Cited by 536Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesGastrointestinal motility and disorders

Gut microbiota and metabolic syndrome

Open access
Festi, Davide, Schiumerini, Ramona, Eusebi, Leonardo Henry, Marasco, Giovanni, Taddia, Martina, Colecchia, Antonio·2014·World Journal of Gastroenterology

Abstract

Gut microbiota exerts a significant role in the pathogenesis of the metabolic syndrome, as confirmed by studies conducted both on humans and animal models. Gut microbial composition and functions are strongly influenced by diet. This complex intestinal "superorganism" seems to affect host metabolic balance modulating energy absorption, gut motility, appetite, glucose and lipid metabolism, as well as hepatic fatty storage. An impairment of the fine balance between gut microbes and host's immune system could culminate in the intestinal translocation of bacterial fragments and the development of "metabolic endotoxemia", leading to systemic inflammation and insulin resistance. Diet induced weight-loss and bariatric surgery promote significant changes of gut microbial composition, that seem to affect the success, or the inefficacy, of treatment strategies. Manipulation of gut microbiota through the administration of prebiotics or probiotics could reduce intestinal low grade inflammation and improve gut barrier integrity, thus, ameliorating metabolic balance and promoting weight loss. However, further evidence is needed to better understand their clinical impact and therapeutic use.

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Crossref · 10.3748/wjg.v20.i43.16079

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138 of 138 references verified0 citation errors · 0 not checkable

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Authors
Festi, D., Schiumerini, R., Eusebi, L. H., Marasco, G., Taddia, M., & Colecchia, A.
Affiliations
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
Venue
World Journal of Gastroenterology
Published
2014
Volume
20
Issue
43
Pages
16079
ISSN
1007-9327 (ISSN-L)
OpenAlex
W2754567481
Cited by
534
References
138
Citations by year
2026: 16 · 2025: 43 · 2024: 39 · 2023: 42 · 2022: 74 · 2021: 71 · 2020: 54 · 2019: 46 · 2018: 41 · 2017: 43 · 2016: 37 · 2015: 28
FWCI
3.39
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by-nc)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut microbiota, metabolic syndrome, diet, energy absorption, intestinal motility, appetite regulation, glucose metabolism, lipid metabolism, bacterial translocation, metabolic endotoxemia, systemic inflammation, insulin resistance, bariatric surgery, weight loss, prebiotics, probiotics, intestinal barrier integrity
MeSH terms
Animals, Diet, Energy Metabolism, Humans, Intestinal Mucosa, Intestines, Obesity, Weight Loss, Treatment Outcome, Bacterial Translocation, Probiotics, Metabolic Syndrome, Caloric Restriction, Bariatric Surgery, Host-Pathogen Interactions, Prebiotics, Microbiota

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