prostaglandin E2, nitric oxide, endothelial nitric oxide synthase, glutathione, NF-κB, TNF-α, anti-inflammatory activity, oral administration
MeSH terms
Administration, Oral, Animals, Cannabidiol, Cannabis, Capsaicin, Chronic Disease, Freund's Adjuvant, Hyperalgesia, Inflammation, Lipid Peroxides, Male, Nitric Oxide, Pain, Pain Measurement, Tumor Necrosis Factor-alpha, Dinoprostone, NF-kappa B, Rats, Wistar, Nitric Oxide Synthase, Sciatic Neuropathy, Rats, Cannabinoid Receptor Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review