Polystyrene micro-/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines
Open accessAbstract
Micro-/nanoplastics (MNPLs), novel environmental pollutants, widely exist in the environment and life and bring health risks. Previous studies have shown that NMPLs can penetrate bone marrow, but whether they cause hematopoietic damage remains uncertain. In this study, C57BL/6J mice were treated with polystyrene MNPLs (PS-MNPLs, 10 μm, 5 μm and 80 nm) at 60 μg doses for 42 days by intragastric administration. We evaluated the hematopoietic toxicity induced by MNPLs and potential mechanisms via combining 16S rRNA, metabolomics, and cytokine chips. The results demonstrated that PS-MNPLs induced hematopoietic toxicity, which was manifested by the disorder of bone marrow cell arrangement, the reduction in colony-forming, self-renewal and differentiation capacity, and the increased proportion of lymphocytes. PS-MNPLs also disrupted the homeostasis of the gut microbiota, metabolism, and inflammation, all of which were correlated with hematotoxicity, suggesting that abnormal gut microbiota-metabolite-cytokine axes might be the crucial pathways in MNPLs-induced hematopoietic injury. In conclusion, our study systematically demonstrated that multi-scale PS-MNPLs induced hematopoietic toxicity via the crosstalk of gut microbiota, metabolites, and cytokines and provided valuable insights into MNPLs toxicity, which was conducive to health risk assessment and informed policy decisions regarding PS-MNPLs.
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Previous studies investigated mammalian models exposed to micro-/nanoplastics for 42 days, identifying erythrocyte reductions linked to changes in HSCs mediated by interactions with gut microbiota and cytokines.
“For example, (Jing et al., 2022) investigated mammalian models exposed to micro-/nanoplastics for 42 days, identifying erythrocyte reductions linked to changes in HSCs mediated by interactions with gut microbiota and cytokines.”
From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Jing et al., 2022
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- Authors
- Jing, J., Zhang, L., Han, L., Wang, J., Zhang, W., Liu, Z., & Gao, A.
- Affiliations
- Capital Medical University (CN)
- Corresponding author
- Gao, Ai
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 161
- Pages
- 107131
- ISSN
- 0160-4120 (ISSN-L)
- OpenAlex
- W4211167922
- Cited by
- 167
- References
- 12
- Citations by year
- 2026: 34 · 2025: 46 · 2024: 44 · 2023: 31 · 2022: 12
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Environment International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Keywords
- hematologic toxicity, hematopoietic damage, gut microbiota, bone marrow, inflammation, metabolomics, cytokines, lymphocyte expansion, self-renewal and differentiation, environmental pollutants
- MeSH terms
- Gastrointestinal Microbiome, Microplastics, Animals, Mice, Inbred C57BL, Polystyrenes, RNA, Ribosomal, 16S, Cytokines, Mice
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