Cited by 439Advanced Drug Delivery SystemsAdvancements in Transdermal Drug DeliveryNanoparticle-Based Drug Delivery

Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes

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Wu, Iren Yeeling, Bala, Sonali, Škalko-Basnet, Nataša, di Cagno, Massimiliano Pio·2019·European Journal of Pharmaceutical Sciences

Abstract

The aim of this work was to clarify the dynamics behind the influence of ionic strength on the changes in drug release from large unilamellar vesicles (LUVs). For this purpose, we have investigated the transport of two different model drugs (caffeine and hydrocortisone) formulated into liposomes through different types of barriers with different retention properties (regenerated cellulose and the newly introduced biomimetic barrier, Permeapad®). Drug release from liposomes was studied utilizing the standard Franz diffusion cells. LUV dispersions were exposed to the isotonic, hypotonic and hypertonic environment (difference of 300 mOsm/kg between the initial LUVs and the environment) and experimental data treated with both linear and non-linear (Korsmeyer-Peppas) regression models. To alter the rigidity of the liposomal membranes, cholesterol was introduced in the liposomal barriers (up to 25% w/w). Korsmeyer-Peppas model was proven to be suited to analyse experimental data throughout the experimental time frame, providing important additive information in comparison to standard linear approximation. The obtained results are highly relevant as they improve the interpretation of drug release kinetics from LUVs under osmotic stress. Moreover, the findings can be utilized in the development of liposomal formulations intended for nose-to-brain targeted drug delivery.

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Crossref · 10.1016/j.ejps.2019.105026

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Authors
Wu, I. Y., Bala, S., Škalko-Basnet, N., & di Cagno, M. P.
Affiliations
UiT The Arctic University of Norway (NO)
Venue
European Journal of Pharmaceutical Sciences
Publisher
Elsevier BV
Published
2019-10
Volume
138
Pages
105026
ISSN
0928-0987 (ISSN-L)
OpenAlex
W2966544855
Cited by
439
References
50
Citations by year
2026: 90 · 2025: 107 · 2024: 78 · 2023: 63 · 2022: 47 · 2021: 31 · 2020: 22 · 2019: 1
FWCI
10.77
Type
journal article
Language
en
Open access
Locations
  • European Journal of Pharmaceutical Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
Funders
University of Tromsø - The Arctic University of Norway
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
liposomes, drug release kinetics, Korsmeyer-Peppas model, large unilamellar vesicles, ionic strength, osmotic stress, caffeine, cortisol, cholesterol, membrane rigidity, nose-to-brain delivery, Franz diffusion cell
MeSH terms
Cholesterol, Diffusion, Pharmaceutical Preparations, Kinetics, Liposomes, Membranes, Drug Delivery Systems, Drug Liberation

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