A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Open accessAbstract
Ascertaining when and where genes are expressed is of crucial importance to understanding or predicting the physiological role of genes and proteins and how they interact to form the complex networks that underlie organ development and function. It is, therefore, crucial to determine on a genome-wide level, the spatio-temporal gene expression profiles at cellular resolution. This information is provided by colorimetric RNA in situ hybridization that can elucidate expression of genes in their native context and does so at cellular resolution. We generated what is to our knowledge the first genome-wide transcriptome atlas by RNA in situ hybridization of an entire mammalian organism, the developing mouse at embryonic day 14.5. This digital transcriptome atlas, the Eurexpress atlas (http://www.eurexpress.org), consists of a searchable database of annotated images that can be interactively viewed. We generated anatomy-based expression profiles for over 18,000 coding genes and over 400 microRNAs. We identified 1,002 tissue-specific genes that are a source of novel tissue-specific markers for 37 different anatomical structures. The quality and the resolution of the data revealed novel molecular domains for several developing structures, such as the telencephalon, a novel organization for the hypothalamus, and insight on the Wnt network involved in renal epithelial differentiation during kidney development. The digital transcriptome atlas is a powerful resource to determine co-expression of genes, to identify cell populations and lineages, and to identify functional associations between genes relevant to development and disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In rodents, brain- and transcriptome-wide cellular-resolution maps of transcript distributions are useful resources to complement genomic sequence data.
“In rodents, brain- and transcriptome-wide, cellular-resolution maps of transcript distributions are widely useful resources to complement genomic sequence data1, 2, 3.”
From An anatomically comprehensive atlas of the adult human brain transcriptome (2012) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696 · see citing works
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572 · see citing works
The ENCODE Project Consortium (2007) · Nature · doi:10.1038/nature05874 · Cited by 5,223 · see citing works
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,068 · see citing works
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570 · see citing works
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · see citing works
The cytoarchitectonic organization of the spinal cord in the cat
Rexed, B. (1952) · The Journal of Comparative Neurology · doi:10.1002/cne.900960303 · Cited by 1,633 · see citing works
Sultan, M., Schulz, M. H., Richard, H., Magen, A., Klingenhoff, A., Scherf, M., Seifert, M., Borodina, T., Soldatov, A., Parkhomchuk, D., et al. (2008) · Science · doi:10.1126/science.1160342 · Cited by 1,293 · see citing works
Self-citationTowards an integrated view of Wnt signaling in development
van Amerongen, R., & Nusse, R. (2009) · Development · doi:10.1242/dev.033910 · Cited by 1,168 · see citing works
Lécuyer, E., Yoshida, H., Parthasarathy, N., Alm, C., Babak, T., Cerovina, T., Hughes, T. R., Tomancak, P., & Krause, H. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.003 · Cited by 967 · see citing works
Large-Scale Transcriptional Activity in Chromosomes 21 and 22
Kapranov, P., Cawley, S. E., Drenkow, J., Bekiranov, S., Strausberg, R. L., Fodor, S. P. A., & Gingeras, T. (2002) · Science · doi:10.1126/science.1068597 · Cited by 871 · see citing works
Forebrain gene expression domains and the evolving prosomeric model
Puelles, L., & Rubenstein, J. L. R. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00234-0 · Cited by 734 · see citing works
The journey of developing hematopoietic stem cells
Mikkola, H. K. A., & Orkin, S. H. (2006) · Development · doi:10.1242/dev.02568 · Cited by 577 · see citing works
The Embryonic Vertebrate Forebrain: the Prosomeric Model
Rubenstein, J. L. R., Martinez, S., Shimamura, K., & Puelles, L. (1994) · Science · doi:10.1126/science.7939711 · Cited by 535 · see citing works
Self-citationGenePaint.org: an atlas of gene expression patterns in the mouse embryo
Visel, A. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh029 · Cited by 528 · see citing works
Global analysis of patterns of gene expression during Drosophilaembryogenesis
Tomančák, P., Berman, B. P., Beaton, A., Weiszmann, R., Kwan, E., Hartenstein, V., Celniker, S., & Rubin, G. M. (2007) · Genome biology · doi:10.1186/gb-2007-8-7-r145 · Cited by 453 · see citing works
Segmental organization of embryonic diencephalon
Figdor, M. C., & Stern, C. D. (1993) · Nature · doi:10.1038/363630a0 · Cited by 401 · see citing works
A genomic atlas of mouse hypothalamic development
Shimogori, T., Lee, D. A., Miranda-Angulo, A., Yang, Y., Wang, H., Jiang, L., Yoshida, A. C., Kataoka, A., Mashiko, H., Avetisyan, M., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2545 · Cited by 382 · see citing works
Circulation and Chemotaxis of Fetal Hematopoietic Stem Cells
Christensen, J. L., Wright, D. E., Wagers, A. J., & Weissman, I. L. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020075 · Cited by 358 · see citing works
Lemaigre, F. P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.035 · Cited by 263 · see citing works
Magdaleno, S. M., Jensen, P., Brumwell, C. L., Seal, A., Lehman, K., Asbury, A., Cheung, T., Cornelius, T., Batten, D., Eden, C., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040086 · Cited by 222 · see citing works
Human chromosome 21 gene expression atlas in the mouse
Reymond, A., Marigo, V., Yaylaoglu, M., Leoni, A., Ucla, C., Scamuffa, N., Caccioppoli, C., Dermitzakis, E. T., Lyle, R., Banfi, S., et al. (2002) · Nature · doi:10.1038/nature01178 · Cited by 219 · see citing works
Self-citationAtlas of Gene Expression in the Developing Kidney at Microanatomic Resolution
Brunskill, E. W., Aronow, B. J., Georgas, K. M., Rumballe, B. A., Valerius, M. T., Aronow, J. E., Kaimal, V., Jegga, A. G., Grimmond, S. M., McMahon, A. P., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.09.007 · Cited by 213 · see citing works
VA Opsin-Based Photoreceptors in the Hypothalamus of Birds
Halford, S., Pires, S. S., Turton, M., Zheng, L., González-Menéndez, I., Davies, W. I. L., Peirson, S. N., García-Fernández, J. M., Hankins, M. W., & Foster, F. (2009) · Current Biology · doi:10.1016/j.cub.2009.06.066 · Cited by 169 · see citing works
Yaylaoglu, M., Titmus, A., Visel, A., Álvarez-Bolado, G., Christina Thaller, B., & Gregor Eichele, C. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20441 · Cited by 163 · see citing works
A gene expression map of human chromosome 21 orthologues in the mouse
initiative, T. H. E. M., *Group 1:, Gitton, Y., Dahmane, N., Baik, S., Ruiz i Altaba, A., *Group 2:, Neidhardt, L., Scholze, M., Herrmann, B. G., et al. (2002) · Nature · doi:10.1038/nature01270 · Cited by 127 · see citing works
Self-citationWNT/β-catenin signaling in nephron progenitors and their epithelial progeny
Schmidt-Ott, K. M., & Barasch, J. M. (2008) · Kidney International · doi:10.1038/ki.2008.322 · Cited by 118 · see citing works
A Database for Mouse Development
Ringwald, M., Baldock, R., Bard, J., Kaufman, M. H., Eppig, J. T., Richardson, J. E., Nadeau, J. H., & Davidson, D. R. (1994) · Science · doi:10.1126/science.8091224 · Cited by 110 · see citing works
Self-citationTranscriptional mechanisms controlling motor neuron diversity and connectivity
di Sanguinetto, S. D. T., Dasen, J. S., & Arber, S. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.04.002 · Cited by 109 · see citing works
EMAGE: a spatial database of gene expression patterns during mouse embryo development
Christiansen, J. H. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj006 · Cited by 100 · see citing works
Molecular regulation of kidney development: is the answer blowing in the Wnt?
Merkel, C. E., Karner, C. M., & Carroll, T. J. (2007) · Pediatric Nephrology · doi:10.1007/s00467-007-0504-4 · Cited by 89 · see citing works
A transcriptome atlas of the mouse brain at cellular resolution
Carson, J. P., Thaller, C., & Eichele, G. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00356-2 · Cited by 81 · see citing works
Self-citationThe mouse Gene Expression Database (GXD): updates and enhancements
Hill, D. P. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh069 · Cited by 79 · see citing works
Vieira, C., & Martı́nez, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.032 · Cited by 67 · see citing works
Regulatory Pathway Analysis by High-Throughput In Situ Hybridization
Visel, A., Carson, J. P., Oldekamp, J., Warnecke, M., Jakubcakova, V., Zhou, X., Shaw, C. A., Álvarez-Bolado, G., & Gregor Eichele, C. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030178 · Cited by 64 · see citing works
The Development of the Thalamic Motor Learning Area Is Regulated by Fgf8 Expression
Martinez-Ferre, A., & Martı́nez, S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2625-09.2009 · Cited by 52 · see citing works
Garcı́a-Calero, E., Fernández-Garre, P., Martı́nez, S., & Puelles, L. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.05.545 · Cited by 41 · see citing works
Puelles, L. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082589lp · Cited by 21 · see citing works
The Morphological Pattern of the Vertebrate Brain
Nieuwenhuys, R. (1999) · European Journal of Morphology · doi:10.1076/ejom.37.2.81.4746 · Cited by 12 · see citing works
The Morphological Pattern of the Vertebrate Brain
Nieuwenhuys, R. (1999) · European Journal of Morphology · doi:10.1076/ejom.37.2-3.0081 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
An anatomically comprehensive atlas of the adult human brain transcriptome
Hawrylycz, M. J., Lein, E. S., Guillozet-Bongaarts, A. L., Shen, E. H., Ng, L., Miller, J. A., van de Lagemaat, L. N., Smith, K. A., Ebbert, A., Riley, Z. L., et al. (2012) · Nature · doi:10.1038/nature11405 · Cited by 3,083 · see citing works
Mapping the Mouse Cell Atlas by Microwell-Seq
Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.001 · Cited by 1,597 · see citing works
Computational and analytical challenges in single-cell transcriptomics
Stegle, O., Teichmann, S. A., & Marioni, J. C. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3833 · Cited by 1,170 · see citing works
Highly Multiplexed Subcellular RNA Sequencing in Situ
Lee, J. H., Daugharthy, E. R., Scheiman, J., Kalhor, R., Yang, J. L., Ferrante, T. C., Terry, R., Jeanty, S. S. F., Li, C., Amamoto, R., et al. (2014) · Science · doi:10.1126/science.1250212 · Cited by 973 · see citing works
The BioMart community portal: an innovative alternative to large, centralized data repositories
Smedley, D., Haider, S., Durinck, S., Pandini, L., Provero, P., Allen, J., Arnaiz, O., Awedh, M. H., Baldock, R., Barbiera, G., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv350 · Cited by 755 · see citing works
Self-citationBrain barriers: Crosstalk between complex tight junctions and adherens junctions
Tietz, S., & Engelhardt, B. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412147 · Cited by 551 · see citing works
Differentiated kidney epithelial cells repair injured proximal tubule
Kusaba, T., Lalli, M., Kramann, R., Kobayashi, A., & Humphreys, B. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310653110 · Cited by 476 · see citing works
The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina
Rodriguez, A. R., de Sevilla Müller, L. P., & Brecha, N. C. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23521 · Cited by 483 · see citing works
A cellular and spatial map of the choroid plexus across brain ventricles and ages
Dani, N., Herbst, R. H., McCabe, C., Green, G. S., Kaiser, K., Head, J. P., Cui, J., Shipley, F. B., Jang, A., Dionne, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.003 · Cited by 388 · see citing works
A High-Resolution Enhancer Atlas of the Developing Telencephalon
Visel, A., Taher, L., Girgis, H., May, D., Golonzhka, O., Hoch, R. V., McKinsey, G. L., Pattabiraman, K., Silberberg, S. N., Blow, M. J., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.041 · Cited by 257 · see citing works
The Choroid Plexus in Healthy and Diseased Brain
Kaur, C., Rathnasamy, G., & Ling, E.-A. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlv030 · Cited by 176 · see citing works
Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex
Lui, J. H., Nowakowski, T. J., Pollen, A. A., Javaherian, A., Kriegstein, A. R., & Oldham, M. C. (2014) · Nature · doi:10.1038/nature13973 · Cited by 166 · see citing works
LDLRAD3 is a receptor for Venezuelan equine encephalitis virus
Ma, H., Kim, A. S., Kafai, N. M., Earnest, J. T., Shah, A. P., Case, J. B., Basore, K., Gilliland, T. C., Sun, C., Nelson, C. A., et al. (2020) · Nature · doi:10.1038/s41586-020-2915-3 · Cited by 161 · see citing works
Vallecillo-García, P., Orgeur, M., vom Hofe-Schneider, S., Stumm, J., Kappert, V., Ibrahim, D. M., Börno, S. T., Hayashi, S., Relaix, F., Hildebrandt, K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01120-3 · Cited by 126 · see citing works
Self-citationDevelopment, Maturation, and Necessity of Transcription Factors in the Mouse Suprachiasmatic Nucleus
VanDunk, C., Hunter, L. A., & Gray, P. A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5385-10.2011 · Cited by 89 · see citing works
Kaiser, K., Gyllborg, D., Procházka, J., Salašová, A., Kompaníková, P., Molina, F. L., Laguna-Goya, R., Radaszkiewicz, T., Harnoš, J., Procházková, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09298-4 · Cited by 87 · see citing works
<i>FAM46A</i> mutations are responsible for autosomal recessive osteogenesis imperfecta
Doyard, M., Bacrot, S., Huber, C., Di Rocco, M., Goldenberg, A., Aglan, M. S., Brunelle, P., Temtamy, S., Michot, C., Otaify, G. A., et al. (2018) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2017-104999 · Cited by 75 · see citing works
Roy, A., Francius, C., Rousso, D. L., Seuntjens, E., Debruyn, J., Luxenhofer, G., Huber, A. B., Huylebroeck, D., Novitch, B. G., & Clotman, F. (2012) · Development · doi:10.1242/dev.078501 · Cited by 75 · see citing works
Šestak, M. S., Božičević, V., Bakarić, R., Dunjko, V., & Domazet-Lošo, T. (2013) · Frontiers in Zoology · doi:10.1186/1742-9994-10-18 · Cited by 42 · see citing works
Prdm8 regulates the morphological transition at multipolar phase during neocortical development
Inoue, M., Kuroda, T., Honda, A., Komabayashi-Suzuki, M., Komai, T., Shinkai, Y., & Mizutani, K.-I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086356 · Cited by 41 · see citing works
Puelles, L., Diaz, C., Stühmer, T., Ferran, J. L., Martínez‐de la Torre, M., & Rubenstein, J. L. R. (2021) · Journal of Comparative Neurology · doi:10.1002/cne.24952 · Cited by 35 · see citing works
Chan, W. H., Komada, M., Fukushima, T., Southard-Smith, E. M., Anderson, C. R., & Wakefield, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-40501-0 · Cited by 24 · see citing works
Dori, M., Cavalli, D., Lesche, M., Massalini, S., Alieh, L. H. A., de Toledo, B. C., Khudayberdiev, S., Schratt, G., Dahl, A., & Calegari, F. (2020) · Development · doi:10.1242/dev.190520 · Cited by 22 · see citing works
Caporale, A. L., Cinalli, A. R., Rubinstein, M., & Franchini, L. F. (2024) · Molecular Biology and Evolution · doi:10.1093/molbev/msae186 · Cited by 7 · see citing works
“5 WT embryos by in situ hybridization recapitulated the patterns reported in the Developing Allen Mouse Brain and GenePaint atlases (Diez-Roux et al. 2011; Thompson et al. 2014) with strong labeling in the developing lateral ganglionic eminence, diencephalon, mesenceph-alon (tegmentum and m1),…”
BackgroundMethod
- Authors
- Diez-Roux, G., Banfi, S., Sultan, M., Geffers, L., Anand, S., Rozado, D., Magen, A., Canidio, E., Pagani, M., Peluso, I., Lin-Marq, N., Koch, M., Bilio, M., Cantiello, I., Verde, R., De Masi, C., Bianchi, S. A., Cicchini, J., Perroud, E., Mehmeti, S., Dagand, E., Schrinner, S., Nürnberger, A., Schmidt, K., Metz, K., Zwingmann, C., Brieske, N., Springer, C., Hernandez, A. M., Herzog, S., Grabbe, F., Sieverding, C., Fischer, B., Schrader, K., Brockmeyer, M., Dettmer, S., Helbig, C., Alunni, V., Battaini, M.-A., Mura, C., Henrichsen, C. N., Garcia-Lopez, R., Echevarria, D., Puelles, E., Garcia-Calero, E., Kruse, S., Uhr, M., Kauck, C., Feng, G., Milyaev, N., Ong, C. K., Kumar, L., Lam, M., Semple, C. A., Gyenesei, A., Mundlos, S., Radelof, U., Lehrach, H., Sarmientos, P., Reymond, A., Davidson, D. R., Dollé, P., Antonarakis, S. E., Yaspo, M.-L., Martinez, S., Baldock, R. A., Eichele, G., & Ballabio, A.
- Affiliations
- Telethon Institute Of Genetics And Medicine (IT)
- Max Planck Institute for Molecular Genetics (DE)
- Max Planck Institute for Biophysical Chemistry (DE)
- University of Geneva (CH)
- Phénotypage et ingénierie précliniques des systèmes d’organismes modèles (FR)
- Instituto de Neurociencias (ES)
- Western General Hospital (GB)
- University of Lausanne (CH)
- Centre National de la Recherche Scientifique (FR)
- Baylor College of Medicine (US)
- Corresponding author
- Davidson, Duncan R.
- Dollé, Pascal
- Antonarakis, Stylianos E.
- Yaspo, Marie-Laure
- Baldock, Richard A.
- Ballabio, Andrea
- ORCID
- Banfi, Sandro
- Sultan, Marc
- Geffers, Lars
- Anand, Santosh
- Rozado, David
- Pagani, Massimiliano
- Bilio, Marchesa
- Verde, Roberta
- Bianchi, Salvatore A.
- Dagand, Emilie
- Herzog, Sarah
- Fischer, Barbara
- Mura, Carole
- Puelles, Eduardo
- Ong, Chuang Kee
- Kumar, Lalit
- Semple, Colin A.
- Gyenesei, Attila
- Mundlos, Stefan
- Reymond, Alexandre
- Dollé, Pascal
- Antonarakis, Stylianos E.
- Yaspo, Marie-Laure
- Baldock, Richard A.
- Ballabio, Andrea
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-01-18
- Volume
- 9
- Issue
- 1
- Pages
- e1000582
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC3022534
- OpenAlex
- W2126867710
- Cited by
- 638
- References
- 41
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 52 · 2023: 11 · 2022: 28 · 2021: 42 · 2020: 39 · 2019: 37 · 2018: 50 · 2017: 45 · 2016: 37 · 2015: 52 · 2014: 60 · 2013: 64 · 2012: 61
- FWCI
- 28.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
- IRIS (submittedVersion)
- HAL (submittedVersion, other-oa)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion, cc-by)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- univOAK (4 institutions : Université de Strasbourg, Université de Haute Alsace, INSA Strasbourg, Bibliothèque Nationale et Universitaire de Strasbourg) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Association pour la Recherche sur le Cancer
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Ministerio de Economía y Competitividad (BFU2008-00588, CSD2007-00023)
- Max-Planck-Gesellschaft
- Centro de Investigación Biomédica en Red de Salud Mental
- Medical Research Council
- Instituto de Salud Carlos III (DIGESIC-MEC BFU2008-00588, 00023)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Keywords
- mouse embryo, transcriptome atlas, spatiotemporal gene expression, RNA in situ hybridization, tissue-specific genes, tissue-specific markers, telencephalon, hypothalamus, Wnt signaling, kidney development, microRNA
- MeSH terms
- Animals, Atlases as Topic, Embryo, Mammalian, Mice, Inbred C57BL, Organ Specificity, Internet, Gene Expression Profiling, Databases, Genetic, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
