Cited by 192Cellular Mechanics and InteractionsElasticity and Material ModelingHydrogels: synthesis, properties, applications

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Complex mechanics of the heterogeneous extracellular matrix in cancer

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Malandrino, Andrea, Mak, Michael, Kamm, Roger D., Moeendarbary, Emad·2018·Extreme Mechanics Letters

DOI 10.1016/j.eml.2018.02.003PMC PMC6097546

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Abstract

The extracellular matrix (ECM) performs many critical functions, one of which is to provide structural and mechanical integrity, and many of the constituent proteins have clear mechanical roles. The composition and structural characteristics of the ECM are widely variable among different tissues, suiting diverse functional needs. In diseased tissues, particularly solid tumors, the ECM is complex and influences disease progression. Cancer and stromal cells can significantly influence the matrix composition and structure and thus the mechanical properties of the tumor microenvironment (TME). In this review, we describe the interactions that give rise to the structural heterogeneity of the ECM and present the techniques that are widely employed to measure ECM properties and remodeling dynamics. Furthermore, we review the tools for measuring the distinct nature of cell-ECM interactions within the TME.

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Authors: Malandrino, A., Mak, M., Kamm, R. D., & Moeendarbary, E.
Affiliations: European Molecular Biology Laboratory (ES)
Yale University (US)
Massachusetts Institute of Technology (US)
University College London (GB)
Corresponding author: Malandrino, Andrea
Mak, Michael
Kamm, Roger D.
Moeendarbary, Emad
ORCID: Malandrino, Andrea
Mak, Michael
Kamm, Roger D.
Moeendarbary, Emad
Venue: Extreme Mechanics Letters
Publisher: Elsevier BV
Published: 2018-05
Volume: 21
Pages: 25-34
ISSN: 2352-4316 (ISSN-L)
DOI: 10.1016/j.eml.2018.02.003
PMC: PMC6097546
OpenAlex: W2794352591
Cited by: 192
References: 136
Citations by year: 2026: 16 · 2025: 13 · 2024: 12 · 2023: 28 · 2022: 20 · 2021: 35 · 2020: 36 · 2019: 27 · 2018: 4
FWCI: 2.87
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 20 d)
Locations: Extreme Mechanics Letters (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
UCL Discovery (University College London) (submittedVersion)
Elsevier eBooks
Funders: People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (625500)
U.S. National Cancer Institute (U01 CA202177-01)
Cancer Research UK Multidisciplinary Award (C57744/A22057)
Wellcome Trust-Massachusetts Institute of Technology Fellowship (WT103883)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords: extracellular matrix, tumor microenvironment, extracellular matrix remodeling, cell-matrix interactions, cancer, tumor stroma, ECM composition

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Complex mechanics of the heterogeneous extracellular matrix in cancer

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