Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes
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Abstract
In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.
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Exposure of NOD mice to a single PFAS or a mixture of congeners results in decreased phospholipids, increased lithocholic acid, and accelerated insulitis.
“In addition, exposure of”
From Exposure to per- and polyfluoroalkyl substances in early pregnancy, risk of gestational diabetes mellitus, potential pathways, and influencing factors in pregnant women: A nested case-control study (2023) · cites this paper as McGlinchey et al., 2020
Section 3.5 reports decreased phospholipids after exposure to either PFUnDA or a PFAS-containing POP mixture. Section 3.6 reports increased lithocholic acid only for the POP-mixture mice, not for the single-PFAS group. Section 3.5 says two earlier NOD-mouse studies suggest that maternal PFAS exposure accelerates insulitis; it does not present that outcome as a result established by the lipid analyses here. Page numbers are unavailable in our copy. (LLM, conf=0.86)
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- Authors
- McGlinchey, A., Sinioja, T., Lamichhane, S., Sen, P., Bodin, J., Siljander, H., Dickens, A. M., Geng, D., Carlsson, C., Duberg, D., Ilonen, J., Virtanen, S. M., Dirven, H., Berntsen, H. F., Zimmer, K., Nygaard, U. C., Orešič, M., Knip, M., & Hyötyläinen, T.
- Affiliations
- Örebro University (SE)
- Åbo Akademi University (FI)
- Norwegian Institute of Public Health (NO)
- University of Helsinki (FI)
- University of Turku (FI)
- Tampere University (FI)
- National Institute of Occupational Health (NO)
- Tampere University Hospital (FI)
- Corresponding author
- Orešič, Matej
- Knip, Mikael
- Hyötyläinen, Tuulia
- ORCID
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 143
- Pages
- 105935
- ISSN
- 0160-4120 (ISSN-L)
- OpenAlex
- W3040597861
- Cited by
- 61
- References
- 45
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 5
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Environment International (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Työväentutkimus Vuosikirja (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (1DP3DK094338-01)
- Academy of Finland (323171, 250114)
- Stiftelsen för Kunskaps- och Kompetensutveckling (2020, MTBLS875)
- Svenska Forskningsrådet Formas (2019-00869)
- Vetenskapsrådet (2016-05176)
- Juvenile Diabetes Research Foundation International (2-SRA-2016-341-S-B, 292568, 2-SRA-2016-289-S-B)
- National Institutes of Health
- Novo Nordisk Fonden (NNF19OC0057418)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- perfluorinated compounds, prenatal exposure, type 1 diabetes, islet autoantibodies, lithocholic acid, insulitis, NOD mice, environmental pollutants
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Environmental Pollutants, Female, Finland, Fluorocarbons, Phospholipids, Pregnancy, Prenatal Exposure Delayed Effects
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