Bisphenol A alters gut microbiome: Comparative metagenomics analysis
Abstract
Mounting evidence has shown that an alteration of the gut microbiota is associated with diet, and plays an important role in animal health and metabolic diseases. However, little is known about the influence of environmental contaminants on the gut microbial community. Bisphenol A (BPA), which is widely used for manufacturing plastic products, has recently been classified as an environmental obesogen. Although many studies have demonstrated the metabolic-disrupting effects of BPA on liver and pancreatic functions, the possible effects of this synthetic compound on the metabolic diversity of the intestinal microbiota is unknown. Using 16S rRNA gene sequencing analysis on caecum samples of CD-1 mice, the present study aimed to test the hypothesis that dietary BPA intake may influence the gut microbiota composition and functions, an important attributing factor to development of the metabolic syndrome. A high-fat diet (HFD) and high-sucrose diet (HSD) were included as the positive controls for comparing the changes in the intestinal microbial profiles. Our results demonstrated a significant reduction of species diversity in the gut microbiota of BPA-fed mice. Alpha and beta diversity analyses showed that dietary BPA intake led to a similar gut microbial community structure as that induced by HFD and HSD in mice. In addition, comparative analysis of the microbial communities revealed that both BPA and a HFD favored the growth of Proteobacteria, a microbial marker of dysbiosis. Co…
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Exposure to BPA through diet results in a dramatic reduction in species diversity of gut microbiota in rodents, while increasing the abundance of Proteobacteria and Helicobacteraceae, and reducing Clostridia.
“Exposure to BPA through diet results in a dramatic reduction in species diversity of gut microbiota in rodents, while increasing the abundance of Proteobacteria and Helicobacteraceae, and reducing Clostridia (Lai et al., 2016).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Lai et al., 2016
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- Authors
- Lai, K.-P., Chung, Y.-T., Li, R., Wan, H.-T., & Wong, C. K.-C.
- Affiliations
- City University of Hong Kong (HK)
- Hong Kong Baptist University (HK)
- Corresponding author
- Lai, Keng-Po
- Wong, Chris Kong-Chu
- Venue
- Environmental Pollution
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 218
- Pages
- 923-930
- ISSN
- 0269-7491 (ISSN-L)
- OpenAlex
- W2507801963
- Cited by
- 175
- References
- 11
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 29 · 2023: 14 · 2022: 22 · 2021: 24 · 2020: 22 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 1
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Pollution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Strategic Development Fund (SDF11-1215-P07, SDF15-1012-P04)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- bisphenol A, gut microbiota, dysbiosis, high-fat diet, high-sucrose diet, Proteobacteria, Helicobacteraceae, Firmicutes, Clostridia, microbial diversity, metabolic syndrome, dietary exposure, ICR mice
- MeSH terms
- Gastrointestinal Microbiome, Bisphenol A Compounds, Animals, Benzhydryl Compounds, Clostridium, Environmental Pollutants, Intestinal Mucosa, Intestines, Liver, Male, Phenols, RNA, Ribosomal, 16S, Proteobacteria, Heliconiaceae, Mice, Metagenomics, Diet, High-Fat, Microbiota
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