Cited by 61Per- and polyfluoroalkyl substances researchDiabetes and associated disordersEffects and risks of endocrine disrupting chemicals

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

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McGlinchey, Aidan, Sinioja, Tim, Lamichhane, Santosh, Sen, Partho, Bodin, Johanna, Siljander, Heli, Dickens, Alex M., Geng, Dawei +11 more·2020·Environment International

Published version of a preprint

Abstract

In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.

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Authors
McGlinchey, A., Sinioja, T., Lamichhane, S., Sen, P., Bodin, J., Siljander, H., Dickens, A. M., Geng, D., Carlsson, C., Duberg, D., Ilonen, J., Virtanen, S. M., Dirven, H., Berntsen, H. F., Zimmer, K., Nygaard, U. C., Orešič, M., Knip, M., & Hyötyläinen, T.
Affiliations
  • Örebro University (SE)
  • Åbo Akademi University (FI)
  • Norwegian Institute of Public Health (NO)
  • University of Helsinki (FI)
  • University of Turku (FI)
  • Tampere University (FI)
  • National Institute of Occupational Health (NO)
  • Tampere University Hospital (FI)
Corresponding author
  • Orešič, Matej
  • Knip, Mikael
  • Hyötyläinen, Tuulia
Venue
Environment International
Publisher
Elsevier BV
Published
2020-10
Volume
143
Pages
105935
ISSN
0160-4120 (ISSN-L)
OpenAlex
W3040597861
Cited by
61
References
45
Citations by year
2026: 5 · 2025: 8 · 2024: 12 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 5
FWCI
3.33
Type
journal article
Language
en
Open access
Locations
  • Environment International (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Työväentutkimus Vuosikirja (submittedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (1DP3DK094338-01)
  • Academy of Finland (323171, 250114)
  • Stiftelsen för Kunskaps- och Kompetensutveckling (2020, MTBLS875)
  • Svenska Forskningsrådet Formas (2019-00869)
  • Vetenskapsrådet (2016-05176)
  • Juvenile Diabetes Research Foundation International (2-SRA-2016-341-S-B, 292568, 2-SRA-2016-289-S-B)
  • National Institutes of Health
  • Novo Nordisk Fonden (NNF19OC0057418)
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords
perfluorinated compounds, prenatal exposure, type 1 diabetes, islet autoantibodies, lithocholic acid, insulitis, NOD mice, environmental pollutants
MeSH terms
Animals, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Environmental Pollutants, Female, Finland, Fluorocarbons, Phospholipids, Pregnancy, Prenatal Exposure Delayed Effects

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