Modulation of Fecal Clostridiales Bacteria and Butyrate by Probiotic Intervention with Lactobacillus paracasei DG Varies among Healthy Adults
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Background The modulation of gut microbiota is considered to be the first target to establish probiotic efficacy in a healthy population.Objective This study was conducted to determine the impact of a probiotic on the intestinal microbial ecology of healthy volunteers.Methods High-throughput 16S ribosomal RNA gene sequencing was used to characterize the fecal microbiota in healthy adults (23-55 y old) of both sexes, before and after 4 wk of daily consumption of a capsule containing at least 24 billion viable Lactobacillus paracasei DG cells, according to a randomized, double-blind, crossover placebo-controlled design.Results Probiotic intake induced an increase in Proteobacteria (P = 0.006) and in the Clostridiales genus Coprococcus (P = 0.009), whereas the Clostridiales genus Blautia (P = 0.036) was decreased; a trend of reduction was also observed for Anaerostipes (P = 0.05) and Clostridium (P = 0.06). We also found that the probiotic effect depended on the initial butyrate concentration. In fact, participants with butyrate >100 mmol/kg of wet feces had a mean butyrate reduction of 49 ± 21% and a concomitant decrease in the sum of 6 Clostridiales genera, namely Faecalibacterium, Blautia, Anaerostipes, Pseudobutyrivibrio, Clostridium, and Butyrivibrio (P = 0.021), after the probiotic intervention. In contrast, in participants with initial butyrate concentrations <25 mmol/kg of wet feces, the probiotic contributed to a 329 ± 255% (mean ± SD) increment in butyrate concomitantly with an ∼55% decrease in Ruminococcus (P = 0.016) and a 150% increase in an abundantly represented unclassified Bacteroidales genus (P = 0.05).Conclusions The intake of L. paracasei DG increased the Blautia:Coprococcus ratio, which, according to the literature, can potentially confer a health benefit on the host. The probiotic impact on the microbiota and on short-chain fatty acids, however, seems to strictly depend on the initial characteristics of the intestinal microbial ecosystem. In particular, fecal butyrate concentrations could represent an important biomarker for identifying subjects who may benefit from probiotic treatment. This trial was registered at www.controlled-trials.com/isrctn as ISRCTN56945491.
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Lactobacillus paracasei DG modulated fecal butyrate concentration in healthy subjects.
“the probiotic Lactobacillus paracasei DG modulated fecal butyrate concentration in healthy subjects [241]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [241]
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QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03006-05 · Cited by 10,891 · see citing works
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533 · see citing works
The gut microbiota--masters of host development and physiology
Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681 · see citing works
UniFrac: an effective distance metric for microbial community comparison
Lozupone, C., Lladser, M. E., Knights, D., Stombaugh, J., & Knight, R. (2011) · The ISME Journal · doi:10.1038/ismej.2010.133 · Cited by 2,825 · see citing works
Bailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., & Lyte, M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.023 · Cited by 1,123 · see citing works
Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041 · see citing works
Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976 · see citing works
Duncan, S. H., Belenguer, A., Holtrop, G., Johnstone, A. M., Flint, H. J., & Lobley, G. E. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02340-06 · Cited by 941 · see citing works
Swidsinski, A., Weber, J., Loening-Baucke, V., Hale, L. P., & Lochs, H. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.7.3380-3389.2005 · Cited by 894 · see citing works
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works
Intestinal microbiota in human health and disease: the impact of probiotics
Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0229-7 · Cited by 724 · see citing works
Taverniti, V., & Guglielmetti, S. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0218-x · Cited by 703 · see citing works
Self-citationMalinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699 · see citing works
LeBlanc, J. G., Laiño, J. E., del Valle, M. J., Vannini, V., van Sinderen, D., Taranto, M. P., de Valdez, G. F., de Giori, G. S., & Sesma, F. (2011) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2011.05157.x · Cited by 529 · see citing works
Koren, O., Knights, D., Gonzalez, A., Waldron, L., Segata, N., Knight, R., Huttenhower, C., & Ley, R. E. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002863 · Cited by 508 · see citing works
Metatranscriptomic Approach to Analyze the Functional Human Gut Microbiota
Gosalbes, M. J., Durbán, A., Pignatelli, M., Abellan, J. J., Jiménez‐Hernández, N., Pérez‐Cobas, A. E., Latorre, A., & Moyá, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017447 · Cited by 379 · see citing works
Shen, J., Zuo, Z.-X., & Mao, A.-P. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000437495.30052.be · Cited by 364 · see citing works
Leonel, A. J., & Alvarez-Leite, J. I. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835665fa · Cited by 362 · see citing works
Liu, C., Finegold, S. M., Song, Y., & Lawson, P. A. (2008) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.65208-0 · Cited by 359 · see citing works
Microbes and Microbial Technology
Ahmad, I., Ahmed, F. K., & Pichtel, J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7931-5 · Cited by 353 · see citing works
Kim, S.-W., Suda, W., Kim, S., Oshima, K., Fukuda, S., Ohno, H., Morita, H., & Hattori, M. (2013) · DNA Research · doi:10.1093/dnares/dst006 · Cited by 338 · see citing works
Rastogi, G., & Sani, R. K. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7931-5_2 · Cited by 332 · see citing works
Linking the gut microbiota to human health
Robles, V., & Guarner, F. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114512005235 · Cited by 307 · see citing works
Azad, M. B., Konya, T., Maughan, H., Guttman, D. S., Field, C. J., Sears, M. R., Becker, A. B., Scott, J. A., Kozyrskyj, A. L., & CHILD Study Investigators (2013) · Allergy Asthma and Clinical Immunology · doi:10.1186/1710-1492-9-15 · Cited by 305 · see citing works
Assessing the Fecal Microbiota: An Optimized Ion Torrent 16S rRNA Gene-Based Analysis Protocol
Milani, C., Hevia, A., Foroni, E., Duranti, S., Turroni, F., Lugli, G. A., Sánchez, B., Martín, R., Gueimonde, M., van Sinderen, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068739 · Cited by 304 · see citing works
Self-citationGuglielmetti, S., Mora, D., Gschwender, M., & Popp, K. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04633.x · Cited by 287 · see citing works
Self-citationHuman gut microbiota community structures in urban and rural populations in Russia
Tyakht, A., Kostryukova, E., Popenko, A., Belenikin, M. S., Pavlenko, A. V., Larin, A. K., Karpova, I. Y., Selezneva, O. V., Semashko, T. A., Ospanova, E. A., et al. (2013) · Nature Communications · doi:10.1038/ncomms3469 · Cited by 283 · see citing works
Storage conditions of intestinal microbiota matter in metagenomic analysis
Cardona, S. T., Eck, A., Cassellas, M., Gallart, M., Alastrue, C., Dore, J. M., Azpiroz, F., Roca, J., Guarner, F., & Manichanh, C. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-158 · Cited by 275 · see citing works
McHardy, I. H., Li, X., Tong, M., Ruegger, P., Jacobs, J., Borneman, J., Anton, P., & Braun, J. (2013) · Microbiome · doi:10.1186/2049-2618-1-26 · Cited by 234 · see citing works
McOrist, A. L., Miller, R. B., Bird, A. R., Keogh, J. B., Noakes, M., Topping, D. L., & Conlon, M. A. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.128504 · Cited by 231 · see citing works
Parkes, G. C., Rayment, N. B., Hudspith, B. N., Petrovska, L., Lomer, M. C., Brostoff, J., Whelan, K., & Sanderson, J. D. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01803.x · Cited by 200 · see citing works
Bourdu, S., Dapoigny, M., Chapuy, E., Artigue, F., Vasson, M.-P., Dechelotte, P., Bommelaer, G., Eschalier, A., & Ardid, D. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.082 · Cited by 176 · see citing works
Payne, A. N., Chassard, C., Zimmermann, M. B., Müller, P., Stinca, S., & Lacroix, C. (2011) · Nutrition and Diabetes · doi:10.1038/nutd.2011.8 · Cited by 165 · see citing works
Lyra, A., Rinttilä, T., Nikkilä, J., Krogius-Kurikka, L., Kajander, K., Malinen, E., Mättö, J., Mäkelä, L., & Palva, A. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5936 · Cited by 160 · see citing works
Tursi, A., Brandimarte, G., Elisei, W., Picchio, M., Forti, G., Pianese, G., Rodinò, S., D'Amico, T., Sacca', N., Portincasa, P., et al. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12463 · Cited by 157 · see citing works
Higher level of faecal SCFA in women correlates with metabolic syndrome risk factors
Teixeira, T. F. S., Grześkowiak, Ł., Franceschini, S. D. C. C., Bressan, J., Ferreira, C. L. D. L. F., & Pelúzio, M. D. C. G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002723 · Cited by 138 · see citing works
Matsumoto, K., Takada, T., Shimizu, K., Moriyama, K., Kawakami, K., Hirano, K., Kajimoto, O., & Nomoto, K. (2010) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2010.05.016 · Cited by 134 · see citing works
The active human gut microbiota differs from the total microbiota
Peris-Bondia, F., Latorre, A., Artacho, A., Moya, A., & D'Auria, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022448 · Cited by 113 · see citing works
Renata D'Incà, Barollo, M., Scarpa, M., Grillo, A. R., Brun, P., Vettorato, M. G., Castagliuolo, I., & Sturniolo, G. C. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1384-1 · Cited by 99 · see citing works
Goossens, D. A. M., Jonkers, D. M. A. E., Rüssel, M. G., Stobberingh, E. E., van den Bogaard, A. E. J. M., & Stockbrügger, R. W. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01708.x · Cited by 99 · see citing works
Tursi, A., Brandimarte, G., Giorgetti, G. M., & Modeo, M. E. (2004) · PubMed · Cited by 93 · see citing works
The Fermentation of Different Dietary Fibers Is Associated with Fecal Clostridia Levels in Men
Chinda, D., Nakaji, S., Sugawara, K., Fukuda, S., Sakamoto, J., Shimoyama, T., Nakamura, T., Fujisawa, T., & Terada, A. (2004) · Journal of Nutrition · doi:10.1093/jn/134.8.1881 · Cited by 40 · see citing works
The design of probiotic studies to substantiate health claims.
Gibson, G. R., Brummer, R. J., Isolauri, E., Lochs, H. H., Morelli, L., Ockhuizen, T., Rowland, I. R., Schrezenmeir, J., Stanton, C., & Verbeke, K. (2011) · Gut Microbes · doi:10.4161/gmic.2.5.18002 · Cited by 35 · see citing works
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- Leonel AJ, Alvarez-Leite JI. Butyrate: implications for intestinal function. Curr Opin Clin Nutr Metab Care 2012;15:474-9.
Cited by
Sorted by citations
Zmora, N., Zilberman-Schapira, G., Suez, J., Mor, U., Dori-Bachash, M., Bashiardes, S., Kotler, E., Zur, M., Regev-Lehavi, D., Brik, R. B.-Z., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.041 · Cited by 1,695 · see citing works
Mechanisms of action of probiotics
Plaza-Diaz, J., Ruiz-Ojeda, F. J., Gil-Campos, M., & Gil, A. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy063 · Cited by 1,423 · see citing works
The pros, cons, and many unknowns of probiotics
Suez, J., Zmora, N., Segal, E., & Elinav, E. (2019) · Nature Medicine · doi:10.1038/s41591-019-0439-x · Cited by 1,398 · see citing works
Probiotics, gut microbiota, and their influence on host health and disease
Sánchez, B., Delgado, S., Blanco‐Míguez, A., Lourenço, A., Gueimonde, M., & Margolles, A. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600240 · Cited by 1,104 · see citing works
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,107 · see citing works
Diet-microbiota interactions and personalized nutrition
Kolodziejczyk, A. A., Zheng, D., & Elinav, E. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0256-8 · Cited by 879 · see citing works
Li, B., Ding, Y., Cheng, X., Sheng, D., Xu, Z., Rong, Q., Wu, Y., Zhao, H., Ji, X., & Zhang, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125492 · Cited by 711 · see citing works
Shaping the Future of Probiotics and Prebiotics
Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., et al. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.003 · Cited by 637 · see citing works
Fate, activity, and impact of ingested bacteria within the human gut microbiota
Derrien, M., & van Hylckama Vlieg, J. E. T. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.03.002 · Cited by 605 · see citing works
The role of the gut microbiome and its metabolites in metabolic diseases
Wu, J., Wang, K., Wang, X., Pang, Y., & Jiang, C. (2020) · Protein & Cell · doi:10.1007/s13238-020-00814-7 · Cited by 584 · see citing works
Kristensen, N. B., Bryrup, T., Allin, K. H., Nielsen, T., Hansen, T. H., & Pedersen, O. (2016) · Genome Medicine · doi:10.1186/s13073-016-0300-5 · Cited by 561 · see citing works
Canani, R. B., Sangwan, N., Stefka, A. T., Nocerino, R., Paparo, L., Aitoro, R., Calignano, A., Khan, A. A., Gilbert, J. A., & Nagler‐Anderson, C. (2015) · The ISME Journal · doi:10.1038/ismej.2015.151 · Cited by 525 · see citing works
Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria
Fu, X., Liu, Z., Zhu, C., Mou, H., & Kong, Q. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1542587 · Cited by 497 · see citing works
Sáez‐Lara, M. J., Robles-Sánchez, C., Ruiz‐Ojeda, F. J., Plaza‐Díaz, J., & Gil, Á. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060928 · Cited by 331 · see citing works
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies
Distrutti, E., Monaldi, L., Ricci, P., & Fiorucci, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2219 · Cited by 320 · see citing works
Roles of Sex Hormones and Gender in the Gut Microbiota
Yoon, K., & Kim, N. (2021) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20208 · Cited by 305 · see citing works
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health
De Filippis, F., Pasolli, E., & Ercolini, D. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa015 · Cited by 303 · see citing works
Nishida, K., Sawada, D., Kuwano, Y., Tanaka, H., & Rokutan, K. (2019) · Nutrients · doi:10.3390/nu11081859 · Cited by 292 · see citing works
A review of probiotic supplementation in healthy adults: helpful or hype?
Khalesi, S., Bellissimo, N., Vandelanotte, C., Williams, S., Stanley, D., & Irwin, C. (2019) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0135-9 · Cited by 242 · see citing works
Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis
Xu, X., Jia, X., Mo, L., Liu, C.-C., Zheng, L.-W., Yuan, Q., & Zhou, X.-D. (2017) · Bone Research · doi:10.1038/boneres.2017.46 · Cited by 183 · see citing works
Yılmaz, İ., Dolar, M. E., & Özpınar, H. (2019) · Turkish Journal of Gastroenterology · doi:10.5152/tjg.2018.18227 · Cited by 193 · see citing works
Chakravarthy, S. K., Jayasudha, R., Prashanthi, G. S., Ali, M. H., Sharma, S., Tyagi, M., & Shivaji, S. (2018) · Indian Journal of Microbiology · doi:10.1007/s12088-018-0746-9 · Cited by 193 · see citing works
Microbiota and Lifestyle: A Special Focus on Diet
Redondo-Useros, N., Nova, E., González-Zancada, N., Díaz, L. E., Gómez-Martínez, S., & Marcos, A. (2020) · Nutrients · doi:10.3390/nu12061776 · Cited by 189 · see citing works
Mancabelli, L., Milani, C., Lugli, G. A., Turroni, F., Mangifesta, M., Viappiani, A., Ticinesi, A., Nouvenne, A., Meschi, T., van Sinderen, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10663-w · Cited by 182 · see citing works
Self-citationAnalysis of short-chain fatty acids in human feces: A scoping review
Primec, M., Mičetić‐Turk, D., & Langerholc, T. (2017) · Analytical Biochemistry · doi:10.1016/j.ab.2017.03.007 · Cited by 164 · see citing works
Jing, J., Zhang, L., Han, L., Wang, J., Zhang, W., Liu, Z., & Gao, A. (2022) · Environment International · doi:10.1016/j.envint.2022.107131 · Cited by 167 · see citing works
van Deuren, T., Blaak, E. E., & Canfora, E. E. (2022) · Obesity Reviews · doi:10.1111/obr.13498 · Cited by 162 · see citing works
Balzaretti, S., Taverniti, V., Guglielmetti, S., Fiore, W., Minuzzo, M., Ngehnyuiy, N. H., Ngere, J. B., Sadiq, S., Humphreys, P. N., & Laws, A. P. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.02702-16 · Cited by 148 · see citing works
Self-citationButyrate generated by gut microbiota and its therapeutic role in metabolic syndrome
Bridgeman, S. C., Northrop, W., Melton, P. E., Ellison, G., Newsholme, P., & Mamotte, C. D. S. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105174 · Cited by 131 · see citing works
Notting, F., Pirovano, W., Sybesma, W., & Kort, R. (2023) · Gut Microbiome · doi:10.1017/gmb.2023.14 · Cited by 133 · see citing works
Qu, Y., Yang, C., Ren, Q., Ma, M., Dong, C., & Hashimoto, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-16060-7 · Cited by 128 · see citing works
Jäger, R., Zaragoza, J., Purpura, M., Iametti, S., Marengo, M., Tinsley, G. M., Anzalone, A., Oliver, J., Fiore, W., Biffi, A., et al. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09656-5 · Cited by 112 · see citing works
Self-citationProbiotic-directed modulation of gut microbiota is basal microbiome dependent
Hou, Q., Zhao, F., Liu, W., Lv, R., Khine, W. W. T., Han, J., Sun, Z., Lee, Y. K., & Zhang, H. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1736974 · Cited by 120 · see citing works
Therapeutic Potential of Butyrate for Treatment of Type 2 Diabetes
Arora, T., & Tremaroli, V. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.761834 · Cited by 124 · see citing works
Cremon, C., Guglielmetti, S., Gargari, G., Taverniti, V., Castellazzi, A. M., Valsecchi, C., Tagliacarne, S. C., Fiore, W., Bellini, M., Bertani, L., et al. (2017) · United European Gastroenterology Journal · doi:10.1177/2050640617736478 · Cited by 114 · see citing works
Self-citationGargari, G., Taverniti, V., Gardana, C., Cremon, C., Canducci, F., Pagano, I., Barbaro, M. R., Bellacosa, L., Castellazzi, A. M., Valsecchi, C., et al. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14271 · Cited by 98 · see citing works
Self-citationBoudry, G., Hamilton, M. K., Chichlowski, M., Wickramasinghe, S., Barile, D., Kalanetra, K. M., Mills, D. A., & Raybould, H. E. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-11890 · Cited by 98 · see citing works
Olvera-Rosales, L. B., Cruz-Guerrero, A. E., Ramírez‐Moreno, E., Lira, A. Q., Contreras‐López, E., Ordaz, J. J., Ovando, A. C., Añorve‐Morga, J., Calderón‐Ramos, Z. G., Arias‐Rico, J., et al. (2021) · Foods · doi:10.3390/foods10061261 · Cited by 101 · see citing works
Emerging connections between gut microbiome bioenergetics and chronic metabolic diseases
Daisley, B. A., Koenig, D. W., Engelbrecht, K. C., Doney, L., Hards, K., Al, K. F., Reid, G., & Burton, J. P. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110087 · Cited by 83 · see citing works
Yang, G., Peng, M., Tian, X., & Dong, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-05312-1 · Cited by 81 · see citing works
Probiotics in the next-generation sequencing era
Suez, J., Zmora, N., & Elinav, E. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1586039 · Cited by 82 · see citing works
Gargari, G., Taverniti, V., Balzaretti, S., Ferrario, C., Gardana, C., Simonetti, P., & Guglielmetti, S. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.01753-16 · Cited by 79 · see citing works
Self-citationSingh, R. P., Shadan, A., & Ma, Y. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09992-8 · Cited by 81 · see citing works
Yu, X., Yin, J., Li, L., Luan, C., Zhang, J., Zhao, C., & Li, S. (2015) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1501.01022 · Cited by 76 · see citing works
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2022) · Kompass Nutrition & Dietetics · doi:10.1159/000523712 · Cited by 79 · see citing works
Huang, J., Yang, Z., Li, Y., Chai, X., Liang, Y., Lin, B., Ye, Z., Zhang, S., Che, Z., Zhang, H., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02943-x · Cited by 73 · see citing works
Huang, X., Liu, L., Zhao, J., Zhang, J., & Cai, Z. C. (2018) · Applied Soil Ecology · doi:10.1016/j.apsoil.2018.11.011 · Cited by 73 · see citing works
Hori, T., Matsuda, K., & Oishi, K. (2020) · Microorganisms · doi:10.3390/microorganisms8091401 · Cited by 75 · see citing works
Captivity reduces diversity and shifts composition of the Brown Kiwi microbiome
Juan, P. A. S., Castro, I., & Dhami, M. K. (2021) · Animal Microbiome · doi:10.1186/s42523-021-00109-0 · Cited by 69 · see citing works
Aggarwal, A., Sarangi, A. N., Gaur, P., Shukla, A. K., & Aggarwal, R. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12900 · Cited by 66 · see citing works
Liu, J., Lv, M., Sun, A., Ding, J., Wang, Y., Chang, X., & Chen, L. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133810 · Cited by 64 · see citing works
Utilizing the fecal microbiota to understand foal gut transitions from birth to weaning
Torre, U. D. L., Henderson, J., Furtado, K. L., Pedroja, M., Elenamarie, O., Mora, A., Pechanec, M. Y., Maga, E. A., & Mienaltowski, M. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216211 · Cited by 62 · see citing works
Liu, J., Ye, T., Zhang, Y., Zhang, R., Kong, Y., Zhang, Y., & Sun, J. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05038 · Cited by 61 · see citing works
Gargari, G., Mantegazza, G., Cremon, C., Taverniti, V., Valenza, A., Barbaro, M., Marasco, G., Duncan, R., Fiore, W., Ferrari, R., et al. (2024) · Gut microbes · doi:10.1080/19490976.2023.2298246 · Cited by 55 · see citing works
Self-citationChronic kidney disease, uremic milieu, and its effects on gut bacterial microbiota dysbiosis
Chaves, L. D., McSkimming, D. I., Bryniarski, M. A., Honan, A. M., Abyad, S., Thomas, S. A., Wells, S., Buck, M. J., Sun, Y., Genco, R. J., et al. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00092.2018 · Cited by 59 · see citing works
Plaza‐Díaz, J., Fernández-Caballero, J. Á., Chueca, N., García, F., Gómez‐Llorente, C., Sáez‐Lara, M. J., Fontana, L., & Gil, Á. (2015) · Nutrients · doi:10.3390/nu7063999 · Cited by 58 · see citing works
Zhang, C., Ma, K., Nie, K., Deng, M., Luo, W., Wu, X., Huang, Y., & Wang, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.973046 · Cited by 60 · see citing works
Jayasudha, R., Chakravarthy, S. K., Prashanthi, G. S., Sharma, S., Garg, P., Murthy, S. I., & Shivaji, S. (2018) · Journal of Biosciences · doi:10.1007/s12038-018-9798-6 · Cited by 57 · see citing works
Endam, L. M., Alromaih, S., González, E., Madrenas, J., Cousineau, B., Renteria, A. E., & Desrosiers, M. Y. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00440 · Cited by 56 · see citing works
Dietary Intake Mediates Ethnic Differences in Gut Microbial Composition
Borrello, K., Lim, U., Park, S., Monroe, K. R., Maskarinec, G., Boushey, C. J., Wilkens, L. R., Randolph, T. W., Marchand, L. L., Hullar, M. A. J., et al. (2022) · Nutrients · doi:10.3390/nu14030660 · Cited by 53 · see citing works
Guglielmetti, S., Bernardi, S., Del Bo’, C., Cherubini, A., Porrini, M., Gargari, G., Hidalgo-Liberona, N., Gonzalez-Dominguez, R., Peron, G., Zamora-Ros, R., et al. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-1472-9 · Cited by 51 · see citing works
Self-citationZambelli, P., Tamborini, L., Cazzamalli, S., Pinto, A., Arioli, S., Balzaretti, S., Plou, F. J., Fernández‐Arrojo, L., Molinari, F., Conti, P., et al. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.06.002 · Cited by 49 · see citing works
Redondo, N., Gheorghe, A., Díaz, L. E., Villavisencio, B., Marcos, A., & Nova, E. (2019) · Nutrients · doi:10.3390/nu11030651 · Cited by 49 · see citing works
Taverniti, V., Cesari, V., Gargari, G., Rossi, U. G., Biddau, C., Lecchi, C., Fiore, W., Arioli, S., Toschi, I., & Guglielmetti, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.706135 · Cited by 48 · see citing works
Self-citationIn vitro assessment of probiotic and functional properties of Bacillus coagulans T242
Sui, L., Zhu, X., Wu, D., Ma, T., Tuo, Y., Jiang, S., Qian, F., & Mu, G. (2020) · Food Bioscience · doi:10.1016/j.fbio.2020.100675 · Cited by 46 · see citing works
Probiotic strains and mechanistic insights for the treatment of type 2 diabetes
Hampe, C. S., & Roth, C. L. (2017) · Endocrine · doi:10.1007/s12020-017-1433-z · Cited by 45 · see citing works
Zhao, C., Liu, L., Liu, Q., Li, F., Zhang, L., Zhu, F., Shao, T., Barve, S. S., Chen, Y., Li, X., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.020 · Cited by 46 · see citing works
Botelho, P. B., Ferreira, M. V. R., Araújo, A. D. M., Mendes, M. M., & Nakano, E. Y. (2020) · Nutrition · doi:10.1016/j.nut.2020.110890 · Cited by 47 · see citing works
Koirala, R., Gargari, G., Arioli, S., Taverniti, V., Fiore, W., Grossi, E., Anelli, G. M., Cetin, I., & Guglielmetti, S. (2020) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiaa084 · Cited by 44 · see citing works
Self-citationMarelli, G., Erreni, M., Anselmo, A., Taverniti, V., Guglielmetti, S., Mantovani, A., & Allavena, P. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2501 · Cited by 43 · see citing works
Self-citationPusceddu, M. M., Murray, K. M., & Gareau, M. G. (2018) · Current Pathobiology Reports · doi:10.1007/s40139-018-0160-3 · Cited by 42 · see citing works
Scharf, M. W., Marques, T. M., Markgren, M., Löfvendahl, L., Brummer, R. J., & Wall, R. (2020) · Biomolecules · doi:10.3390/biom10050766 · Cited by 41 · see citing works
The Effect of Microbiota on Colon Carcinogenesis
Yoon, K., & Kim, N. (2018) · Journal of Cancer Prevention · doi:10.15430/jcp.2018.23.3.117 · Cited by 41 · see citing works
Gomes, M. J. C., Martino, H. S. D., & Tako, E. (2021) · Nutrients · doi:10.3390/nu13010189 · Cited by 41 · see citing works
Li, J., Li, Y., Zhao, J., Li, L., Wang, Y., Chen, F., Li, Y., Cheng, R., He, F., Ze, X., et al. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03447-2 · Cited by 40 · see citing works
Chen, M., Chen, C., Huang, Y., Tseng, C., Hsu, J.-T., Yi-fen, L., Fang, Y., Wu, M., & Liou, J. (2021) · Helicobacter · doi:10.1111/hel.12857 · Cited by 39 · see citing works
Arioli, S., Koirala, R., Taverniti, V., Fiore, W., & Guglielmetti, S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01720 · Cited by 38 · see citing works
Self-citationLee, S. H., You, H. S., Kang, H., Kang, S. S., & Hyun, S. H. (2020) · Nutrients · doi:10.3390/nu12103112 · Cited by 38 · see citing works
Moser, A. M., Spindelboeck, W., Halwachs, B., Strohmaier, H. M., Kump, P. K., Gorkiewicz, G., & Högenauer, C. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1826-7 · Cited by 37 · see citing works
ZAPATA-RAMÍREZ, O., Cervantes, A., Barreras, A., Monge-Navarro, F. J., González-Vizcarra, V. M., Estrada-Angulo, A., Urías-Estrada, J. D., Corona, L., Zinn, R. A., Martínez-Álvarez, I. G., et al. (2021) · Small Ruminant Research · doi:10.1016/j.smallrumres.2021.106538 · Cited by 37 · see citing works
Sanders, M. E., & Hill, C. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.04.017 · Cited by 36 · see citing works
21st century toolkit for optimizing population health through precision nutrition
O'Sullivan, A., Henrick, B., Dixon, B., Barile, D., Zivkovic, A., Smilowitz, J., Lemay, D., Martin, W., German, J. B., & Schaefer, S. E. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1348335 · Cited by 36 · see citing works
Yang, G., Tian, X., & Dong, S. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.734284 · Cited by 36 · see citing works
The intestinal microbiota as a therapeutic target in the treatment of NAFLD and ALD
Huang, W., & Kong, D. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111235 · Cited by 35 · see citing works
Liu, J., Bai, Y., Liu, F., Kohn, R. A., Tadesse, D. A., Sarria, S., Li, R. W., & Song, J. (2022) · Animals · doi:10.3390/ani12212995 · Cited by 34 · see citing works
Chen, S., Ou, Y., Zhao, L., Li, Y., Qiao, Z., Hao, Y., & Ren, F. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17085 · Cited by 34 · see citing works
Kim, D. S., Ko, B., Ryuk, J. A., & Park, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082900 · Cited by 34 · see citing works
The vaginal isolate Lactobacillus paracasei LPC-S01 (DSM 26760) is suitable for oral administration
Balzaretti, S., Taverniti, V., Rondini, G., Marcolegio, G., Minuzzo, M., Remagni, M. C., Fiore, W., Arioli, S., & Guglielmetti, S. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00952 · Cited by 33 · see citing works
Self-citationCharacterization and Functional Test of Canine Probiotics
Jang, H., Son, S., Kim, J.-A., Jung, M. Y., Choi, Y., Kim, D., Lee, H., Shin, D., & Kim, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.625562 · Cited by 32 · see citing works
The primate gut mycobiome-bacteriome interface is impacted by environmental and subsistence factors
Sharma, A. K., Davison, S., Pafčo, B., Clayton, J. B., Rothman, J. M., McLennan, M. R., Cibot, M., Fuh, T. N., Vodička, R., Robinson, C. J., et al. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00274-3 · Cited by 31 · see citing works
Gut Microbiota Alteration After Long-Term Consumption of Probiotics in the Elderly
Gao, R., Zhang, X., Huang, L., Shen, R., & Qin, H. (2018) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-018-9403-1 · Cited by 32 · see citing works
Garcia-Mansilla, M. J., Rodríguez‐Sojo, M. J., Lista, A. R., Mosqueda, C. V. A., Ruiz‐Malagón, A. J., Gálvez, J., Rodríguez‐Nogales, A., & Rodríguez, M. J. (2024) · Nutrients · doi:10.3390/nu17010155 · Cited by 30 · see citing works
Brüssow, H. (2016) · Microbial Biotechnology · doi:10.1111/1751-7915.12391 · Cited by 30 · see citing works
Duarte, V. D. S., Cruz, B. C. D. S., Tarrah, A., Dias, R. S., Moreira, L. D. P. D., Lemos, W. J. F., Silva, L. C. F., Santana, G. R., de Oliveira, L. L., Pelúzio, M. D. C. G., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8121994 · Cited by 30 · see citing works
Zou, F., Zeng, D., Wen, B., Sun, H., Zhou, Y., Yang, M., Peng, Z., Xu, S., Wang, H., Fu, X., et al. (2016) · AMB Express · doi:10.1186/s13568-016-0273-1 · Cited by 29 · see citing works
Ale, E. C., Bourin, M. J. B., Peralta, G. H., Burns, P., Ávila, O. B., Contini, L., Reinheimer, J. A., & Binetti, A. G. (2019) · International Dairy Journal · doi:10.1016/j.idairyj.2019.04.014 · Cited by 29 · see citing works
Gupta, H., Kim, S. H., Kim, S. K., Han, S. H., Kwon, H. C., & Suk, K. T. (2022) · Microorganisms · doi:10.3390/microorganisms10071474 · Cited by 28 · see citing works
Understanding interactions among diet, host and gut microbiota for personalized nutrition
Li, C. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121265 · Cited by 28 · see citing works
Radicioni, M. M., Koirala, R., Fiore, W., Leuratti, C., Guglielmetti, S., & Arioli, S. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1860-5 · Cited by 27 · see citing works
Self-citationSex Difference of Colon Adenoma Pathway and Colorectal Carcinogenesis
Choi, Y., & Kim, N. (2023) · The World Journal of Men s Health · doi:10.5534/wjmh.230085 · Cited by 30 · see citing works
- Authors
- Ferrario, C., Taverniti, V., Milani, C., Fiore, W., Laureati, M., De Noni, I., Stuknyte, M., Chouaia, B., Riso, P., & Guglielmetti, S.
- Affiliations
- University of Milan (IT)
- University of Parma (IT)
- Sofar (Italy) (IT)
- Corresponding author
- Guglielmetti, Simone
- ORCID
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 144
- Issue
- 11
- Pages
- 1787-1796
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2162642016
- Cited by
- 228
- References
- 48
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 19 · 2023: 14 · 2022: 35 · 2021: 40 · 2020: 22 · 2019: 19 · 2018: 18 · 2017: 12 · 2016: 13 · 2015: 11
- FWCI
- 17.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc)
- BOA (University of Milano-Bicocca) (submittedVersion, other-oa)
- ARCA (Università Ca' Foscari Venezia) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, fecal microbiota, Clostridiales, butyrate, short-chain fatty acids, Proteobacteria, Ruminococcus, Faecalibacterium, Bacteroidales, healthy adults, gut microbiota modulation, 16S rRNA gene sequencing
- MeSH terms
- Adult, Double-Blind Method, Feces, Female, Humans, Lactobacillus, Male, Middle Aged, Gram-Positive Endospore-Forming Rods, Probiotics, Butyric Acid, Young Adult
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