Long-lasting behavioral effects of juvenile trauma in an animal model of PTSD associated with a failure of the autonomic nervous system to recover

Cohen, Hagit; Kaplan, Zeev; Matar, Michael A.; Loewenthal, Uri; Zohar, Joseph; Richter-Levin, Gal

doi:10.1016/j.euroneuro.2006.11.003

Cited by 84Posttraumatic Stress Disorder ResearchHeart Rate Variability and Autonomic ControlStress Responses and Cortisol

Long-lasting behavioral effects of juvenile trauma in an animal model of PTSD associated with a failure of the autonomic nervous system to recover

Cohen, Hagit, Kaplan, Zeev, Matar, Michael A., Loewenthal, Uri, Zohar, Joseph, Richter-Levin, Gal·2007·European Neuropsychopharmacology

DOI 10.1016/j.euroneuro.2006.11.003

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Abstract

Background Early life exposure to potentially traumatic experiences (PTEs) significantly increases the risk of responding more severely to stressful events experienced in adulthood. The aim of this study was to assess the autonomic nervous system (ANS) response to exposure to two PTEs in youth and again in adulthood, in terms of heart rate and heart rate variability in animals that responded to the PTE dramatically as compared to those that displayed virtually no behavioral response and to control animals.Methods The prevalence of individuals displaying extreme anxiety-like behavioral responses to the PTE (predator urine or elevated platform) was assessed in the elevated plus-maze and startle response paradigms. Behavioral paradigms were complemented by assessment of the involvement of the ANS in relation to changes in behavior.Results Juvenile trauma increases the vulnerability for developing long-term behavioral disruptions, taken to represent post-traumatic stress symptoms, after a second exposure to the same stressor in adulthood. PTSD-like behaviors and persisting physiological abnormalities resulted from disturbed recovery from the initial stress response.Conclusions Exposure to a PTE during youth can have significant and long-lasting effects in adulthood and predispose the individual to PTSD upon subsequent re-exposure. Monitoring of ANS parameters confirms that development of extreme long-term (PTSD-like) behavioral changes is associated with a failure of recovery from the initial ANS responses to stress exposure.

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Exposure to cigarette smoke at the time of stressful experience potentiates fear conditioning and makes long-term post-traumatic stress and autonomic imbalance more likely.
“Exposure to CS at the time of stressful experience potentiates fear conditioning (Davis et al., 2006; Cohen et al., 2007; Kutlu and Gould, 2015), and makes long-term post-traumatic stress and autonomic imbalance more likely (van der Velden et al., 2008).”
From Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke (2017) · cites this paper as Cohen et al., 2007

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Authors: Cohen, H., Kaplan, Z., Matar, M. A., Loewenthal, U., Zohar, J., & Richter-Levin, G.
Affiliations: Ben-Gurion University of the Negev (IL)
Tel Aviv University (IL)
Corresponding author: Cohen, Hagit
ORCID: Cohen, Hagit
Zohar, Joseph
Venue: European Neuropsychopharmacology
Publisher: Elsevier BV
Published: 2007-05
Volume: 17
Issue: 6-7
Pages: 464-477
ISSN: 0924-977X (ISSN-L)
DOI: 10.1016/j.euroneuro.2006.11.003
OpenAlex: W2018368505
Cited by: 84
References: 36
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 3
FWCI: 5.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
Israel Academy of Sciences and Humanities
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: post-traumatic stress disorder, early trauma, autonomic nervous system, heart rate variability, heart rate, anxiety-like behavior, elevated platforms, startle response, elevated plus maze, animal model of PTSD
MeSH terms: Aging, Animals, Autonomic Nervous System, Behavior, Animal, Depression, Disease Models, Animal, Heart Rate, Male, Predatory Behavior, Stress Disorders, Post-Traumatic, Stress, Psychological, Rats, Wistar, Rats

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Long-lasting behavioral effects of juvenile trauma in an animal model of PTSD associated with a failure of the autonomic nervous system to recover

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