The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Perfluoroalkyl substances and lipid concentrations in plasma during pregnancy among women in the Norwegian Mother and Child Cohort Study
Open accessAbstract
Background Perfluoroalkyl substances (PFASs) are widespread and persistent environmental pollutants. Previous studies, primarily among non-pregnant individuals, suggest positive associations between PFAS levels and certain blood lipids. If there is a causal link between PFAS concentrations and elevated lipids during pregnancy, this may suggest a mechanism by which PFAS exposure leads to certain adverse pregnancy outcomes, including preeclampsia. Methods This cross-sectional analysis included 891 pregnant women enrolled in the Norwegian Mother and Child (MoBa) Cohort Study in 2003–2004. Non-fasting plasma samples were obtained at mid-pregnancy and analyzed for nineteen PFASs. Total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, and triglycerides were measured in plasma. Linear regression was used to quantify associations between each PFAS exposure and each lipid outcome. A multiple PFAS model was also fitted. Results Seven PFASs were quantifiable in >50% of samples. Perfluorooctane sulfonate (PFOS) concentration was associated with total cholesterol, which increased 4.2 mg/dL per interquartile shift (95% CI=0.8, 7.7) in adjusted models. Five of the seven PFASs studied were positively associated with HDL cholesterol, and all seven had elevated HDL associated with the highest quartile of exposure. Perfluoroundecanoic acid showed the strongest association with HDL: HDL increased 3.7 mg/dL per interquartile shift (95% CI=2.5, 4.9). Conclusion Plasma concentrations of PFASs were positively associated with HDL cholesterol, and PFOS was positively associated with total cholesterol in this sample of pregnant Norwegian women. While elevated HDL is not an adverse outcome per se, elevated total cholesterol associated with PFASs during pregnancy could be of concern if causal.
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Cites
Mensink, R. P., Zock, P. L., Kester, A. D., & Katan, M. B. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.5.1146 · Cited by 2,811
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
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Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
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Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
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Trends in Exposure to Polyfluoroalkyl Chemicals in the U.S. Population: 1999−2008
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“The median plasma concentrations of the seven PFASs in this study were comparable to reported serum levels from 2006 in Norway (Haug et al., 2009b) and somewhat lower than reported serum levels from the United States in the same year (Kato et al., 2011).”
BackgroundResultThe toxicology of perfluorooctanoate
Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742
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Cited by
Fenton, S. E., Ducatman, A., Boobis, A., DeWitt, J. C., Lau, C., Ng, C., Smith, J. S., & Roberts, S. M. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4890 · Cited by 2,445
Risk to human health related to the presence of perfluoroalkyl substances in food
Panel), E. P. O. C. I. T. F. C. (. C., Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Leblanc, J., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6223 · Cited by 989
Self-citationDevelopmental origins of metabolic diseases
Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2021) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 466
Mamsen, L. S., Björvang, R. D., Mucs, D., Vinnars, M.-T., Papadogiannakis, N., Lindh, C. H., Andersen, C. Y., & Damdimopoulou, P. (2019) · Environment International · doi:10.1016/j.envint.2019.01.010 · Cited by 338
Starling, A. P., Adgate, J. L., Hamman, R. F., Kechris, K., Calafat, A. M., Ye, X., & Dabelea, D. (2017) · Environmental Health Perspectives · doi:10.1289/ehp641 · Cited by 142
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Metadata
- Authors
- Starling, A. P., Engel, S. M., Whitworth, K. W., Richardson, D. B., Stuebe, A. M., Daniels, J. L., Haug, L. S., Eggesbø, M., Becher, G., Sabaredzovic, A., Thomsen, C., Wilson, R. E., Travlos, G. S., Hoppin, J. A., Baird, D. D., & Longnecker, M. P.
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 62
- Pages
- 104-112
- ISSN
- 0160-4120 (ISSN-L)
- OpenAlex
- W2036099712
- Cited by
- 170
- References
- 13
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Starling, A. P., Engel, S. M., Whitworth, K. W., Richardson, D. B., Stuebe, A. M., Daniels, J. L., Haug, L. S., Eggesbø, M., Becher, G., Sabaredzovic, A., Thomsen, C., Wilson, R. E., Travlos, G. S., Hoppin, J. A., Baird, D. D., & Longnecker, M. P. (2014). Perfluoroalkyl substances and lipid concentrations in plasma during pregnancy among women in the Norwegian Mother and Child Cohort Study. Environment International. https://doi.org/10.1016/j.envint.2013.10.004
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