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Complex mechanics of the heterogeneous extracellular matrix in cancer
Open accessAbstract
The extracellular matrix (ECM) performs many critical functions, one of which is to provide structural and mechanical integrity, and many of the constituent proteins have clear mechanical roles. The composition and structural characteristics of the ECM are widely variable among different tissues, suiting diverse functional needs. In diseased tissues, particularly solid tumors, the ECM is complex and influences disease progression. Cancer and stromal cells can significantly influence the matrix composition and structure and thus the mechanical properties of the tumor microenvironment (TME). In this review, we describe the interactions that give rise to the structural heterogeneity of the ECM and present the techniques that are widely employed to measure ECM properties and remodeling dynamics. Furthermore, we review the tools for measuring the distinct nature of cell-ECM interactions within the TME.
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“The ability to exert local control over chemical and mechanical properties allows researchers to duplicate the heterogeneity in stiffness and composition found in organs, generate interfaces between materials similar to those found in the ECM, and duplicate essential elements of material microstructure; each of these controls has implications for organ function and disease131,132.”
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Cites
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151
Alberts, B., Johnson, A. D., Lewis, J. H., RAFF, M. C., Roberts, K. J., & Walter, P. (2007) · W.W. Norton eBooks · doi:10.1201/9780203833445 · Cited by 4,591
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101
Tensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941
Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains
Ritter, M., Schmidt, S., Jakab, M., Paulmichl, M., & Henderson, R. M. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350122 · Cited by 3,923
Tumour-cell invasion and migration: diversity and escape mechanisms
Friedl, P., & Wolf, K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1075 · Cited by 3,350
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Mao, X., Xu, J., Wang, W., Liang, C., Hua, J., Liu, J., Zhang, B., Meng, Q., Yu, X., & Shi, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01428-1 · Cited by 2,290
Cox, T. R. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-020-00329-7 · Cited by 1,015
Fiori, M. E., Franco, S. D., Villanova, L., Bianca, P., Stassi, G., & Maria, R. D. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0994-2 · Cited by 661
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Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 546
Towards organoid culture without Matrigel
Kozlowski, M. T., Crook, C. J., & Ku, H. T. (2021) · Communications Biology · doi:10.1038/s42003-021-02910-8 · Cited by 409
Collagen in tendon, ligament, and bone healing. A current review.
Liu, S. H., Yang, R. S., Al-Shaikh, R. A., & Lane, J. M. (1995) · PubMed · Cited by 323
Mierke, C. T. (2019) · Reports on Progress in Physics · doi:10.1088/1361-6633/ab1628 · Cited by 267
The mechanics of fibrillar collagen extracellular matrix
Sun, B. (2021) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2021.100515 · Cited by 235
Urbanczyk, M., Layland, S. L., & Schenke‐Layland, K. (2019) · Matrix Biology · doi:10.1016/j.matbio.2019.11.005 · Cited by 201
Metabolic heterogeneity in cancer
Demicco, M., Liu, X., Leithner, K., & Fendt, S. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00963-z · Cited by 186
He, X., Yang, Y., Han, Y., Cao, C., Zhang, Z., Li, L., Xiao, C., Guo, H., Wang, L., Han, L., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209260120 · Cited by 159
Decellularized Extracellular Matrix for Bioengineering Physiomimetic 3D in Vitro Tumor Models
Ferreira, L. P., Gaspar, V. M., & Mano, J. F. (2020) · Trends in Biotechnology · doi:10.1016/j.tibtech.2020.04.006 · Cited by 153
Zhang, C., Qin, C., Dewanjee, S., Bhattacharya, H., Chakraborty, P., Jha, N. K., Gangopadhyay, M., Jha, S. K., & Liu, Q. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01932-0 · Cited by 134
Ouni, E., Bouzin, C., Dolmans, M., Marbaix, É., Ruys, S. P. D., Vertommen, D., & Amorim, C. A. (2020) · Human Reproduction · doi:10.1093/humrep/deaa100 · Cited by 132
Xin, Y., Li, K., Huang, M. L., Liang, C., Siemann, D. W., Wu, L., Tan, Y., & Tang, X. (2023) · Oncogene · doi:10.1038/s41388-023-02844-x · Cited by 134
Unravelling cell migration: defining movement from the cell surface
Merino-Casallo, F., Gómez‐Benito, M. J., Hervás-Raluy, S., & García‐Aznar, J. M. (2022) · Cell Adhesion & Migration · doi:10.1080/19336918.2022.2055520 · Cited by 123
Recent advances in regenerative medicine strategies for cancer treatment
Mansouri, V., Beheshtizadeh, N., Gharibshahian, M., Sabouri, L., Varzandeh, M., & Rezaei, N. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111875 · Cited by 115
3D Cancer Models: The Need for a Complex Stroma, Compartmentalization and Stiffness
Pape, J., Emberton, M., & Cheema, U. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.660502 · Cited by 99
3D In Vitro Models for Investigating the Role of Stiffness in Cancer Invasion
Micalet, A., Moeendarbary, E., & Cheema, U. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01530 · Cited by 100
Self-citationAnguiano, M., Morales, X., Castilla, C., Rodríguez‐Pena, A., Ederra, C., Martı́nez, M., Ariz, M., Esparza, M., Amaveda, H., Mora, M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0220019 · Cited by 92
Privat‐Maldonado, A., Bengtson, C., Razzokov, J., Smits, E., & Bogaerts, A. (2019) · Cancers · doi:10.3390/cancers11121920 · Cited by 90
Mechanical signatures in cancer metastasis
Agrawal, A., Javanmardi, Y., Watson, S. A., Serwinski, B., Djordjevic, B., Li, W., Aref, A. R., Jenkins, R. W., & Moeendarbary, E. (2025) · npj Biological Physics and Mechanics. · doi:10.1038/s44341-024-00007-x · Cited by 89
Self-citationMechanical forces in the tumor microenvironment: roles, pathways, and therapeutic approaches
Zhang, Y., Fu, Q., Sun, W., Yue, Q., He, P., Niu, D., & Zhang, M. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06306-8 · Cited by 92
Mimicking the Natural Basement Membrane for Advanced Tissue Engineering
Jain, P., Rauer, S. B., Möller, M., & Singh, S. (2022) · Biomacromolecules · doi:10.1021/acs.biomac.2c00402 · Cited by 86
Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma
Zhang, J., Gu, C., Song, Q., Zhu, M., Xu, Y., Xiao, M., & Zheng, W. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00488-y · Cited by 79
Addressing Patient Specificity in the Engineering of Tumor Models
Bray, L. J., Hutmacher, D. W., & Bock, N. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00217 · Cited by 79
Mechanical Cues Affect Migration and Invasion of Cells From Three Different Directions
Mierke, C. T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.583226 · Cited by 80
Zhu, H.-E., Chen, H., Wang, J., Zhou, L., & Liu, S. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s194568 · Cited by 75
Deptuła, P., Łysik, D., Pogoda, K., Cieśluk, M., Namiot, A., Mystkowska, J., Król, G., Głuszek, S., Janmey, P. A., & Bucki, R. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00975 · Cited by 74
The role of extracellular matrix viscoelasticity in development and disease
Courbot, O., & Elósegui-Artola, A. (2025) · npj Biological Physics and Mechanics. · doi:10.1038/s44341-025-00014-6 · Cited by 77
Exploring the clinical value of tumor microenvironment in platinum-resistant ovarian cancer
Ghoneum, A., Almousa, S., Warren, B., Abdulfattah, A. Y., Shu, J., Abouelfadl, H., Gonzalez, D., Livingston, C., & Said, N. A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.024 · Cited by 72
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Sun, I., Yoon, H. Y., Lim, D., & Kim, K. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00082 · Cited by 68
Metastasis: crosstalk between tissue mechanics and tumour cell plasticity
Coban, B., Bergonzini, C., Zweemer, A. J. M., & Danen, E. H. J. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01150-7 · Cited by 62
Zhang, Y., Pei, P., Zhou, H., Xie, Y., Yang, S., Shen, W., Hu, L. T., Zhang, Y., Liu, T., & Yang, K. (2023) · ACS Nano · doi:10.1021/acsnano.2c12463 · Cited by 62
For and against tumor microenvironment: Nanoparticle-based strategies for active cancer therapy
Karimi, S., Bakhshali, R., Bolandi, S., Zahed, Z., Zadeh, S. S. M., Zenjanab, M. K., & Jahanban‐Esfahlan, R. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101626 · Cited by 60
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Colin‐York, H., Javanmardi, Y., Barbieri, L., Li, D., Korobchevskaya, K., Guo, Y., Hall, C. M., Taylor, A., Khuon, S., Sheridan, G. K., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b01196 · Cited by 60
Self-citationGarcia‐Gonzalez, D., Moreno, M. Á., Valencia, L., Árias, A., & Velasco, D. (2021) · Composites Part B Engineering · doi:10.1016/j.compositesb.2021.108796 · Cited by 60
Organotypic 3D decellularized matrix tumor spheroids for high-throughput drug screening
Ferreira, L. P., Gaspar, V. M., Mendes, L., Duarte, I. F., & Mano, J. F. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120983 · Cited by 59
Engineering extracellular matrix to improve drug delivery for cancer therapy
He, X., Yang, Y., Li, L., Zhang, P., Guo, H., Liu, N., Yang, X., & Xu, F. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.06.029 · Cited by 54
Tran, M. G. B., Latifoltojar, A., Neves, J. B., Papoutsaki, M., Gong, F., Comment, A., Costa, A. S. H., Glaser, M., Tran‐Dang, M., Sheikh, S. E., et al. (2019) · BJR|case reports · doi:10.1259/bjrcr.20190003 · Cited by 53
Ansardamavandi, A., & Tafazzoli‐Shadpour, M. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119103 · Cited by 53
Matrix stiffness regulates microvesicle-induced fibroblast activation
Schwager, S. C., Bordeleau, F., Zhang, J., Antonyak, M. A., Cerione, R. A., & Reinhart-King, C. A. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00418.2018 · Cited by 50
Role of tumour-derived exosomes in metastasis
Bai, S., Wei, Y., Liu, R., Xu, R., Li, X., & Du, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112657 · Cited by 50
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Lee, G., Han, S., Lee, J., Kim, H., & Kim, D. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01230 · Cited by 47
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Ladányi, A., & Tímár, J. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.011 · Cited by 42
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Ebata, H., Moriyama, K., Kuboki, T., & Kidoaki, S. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119647 · Cited by 39
Brill‐Karniely, Y., Dror, D., Duanis‐Assaf, T., Goldstein, Y., Schwob, O., Millo, T., Orehov, N., Stern, T., Jaber, M., Loyfer, N., et al. (2020) · Science Advances · doi:10.1126/sciadv.aax2861 · Cited by 37
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Spill, F., Bakal, C., & Mak, M. (2018) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2018.07.002 · Cited by 36
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Zhu, S., Zhang, T., Gao, H., Jin, G., Yang, J., He, X., Guo, H., & Xu, F. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300103 · Cited by 33
Mierke, C. T. (2024) · Biomolecules · doi:10.3390/biom14020184 · Cited by 33
Hervás-Raluy, S., Wirthl, B., Guerrero, P. E., Rei, G. R., Nitzler, J., Coronado, E., de Mora, J. F., Schrefler, B. A., Gómez‐Benito, M. J., García‐Aznar, J. M., et al. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106895 · Cited by 31
Korgaonkar, N., & Yadav, K. S. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117060 · Cited by 30
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Avendano, A., Cortes-Medina, M. G., & Song, J. W. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00006 · Cited by 29
Gong, Z., Wisdom, K. M., McEvoy, E., Chang, J., Adebowale, K., Price, C. C., Chaudhuri, O., & Shenoy, V. B. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109047 · Cited by 29
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Self-citationTang, K., Zheng, Y., Hu, G., Xin, Y., Li, K., Zhang, C., Chen, X., Zhang, B., Li, X., Hu, B., et al. (2025) · Science Advances · doi:10.1126/sciadv.adq2881 · Cited by 28
Pokki, J., Zisi, I., Schulman, E., Indana, D., & Chaudhuri, O. (2021) · Biomedical Microdevices · doi:10.1007/s10544-021-00547-2 · Cited by 27
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Self-citationMicalet, A., Pape, J., Bakkalci, D., Javanmardi, Y., Hall, C. M., Cheema, U., & Moeendarbary, E. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201749 · Cited by 28
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Yi, X., Jin, X., Hu, Y., Shen, Z., Zheng, X., Luo, D., Xu, T., Yan, J., & Huang, P. C. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00474 · Cited by 25
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Hoang, V. T., Matossian, M. D., Uçar, D. A., Elliott, S. G., La, J., Wright, M. K., Burks, H. E., Perles, A., Hossain, F. M., King, C. T., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01164 · Cited by 24
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Cheung, B. C. H., Abbed, R. J., Wu, M., & Leggett, S. E. (2024) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-103122-031130 · Cited by 23
Bowers, H. J., Fannin, E. E., Thomas, A., & Weis, J. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68324-4 · Cited by 23
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Garcia‐Gonzalez, D., & Muñoz‐Barrutia, A. (2020) · Extreme Mechanics Letters · doi:10.1016/j.eml.2020.100928 · Cited by 23
Millet, M., Messaoud, R. B., Luthold, C., & Bordeleau, F. (2019) · Micromachines · doi:10.3390/mi10060418 · Cited by 24
Begum, H. M., Ta, H. P., Zhou, H., Ando, Y., Kang, D. S., Nemes, K., Mariano, C. F., Hao, J., Yu, M., & Shen, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-47593-8 · Cited by 22
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Evans, J. J., Alkaisi, M. M., & Sykes, P. H. (2019) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-019-00888-z · Cited by 20
Desa, D. E., Strawderman, R. L., Wu, W., Hill, R. L., Smid, M., Martens, J. W. M., Turner, B. M., & Brown, E. B. (2020) · BMC Cancer · doi:10.1186/s12885-020-07713-4 · Cited by 22
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Dehghani, H., & Zilian, A. (2020) · Computational Mechanics · doi:10.1007/s00466-020-01868-4 · Cited by 21
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Li, X., Liu, J., Sun, H., Zou, Y., Chen, J., Chen, Y., Chen, C., & Wu, X. (2020) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5158 · Cited by 19
Sikic, L., Schulman, E., Kosklin, A., Saraswathibhatla, A., Chaudhuri, O., & Pokki, J. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c01327 · Cited by 19
Cooley, M. B., Wulftange, W. J., Wegierak, D., Goreke, U., Abenojar, E., Gurkan, U. A., & Exner, A. A. (2023) · Lab on a Chip · doi:10.1039/d3lc00514c · Cited by 18
Kolbe, N., Sfakianakis, N., Stinner, C., Surulescu, C., & Lenz, J. (2020) · Discrete and Continuous Dynamical Systems - B · doi:10.3934/dcdsb.2020284 · Cited by 18
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Hassan, G., Afify, S. M., Kitano, S., Seno, A., Ishii, H., Shang, Y., Matsusaki, M., & Seno, M. (2020) · Processes · doi:10.3390/pr9010045 · Cited by 17
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Metadata
- Authors
- Malandrino, A., Mak, M., Kamm, R. D., & Moeendarbary, E.
- Affiliations
- European Molecular Biology Laboratory (ES)
- Yale University (US)
- Massachusetts Institute of Technology (US)
- University College London (GB)
- Corresponding author
- Malandrino, Andrea
- Mak, Michael
- Kamm, Roger D.
- Moeendarbary, Emad
- Venue
- Extreme Mechanics Letters
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 21
- Pages
- 25-34
- ISSN
- 2352-4316 (ISSN-L)
- PMC
- PMC6097546
- OpenAlex
- W2794352591
- Cited by
- 192
- References
- 136
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 12 · 2023: 28 · 2022: 20 · 2021: 35 · 2020: 36 · 2019: 27 · 2018: 4
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Extreme Mechanics Letters (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- UCL Discovery (University College London) (submittedVersion)
- Elsevier eBooks
- Funders
- People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (625500)
- U.S. National Cancer Institute (U01 CA202177-01)
- Cancer Research UK Multidisciplinary Award (C57744/A22057)
- Wellcome Trust-Massachusetts Institute of Technology Fellowship (WT103883)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Keywords
- extracellular matrix, tumor microenvironment, extracellular matrix remodeling, cell-matrix interactions, cancer, tumor stroma, ECM composition
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