Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability

Maderuelo, Cristina; Lanao, Jose M.; Zarzuelo, Aránzazu

doi:10.1016/j.ejps.2019.105019

Cited by 147Drug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsPharmaceutical studies and practices

Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability

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Maderuelo, Cristina, Lanao, Jose M., Zarzuelo, Aránzazu·2019·European Journal of Pharmaceutical Sciences

DOI 10.1016/j.ejps.2019.105019

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Abstract

Enteric coating is a common procedure in the development of oral pharmaceutical dosage forms. The main advantage of enteric coating is that it protects the drug from acidic pH and enzymatic degradation in the stomach while protecting it from the undesirable effects of some drugs. There is certain controversy regarding the real influence of enteric coating on the bioavailability of many drugs. Various scientific articles have demonstrated an improvement in the extent of bioavailability of some drugs when enteric coating is used. In recent years, there have been many studies examining different formulation strategies for monolithic and multiparticulate systems, including different pharmaceutical oral dosage forms and delivery systems based on the combined use of enteric coating and other methods that improve the bioavailability of drugs administered orally. However, the real bioavailability, serum levels and therapeutic effect of these drugs may be influenced by gastrointestinal pH values, gastrointestinal environment, inter-individual or intra-individual variability in gastric emptying and gastrointestinal transit time, interpatient variability associated with the type of polymer used for enteric coating or other formulation variables. It deserves special attention to know the real influence of enteric coating on the bioavailability of new oral dosage forms.

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Enteric coating protects orally administered formulations from damage by acidic pH and increases absorption in the intestine.
“Enteric coating is the usual procedure used to protect orally administered formulations from damage by acidic pH to avoid undesirable effects on the stomach, and is used to increase absorption in the intestine [37].”
From Effects of Enteric-Coated Formulation of Sodium Bicarbonate on Bicarbonate Absorption and Gastrointestinal Discomfort (2024) · cites this paper as [37]

International Commission on Radiological Protection
(1969) · Radiology · doi:10.1148/93.6.1298 · Cited by 2,153 · see citing works
Manual of pharmacologic calculations with computer programs
(1988) · International Journal of Biochemistry · doi:10.1016/0020-711x(88)90084-5 · Cited by 1,458 · see citing works
Pharmaceutics : the science of dosage form design
Aulton, M. E. (2002) · Churchill Livingstone eBooks · Cited by 1,329 · see citing works
Encyclopedia Of Controlled Drug Delivery
Mathiowitz, E. (1999) · Medical Entomology and Zoology · Cited by 851 · see citing works
Biologically erodable microspheres as potential oral drug delivery systems
Mathiowitz, E., Jacob, J. S., Jong, Y. S., Carino, G. P., Chickering, D. E., Chaturvedi, P., Santos, C. A., Vijayaraghavan, K., Montgomery, S., Bassett, M., et al. (1997) · Nature · doi:10.1038/386410a0 · Cited by 823 · see citing works
3D printing in pharmaceutics: A new tool for designing customized drug delivery systems
Goole, J., & Amighi, K. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.12.071 · Cited by 663 · see citing works
A Mechanistic Approach to Understanding the Factors Affecting Drug Absorption: A Review of Fundamentals
Martinez, M. N., & Amidon, G. L. (2002) · The Journal of Clinical Pharmacology · doi:10.1177/00970002042006005 · Cited by 651 · see citing works
Intraluminal pH of the human gastrointestinal tract.
Fallingborg, J. (1999) · PubMed · Cited by 642 · see citing works
Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation
Yang, L., Chu, J. S., & Fix, J. A. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00004-2 · Cited by 562 · see citing works
Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats
DeSesso, J. M., & Jacobson, C. F. (2001) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(00)00136-8 · Cited by 528 · see citing works
3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics
Goyanes, Á., Wang, J., Buanz, A. B. M., Martı́nez-Pacheco, R., Telford, R., Gaisford, S., & Basit, A. W. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00510 · Cited by 516 · see citing works
Size-Dependent Bioadhesion of Micro- and Nanoparticulate Carriers to the Inflamed Colonic Mucosa
Lamprecht, A., Schäfer, U., & Lehr, C.-M. (2001) · Pharmaceutical Research · doi:10.1023/a:1011032328064 · Cited by 507 · see citing works
Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review
Sosnik, A., das Neves, J., & Sarmento, B. F. C. C. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.07.010 · Cited by 489 · see citing works
Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches
Amidon, S., Brown, J. E., & Dave, V. S. (2015) · AAPS PharmSciTech · doi:10.1208/s12249-015-0350-9 · Cited by 474 · see citing works
Eudragit®: a technology evaluation
Thakral, S., Thakral, N. K., & MAJUMDAR, D. K. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.736962 · Cited by 460 · see citing works
Gut instincts: Explorations in intestinal physiology and drug delivery
McConnell, E. L., Fadda, H. M., & Basit, A. W. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.05.012 · Cited by 432 · see citing works
Pharmaceutics: The science of dosage form design
Peppas, N. A. (1989) · Journal of Controlled Release · doi:10.1016/0168-3659(89)90050-3 · Cited by 402 · see citing works
Carrier-Mediated Intestinal Transport of Drugs
Tsuji, A., & Tamai, I. (1996) · Pharmaceutical Research · doi:10.1023/a:1016086003070 · Cited by 392 · see citing works
Enteral Absorption of Insulin in Rats from Mucoadhesive Chitosan-Coated Liposomes
Takeuchi, H., Yamamoto, H., Niwa, T., Hino, T., & Kawashimà, Y. (1996) · Pharmaceutical Research · doi:10.1023/a:1016009313548 · Cited by 389 · see citing works
Food, gastrointestinal pH, and models of oral drug absorption
Abuhelwa, A. Y., Williams, D. B., Upton, R. N., & Foster, D. J. R. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.11.034 · Cited by 353 · see citing works
A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
Muheem, A., Shakeel, F., Jahangir, M. A., Anwar, M., Mallick, N., Jain, G. K., Warsi, M. H., & Ahmad, F. J. (2014) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2014.06.004 · Cited by 343 · see citing works
Oral delivery of macromolecular drugs: Where we are after almost 100 years of attempts
Moroz, E., Matoori, S., & Leroux, J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.01.010 · Cited by 336 · see citing works
Pharmacokinetics and Bioavailability of Mycophenolate Mofetil in Healthy Subjects after Single‐Dose Oral and Intravenous Administration
Bullingham, R. E. S., Monroe, S., Nicholls, A. J., & Hale, M. (1996) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1996.tb04207.x · Cited by 318 · see citing works
Intestinal absorption of magnesium from food and supplements.
Fine, K. D., Ana, C. A. S., Porter, J. L., & Fordtran, J. S. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115317 · Cited by 291 · see citing works
Enteric-coated capsules filled with freeze-dried chitosan/poly(γ-glutamic acid) nanoparticles for oral insulin delivery
Sonaje, K., Chen, Y., Chen, H., Wey, S., Juang, J., Nguyen, H.-N., Hsu, C., Lin, K., & Sung, H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.042 · Cited by 282 · see citing works
Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin
Wong, C. Y. J., Al‐Salami, H., & Dass, C. R. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.12.036 · Cited by 271 · see citing works
Bioavailability Improvement of Mycophenolic Acid Through Amino Ester Derivatization
Lee, W. A., Gu, L., Miksztal, A. R., Chu, N., Leung, K., & Nelson, P. H. (1990) · Pharmaceutical Research · doi:10.1023/a:1015828802490 · Cited by 254 · see citing works
Pharmaceutical Pelletization Technology
Ghebre-Sellassie, I. (2022) · CRC Press eBooks · doi:10.1201/9781003066231 · Cited by 253 · see citing works
Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives
Kotla, N. G., Rana, S., Sivaraman, G., Sunnapu, O., Vemula, P. K., Pandit, A. S., & Rochev, Y. A. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.021 · Cited by 246 · see citing works
Effect of Enteric Coating on Antiplatelet Activity of Low-Dose Aspirin in Healthy Volunteers
Cox, D. M., Maree, A. O., Dooley, M., Conroy, R. M., Byrne, M. F., & Fitzgerald, D. J. (2006) · Stroke · doi:10.1161/01.str.0000231683.43347.ec · Cited by 243 · see citing works
Enteric coated HPMC capsules designed to achieve intestinal targeting
Cole, E. T., Scott, R. A., Connor, A. L., Wilding, I. R., Petereit, H.-U., Schminke, C., Beckert, T. E., & Cadé, D. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00871-7 · Cited by 241 · see citing works
Application of Cellulose and Cellulose Derivatives in Pharmaceutical Industries
Shokri, J., & Adibki, K. (2013) · InTech eBooks · doi:10.5772/55178 · Cited by 230 · see citing works
Peroral Route: An Opportunity for Protein and Peptide Drug Delivery
Sood, A., & Panchagnula, R. (2001) · Chemical Reviews · doi:10.1021/cr000700m · Cited by 222 · see citing works
Tableting of coated pellets
Bodmeier, R. A. (1997) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(96)00028-8 · Cited by 198 · see citing works
pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model
Makhlof, A., Tozuka, Y., & Takeuchi, H. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.12.013 · Cited by 192 · see citing works
Cellulose esters in drug delivery
Edgar, K. J. (2006) · Cellulose · doi:10.1007/s10570-006-9087-7 · Cited by 190 · see citing works
pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs
Wang, X., & Zhang, Q. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.07.014 · Cited by 189 · see citing works
Oral delivery of insulin for treatment of diabetes: status quo, challenges and opportunities
Wong, C. Y. J., Martinez, J., & Dass, C. R. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12607 · Cited by 185 · see citing works
Design of Controlled Release Drug Delivery Systems
Li, X., & Jasti, B. (2005) · Cited by 154 · see citing works
Enteric Coating and Aspirin Nonresponsiveness in Patients With Type 2 Diabetes Mellitus
Bhatt, D. L., Großer, T., Dong, J.-F., Logan, D. K., Jeske, W. P., Angiolillo, D. J., Frelinger, A. L., Lei, L., Liang, J., Moore, J. E., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.050 · Cited by 150 · see citing works
Formulation and characterization of 5-Fluorouracil enteric coated nanoparticles for sustained and localized release in treating colorectal cancer
Tummala, S., Kumar, M. N. S., & Prakash, A. (2014) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2014.11.010 · Cited by 148 · see citing works
Chronotherapeutic strategy: Rhythm monitoring, manipulation and disruption☆
Ohdo, S. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.01.006 · Cited by 146 · see citing works
A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption—Part I: Gastrointestinal pH
Abuhelwa, A. Y., Foster, D. J. R., & Upton, R. N. (2016) · The AAPS Journal · doi:10.1208/s12248-016-9952-8 · Cited by 141 · see citing works
Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets
Maurer, J. M., Schellekens, R. C. A., van Rieke, H. M., Wanke, C., Iordanov, V. P., Stellaard, F., Wutzke, K. D., Dijkstra, G. D. H., van der Zee, M., Woerdenbag, H. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129076 · Cited by 135 · see citing works
Evolution of a physiological pH6.8 bicarbonate buffer system: Application to the dissolution testing of enteric coated products
Liu, F., Merchant, H. A., Kulkarni, R. P., Alkademi, M., & Basit, A. W. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.01.001 · Cited by 125 · see citing works
Pharmaceutical Applications of Shellac: Moisture-Protective and Taste-Masking Coatings and Extended-Release Matrix Tablets
Pearnchob, N., Siepmann, J., & Bodmeier, R. A. (2003) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120024188 · Cited by 124 · see citing works
Oral delivery of peptides and proteins using lipid-based drug delivery systems
Li, P., Nielsen, H. M., & Müllertz, A. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.717068 · Cited by 116 · see citing works
Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells
Stein, J. M., Ries, J., & Barrett, K. E. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.1.g203 · Cited by 116 · see citing works
Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption.
Varum, F., Merchant, H., & Basit, A. (2010) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2010.04.046 · Cited by 111 · see citing works
Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy
Yoo, J., Naeem, M., Choi, M., Cao, J., Yoon, S., Kim, M., Jung, Y., Lee, J., Moon, H. R., Ikram, M., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s88672 · Cited by 107 · see citing works
Development of an Oral Drug Delivery System Targeting Immune-Regulating Cells in Experimental Inflammatory Bowel Disease: A New Therapeutic Strategy
Nakase, H., Okazaki, K., Tabata, Y., Uose, S., Ohana, M., Uchida, K., Matsushima, Y., Kawanami, C., Oshima, C., Ikada, Y., et al. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35256-5 · Cited by 101 · see citing works
Enteric polymers as binders and coating materials in multiple-unit site-specific drug delivery systems
Marvola, M., Nykänen, P., Rautio, S., Isonen, N., & Autere, A.-M. (1999) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(98)00032-3 · Cited by 101 · see citing works
Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading
Li, P., Tan, A., Prestidge, C. A., Nielsen, H. M., & Müllertz, A. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.10.039 · Cited by 100 · see citing works
Hot-melt coating with lipid excipients
Jannin, V., & Cuppok, Y. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.10.026 · Cited by 95 · see citing works
Enteric-Coated Mycophenolate Sodium
Behrend, M., & Braun, F. (2005) · Drugs · doi:10.2165/00003495-200565080-00001 · Cited by 92 · see citing works
Influence of food on the absorption of acetylsalicylic acid from enteric-coated dosage forms
Bogentoft, C. B., Carlsson, I., Ekenved, G., & Magnusson, A. (1978) · European Journal of Clinical Pharmacology · doi:10.1007/bf00611905 · Cited by 90 · see citing works
Dry powder coating of pharmaceuticals: A review
Sauer, D., Cerea, M., DiNunzio, J. C., & McGinity, J. W. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.02.032 · Cited by 90 · see citing works
Electrostatic powder coating: Principles and pharmaceutical applications
Prasad, L. K., McGinity, J. W., & Williams, R. O. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.04.016 · Cited by 82 · see citing works
Review article: similarities and differences among delayed‐release proton‐pump inhibitor formulations
Horn, J. R., & Howden, C. W. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02714.x · Cited by 79 · see citing works
Preparation of Eudragit L 100-55 enteric nanoparticles by a novel emulsion diffusion method
Hao, S., Wang, B., Wang, Y., Zhu, L., Wang, B., & Guo, T. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.02.036 · Cited by 79 · see citing works
A dynamic system for the simulation of fasting luminal pH-gradients using hydrogen carbonate buffers for dissolution testing of ionisable compounds
Garbacz, G., Kołodziej, B., Koziolek, M., Weitschies, W., & Klein, S. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.09.020 · Cited by 76 · see citing works
The new era of biotech insulin analogues
Brange, J. (1997) · Diabetologia · doi:10.1007/s001250051400 · Cited by 74 · see citing works
A review on recent advances of enteric coating
Hussan, S. D. (2012) · IOSR Journal of Pharmacy (IOSRPHR) · doi:10.9790/3013-2610511 · Cited by 74 · see citing works
Printfills: 3D printed systems combining fused deposition modeling and injection volume filling. Application to colon-specific drug delivery
Linares, V., Casas, M., & Caraballo, I. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.11.021 · Cited by 73 · see citing works
Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability
AboulFotouh, K., Allam, A., El‐Badry, M., & El‐Sayed, A. M. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.03.034 · Cited by 73 · see citing works
Oral immunotherapy with short ragweed extract in a novel encapsulated preparation: A double-blind study☆☆☆★★★
Litwin, A., Flanagan, M. P., Entis, G., Gottschlich, G. M., Esch, R. E., Gartside, P. S., & Michael, J. G. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70191-x · Cited by 70 · see citing works
An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets
Fan, T., Wei, S., Yan, W. W., Chen, D. B., & Li, J. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00508-9 · Cited by 69 · see citing works
Exploration of polymethacrylate structure–property correlations: Advances towards combinatorial and high-throughput methods for biomaterials discovery
Holmes, P. F., Bohrer, M., & Kohn, J. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.05.002 · Cited by 67 · see citing works
Microporous bilayer osmotic tablet for colon-specific delivery
Chaudhary, A., Tiwari, N., Jain, V. K., & Singh, R. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.01.004 · Cited by 66 · see citing works
Bioavailability of Mycophenolate Mofetil and Enteric‐Coated Mycophenolate Sodium Is Differentially Affected by Pantoprazole in Healthy Volunteers
Rupprecht, K., Schmidt, C., Raspé, A., Schweda, F., Shipkova, M., Fischer, W. H., Bucher, M., Kees, F., & Faerber, L. (2009) · The Journal of Clinical Pharmacology · doi:10.1177/0091270009344988 · Cited by 64 · see citing works
Enteric coating of mycophenolate sodium: a rational approach to limit topical gastrointestinal lesions and extend the therapeutic index of mycophenolate
Bjarnason, I. (2001) · Transplantation Proceedings · doi:10.1016/s0041-1345(01)02377-6 · Cited by 60 · see citing works
Omeprazole Impairs the Absorption of Mycophenolate Mofetil But Not of Enteric‐Coated Mycophenolate Sodium in Healthy Volunteers
Kees, M. G., Steinke, T., Moritz, S., Rupprecht, K., Paulus, E., Kees, F., Bucher, M., & Faerber, L. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270011412968 · Cited by 58 · see citing works
Cutting-edge technologies in colon-targeted drug delivery systems
Patel, M. M. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.597739 · Cited by 54 · see citing works
Enteric-coated mycophenolate sodium: results of two pivotal global multicenter trials
Granger, D. K. (2001) · Transplantation Proceedings · doi:10.1016/s0041-1345(01)02378-8 · Cited by 54 · see citing works
Improved bioavailability of orally delivered insulin using Eudragit-L30D coated PLGA microparticles
Naha, P. C., Kanchan, V., Manna, P. K., & Panda, A. K. (2008) · Journal of Microencapsulation · doi:10.1080/02652040801903843 · Cited by 53 · see citing works
In vitro release and in vivo absorption in beagle dogs of meloxicam from Eudragit® FS 30 D-coated pellets
Gao, C., Huang, J., Jiao, Y., Li, S., Liu, Y., Li, Y., & Mei, X. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.05.035 · Cited by 51 · see citing works
Predicting the gastrointestinal behaviour of modified-release products: Utility of a novel dynamic dissolution test apparatus involving the use of bicarbonate buffers
Merchant, H. A., Goyanes, Á., Parashar, N., & Basit, A. W. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.09.003 · Cited by 51 · see citing works
In vitro and in vivo evaluation of ofloxacin sustained release pellets
Cui, Y., Zhang, Y. X., & Tang, X. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.04.014 · Cited by 48 · see citing works
Acid decomposition of omeprazole in the absence of thiol: A differential pulse polarographic study at the static mercury drop electrode (SMDE)
Qaisi, A. M., Tutunji, M. F., & Tutunji, L. F. (2005) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20546 · Cited by 46 · see citing works
Efficacy of combination therapy with probiotics and mosapride in patients with<scp>IBS</scp>without diarrhea: a randomized, double‐blind, placebo‐controlled, multicenter, phase II trial
Choi, C. H., Kwon, J. G., Kim, S. K., Myung, S. ‐., Park, K. S., Sohn, C. ‐., Rhee, P. ‐., Lee, K. J., Lee, O. Y., Jung, H. ‐., et al. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12544 · Cited by 46 · see citing works
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications
Hu, M., & Xiao-ling, L. (2011) · Cited by 45 · see citing works
Development and Characterization of Enteric-Coated Immediate-Release Pellets of Aceclofenac by Extrusion/Spheronization Technique Using κ-Carrageenan as a Pelletizing Agent
Kilor, V. A., Sapkal, N. P., Avari, J. G., & Shewale, B. D. (2010) · AAPS PharmSciTech · doi:10.1208/s12249-010-9389-9 · Cited by 44 · see citing works
Plasma prednisolone levels from enteric and non‐enteric coated tablets estimated by an original technique.
Morrison, P., Bradbrook, I., & Rogers, H. (1977) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1977.tb00792.x · Cited by 43 · see citing works
Mucoadhesive platforms for targeted delivery to the colon
Varum, F., Veiga, F., Sousa, J., & Basit, A. W. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.08.006 · Cited by 43 · see citing works
Toward Biopredictive Dissolution for Enteric Coated Dosage Forms
Al-Gousous, J., Amidon, G. L., & Langguth, P. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00077 · Cited by 42 · see citing works
Formulation and evaluation of enteric coated tablets of proton pump inhibitor.
Nair, A. B., Gupta, R., Kumria, R., Jacob, S., & Attimarad, M. (2010) · Europe PMC (PubMed Central) · Cited by 40 · see citing works
In-vitro and in-vivo evaluation of enteric-coated starch-based pellets prepared via extrusion/spheronisation
DUKICOTT, A., deBeer, T., Remon, J. P., Baeyens, W., Foreman, P., & Vervaet, C. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.04.019 · Cited by 40 · see citing works
Preparation andin vitroevaluation of 5-fluorouracil-loaded PCL nanoparticles for colon cancer treatment
Öztürk, K., Mashal, A. R., Yegin, B. A., & Çalış, S. (2015) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2015.1116565 · Cited by 40 · see citing works
International Commission on Radiological Protection
(1974) · Radiology · doi:10.1148/110.1.232c · Cited by 40 · see citing works
Oral Delivery of Macromolecular Drugs
Bernkop‐Schnürch, A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0200-9 · Cited by 39 · see citing works
Factorial designed 5-fluorouracil-loaded microsponges and calcium pectinate beads plugged in hydroxypropyl methylcellulose capsules for colorectal cancer
Gupta, A., Tiwari, G., Tıwarı, R., & Srivastava, R. K. (2015) · International Journal of Pharmaceutical Investigation · doi:10.4103/2230-973x.167688 · Cited by 39 · see citing works
In-vitroevaluation of enteric coated insulin tablets containing absorption enhancer and enzyme inhibitor
Wong, C. Y. J., Martinez, J., Carnagarin, R., & Dass, C. R. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12694 · Cited by 38 · see citing works
Pharmacokinetic study on gastrointestinal absorption of insulinomimetic vanadyl complexes in rats by ESR spectroscopy
Fugono, J., Yasui, H., & Sakurai, H. (2001) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357011776531 · Cited by 38 · see citing works
Design and in vivo evaluation of a patch delivery system for insulin based on thiolated polymers
Grabovac, V., Föger, F., & Bernkop‐Schnürch, A. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.06.052 · Cited by 37 · see citing works
Efficacy of Omeprazole Powder Paste or Enteric-Coated Formulation in Healing of Gastric Ulcers in Horses
Birkmann, K., Junge, H., Maischberger, E., Eser, M. W., & Schwarzwald, C. C. (2014) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12341 · Cited by 37 · see citing works
Enhanced gastric stability of esomeprazole by molecular interaction and modulation of microenvironmental pH with alkalizers in solid dispersion
Nguyen, H. V., Baek, N., & Lee, B. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.03.047 · Cited by 37 · see citing works
Enteric Coating Can Lead to Reduced Antiplatelet Effect of Low‐Dose Acetylsalicylic Acid
Haastrup, P., Grønlykke, T. B., & Jarbøl, D. E. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12362 · Cited by 36 · see citing works
Preparation and evaluation of duloxetine hydrochloride enteric-coated pellets with different enteric polymers
Chen, K., Sun, Y. H., Li, B. J., Fan, R., Zhang, J., Yao, Y., & He, Z. (2016) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2016.08.007 · Cited by 36 · see citing works
Unpredictable Performance of pH-Dependent Coatings Accentuates the Need for Improved Predictive in Vitro Test Systems
Al-Gousous, J., Tsume, Y., Fu, M., Salem, I. I., & Langguth, P. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00877 · Cited by 34 · see citing works
Immunologic Effects of Encapsulated Short Ragweed Extract: a Potent New Agent for Oral Immunotherapy
Litwin, A., Flanagan, M. P., Entis, G., Gottschlich, G. M., Michael, J. G., Esch, R. E., & Gartside, P. S. (1996) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63499-0 · Cited by 33 · see citing works
Overview of factors affecting oral drug absorption
Song, N., Zhang, S., & Liu, C. (2004) · Cited by 33 · see citing works
Accelerating the dissolution of enteric coatings in the upper small intestine: Evolution of a novel pH 5.6 bicarbonate buffer system to assess drug release
Varum, F., Merchant, H. A., Goyanes, Á., Assi, P., Zboranová, V., & Basit, A. W. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.04.019 · Cited by 33 · see citing works
Designing optimal formulations for hot-melt coating
Lopes, D. G., Salar-Behzadi, S., & Zimmer, A. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.08.086 · Cited by 33 · see citing works
Colon-targeted delivery of solubilized bisacodyl by doubly enteric-coated multiple-unit tablet
Park, H. J., Jung, H. J., Ho, M. J., Lee, D. R., Cho, H. R., Choi, Y. S., Jun, J.-H., Son, M., & Kang, M. J. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.03.006 · Cited by 31 · see citing works
Modulation of microenvironmental pH and utilization of alkalizers in crystalline solid dispersion for enhanced solubility and stability of clarithromicin
Park, J.-B., Park, Y.-J., Kang, C.-Y., & Lee, B. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0471-9 · Cited by 30 · see citing works
Enteric-coated sustained-release nanoparticles by coaxial electrospray: preparation, characterization, and in vitro evaluation
Hao, S., Wang, B., Wang, Y., & Xu, Y. (2014) · Journal of Nanoparticle Research · doi:10.1007/s11051-013-2204-2 · Cited by 30 · see citing works
The proton pump inhibitor pantoprazole and its interaction with enteric-coated mycophenolate sodium in transplant recipients
Kofler, S., Wolf, C., Shvets, N., Sisic, Z., Müller, T., Behr, J., Sohn, H., Vogeser, M., Shipkova, M., Meiser, B., et al. (2011) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2010.12.003 · Cited by 30 · see citing works
Use of bicarbonate buffer systems for dissolution characterization of enteric-coated proton pump inhibitor tablets
Shibata, H., Yoshida, H., Izutsu, K., & Goda, Y. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12540 · Cited by 30 · see citing works
Development and characterization of colon specific drug delivery system bearing 5-ASA and camylofine dihydrochloride for the treatment of ulcerative colitis
Dubey, R., Dubey, R., Omrey, P., Vyas, S. P., & Jain, S. (2010) · Journal of drug targeting · doi:10.3109/10611860903572933 · Cited by 29 · see citing works
Preparation and in vitro–in vivo evaluation of double layer coated and matrix sustained release pellet formulations of diclofenac potassium
Fu, J., Wang, X., Xu, L., Meng, J., Weng, Y., Li, G., He, H., & Tang, X. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.12.043 · Cited by 28 · see citing works
Formulation and in Vitro and in Vivo Availability of Diclofenac Sodium Enteric-Coated Beads
Hosny, E. A., El-Mahrouk, G. M., & Gouda, M. W. (1998) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049809082368 · Cited by 27 · see citing works
Development and characterization of enteric-coated microparticles of biochanin A for their beneficial pharmacological potential in estrogen deficient-hypertension
Sachdeva, C., Mishra, N., & Sharma, S. (2015) · Drug Delivery · doi:10.3109/10717544.2015.1114046 · Cited by 25 · see citing works
Preparation and in vitro/in vivo characterization of enteric-coated nanoparticles loaded with the antihypertensive peptide VLPVPR
Sun, H., Liu, D., Li, Y., Tang, X., & Cong, Y. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s56092 · Cited by 25 · see citing works
An Overview on Polymethacrylate Polymers in Gastroretentive Dosage Forms
Gupta, P., Kumar, M., & Sachan, N. (2015) · Open Pharmaceutical Sciences Journal · doi:10.2174/1874844901502010031 · Cited by 24 · see citing works
Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/In-vivo Evaluation in Induced Ulcerative Colitis in Rat.
Varshosaz, J., Emami, J., Tavakoli, N., Minaiyan, M., Rahmani, N., Dorkoosh, F. A., & Mahzouni, P. (2012) · Europe PMC (PubMed Central) · Cited by 23 · see citing works
Preparation and characterization of mucoadhesive enteric-coating ginsenoside-loaded microparticles
Baek, J.-S., Yeon, W.-G., Lee, C.-A., Hwang, S., Park, J., Kim, D.-C., & Cho, C. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0395-4 · Cited by 23 · see citing works
A Survey of the Stability of Omeprazole Products from 13 Countries
Davidson, A. G., & McCallum, A. (1996) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049609063235 · Cited by 23 · see citing works
Henderson—Hasselbalch Equation
Tallarida, R. J., & Murray, R. B. (1987) · Springer eBooks · doi:10.1007/978-1-4612-4974-0_24 · Cited by 22 · see citing works
Enteric-coating capsulation of insulinomimetic vanadyl sulfate enhances bioavailability of vanadyl species in rats
Fugono, J., Yasui, H., & Sakurai, H. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357021778916 · Cited by 22 · see citing works
An in vitro investigation on acid catalyzed reactions of proton pump inhibitors in the absence of an electrophile
Tutunji, M. F., Qaisi, A. M., El-Eswed, B. I., & Tutunji, L. F. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.05.057 · Cited by 22 · see citing works
Concurrent administration of cimetidine and enteric‐coated prednisolone: effect on plasma levels of prednisolone.
Morrison, P., Rogers, H., Bradbrook, I., & Parsons, C. (1980) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1980.tb00506.x · Cited by 22 · see citing works
Design and in Vitro/in Vivo Evaluation of Multi-layer Film Coated Pellets for Omeprazole
He, W., Fan, L., Du, Q. B., Xiang, B., Li, C., Bai, M., Yong-Zhen, C., & De-ying, C. (2009) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.57.122 · Cited by 21 · see citing works
Preparation and in vitro/in vivo evaluation of esomeprazole magnesium-modified release pellets
Kan, S.-L., Lü, J., Liu, J., & Zhao, Y. (2014) · Drug Delivery · doi:10.3109/10717544.2014.919545 · Cited by 21 · see citing works
Potential in vitro and in vivo colon specific anticancer activity in a HCT-116 xenograft nude mice model: targeted delivery using enteric coated folate modified nanoparticles
Khatik, R., Dwivedi, P., Junnuthula, V., Sharma, K., Chuttani, K., Mishra, A. K., & Mishra, A. K. (2015) · RSC Advances · doi:10.1039/c4ra15114c · Cited by 20 · see citing works
Preclinical models for colonic absorption, application to controlled release formulation development
Lozoya-Agulló, I., González‐Álvarez, I., Merino‐Sanjuán, M., Bermejo, M., & González‐Álvarez, M. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.07.008 · Cited by 17 · see citing works
Formulation-based approach to support early drug discovery and development efforts: a case study with enteric microencapsulation dosage form development for a triarylmethane derivative TRAM-34; a novel potential immunosuppressant
Al-Ghananeem, A. M., Abbassi, M., Shrestha, S., Raman, G., Wulff, H., Pereira, L., & Ansari, A. A. (2009) · Drug Development and Industrial Pharmacy · doi:10.3109/03639040903329554 · Cited by 17 · see citing works
In Vitro Evaluation of Nasogastric Tube Delivery Performance of Esomeprazole Magnesium Delayed-Release Capsules
Hoover, A., Sun, D. D., Wen, H., Jiang, W., Cui, M., Jiang, X., Keire, D. A., & Guo, C. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.04.008 · Cited by 17 · see citing works
Thymopentin-Loaded pH-Sensitive Chitosan Nanoparticles for Oral Administration: Preparation, Characterization, and Pharmacodynamics
Zheng, A., Wang, J., Lü, W.-L., Zhang, X., Zhang, H., Wang, X., & Zhang, Q. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.451 · Cited by 16 · see citing works
Interaction of omeprazole with enteric-coated salicylate tablets.
Nefesoglu, F. Z., Ayanoglu-Dülger, G., Ulusoy, N. B., & IMERYUZ, N. (1998) · PubMed · Cited by 15 · see citing works
Evaluation of polyvinyl acetate phthalate as an enteric coating material
Nesbitt, R. U., GOODHART, F., & GORDON, R. (1985) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(85)90231-5 · Cited by 14 · see citing works
Pharmacokinetics evaluation of soft agglomerates for prompt delivery of enteric pantoprazole-loaded microparticles
Raffin, R. P., Colomé, L. M., Hoffmeister, C. R. D., Colombo, P., Rossi, A., Sonvico, F., Colomé, L. M., Natalini, C. C., Pohlmann, A. R., & Costa, T. D. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.11.015 · Cited by 14 · see citing works
Effect of Antacid on Absorption of Enteric-Coated Aspirin
Feldman, S. L. (1974) · JAMA · doi:10.1001/jama.1974.03230190052026 · Cited by 14 · see citing works
Pharmacokinetics and Relative Bioavailability of a Fixed‐Dose Combination of Enteric‐Coated Naproxen and Non‐Enteric‐Coated Esomeprazole Magnesium
Wang‐Smith, L., Fort, J. G., Zhang, Y., & Sostek, M. B. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270011405500 · Cited by 14 · see citing works
Development of protocatechualdehyde proliposomes-based sustained-release pellets with improved bioavailability and desired pharmacokinetic behavior for angina chronotherapy
Zhang, S., Yan, H., Yu, P., Xia, Y., Zhang, W., & Liu, J. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.08.040 · Cited by 14 · see citing works
Bioavailability of enteric-coated microencapsulated calcium during pregnancy: a randomized crossover trial in Bangladesh
Roth, D. E., Pezzack, B., Mahmud, A. A., Abrams, S. A., Islam, M. M., Phillips, A., Baxter, J. B., Dimitris, M. C., Hawthorne, K. M., Ahmed, T., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.090621 · Cited by 14 · see citing works
Evaluation ofin-vitro dissolution andin-vivo absorption for two different film-coated pellets of clarithromycin
Zhang, X., Chen, X.-Y., Hu, L.-D., Tang, X., Li, S., & Zhong, D. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02973886 · Cited by 13 · see citing works
The Effects of Enteric Coating of Aspirin Tablets on Occult Gastrointestinal Blood Loss
Howe, G. B., Champion, G. D., Corrigan, A. B., Hewson, J. W., Haski, A., Day, R. O., Paull, P., & Graham, G. G. (1977) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1977.tb02315.x · Cited by 13 · see citing works
Enteric-coated tablets improve oral bioavailability of DX-9065, a novel anticoagulant
Fujii, Y., Kanamaru, T., Kikuchi, H., Yamashita, S., & Sakuma, S. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.01.003 · Cited by 12 · see citing works
Pharmacokinetics of Two Enteric-Coated Ketoprofen Products in Humans with or Without Coadministration of Omeprazole and Comparison with Dissolution Findings
Qureshi, S. A., Caillé, G., Lacasse, Y., & McGilveray, I. J. (1994) · Pharmaceutical Research · doi:10.1023/a:1018934526499 · Cited by 12 · see citing works
Nateglinide Controlled Release Tablet Containing Compressionable Enteric Coated Granules
Makino, C., Sakai, H., & Yabuki, A. (2010) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.58.1136 · Cited by 12 · see citing works
Enteric-coated mycophenolate sodium for transplant immunosuppression
Ingle, G. R., & Shah, T. (2005) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp040380 · Cited by 10 · see citing works
In vitro study of the interaction between omeprazole and the metal ions Zn(II), Cu(II), and Co(II).
Hamdan, I. I. (2001) · PubMed · Cited by 9 · see citing works
Absorption of digoxin from a new microencapsulated formulation
Bergdahl, B., Bogentoft, C. B., Jonsson, U. E., & Magnusson, J. O. (1980) · European Journal of Clinical Pharmacology · doi:10.1007/bf00570162 · Cited by 8 · see citing works
Formulation and Evaluation of Microparticles of Metronidazole
Ravi, J., Reddy, K. M., Gnanaprakash, K., Badarinath, A. V., & Chetty, C. M. S. (2010) · Cited by 8 · see citing works
Development of a novel bi-coated combination capsule containing mosapride and probiotics for irritable bowel syndrome
Kim, Y. I., Poudel, B. K., Pradhan, R., Choi, H., Yong, C. S., Woo, J. S., & Kim, J. O. (2014) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2014.954723 · Cited by 6 · see citing works
Preparation of pH-dependent modified-release pellets of urapidil to improve its bioavailability
He, H., Li, H., & Tang, X. (2010) · Pharmaceutical Development and Technology · doi:10.3109/10837451003592191 · Cited by 6 · see citing works
Novel naproxen/esomeprazole magnesium compound pellets based on acid-independent mechanism:in vitroandin vivoevaluation
Lü, J., Kan, S.-L., Zhao, Y., Zhang, W., & Liu, J. (2016) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2016.1151029 · Cited by 5 · see citing works
Oral Insulin Delivery with Various Grades of HPMC on Non-Diabetic Rats
Singh, J., Singh, G. P., Singh, N., & Kaur, H. (2011) · Trends in Medical Research · doi:10.3923/tmr.2011.1.13 · Cited by 4 · see citing works
Novel Formulations for Oral Allergen Vaccination
Polović, N., & Veličković, T. Ć. (2008) · Recent Patents on Inflammation & Allergy Drug Discovery · doi:10.2174/187221308786241956 · Cited by 4 · see citing works
Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption
Ho, P. C. (2011) · doi:10.1002/9781118067598.ch5 · Cited by 3 · see citing works
In vitroandin vivoevaluation of cellacephate microcapsules of sodium salicylate prepared by pan coating
O'connell, M. J. M., & Deasy, P. B. (1985) · Journal of Microencapsulation · doi:10.3109/02652048509031555 · Cited by 2 · see citing works
[In vitro study of a new pancreatic enzyme with high lipase content in enteric coated microtablets].
Vantini, I., Fioretta, A., Bonfante, F. P., Mt, B., Benini, L., & Castellani, G. (1993) · PubMed · Cited by 1 · see citing works

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Oral delivery of proteins and peptides: Challenges, status quo and future perspectives
Zhu, Q., Chen, Z., Paul, P. K., Lü, Y., Wu, W., & Qi, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.04.001 · Cited by 366 · see citing works
Designing antibodies as therapeutics
Carter, P. J., & Rajpal, A. (2022) · Cell · doi:10.1016/j.cell.2022.05.029 · Cited by 275 · see citing works
Chitin and Chitosan: Prospective Biomedical Applications in Drug Delivery, Cancer Treatment, and Wound Healing
Baharlouei, P., & Rahman, M. A. (2022) · Marine Drugs · doi:10.3390/md20070460 · Cited by 265 · see citing works
Microneedle-Based Delivery: An Overview of Current Applications and Trends
Guillot, A. J., Cordeiro, A. S., Donnelly, R. F., Montesinos, M. C., Garrigues, T., & Melero, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12060569 · Cited by 262 · see citing works
Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy
Zhang, D., Zhong, D., Ouyang, J., He, J., Qi, Y., Chen, W., Zhang, X., Tao, W., & Zhou, M. (2022) · Nature Communications · doi:10.1038/s41467-022-28744-4 · Cited by 257 · see citing works
Promising strategies for improving oral bioavailability of poor water-soluble drugs
Rocha, B., de Morais, L. A., Viana, M. C., & Carneiro, G. (2023) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2211801 · Cited by 109 · see citing works
Formulation Strategies to Improve the Stability and Handling of Oral Solid Dosage Forms of Highly Hygroscopic Pharmaceuticals and Nutraceuticals
Ng, L. H., Ling, J. K. U., & Hadinoto, K. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102015 · Cited by 95 · see citing works
pH and its applications in targeted drug delivery
Abdella, S., Abid, F., Youssef, S. H., Kim, S., Afinjuomo, F., Malinga, C., Song, Y., & Garg, S. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103414 · Cited by 85 · see citing works
Natural Macromolecules as Carriers for Essential Oils: From Extraction to Biomedical Application
Stevanović, Z. D., Sieniawska, E., Głowniak, K., Obradović, N. S., & Pajić‐Lijaković, I. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00563 · Cited by 83 · see citing works
Microneedles Drug Delivery Systems for Treatment of Cancer: A Recent Update
Seetharam, A. A., Choudhry, H., Bakhrebah, M. A., Abdulaal, W. H., Gupta, M. S., Rizvi, S. M. D., Alam, Q., Siddaramaiah, Gowda, D. V., & Moin, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111101 · Cited by 82 · see citing works
Dual-modified nanoparticles overcome sequential absorption barriers for oral insulin delivery
Xi, Z., Ahmad, E., Zhang, W., Li, J., Wang, A., Faridoon, Wang, N., Zhu, C., Huang, W., Xu, L., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.045 · Cited by 75 · see citing works
Multiscale Shellac-Based Delivery Systems: From Macro- to Nanoscale
Yuan, Y., He, N., Dong, L., Guo, Q., Zhang, X., Li, B., & Li, L. (2021) · ACS Nano · doi:10.1021/acsnano.1c07121 · Cited by 74 · see citing works
Niosome Preparation Techniques and Structure—An Illustrated Review
Mawazi, S. M., Ge, Y., & Widodo, R. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17010067 · Cited by 75 · see citing works
Spray-dried bacterial cellulose nanofibers: A new generation of pharmaceutical excipient intended for intestinal drug delivery
Meneguin, A. B., Barud, H. D. S., Sábio, R. M., de Sousa, P. Z., Manieri, K. F., de Freitas, L. A. P., Pacheco, G., Alonso, J. D., & Chorilli, M. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116838 · Cited by 61 · see citing works
Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives
Srebro, J., Brniak, W., & Mendyk, A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102043 · Cited by 61 · see citing works
Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease—An Overview
Lopes, S. A., Roque‐Borda, C. A., Duarte, J. L., Filippo, L. D. D., Cardoso, V. M. B., Pavan, F. R., Chorilli, M., & Meneguin, A. B. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112600 · Cited by 57 · see citing works
Oral Delivery of Therapeutic Antibodies with a Transmucosal Polymeric Carrier
Zhu, W., Chao, Y., Jin, Q., Chen, L., Shen, J., Zhu, J., Chai, Y., Lu, P., Yang, N., Chen, M., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c09266 · Cited by 56 · see citing works
Stomach pH before vs. after different bariatric surgery procedures: Clinical implications for drug delivery
Porat, D., Vaynshtein, J., Gibori, R., Avramoff, O., Shaked, G., Dukhno, O., Czeiger, D., Sebbag, G., & Dahan, A. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.01.016 · Cited by 51 · see citing works
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Ganesh, A. N., Heusser, C., Garad, S., & Sánchez-Félix, M. V. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100079 · Cited by 48 · see citing works
In Vitro Methodologies for Evaluating Colon-Targeted Pharmaceutical Products and Industry Perspectives for Their Applications
García, M. A., Varum, F., Al-Gousous, J., Hofmann, M., Page, S., & Langguth, P. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020291 · Cited by 42 · see citing works
Solid oral dosage forms
Awad, A., Trenfield, S. J., & Basit, A. W. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820007-0.00019-2 · Cited by 42 · see citing works
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Zhang, R., Dong, K., Wang, Z., Miao, R., Lu, W., & Wu, X. Y. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081261 · Cited by 39 · see citing works
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Sardou, H. S., Akhgari, A., Mohammadpour, A. H., Namdar, A. B., Kamali, H., Jafarian, A. H., Garekani, H. A., & Sadeghi, F. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.106072 · Cited by 39 · see citing works
Enteric coating of tablets containing an amorphous solid dispersion of an enteric polymer and a weakly basic drug: A strategy to enhance in vitro release
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Kenchegowda, M., Hani, U., Fatease, A. M. A., Haider, N., Ramesh, K. V., Talath, S., Gangadharappa, H. V., Raj, G. K., Padmanabha, S. H., & Osmani, R. A. M. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127172 · Cited by 36 · see citing works
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Roque‐Borda, C. A., Silva, H. R. L., Crusca, E., Serafim, J. A., Meneguin, A. B., Chorilli, M., Macedo, W. C., Teixeira, S. R., Guastalli, E. A. L., Soares, N. M., et al. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.05.011 · Cited by 31 · see citing works
Multidrug Resistance in Cancer Cells: Focus on a Possible Strategy Plan to Address Colon Carcinoma Cells
Karthika, C., Sureshkumar, R., Zehravi, M., Akter, R., Ali, F., Ramproshad, S., Mondal, B., Kundu, M. K., Dey, A., Rahman, M. H., et al. (2022) · Life · doi:10.3390/life12060811 · Cited by 30 · see citing works
Sustained release of insulin from silk microneedles
Cao, J., Liu, Y., Qi, Z., Tao, X., Kundu, S. C., & Lu, S. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103611 · Cited by 27 · see citing works
Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations
Nair, S. T., Kamalasanan, K., Moidu, A., Shyamsundar, P., Nair, L. J., & Venkatesan, P. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.05.156 · Cited by 26 · see citing works
Mucoadhesive nanocrystal-in-microspheres with high drug loading capacity for bioavailability enhancement of silybin
Wang, Y., Li, H., Wang, L., Han, J., Yang, Y., Fu, T., Qiao, H., Wang, Z., & Li, J. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111461 · Cited by 25 · see citing works
A novel natural GRAS-grade enteric coating for pharmaceutical and nutraceutical products
Khoder, M., Schropp, V., Zeitler, S., Pereira, B. C., Habashy, R., Royall, P. G., Wang, J. T.-W., & Alhnan, M. A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119392 · Cited by 25 · see citing works
Engineered nanomaterials for overcoming multifaceted gastrointestinal barriers: Toward precision oral delivery of therapeutics
Liu, Y., Liu, C., An, D.-Y., Deng, S., & Liu, G. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107844 · Cited by 25 · see citing works
The Effect of Capsule-in-Capsule Combinations on In Vivo Disintegration in Human Volunteers: A Combined Imaging and Salivary Tracer Study
Rump, A., Weiss, F. N., Schulz, L. A., Kromrey, M., Scheuch, E., Tzvetkov, M. V., White, T., Durkee, S., Judge, K. W., Jannin, V., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122002 · Cited by 23 · see citing works
Comparison of 5-ASA layered or matrix pellets coated with a combination of ethylcellulose and eudragits L and s in the treatment of ulcerative colitis in rats
Sardou, H. S., Sadeghi, F., Garekani, H. A., Akhgari, A., Jafarian, A. H., Abbaspour, M., & Nokhodchi, A. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122981 · Cited by 22 · see citing works
Modified drug release: Current strategies and novel technologies for oral drug delivery
Trenfield, S. J., & Basit, A. W. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818038-9.00006-5 · Cited by 21 · see citing works
Mesoporous silica nanoparticles: An emerging approach in overcoming the challenges with oral delivery of proteins and peptides
Pamshong, S. R., Bhatane, D., Sarnaik, S., & Alexander, A. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113613 · Cited by 20 · see citing works
Enteric-Coated Polymers Past and Present - A Review
Loh, Y. Y., Enose, A. A., & Garg, V. (2022) · Drug Delivery Letters · doi:10.2174/2210303112666220413081911 · Cited by 19 · see citing works
An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery
Guo, Y., Ji, S., Wang, W., Wong, S., Yen, C., Hu, C., Leung, D., Plise, E. G., Zhang, S. J., Zhang, C., et al. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04008 · Cited by 19 · see citing works
Challenges and Opportunities in the Oral Delivery of Recombinant Biologics
Masloh, S., Culot, M., Gosselet, F., Chevrel, A., Scapozza, L., & Labouebe, M. Z. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051415 · Cited by 19 · see citing works
Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity against HSV-1 and HSV-2 and Synergy with Antiviral Drugs
Yadavalli, T., Mallick, S., Patel, P. A., Koganti, R., Shukla, D., & Date, A. A. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00368 · Cited by 19 · see citing works
Cancer theranostics employing microneedles: Experimental and patented strategies
Alshammari, M. K., Albutayh, B. N. A., Alhabib, B., Alharbi, A. S., Almutairi, Y. S., Kamal, M., Aloraini, M. S., Alotaibi, M. M., Alhusayni, S. J., Al-Ahmad, I. F., et al. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104402 · Cited by 17 · see citing works
The impact of formulation design on the oral bioavailability of omega-3 polyunsaturated fatty acids
Abdelhafez, A., Khabir, Z., Prestidge, C. A., Garcia‐Bennett, A. E., & Joyce, P. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116171 · Cited by 16 · see citing works
Formulation and optimization of pH-sensitive nanocrystals for improved oral delivery
López-Vidal, L., Parodi, P., Actis, M. R., Camacho, N. M., Real, D. A., Paredes, A. J., Irazoqui, F. J., Real, J. P., & Palma, S. D. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01463-z · Cited by 16 · see citing works
Oral dosage forms for drug delivery to the colon: an existing gap between research and commercial applications
Martínez, E., Gamboa, J., Finkielstein, C. V., Cañas, A. I., Osorio, M., Vélez, Y., Llinas, N., & Castro, C. I. (2025) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-025-06868-5 · Cited by 15 · see citing works
Basic Aspects and Properties of Biopolymers
Mazuki, N. F., Saadiah, M. A., Fuzlin, A. F., Khan, N. M., & Samsudin, A. S. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839168048-00001 · Cited by 15 · see citing works
Forging a New Frontier: Antimicrobial Peptides and Nanotechnology Converging to Conquer Gastrointestinal Pathogens
Canales, C. S. C., Roque‐Borda, C. A., Cazorla, J. I. M., Cazorla, R. M. M., Apaza, U. J. P., Silva, V. D. J., Primo, L. M. D. G., Martínez‐Morales, M. J., Sábio, R. M., Santos, H. A., et al. (2025) · Small · doi:10.1002/smll.202501431 · Cited by 15 · see citing works
Chitosan-based oral hydrogel formulations of β-galactosidase to improve enzyme supplementation therapy for lactose intolerance
Fraile-Gutiérrez, I., Iglesias, S., Acosta, N., & Revuelta, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127755 · Cited by 14 · see citing works
Geriatric drug delivery ― barriers, current technologies and the road ahead
Kean, E. A., & Adeleke, O. A. (2024) · Journal of drug targeting · doi:10.1080/1061186x.2024.2386626 · Cited by 13 · see citing works
Formulation Strategy of BCS-II Drugs by Coupling Mechanistic In-Vitro and Nonclinical In-Vivo Data with PBPK: Fundamentals of Absorption-Dissolution to Parameterization of Modelling and Simulation
Shriya, V. A., Nayak, U. Y., Sathyanarayana, M. B., Chaudhari, B. B., & Bhat, K. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03093-9 · Cited by 13 · see citing works
Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers
Kubiatowicz, L. J., Pourafzal, N. N., Zhu, A. T., Guo, Z., Fang, R. H., & Zhang, L. (2025) · Small Methods · doi:10.1002/smtd.202500624 · Cited by 13 · see citing works
Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development
Gardey, E., Brendel, J. C., & Stallmach, A. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202400439 · Cited by 13 · see citing works
Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine
Tiwari, R., Kolli, M., Chauhan, S. S., & Yallapu, M. M. (2024) · ACS Nano · doi:10.1021/acsnano.4c00014 · Cited by 12 · see citing works
Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon
Tran, P. H. L., & Tran, T. T. D. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200917143816 · Cited by 12 · see citing works
Study of antimicrobial efficacy of garlic oil loaded ethosome against clinical microbial isolates of diverse origin
Kumar, A., Singh, B. R., Jay Prakash, S. N., Kumar, S., Bhagirathi, Ahuja, D., Abhishek, A., & Singh, P. P. (2023) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2023.100824 · Cited by 11 · see citing works
Colon targeting in rats, dogs and IBD patients with species-independent film coatings
Ferraro, F., Sonnleitner, L. M., Neut, C., Mahieux, S., Vérin, J., Siepmann, J., & Siepmann, F. (2024) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2024.100233 · Cited by 11 · see citing works
A Novel Alginate Film Based on Nanocoating Approach for Enteric-Release Tablets
Tran, B. N., Tran, K.-L., Nguyen, T.-T., Bui, L.-P. T., & Nguyen, C. N. (2023) · AAPS PharmSciTech · doi:10.1208/s12249-023-02557-0 · Cited by 11 · see citing works
Pharmacomagnetography to evaluate the performance of magnetic enteric-coated tablets in the human gastrointestinal tract
Pinto, L. A., Corá, L. A., Rodrigues, G. S., Prospero, A. G., Soares, G. A., Andreis, U., & Miranda, J. R. D. A. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.02.006 · Cited by 11 · see citing works
The combinative strategy for improving the intestinal stability and cellular absorption of curcumin by enteric coating of the optimized nanostructured lipid carriers
Won, J.-H., Jin, M., Na, Y., Song, B., Yun, T.-S., Hwang, Y.-R., Lee, S., Je, S., Kim, J., Lee, H.-K., et al. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105108 · Cited by 10 · see citing works
Evidence of Reliable Gastro-Resistance of Novel Enteric Ready-to-Fill Capsules Simplifying Pharmaceutical Manufacturing
Urich, J. A. A., Fedorko, A., Hölzer, B., & Khinast, J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112592 · Cited by 10 · see citing works
Advancements in Dissolving Microneedles for Effective Transdermal Delivery in Rheumatoid Arthritis Treatment
Peng, W., Goh, M., Lan, J., Du, M., & Chen, Z. (2025) · Advanced Materials Interfaces · doi:10.1002/admi.202500429 · Cited by 10 · see citing works
LIQUISOLID-PELLETS TECHNIQUE: A RECENT TECHNIQUE FOR ENHANCING SOLUBILITY AND BIOAVAILABILITY OF DRUGS
Kanugo, A. (2020) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2020v12i6.39510 · Cited by 10 · see citing works
Enteric complex layer-coated controlled release of capsaicin from phytosterol/γ-cyclodextrin microparticles via guest exchange reaction with taurocholic acid
Sasako, H., Koyama, K., Higashi, K., Ueda, K., Ishimoto, A., & Moribe, K. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.106038 · Cited by 10 · see citing works
The Influence of Omeprazole on the Dissolution Processes of pH-Dependent Magnetic Tablets Assessed by Pharmacomagnetography
Soares, G. A., Pires, D. W., Pinto, L. A., Rodrigues, G. S., Prospero, A. G., Biasotti, G. G. D. A., Bittencourt, G. N., Stoppa, E. G., Corá, L. A., de Oliveira, R. B., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081274 · Cited by 10 · see citing works
Micro/Nanomotors for Oral Delivery of Drugs: From Design to Application
Xie, C., Luo, Q., Zhang, Y., Fang, Q., Tu, Y., & Liu, K. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300057 · Cited by 9 · see citing works
Acid-Neutralizing Omeprazole Formulation for Rapid Release and Absorption
Ramesh, S., Zvoníček, V., Pěček, D., Pišlová, M., Beránek, J., Hofmann, J., & Dumičić, A. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020161 · Cited by 9 · see citing works
Obtaining and Characterization of Nutraceuticals Based on Linoleic Acid Derivatives Obtained by Green Synthesis and Their Valorization in the Food Industry
Dehelean, C. A., Boru, C., Macasoi, I. G., Dumitrel, Ș.-I., Trandafirescu, C. M., & Alexa, E. (2025) · Nutrients · doi:10.3390/nu17152416 · Cited by 9 · see citing works
Acute enteric-coated sodium bicarbonate has negligible effect on anaerobic performance but affects metabolomics and attenuates the gastrointestinal response
Zhou, N., Fan, Y., Wang, X., Wang, J., & Wu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.996381 · Cited by 8 · see citing works
“Enteric-coated sodium bicarbonate is chosen to be ingested 180 min before exercise due to the additional time required for digestion and absorption in the intestine (Maderuelo et al., 2019).”
Background
Pharmacokinetics and Brain Tumor Delivery Studies of Thymoquinone-Encapsulated Eudragit L100-Coated Solid-Lipid Nanoparticles
Pandi, J. S., Pavadai, P., Sundar, L. M., Murugesan, S., Theivendren, P., Pandian, S. R. K., & Kunjiappan, S. (2024) · Journal of Cluster Science · doi:10.1007/s10876-024-02751-5 · Cited by 8 · see citing works
Enhancing the pharmacokinetics of abiraterone acetate through lipid-based formulations: addressing solubility and food effect challenges
Taheri, A., Almasri, R., Wignall, A. D., Schultz, H. B., Elz, A. S., Ariaee, A., Bremmell, K. E., Joyce, P., & Prestidge, C. A. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01755-y · Cited by 7 · see citing works
Enteric-coating film effect on the delayed drug release of pantoprazole gastro-resistant generic tablets
Arafat, M., Sakkal, M., Bostanudin, M. F., Al-Hanbali, O. A., Yuvaraju, P., Beiram, R., Sadek, B. S., Akour, A. A., & Aburuz, S. (2023) · F1000Research · doi:10.12688/f1000research.140607.1 · Cited by 7 · see citing works
Introduction to different types of dosage forms and commonly used excipients
Barik, A., & Dhar, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91817-6.00002-4 · Cited by 7 · see citing works
Evaluation of the Metabolite Profile of Fish Oil Omega-3 Fatty Acids (n-3 FAs) in Micellar and Enteric-Coated Forms—A Randomized, Cross-Over Human Study
Ibi, A., Chang, C., Kuo, Y. C., Zhang, Y., Du, M., Roh, Y. S., Gahler, R. J., Hardy, M. L., & Solnier, J. (2024) · Metabolites · doi:10.3390/metabo14050265 · Cited by 7 · see citing works
Microdevices to successfully deliver orally administered drugs
Mazzoni, C., & Nielsen, L. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818038-9.00012-0 · Cited by 7 · see citing works
Suppositories with bioactive calcium phosphate nanoparticles for intestinal transfection and gene silencing
Hosseini, S., & Epple, M. (2020) · Nano Select · doi:10.1002/nano.202000150 · Cited by 7 · see citing works
Pharmaceutical polymers for modified drug delivery and controlled release
Sanjanwala, D., Mehta, N. V., & Patravale, V. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95496-9.00006-5 · Cited by 6 · see citing works
Oral Disintegrating Tablets of Proton Pump Inhibitors for Chronic Gastroesophageal Reflux Disease: An Update
Gupta, A., Akhtar, J., Rastogi, K., Badruddeen, B., Khan, M. I., & Ahmad, M. (2023) · Current Drug Research Reviews · doi:10.2174/2589977515666230221160449 · Cited by 6 · see citing works
Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
Marcelo, G. A., Montpeyó, D., Galhano, J., Martínez‐Máñez, R., Capelo, J. L., Lorenzo, J., Lodeiro, C., & Oliveira, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076612 · Cited by 7 · see citing works
The Effect of Alginate and κ-Carrageenan on the Stability of Pickering Emulsions Stabilized by Shellac-Based Nanoparticles
Delmar, K., Kablan, R., Amiram, G., Levi, C. S., Lesmes, U., & Bianco‐Peled, H. (2025) · Polysaccharides · doi:10.3390/polysaccharides6020035 · Cited by 5 · see citing works
Going green: Development of a sustainable lipid-based enteric coating formulation for low-dose aspirin multiparticulate systems
Schertel, S., Corzo, C., Leitner, L., Karrer, J., Engel, D. J., Teichmann, Y., Zimmer, A., & Salar-Behzadi, S. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121453 · Cited by 5 · see citing works
Silicon-Based Piezo Micropumps Enable Fully Flexible Drug Delivery Patterns
Plano, D., Kibler, S., Rudolph, N., Zett, O., & Dressman, J. (2024) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2024.01.003 · Cited by 5 · see citing works
Research progress on the performance of expandable systems for long-term gastric retention
Jin, X., Li, H., Zhang, W., Qin, K., & Wu, C. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.01.002 · Cited by 5 · see citing works
Modified Release 3D-Printed Capsules Containing a Ketoprofen Self-Nanoemulsifying System for Personalized Medical Application
Shaqour, B., Natsheh, H., Kittana, N., Jaradat, N. A., Abualhasan, M., Eid, A. M., Moqady, R., AbuHijleh, A., Alsaleem, S. A., Ratrout, S., et al. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00476 · Cited by 5 · see citing works
Effects of Enteric-Coated Formulation of Sodium Bicarbonate on Bicarbonate Absorption and Gastrointestinal Discomfort
Jiang, F.-L., Jeong, D.-H., Eom, S.-H., Lee, H.-M., Cha, B.-J., Park, J.-S., Kwon, R., Nam, J.-Y., Yu, H.-S., Heo, S.-H., et al. (2024) · Nutrients · doi:10.3390/nu16050744 · Cited by 4 · see citing works
“Given that sodium bicarbonate could become instable due to gastric acid, enteric coating might increase bicarbonate absorption while reducing its side effects [37–40].”
Background
Chrono-Colonic Delivery in Engineering Time-Responsive Systems for Site-Specific Therapy
Sarkar, R., Biswas, P., Mukherjee, D. R., Tanbir, S., Biswas, B., Rahaman, M. M., & Santra, S. (2025) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v15i10.7398 · Cited by 4 · see citing works
Exosome-like nanovesicles from acerola for CRISPR-Cas9 ribonucleoprotein delivery to the central nervous system
Nagamatsu, Y., Umezu, T., Hong, T., Niijima, T., Ohno, S.-I., Harada, Y., Kanekura, K., Ochiya, T., & Kuroda, M. (2026) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2026.102896 · Cited by 4 · see citing works
Viability and Gastrointestinal Tolerance of Commercial Probiotic Products
Azhar, M. A., Munaim, M. S. A., Hasan, M., & Zularisam, A. W. (2020) · International Journal of Pharma Medicine and Biological Sciences · doi:10.18178/ijpmbs.9.3.117-121 · Cited by 4 · see citing works
Nanoformulations-based functionalized boron nitride nanosheets delivering nicotinamide mononucleotide with enhanced in vitro anti-aging properties
AbouAitah, K., Turk, A., Bu, Y., Sabbagh, F., Lee, M. K., & Kim, B. S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106846 · Cited by 4 · see citing works
Next generation capsules: emerging technologies in capsule fabrication and targeted oral drug delivery
Millet, E., O’Shea, J. P., Griffin, B. T., Dumont, C., & Jannin, V. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107277 · Cited by 4 · see citing works
Enteric-Coated Cologrit Tablet Exhibit Robust Anti-Inflammatory Response in Ulcerative Colitis-like In-Vitro Models by Attuning NFκB-Centric Signaling Axis
Balkrishna, A., Singh, R., Gohel, V., Arora, S., Dev, R., Bhattacharya, K., & Varshney, A. (2022) · Pharmaceuticals · doi:10.3390/ph16010063 · Cited by 4 · see citing works
Design and Testing of a Superelastic Nitinol Tissue Attachment Mechanism for Long-Term Gastrointestinal Device Retention
Mau, M. M., Sarker, S., Harris, S. P., & Terry, B. S. (2023) · Journal of Medical Devices · doi:10.1115/1.4057058 · Cited by 4 · see citing works
The impact of triethyl citrate leaching from HPMC-phthalate based isolated films on film permeability and thermal properties
Jariwala, N., Preda, F.-M., Faure, A., & den Mooter, G. V. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126252 · Cited by 3 · see citing works
Calcified Phospholipid Complex of Glycyrrhizic Acid for an Enhanced Oral Absorption
Shi, Q., Yang, M., Li, J., Wang, W., Wu, T., & Yin, T. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00923 · Cited by 3 · see citing works
Exploring Immersion Coating as a Cost-Effective Method for Small-Scale Production of Enteric-Coated Gelatin Capsules
Sabbatini, B., Perinelli, D. R., Palmieri, G. F., Cespi, M., & Bonacucina, G. (2024) · Pharmaceuticals · doi:10.3390/ph17040433 · Cited by 3 · see citing works
Synthesis and characterization of Poly(N-Acryloyl 6-aminocaproic acid) for intestine-specific drug delivery
Kang, Y., Wu, D., Zhang, T., Zhang, Y., Zhong, Y., Chen, S. R., Wang, X., & Chai, X. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106760 · Cited by 3 · see citing works
Technical and regulatory perspective on acid stage dissolution assessed via optical coherence tomography (Part 1: Release Scenario)
Urich, J. A. A., Wolfgang, M., García, R. A. L., West, H., & Khinast, J. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126044 · Cited by 3 · see citing works
Advances in Pharmaceutical Coatings and Coating Materials
Ranjan, A., Adhikari, P., Verma, R. K., Parthiban, A., Singh, M., & Kumar, A. (2024) · doi:10.1002/9781394263172.ch7 · Cited by 3 · see citing works
Tableting of nanoparticle-based formulations for oral delivery: Enhancing biopharmaceutical performance
Peñaloza, S., Rozas, R., Núñez-Salinas, A., Pérez-Arancibia, R., Ortiz, A. C., Morales, J. O., & Arriagada, F. (2026) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-026-00606-0 · Cited by 2 · see citing works
Toward autonomous robotic-assisted and microrobotic surgery
Yang, S., Kang, B. H., Min, H., Wachs, J. P., Alambeigi, F., Desai, J. P., Dupont, P. E., Yaeger, K., Anderson, K., Kuntz, A., et al. (2026) · Science Advances · doi:10.1126/sciadv.aec4197 · Cited by 3 · see citing works
In vitro and in vivo particle coating for oral targeting and drug delivery
Benetti, C., Colombo, P., & Wong, T. W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-444-63240-1.00009-7 · Cited by 2 · see citing works

Enteric-coated mycophenolate sodium: results of two pivotal global multicenter trials
Granger, D. K. (2001) · Transplantation Proceedings · doi:10.1016/s0041-1345(01)02378-8 · Cited by 54 · see citing works
Enteric coating of mycophenolate sodium: a rational approach to limit topical gastrointestinal lesions and extend the therapeutic index of mycophenolate
Bjarnason, I. (2001) · Transplantation Proceedings · doi:10.1016/s0041-1345(01)02377-6 · Cited by 60 · see citing works
Effect of Dissolving pH of Enteric Coating Agent on Bioavailability of Enteric Coated Tablets of Erythromycin in Man
Watanabe, Y., SANO, M., Motohashi, K., & Yoneda, R. (1978) · YAKUGAKU ZASSHI · doi:10.1248/yakushi1947.98.8_1092 · Cited by 4 · see citing works
A review on recent advances of enteric coating
Hussan, S. D. (2012) · IOSR Journal of Pharmacy (IOSRPHR) · doi:10.9790/3013-2610511 · Cited by 74 · see citing works
Unpredictable Performance of pH-Dependent Coatings Accentuates the Need for Improved Predictive in Vitro Test Systems
Al-Gousous, J., Tsume, Y., Fu, M., Salem, I. I., & Langguth, P. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00877 · Cited by 34 · see citing works

Authors: Maderuelo, C., Lanao, J. M., & Zarzuelo, A.
Affiliations: Universidad de Salamanca (ES)
ORCID: Maderuelo, Cristina
Lanao, Jose M.
Venue: European Journal of Pharmaceutical Sciences
Publisher: Elsevier BV
Published: 2019-10
Volume: 138
Pages: 105019
ISSN: 0928-0987 (ISSN-L)
DOI: 10.1016/j.ejps.2019.105019
OpenAlex: W2965827201
Cited by: 147
References: 157
Citations by year: 2026: 17 · 2025: 31 · 2024: 19 · 2023: 24 · 2022: 24 · 2021: 16 · 2020: 16
FWCI: 1.34
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: European Journal of Pharmaceutical Sciences (publishedVersion)
PubMed (publishedVersion)
Gredos (University of Salamanca) (publishedVersion, cc-by)
Hispana (submittedVersion, cc-by)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: enteric coating, oral solid dosage forms, drug bioavailability, gastrointestinal pH, gastroprotection, multiparticulate dosage forms, gastrointestinal transit time, gastric emptying, interindividual variability
MeSH terms: Administration, Oral, Biological Availability, Chemistry, Pharmaceutical, Dosage Forms, Pharmaceutical Preparations, Gastric Emptying, Gastrointestinal Transit, Humans, Drug Delivery Systems

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Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability

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