Complex mechanics of the heterogeneous extracellular matrix in cancer

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Tissue Cells Feel and Respond to the Stiffness of Their Substrate

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Tensional homeostasis and the malignant phenotype

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Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains

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Microfluidic Templating of Spatially Inhomogeneous Protein Microgels

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Organoids as Complex In Vitro Models for Studying Radiation-Induced Cell Recruitment

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Machine learning and artificial intelligence: Enabling the clinical translation of atomic force microscopy-based biomarkers for cancer diagnosis

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A microstructure-based modeling approach to assess aging-sensitive mechanics of human intervertebral disc

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Nanomechanical Hallmarks of Helicobacter pylori Infection in Pediatric Patients

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Enhanced cancer cell invasion caused by fibroblasts when fluid flow is present

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Stromal cells regulate mechanics of tumour spheroid

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Dermal fibroblasts and triple-negative mammary epithelial cancer cells differentially stiffen their local matrix

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A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment

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Oxygen-dependent contraction and degradation of the extracellular matrix mediated by interaction between tumor and endothelial cells

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Identification of Hub lncRNAs Along With lncRNA-miRNA-mRNA Network for Effective Diagnosis and Prognosis of Papillary Thyroid Cancer

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Coupling of Fibrin Reorganization and Fibronectin Patterning by Corneal Fibroblasts in Response to PDGF BB and TGFβ1

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Biological gel-based microchamber array for tumor cell proliferation and migration studies in well-controlled biochemical gradients

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Finite element analysis of the influence of cyclic strain on cells anchored to substrates with varying properties

Banerjee, A., Khan, M. P., Barui, A., Datta, P., Chowdhury, A. R., & Bhowmik, K. (2021) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-021-02453-4 · Cited by 10

Evaluation of femtosecond-LA-ICP-TOFMS for multi-elemental mapping at cellular resolution of human-tissue from cancer patients

Pisonero, J., Calon, A., Linares, J., Méndez-Vicente, A., Nistal, A. M., & Bordel, N. (2024) · Optics & Laser Technology · doi:10.1016/j.optlastec.2024.111527 · Cited by 9

Impact of the ECM on the Mechanical Memory of Cancer Cells

Mierke, C. T. (2025) · Cells · doi:10.3390/cells14211707 · Cited by 10

A lesson from earthquake engineering for selectively damaging cancer cell structures

Fraldi, M., Cutolo, A., Carotenuto, A. R., Palumbo, S., & Pugno, N. M. (2021) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2021.104533 · Cited by 9

Biomaterial-based platforms for cancer stem cell enrichment and study

Luo, C., Ding, Z. J., Tu, Y., Tan, J., Luo, Q., & Song, G. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0420 · Cited by 9

Tumor growth towards lower extracellular matrix conductivity regions under Darcy’s Law and steady morphology

Zheng, X., Zhao, K., Jackson, T. L., & Lowengrub, J. S. (2022) · Journal of Mathematical Biology · doi:10.1007/s00285-022-01759-7 · Cited by 8

Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis

Li, L., Sun, B., & Sun, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.998417 · Cited by 8

Remodelling of the fibre-aggregate structure of collagen gels by cancer-associated fibroblasts: A time-resolved grey-tone image analysis based on stochastic modelling

Gommes, C., Louis, T., Bourgot, I., Noël, A., Blacher, S., & Maquoi, E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.988502 · Cited by 8

Patient-Derived Xenografts as an Innovative Surrogate Tumor Model for the Investigation of Health Disparities in Triple Negative Breast Cancer

Matossian, M. D., Giardina, A. A., Wright, M. K., Elliott, S. G., Loch, M. M., Nguyen, K., Zea, A. H., Lau, F. H., Moroz, K., Riker, A. I., et al. (2020) · Women s Health Reports · doi:10.1089/whr.2020.0037 · Cited by 9

Environment-responsive polydopamine nanoparticle cross-linked phenylboronic-grafted hyaluronic acid with enzyme-like properties for tumor synergistic therapy

Ji, Q., Zhu, M., Li, X., CHENG, W. ‐., & Fang, Z. (2025) · Nanoscale · doi:10.1039/d5nr00964b · Cited by 7

Transcriptome profiling of patient-derived tumor xenografts suggests novel extracellular matrix-related signatures for gastric cancer prognosis prediction

Deng, Z., Guo, T., Bi, J., Wang, G., Hu, Y., Du, H., Zhou, Y., Jia, S., Xing, X., & Ji, J. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04473-0 · Cited by 7

Deciphering the immunological and prognostic features of bladder cancer through platinum-resistance-related genes analysis and identifying potential therapeutic target P4HB

Xiong, S., Li, S., Zeng, J., Nie, J., Liu, T., Liu, X., Chen, L., Fu, B., Deng, J., & Xu, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1253586 · Cited by 7

Identifying key genes and small molecule compounds for nasopharyngeal carcinoma by various bioinformatic analysis

Fang, L., Shi, L., Wang, W., Chen, Q., & Rao, X. (2021) · Medicine · doi:10.1097/md.0000000000027257 · Cited by 8

The Protein Mat(ters)—Revealing the Biologically Relevant Mechanical Contribution of Collagen- and Fibronectin-Coated Micropatterns

Horvath, A. N., Holenstein, C. N., Silván, U., & Snedeker, J. G. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b12430 · Cited by 7

Hippo signaling in mechanobiology: Mechanical control of YAP/TAZ and their roles in disease

Kim, Y., Lee, H., Lee, J.-H., Kim, W., & Cha, B. (2026) · Mechanobiology · doi:10.1177/29780241261430920 · Cited by 7

Single Cell Micro-Pillar-Based Characterization of Endothelial and Fibroblast Cell Mechanics

Eckert, J., Abouleila, Y., Schmidt, T., & Mashaghi, A. (2021) · Micro · doi:10.3390/micro1020018 · Cited by 5

Application of cell laden hydrogels with temporally tunable stiffness in biomedical research

Ahmadiankia, N., Goli-Malekabadi, Z., & Pournaghmeh, S. (2023) · Journal of Biomaterials Applications · doi:10.1177/08853282231182491 · Cited by 5

Elastography mapped by deep convolutional neural networks

Liu, D., Kruggel, F., & Sun, L. (2021) · Science China Technological Sciences · doi:10.1007/s11431-020-1726-5 · Cited by 5

Mathematical Models for Ultrasound Elastography: Recent Advances to Improve Accuracy and Clinical Utility

Farajpour, A., & Ingman, W. V. (2024) · Bioengineering · doi:10.3390/bioengineering11100991 · Cited by 4

Rapid curing dynamics of PEG-thiol-ene resins allow facile 3D bioprinting and in-air cell-laden microgel fabrication

Jang, L. K., Ahlquist, J., Ye, C., Trujillo, J., Triplett, M., Moya, M. L., Robertson, C., Hynes, W. F., & Wasson, E. M. (2024) · Biomedical Materials · doi:10.1088/1748-605x/ad8540 · Cited by 4

New perspectives on the potential mechanisms, prevention and treatment of deep vein thrombosis complicated by lung cancer

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Deep learning reveals how cells pull, buckle, and navigate fibrous environments

Padhi, A., Daw, A., Agashe, A., Sawhney, M., Talukder, M. M., Pour, M. M. H., Jafari, M., Genin, G. M., Alisafaei, F., Kale, S., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2424047122 · Cited by 4

Gelatin-methacryloyl hydrogel stiffness influences epithelial-mesenchymal transition in MCF7 but not MDA-MB-231 breast cancer cells in 3D culture

Wise, J., Currie, M. J., Woodfield, T. B. F., Lim, K. S., & Phillips, E. (2026) · Biology Open · doi:10.1242/bio.062212 · Cited by 5

Integration of Matrisome Omics: Towards System Biology of the Tumor Matrisome

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Biomatrices that mimic the cancer extracellular environment

Amorim, S., Reis, R. L., & Pires, R. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818128-7.00004-6 · Cited by 4

Force balancing ACT-IN the tumor microenvironment: Cytoskeletal modifications in cancer and stromal cells to promote malignancy

Dawson, M., Xuan, B., Hsu, J., & Ghosh, D. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.09.005 · Cited by 4

3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay

Wu, D., Guan, X., Yang, T., Yan, J., Zhu, B., Zhou, J., Guo, Y., & Lu, Y. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102176 · Cited by 3

Invasive cancer cells soften collagen networks and disrupt stress-stiffening via volume exclusion, contractility and adhesion

Nagle, I., Tavasso, M., Bordoloi, A., Muntz, I., Koenderink, G. H., & Boukany, P. E. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.08.036 · Cited by 3

Targeting the extracellular matrix in precision medicine: opportunities for diagnostics and therapeutics

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Mechanobiology‐Driven Metabolic Reprogramming: Integrative Roles of YAP/TAZ Signaling and Extracellular Matrix Dynamics

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Why 3D in vitro cancer models are the future of cancer research?

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Stochastic dynamics of substrate non-uniform stiffness affecting molecular adhesion in cell–substrate interface subjected to tensile loading

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Stromal Barriers Within the Tumor Microenvironment and Obstacles to Nanomedicine

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Viscoelastic phenotyping of meningiomas reveals biomechanical classes and intratumoral heterogeneity

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Targeting the Tumor Microenvironment to Overcome Resistance to Therapy

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Strain-dependent elastography of cancer cells reveals heterogeneity and stiffening due to attachment

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Quantifying the Influence of X-Ray Irradiation on Cell-Size-Scale Viscoelasticity of Collagen Type 1

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Flow-Induced Intermittent Transport Shapes Colloid Filtration in Complex Media

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Surface Stiffness Has No Impact on MCF-7 Sensitivity to Doxorubicin

Šimoliūnas, E., Jasmontaitė, D., Skinderskis, A., Rinkūnaitė, I., Alksnė, M., Liudvinaitis, M., & Baltriukienė, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210192 · Cited by 2

Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation

Hajal, C. (2018) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 2

Differentiating radiation necrosis from recurrent brain metastases using magnetic resonance elastographyPreprint

Aunan‐Diop, J. S., Friismose, A. I., Yin, Z., Hojo, E., Petersen, J. K., Grønhøj, M. H., Pedersen, C. B., Mussmann, B. R., Halle, B., & Poulsen, F. R. (2026) · medRxiv · doi:10.64898/2026.03.04.26347674 · Cited by 2

TGF-β1 and its signal molecules: are they correlated with the elasticity characteristics of breast lesions?

Zhang, M. K., Wang, B., Li, S. Y., Liu, G., & Wang, Z. (2021) · BMC Cancer · doi:10.1186/s12885-021-09036-4 · Cited by 1

Metastasis Models: Thermodynamics and Complexity

Guerra, A., Betancourt-Mar, J. A., Llanos-Pérez, J. A., Mansilla, R., & Nieto-Villar, J. M. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3577-3_4 · Cited by 1

The Performance of MR Cytometry Imaging in Differentiating High‐ and Low‐Grade Bladder Cancer

Chen, L., Jin, C., Guo, E., Liu, F., Wang, Y., Zhu, J., Zhang, X., Zhang, J., Xu, Z., Bai, X., et al. (2026) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.70232 · Cited by 1

Engineering peptide-drug conjugates for targeted cancer therapy: design principle, theranostic imaging, and translational challenges

Kumar, A., Sharma, R., & Yadav, A. K. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115960 · Cited by 1

Elastography mapped by untangling compressional and shear deformation

Liu, D., & Sun, L. (2020) · Extreme Mechanics Letters · doi:10.1016/j.eml.2020.100669 · Cited by 1

Decellularized Matrix Hydrogels for In Vitro Disease Modeling

Ferreira, L. P., Monteiro, M. V., Gaspar, V. M., & Mano, J. F. (2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781839161124-00626 · Cited by 1

Water–Air Interface to Mimic In Vitro Tumoral Cell Migration in Complex Micro-Environments

Conti, M., Bolzan, I., Zilio, S. D., Parisse, P., Andolfi, L., & Lazzarino, M. (2022) · Biosensors · doi:10.3390/bios12100822 · Cited by 1

A prognostic model for bladder cancer based on cytoskeleton-related genes

Peng, C., Guo, S., Yang, Z., Li, X., Su, Q., & Mo, W. (2023) · Medicine · doi:10.1097/md.0000000000033538 · Cited by 1

Resolving Filament Level Mechanics in Collagen Networks using Activity MicroscopyPreprint

Lissek, E. N., Bartsch, T. F., & Florin, E. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/382903 · Cited by 1

Design and Engineering of 3D Collagen-Fibronectin Scaffolds for Wound Healing and Cancer Research

Asadishekari, M. (2018) · uO Research (University of Ottawa) · doi:10.20381/ruor-22631 · Cited by 1

Computational Systems Mechanobiology of Tumor-Induced Angiogenesis

Mostofinejad, A. (2019) · UWSpace (University of Waterloo) · Cited by 1

Supramolecular Assemblies of Glycopeptides as Mimics of the Extracellular Matrix

da Costa, D. S., Brito, A., Reis, R. L., & Pashkuleva, I. (2022) · Wiley eBooks · doi:10.1002/9783527825820.ch7 · Cited by 1

Two-Photon Microscopy of Stroma ex vivo for the Express Diagnostics of Breast Cancer

Sergeeva, E. A., Kirillin, M., Dudenkova, V. V., Pavlov, M. V., Orlinskaya, N. Y., & Shakhova, N. M. (2019) · Современные технологии в медицине · doi:10.17691/stm2019.11.3.12

Characterizing the role of extracellular matrix in non-small cell lung carcinoma metastasis using a 3D microenvironment mimetic in-vitro culture system.

Saforo, D. (2019) · doi:10.18297/etd/3260

Vascularized adipose tissue in a 3D microfluidic chip for the study of ovarian cancer intraperitoneal metastases

Ibrahim, L. I. (2019)

Phenotypic evolution of cancer cells: structural requirements for survival

Atrian, F., & Lelièvre, S. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102983-1.00002-8

Linked in: the extracellular matrix network in tumour dissemination

Leb‐Reichl, V., Guttmann‐Gruber, C., & Hofbauer, J. P. (2020) · British Journal of Dermatology · doi:10.1111/bjd.19617

Tuneable 3D biocompatible scaffolds for biological and biophysical solid-tumour microenvironment studies; applications in Ovarian Cancer

Paradiso, F. (2022) · Cronfa (Swansea University) · doi:10.23889/suthesis.60122

A prognostic model for bladder cancer based on cytoskeleton-related genesPreprint

Peng, C., Guo, S., Yang, Z., Li, X., Su, Q., & Mo, W. (2022) · Research Square · doi:10.21203/rs.3.rs-1955240/v1

A prognostic model for bladder cancer based on cytoskeleton-related genesPreprint

Peng, C., Guo, S., Yang, Z., Li, X., Su, Q., & Mo, W. (2022) · Research Square · doi:10.21203/rs.3.rs-1955240/v2

Interplay among cell migration, shaping, and traction force on a matrix with cell-scale stiffness heterogeneity

Ebata, H., & Kidoaki, S. (2022) · Biophysics and Physicobiology · doi:10.2142/biophysico.bppb-v19.0036

Mimicking Mechanical Features of the Tumor Microenvironment

Mierke, C. T. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166013-00060

Tumour-on-a-chip

Cho, W.-W., Park, W., Cho, D., & Yi, H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823536-2.00003-1

Characterizing the extracellular matrix for regulating cell behaviors by atomic force microscopy

Li, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95360-3.00002-2

Development and validation of automated opto-mechatronic screening solutions for 3D tumour model engineering

Kahl, M. (2023) · Queensland University of Technology · doi:10.5204/thesis.eprints.242772

Progress of the Study on Type III Collagen in Breast Cancer

刘, 潇. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1441294

Micromechanobiology: A micromechanics approach to mechanobiology

Onck, P. R., & der Giessen, E. V. (2025) · European Journal of Mechanics - A/Solids · doi:10.1016/j.euromechsol.2025.105893

“Three-birds-one-stone” environment responsive delivery system with tumor microenvironment remodeling to enhance solid tumor therapy

Deng, C., Shen, D., Li, M., Zhang, C., & Wang, Q. (2026) · Cancer Nanotechnology · doi:10.1186/s12645-026-00368-z

Microstructure-Level Investigation of Nanoparticle Transport in Collagen Hydrogels for Advancing Nanomedicine Design and Delivery Strategies

Akalın, A. A., Dağistan, E., & Özçelikkale, A. (2026) · Lecture notes in mechanical engineering · doi:10.1007/978-3-032-16138-3_2

Multi-physics and multi-scale modeling of laminated soft tissues : application to the multi-axial response of human intervertebral disc

Kandil, K. (2020) · theses.fr (ABES) · doi:10.70675/9272345dz25caz4286z801cz40c85f84a925

Techniques for quantifying cell-scale dynamic mechanical interactions in extracellular matrices

Pokki, J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30048-6.00009-7

Dynamic mechanical three-way crosstalk at the interfaces of cancer cells, immune cells, like macrophages and stromal cells

Mierke, C. T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30048-6.00002-4

Extracellular Vesicles: A Conduit for Nanomaterial to Travel into Solid Tumors

Wu, X., & Pang, H. (2026) · Nano Letters · doi:10.1021/acs.nanolett.6c01550

Nanoscale Adhesive Architecture Coordinates With Matrix Stiffness to Regulate Stem Cell Aging via Focal Adhesion‐Mediated Chromatin Remodeling and FOXO1 Activation

Lei, J., Xue, R., Liang, Q., Yang, G., Pan, X., Ren, T., Zheng, K., Wei, Q., Gong, Z., & Liu, X. (2026) · Advanced Materials · doi:10.1002/adma.73896

Mechanical memory as a metastatic compass: a comparative framework for understanding organotropism through biophysical priming

Bedir, M. E., Uğuz, A. C., & Ünal, M. (2026) · Cancer and Metastasis Reviews · doi:10.1007/s10555-026-10375-6

Heterogeneity in cancer: molecular mechanisms and therapeutic strategies

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