The role of corticotropin-releasing factor–norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress
Abstract
Naturally occurring variations in maternal care in early postnatal life are associated with the development of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the rat. These effects appear to be mediated by the influence of maternal licking and grooming on the development of central corticotropin-releasing factor (CRF) systems, which regulate the expression of behavioral, endocrine, and autonomic responses to stress through activation of forebrain noradrenergic systems. These findings provide a neurobiologic basis for the observed relationship between early life events and health in adulthood. In more recent studies, we explored the behavioral transmission of individual differences in stress reactivity, and thus, vulnerability to stress-induced illness, across generations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The relationship between quality of early social environment and adult health appears partly mediated by development of individual differences in neural systems underlying behavioral and endocrine stress responses.
“The relationship between the quality of the early social environment and health in adulthood appears to be, in part, mediated by the development of individual differences in neural systems that underlie the expression of behavioral and endocrine responses to stress.26-30”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [28]
Cites
Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092 · see citing works
McEwen, B. S. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.18.2093 · Cited by 4,365 · see citing works
Bowman, P. W. (1963) · AIBS Bulletin · doi:10.2307/1292957 · Cited by 3,654 · see citing works
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170 · see citing works
Self-citationThe psychology of fear and stress
(1988) · Choice Reviews Online · doi:10.5860/choice.26-2399 · Cited by 3,134 · see citing works
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083 · see citing works
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689 · see citing works
How people make their own environments: a theory of genotype greater than environment effects.
Scarr, S., & Mccartney, K. (1983) · Child Development · doi:10.1111/j.1467-8624.1983.tb03884.x · Cited by 2,385 · see citing works
JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739 · see citing works
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638 · see citing works
Self-citationMechanisms of emotional arousal and lasting declarative memory.
Cahill, L., & McGaugh, J. L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01214-9 · Cited by 1,575 · see citing works
Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5335 · Cited by 1,437 · see citing works
Self-citationThe ecology and sociology of the Norway rat
Calhoun, J. B. (1963) · doi:10.5962/bhl.title.112283 · Cited by 1,040 · see citing works
Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, C., Sharma, S., Seckl, J. R., & Plotsky, P. M. (2010) · Developmental Neuroscience · doi:10.1159/000111395 · Cited by 878 · see citing works
Self-citationBrain corticosteroid receptor balance and homeostatic control
de Kloet, E. R. (1991) · Frontiers in Neuroendocrinology · Cited by 842 · see citing works
van der Kooy, D., Koda, L. Y., McGinty, J. F., Gerfen, C. R., & Bloom, F. E. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902240102 · Cited by 733 · see citing works
Infantile Experience and Resistance to Physiological Stress
Levine, S. (1957) · Science · doi:10.1126/science.126.3270.405 · Cited by 659 · see citing works
Do early‐life events permanently alter behavioral and hormonal responses to stressors?
Anisman, H., Zaharia, M. D., Meaney, M. J., & Merali, Z. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00025-2 · Cited by 654 · see citing works
Self-citationCoplan, J. D., Andrews, M. W., Rosenblum, L. A., Owens, M. J., Friedman, S., Gorman, J. M., & Nemeroff, C. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1619 · Cited by 649 · see citing works
Psychiatric morbidity in adult inpatients with childhood histories of sexual and physical abuse
Brown, G. R., & Anderson, B. J. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.1.55 · Cited by 596 · see citing works
(1996) · PubMed · Cited by 547 · see citing works
Physiological and behavioral effects of infantile stimulation
Levine, S., Haltmeyer, G. C., Karas, G. G., & Denenberg, V. H. (1967) · Physiology & Behavior · doi:10.1016/0031-9384(67)90011-x · Cited by 545 · see citing works
Catecholaminergic Modulation of Corticotropin-Releasing Factor and Adrenocorticotropin Secretion
Plotsky, P. M., Cunningham, E. T., & Widmaier, E. P. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-4-437 · Cited by 530 · see citing works
Self-citationLadd, C. O., Owens, M. J., & Nemeroff, C. B. (1996) · Endocrinology · doi:10.1210/endo.137.4.8625891 · Cited by 511 · see citing works
Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls
Bellis, M. D. D., Chrousos, G. P., Dorn, L. D., Burke, L. P., Helmers, K. F., Kling, M. A., Trickett, P. K., & Putnam, F. W. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.2.8106608 · Cited by 508 · see citing works
Meaney, M. J., Aitken, D. H., Viau, V., Sharma, S., & Sarrieau, A. (2008) · Neuroendocrinology · doi:10.1159/000125287 · Cited by 457 · see citing works
Self-citationMediation by Corticotropin Releasing Factor (CRF) of Adenohypophysial Hormone Secretion
RIVIER, C. L., & Plotsky, P. M. (1986) · Annual Review of Physiology · doi:10.1146/annurev.ph.48.030186.002355 · Cited by 443 · see citing works
Self-citationCritical periods, stimulus input, and emotional reactivity: A theory of infantile stimulation.
Denenberg, V. H. (1964) · Psychological Review · doi:10.1037/h0042567 · Cited by 426 · see citing works
Schulkin, J., W. Gold, P., & S. McEwen, B. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00099-1 · Cited by 423 · see citing works
Butler, P., Weiss, J., Stout, J., & Nemeroff, C. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-01-00176.1990 · Cited by 402 · see citing works
Pacák, K., Palkovits, M., Kopin, I. J., & Goldstein, D. S. (1995) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1995.1004 · Cited by 395 · see citing works
Wright, A. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-503_5 · Cited by 379 · see citing works
Higley, J. D., Hasert, M. F., Suomi, S. J., & Linnoila, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7261 · Cited by 368 · see citing works
The Ontogeny of the Hypothalamic‐Pituitary‐Adrenal Axis. The Influence of Maternal Factorsa
Levine, S. D. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39245.x · Cited by 343 · see citing works
Early Sexual Abuse and Clinical Depression in Adult Life
Bifulco, A., Brown, G. W., & Adler, Z. (1991) · British Journal of Psychiatry · doi:10.1192/bjp.159.1.115 · Cited by 335 · see citing works
Maternal Depression Effects on Infants and Early Interventions
Field, T. (1998) · Preventive Medicine · doi:10.1006/pmed.1998.0293 · Cited by 325 · see citing works
Moga, M. M., & Gray, T. S. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902410304 · Cited by 315 · see citing works
Settling nature and nurture into an ontogenetic niche
West, M. J., & King, A. P. (1987) · Developmental Psychobiology · doi:10.1002/dev.420200508 · Cited by 305 · see citing works
(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-77-2-332_3 · Cited by 285 · see citing works
Individual Differences in Maternal Style
Fairbanks, L. A. (1996) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)60343-5 · Cited by 278 · see citing works
Simple Method of Harvesting <i>Limnoria</i> from Nature
Johnson, F. H., & Ray, D. L. (1962) · Science · doi:10.1126/science.135.3506.795-a · Cited by 276 · see citing works
Brindley, D. N., & Rolland, Y. (1989) · Clinical Science · doi:10.1042/cs0770453 · Cited by 269 · see citing works
Pathways to the Secretion of Adrenocorticotropin: A View from the Portal*
Plotsky, P. M. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00231.x · Cited by 258 · see citing works
Self-citationNemeroff, C. B., Bissette, G., Akil, H., & Fink, M. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.158.1.59 · Cited by 253 · see citing works
Meaney, M. J., Aitken, D. H., Bhatnagar, S., & Sapolsky, R. M. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90036-j · Cited by 250 · see citing works
Self-citationLENNART, L. (1977) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-197709000-00016 · Cited by 243 · see citing works
Brady, L. S., Gold, P. W., Herkenham, M. A., Lynn, A. B., & Whitfield, H. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)90459-m · Cited by 236 · see citing works
Meaney, M. J., & Aitken, D. H. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90183-x · Cited by 234 · see citing works
Self-citationThe Amygdala: Corticotropin-Releasing Factor, Steroids, and Stress
Gray, T. S., & Bingaman, E. W. (1996) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v10.i2.10 · Cited by 230 · see citing works
Valentino, R. J., & Foote, S. L. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-03-01016.1988 · Cited by 223 · see citing works
Kraemer, G. W. (1989) · Neuropsychopharmacology · doi:10.1016/0893-133x(89)90021-3 · Cited by 212 · see citing works
Parental bonding and mental health in adolescence.
Canetti, L., Bachar, E., Galili‐Weisstub, E., De-Nour, A. K., & Shalev, A. Y. (1997) · PubMed · Cited by 207 · see citing works
Swiergiel, A. H., Takahashi, L. K., & Kalin, N. H. (1993) · Brain Research · doi:10.1016/0006-8993(93)91432-r · Cited by 199 · see citing works
Heim, C. C., Owens, M. J., Plotsky, P. M., & Nemeroff, C. B. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48279.x · Cited by 197 · see citing works
Self-citationZaharia, M. D., Kulczycki, J., Shanks, N. M., Meaney, M. J., & Anisman, H. (1996) · Psychopharmacology · doi:10.1007/s002130050130 · Cited by 186 · see citing works
Self-citationThe Role of Parental Disciplinary Practices in the Development of Depression and Alcoholism
Holmes, S. J., & Robins, L. N. (1988) · Psychiatry · doi:10.1080/00332747.1988.11024377 · Cited by 184 · see citing works
EARLY STIMULATION OF RODENTS: A CRITICAL REVIEW OF PRESENT INTERPRETATIONS
Daly, M. (1973) · British Journal of Psychology · doi:10.1111/j.2044-8295.1973.tb01370.x · Cited by 183 · see citing works
Viau, V., Sharma, S., Plotsky, P. M., & Meaney, M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01097.1993 · Cited by 181 · see citing works
Self-citationAdverse early experiences affect noradrenergic and serotonergic functioning in adult primates
Rosenblum, L. A., Coplan, J. D., Friedman, S., Bassoff, T., Gorman, J. M., & Andrews, M. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91252-1 · Cited by 180 · see citing works
Lavický, J., & Dunn, A. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03191.x · Cited by 176 · see citing works
Oxytocin Control of Maternal Behavior Regulation by Sex Steroids and Offspring Stimuli<sup>a</sup>
PEDERSEN, C. A. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51916.x · Cited by 172 · see citing works
Schanberg, S. M., Evoniuk, G., & Kuhn, C. M. (1984) · Experimental Biology and Medicine · doi:10.3181/00379727-175-41779 · Cited by 169 · see citing works
Modification of the corticosterone response curve as a function of handling in infancy
Hess, J. L., Denenberg, V. H., ZARROW, M. X., & Pfeifer, W. (1969) · Physiology & Behavior · doi:10.1016/0031-9384(69)90023-7 · Cited by 160 · see citing works
Are There Any Successful Men from Criminogenic Backgrounds?
Farrington, D. P., Gallagher, B., Morley, L., Ledger, R. J. S., & West, D. J. (1988) · Psychiatry · doi:10.1080/00332747.1988.11024387 · Cited by 154 · see citing works
Effects of maternal hormones on ‘timidity’ and attraction to pup-related odors in female rats
Fleming, A. S., Cheung, U. S., Myhal, N., & Kessler, Z. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90019-x · Cited by 151 · see citing works
Parental representations of patients with anxiety neurosis
Parker, G. B. (1981) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1981.tb00647.x · Cited by 151 · see citing works
Sarrieau, A., Sharma, S., & Meaney, M. J. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90162-9 · Cited by 150 · see citing works
Self-citationCoplan, J. D., Trost, R. C., Owens, M. J., Cooper, T. B., Gorman, J. M., Nemeroff, C. B., & Rosenblum, L. A. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.5.473 · Cited by 145 · see citing works
Influences of environmental demand on maternal behavior and infant development
Rosenblum, L. A., & Andrews, M. W. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13266.x · Cited by 144 · see citing works
The Physiological Relevance of Glucocorticoid Endangerment of the Hippocampusa
Sapolsky, R. M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39247.x · Cited by 141 · see citing works
Effects of early experience on adrenocortical reactivity
Ader, R., & Grota, L. J. (1969) · Physiology & Behavior · doi:10.1016/0031-9384(69)90179-6 · Cited by 140 · see citing works
THE INFLUENCE OF CHILDHOOD DISCIPLINARY EXPERIENCE ON THE DEVELOPMENT OF ALCOHOLISM AND DEPRESSION
Holmes, S. J., & Robins, L. N. (1987) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1987.tb01762.x · Cited by 140 · see citing works
Early experience and cross‐generational continuity of mother‐infant contact in vervet monkeys
Fairbanks, L. A. (1989) · Developmental Psychobiology · doi:10.1002/dev.420220703 · Cited by 136 · see citing works
Bhatnagar, S., & Meaney, M. J. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00672.x · Cited by 127 · see citing works
Self-citationRussek, L. G., & Schwartz, G. (1997) · Journal of behavioral medicine · doi:10.1023/a:1025525428213 · Cited by 124 · see citing works
O’Donnell, D., Larocque, S., Seckl, J. R., & Meaney, M. J. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90096-5 · Cited by 122 · see citing works
Self-citationChanges in licking behaviour of rat mother following handling of young
Lee, M. H. S., & Williams, D. I. (1974) · Animal Behaviour · doi:10.1016/s0003-3472(74)80016-3 · Cited by 121 · see citing works
Patchev, V., Montkowski, A., Rouskova, D., Korányi, L., Holsboer, F., & Almeida, O. F. X. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119261 · Cited by 120 · see citing works
Valentino, R. J., Curtis, A. L., Page, M. E., Pavcovich, L. A., & Florin-Lechner, S. M. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60863-7 · Cited by 120 · see citing works
Parenting styles of abusive mothers in group-living rhesus macaques
Maestripieri, D. (1998) · Animal Behaviour · doi:10.1006/anbe.1997.0578 · Cited by 116 · see citing works
Rosenblatt, J. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13259.x · Cited by 116 · see citing works
Corticosteroids, the Aging Brain and Cognition
McEwen, B. S., de Leon, M. J., LUPIEN, S. J., & Meaney, M. J. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00122-2 · Cited by 107 · see citing works
Self-citationCommentary: Is maternal stimulation the mediator of the handling effect in infancy?
Denenberg, V. H. (1999) · Developmental Psychobiology · doi:10.1002/(sici)1098-2302(199901)34:1 · Cited by 107 · see citing works
Factors influencing maternal responsiveness in humans: Usefulness of an animal model
Fleming, A. J. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90014-5 · Cited by 106 · see citing works
Lee, Y., Schulkin, J. A., & Davis, M. (1994) · Brain Research · doi:10.1016/0006-8993(94)90286-0 · Cited by 103 · see citing works
Infantile stimulation and ultrasonic signaling: A possible mediator of early handling phenomena
Bell, R. W., Nitschke, W., Gorry, T. H., & Zachman, T. A. (1971) · Developmental Psychobiology · doi:10.1002/dev.420040209 · Cited by 96 · see citing works
Owens, M. J., Vargas, M. A., Knight, D. L., & Nemeroff, C. B. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20232-4 · Cited by 94 · see citing works
Intergenerational Transmission of Parental Bonding Among Women
Miller, L., KRAMER, R. A., Warner, V., WICKRAMARATNE, P. J., & Weissman, M. M. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199708000-00022 · Cited by 81 · see citing works
GABA Physiology: Modulation by Benzodiazepines and Hormones
Wilson, M. A. (1996) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v10.i1.10 · Cited by 78 · see citing works
Moore, C., Wong, L., Daum, M. C., & Leclair, O. U. (1997) · Developmental Psychobiology · doi:10.1002/(sici)1098-2302(199705)30:4 · Cited by 77 · see citing works
Nest temperature: Effects on maternal behavior, pup development, and interactions with handling
Jans, J. E., & Woodside, B. C. (1990) · Developmental Psychobiology · doi:10.1002/dev.420230607 · Cited by 77 · see citing works
Early experience and emotional development
Denenberg, V. H. (1963) · Scientific American · doi:10.1038/scientificamerican0663-138 · Cited by 73 · see citing works
Long term changes in nest condition and pup grouping following handling of rat litters
Lee, M. H. S., & Williams, D. I. (1975) · Developmental Psychobiology · doi:10.1002/dev.420080113 · Cited by 64 · see citing works
Immature siblings and mother-infant relationships among free-ranging rhesus monkeys on Cayo Santiago
Berman, C. M. (1992) · Animal Behaviour · doi:10.1016/0003-3472(92)90031-4 · Cited by 62 · see citing works
Koegler‐Muly, S. M., Owens, M. J., Ervin, G. N., Kilts, C. D., & Nemeroff, C. B. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00367.x · Cited by 62 · see citing works
The role of lactogenic hormones in maternal behavior in female rats
Bridges, R. S. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13263.x · Cited by 62 · see citing works
Early life events and later development of Ischaemic heart disease
Seckl, J. R. (1993) · The Lancet · doi:10.1016/0140-6736(93)92215-f · Cited by 62 · see citing works
ZARROW, M. X., Campbell, P. S., & Denenberg, V. H. (1972) · Experimental Biology and Medicine · doi:10.3181/00379727-141-36776 · Cited by 60 · see citing works
Learning as adaptation of the infant
Alberts, J. R. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13269.x · Cited by 59 · see citing works
Catecholamines, Stress, and Disease
McCarty, R. C., & Gold, P. E. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199611000-00007 · Cited by 55 · see citing works
Bridges, R. S., & Freemark, M. (1995) · Hormones and Behavior · doi:10.1006/hbeh.1995.1016 · Cited by 50 · see citing works
Roberts, V. J., Barth, S., Meunier, H., & Vale, W. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960115)364:3 · Cited by 45 · see citing works
Schulkin, J. A. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1610349 · Cited by 38 · see citing works
Affect and nurturance: Mechanisms mediating maternal behavior in two female mammals
Fleming, A. S., & Anderson, V. N. (1987) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(87)90049-2 · Cited by 30 · see citing works
Rowe, W. B., Nicot, A. B., Sharma, S., Gully, D., Walker, C., Rostène, W. H., Meaney, M. J., & Quirion, R. (2008) · Neuroendocrinology · doi:10.1159/000127223 · Cited by 24 · see citing works
Self-citationEarly lateral bias in tufted capuchins (Cebus apella)
Westergaard, G. C., Byrne, G., & Suomi, S. J. (1998) · Developmental Psychobiology · doi:10.1002/(sici)1098-2302(199801)32:1 · Cited by 23 · see citing works
Temperament, social competence, and adrenocortical activity in preschoolers
Gunnar, M. R., Tout, K., de Haan, M., Pierce, S., & Stanbury, K. (1997) · Developmental Psychobiology · doi:10.1002/(sici)1098-2302(199707)31:1
Flagged first, then by citations
3 of the 110 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820 · see citing works
Anda, R. F., Felitti, V. J., Bremner, J. D., Walker, J. D., Whitfield, C., Perry, B. D., Dube, S. R., & Giles, W. H. (2006) · European archives of psychiatry and clinical neuroscience · doi:10.1007/s00406-005-0624-4 · Cited by 4,292 · see citing works
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791 · see citing works
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708 · see citing works
Self-citationNeurocognitive mechanisms of anxiety: An integrative account
Bishop, S. J. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.05.008 · Cited by 976 · see citing works
Epigenetic mechanisms and the transgenerational effects of maternal care
Champagne, F. A. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.03.003 · Cited by 812 · see citing works
Self-citationEssex, M. J., Klein, M. H., Cho, E., & Kalin, N. H. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01553-6 · Cited by 698 · see citing works
CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety
McCall, J. G., Al-Hasani, R., Siuda, E. R., Hong, D. Y., Norris, A. J., Ford, C. P., & Bruchas, M. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.002 · Cited by 666 · see citing works
Neurobiological and psychiatric consequences of child abuse and neglect
Heim, C., Shugart, M., Craighead, W. E., & Nemeroff, C. B. (2010) · Developmental Psychobiology · doi:10.1002/dev.20494 · Cited by 613 · see citing works
Research Review: The neurobiology and genetics of maltreatment and adversity
McCrory, E., De Brito, S. A., & Viding, E. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02271.x · Cited by 598 · see citing works
Fluvoxamine for the Treatment of Anxiety Disorders in Children and Adolescents
Walkup, J. T., Labellarte, M. J., Riddle, M. A., Pine, D. S., Greenhill, L., Klein, R., Davies, M., Sweeney, M., Abikoff, H., Hack, S., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104263441703 · Cited by 588 · see citing works
Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
Variations in maternal care in infancy regulate the development of stress reactivity
Caldji, C., Diorio, J. C., & Meaney, M. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01084-2 · Cited by 571 · see citing works
Self-citationModulation of the Hypothalamic-Pituitary-Adrenal Axis by Early Life Stress Exposure
van Bodegom, M., Homberg, J. R., & Henckens, M. J. A. G. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00087 · Cited by 562 · see citing works
Plotsky, P. M., Thrivikraman, K. V., Nemeroff, C. B., Caldji, C., Sharma, S., & Meaney, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300769 · Cited by 522 · see citing works
Self-citationEpigenetic mechanisms mediating the long-term effects of maternal care on development
Champagne, F. A., & Curley, J. P. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.009 · Cited by 504 · see citing works
Self-citationEffects of early adverse experiences on brain structure and function: clinical implications
Kaufman, J., Plotsky, P. M., Nemeroff, C. B., & Charney, D. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00998-7 · Cited by 508 · see citing works
Self-citationHuot, R. L., Thrivikraman, K. V., Meaney, M. J., & Plotsky, P. M. (2001) · Psychopharmacology · doi:10.1007/s002130100701 · Cited by 506 · see citing works
Self-citationKalinichev, M., Easterling, K. W., Plotsky, P. M., & Holtzman, S. G. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00781-5 · Cited by 484 · see citing works
Self-citationCoutinho, S. V., Plotsky, P. M., Sablad, M., Miller, J. C., Zhou, H., Bayati, A. I., McRoberts, J. A., & Mayer, E. A. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00240.2001 · Cited by 456 · see citing works
Self-citationBlair, C. (2006) · Behavioral and Brain Sciences · doi:10.1017/s0140525x06009034 · Cited by 434 · see citing works
Goodman, A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.030 · Cited by 412 · see citing works
Early physical and sexual abuse associated with an adverse course of bipolar illness
Leverich, G. S., McElroy, S. L., Suppes, T. M., Keck, P. E., Denicoff, K. D., Nolen, W. A., Altshuler, L. L., Rush, A. J., Kupka, R., Frye, M. A., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01239-2 · Cited by 415 · see citing works
Sociogenomic Personality Psychology
Roberts, B. W., & Jackson, J. J. (2008) · Journal of Personality · doi:10.1111/j.1467-6494.2008.00530.x · Cited by 392 · see citing works
Applying a cognitive neuroscience perspective to the disorder of psychopathy
Blair, J. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050418 · Cited by 388 · see citing works
Hertenstein, M. J., Verkamp, J. M., Kerestes, A. M., & Holmes, R. M. (2006) · Genetic Social and General Psychology Monographs · doi:10.3200/mono.132.1.5-94 · Cited by 379 · see citing works
Blair, C., Granger, D., & Peters Razza, R. (2005) · Child Development · doi:10.1111/j.1467-8624.2005.00863.x · Cited by 367 · see citing works
Epigenetic programming of stress responses through variations in maternal care
FISH, E. W., SHAHROKH, D., BAGOT, R., CALDJI, C., BREDY, T., SZYF, M., & MEANEY, M. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1330.011 · Cited by 361 · see citing works
Self-citationDiminished cortisol responses to psychosocial stress associated with lifetime adverse events
Elzinga, B. M., Roelofs, K., Tollenaar, M. S., Bakvis, P., van Pelt, J., & Spinhoven, P. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.11.004 · Cited by 364 · see citing works
Pediatric Stress: Hormonal Mediators and Human Development
Charmandari, E., Kino, T., Souvatzoglou, E., & Chrousos, G. P. (2003) · Hormone Research in Paediatrics · doi:10.1159/000069325 · Cited by 364 · see citing works
Taché, Y., Martı́nez, V., Million, M., & Wang, L. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.2.g173 · Cited by 347 · see citing works
Zhang, T. Y., Labonté, B., Wen, X. L., Turecki, G., & Meaney, M. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.149 · Cited by 347 · see citing works
Self-citationNeural Mechanisms Underlying Selective Attention to Threat
Bishop, S. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.016 · Cited by 330 · see citing works
Evolving pathophysiologic models of functional gastrointestinal disorders
Mayer, E. A., & Collins, S. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.33584 · Cited by 326 · see citing works
Cameron, N. M., Champagne, F. A., Parent, C., Fish, E. W., Ozaki-Kuroda, K., & Meaney, M. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.022 · Cited by 320 · see citing works
Self-citationRoceri, M., Cirulli, F., Pessina, C., Peretto, P., Racagni, G., & Riva, M. A. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.011 · Cited by 317 · see citing works
Bremner, J. D., Vythilingam, M., Vermetten, E. H. G. J. M., Adil, J., Khan, S., Nazeer, A., Afzal, N., McGlashan, T. H., Elzinga, B. M., Anderson, G. M., et al. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00067-7 · Cited by 312 · see citing works
Transgenerational transmission of cortisol and PTSD risk
Yehuda, R., & Bierer, L. M. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67009-5 · Cited by 306 · see citing works
Rinne, T., de Kloet, E. R., Wouters, L., Goekoop, J. G., DeRijk, R. H., & van den Brink, W. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01395-1 · Cited by 279 · see citing works
González, A., Lovic, V., Ward, G. R., Wainwright, P. E., & Fleming, A. S. (2000) · Developmental Psychobiology · doi:10.1002/1098-2302(2001)38:1 · Cited by 273 · see citing works
Early maternal separation: a rodent model of depression and a prevailing human condition
Vetulani, J. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71505-6 · Cited by 255 · see citing works
Roth, T. L., & David Sweatt, J. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02282.x · Cited by 246 · see citing works
Long-term effects of childhood abuse on brain and neurobiology
Bremner, J. D. (2003) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(02)00098-6 · Cited by 243 · see citing works
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
Anacker, C., O'Donnell, K. J., & Meaney, M. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/canacker · Cited by 237 · see citing works
Self-citationEarly adversity and adult health outcomes
Taylor, S. E., Way, B. M., & Seeman, T. E. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000411 · Cited by 235 · see citing works
Social epidemiology: social determinants of health in the United States: are we losing ground?
Berkman, L. F. (2009) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.031308.100310 · Cited by 230 · see citing works
Taché, Y., Martı́nez, V., Wang, L., & Million, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705760 · Cited by 228 · see citing works
Sex steroidal hormones and respiratory control
Behan, M., & Wenninger, J. M. (2008) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2008.06.006 · Cited by 209 · see citing works
Roth, T. L., & Sullivan, R. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.032 · Cited by 204 · see citing works
Fleming, A. S., Kraemer, G. W., Gonzalez, A., Lovic, V., Rees, S., & Melo, A. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00793-1 · Cited by 203 · see citing works
Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder
Rasmusson, A. M., Lipschitz, D. S., Wang, S., Hu, S., Vojvoda, D., Bremner, J. D., Southwick, S. M., & Charney, D. S. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01264-1 · Cited by 182 · see citing works
Penza, K. M., Heim, C. C., & Nemeroff, C. B. (2003) · Archives of Women s Mental Health · doi:10.1007/s00737-002-0159-x · Cited by 183 · see citing works
Neurobiology of infant attachment
Moriceau, S., & Sullivan, R. M. (2005) · Developmental Psychobiology · doi:10.1002/dev.20093 · Cited by 180 · see citing works
Early life adversity shapes neural circuit function during sensitive postnatal developmental periods
Malave, L., van Dijk, M. T., & Anacker, C. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02092-9 · Cited by 177 · see citing works
Early life stress impairs fear conditioning in adult male and female rats
Kosten, T. A., Lee, H. J., & Kim, J. J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.009 · Cited by 170 · see citing works
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162 · see citing works
Jarvis, S., Moinard, C., Robson, S. K., Baxter, E., Ormandy, E., Douglas, A. J., Seckl, J. R., Russell, J. A., & Lawrence, A. B. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.05.004 · Cited by 162 · see citing works
Integrated technology for evaluation of brain function and neural plasticity
Rossini, P. M., & Forno, G. D. (2004) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/s1047-9651(03)00124-4 · Cited by 159 · see citing works
Importance of early environment in the development of post-traumatic stress disorder-like behaviors
Imanaka, A., Morinobu, S., Toki, S., & Yamawaki, S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.012 · Cited by 154 · see citing works
The search for determinants of chronic depression: a review of six factors
Riso, L. P., Miyatake, R. K., & Thase, M. E. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00376-7 · Cited by 152 · see citing works
Li, L., Feng, X., Zhou, Z., Zhang, H., Shi, Q., Lei, Z., Shen, P., Yang, Q., Zhao, B., Chen, S., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.005 · Cited by 148 · see citing works
Maternally separated rats show deficits in maternal care in adulthood
Lovic, V., González, A., & Fleming, A. S. (2001) · Developmental Psychobiology · doi:10.1002/dev.1024 · Cited by 149 · see citing works
Dettmer, A. M., Novak, M. A., Suomi, S. J., & Meyer, J. S. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.003 · Cited by 143 · see citing works
Arborelius, L., & Eklund, M. B. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.007 · Cited by 140 · see citing works
Contributions of Psychophysiology to Research on Adult Attachment: Review and Recommendations
Diamond, L. M. (2001) · Personality and Social Psychology Review · doi:10.1207/s15327957pspr0504_1 · Cited by 136 · see citing works
Early life manipulations alter learning and memory in rats
Kosten, T. A., Kim, J. J., & Lee, H. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.003 · Cited by 134 · see citing works
Animal models of depression: are there any?
O'Neil, M. F., & Moore, N. A. (2003) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.496 · Cited by 133 · see citing works
Pryce, C. R., Rüedi‐Bettschen, D., Bahr, N. I., & Feldon, J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.5.883 · Cited by 131 · see citing works
Myers, B., Scheimann, J. R., Franco, A. C. G., & Herman, J. P. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.011 · Cited by 125 · see citing works
Calkins, S. D., Graziano, P. A., Berdan, L. E., Keane, S. P., & Degnan, K. A. (2008) · Developmental Psychobiology · doi:10.1002/dev.20344 · Cited by 127 · see citing works
Heuser, I., & Lammers, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00048-4 · Cited by 126 · see citing works
Post, R. M., & Leverich, G. S. (2006) · Development and Psychopathology · doi:10.1017/s0954579406060573 · Cited by 126 · see citing works
Corticotropin-releasing hormone and animal models of anxiety: gene–environment interactions
Bakshi, V. P., & Kalin, N. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01082-9 · Cited by 124 · see citing works
Rodent model of infant attachment learning and stress
Moriceau, S., Roth, T. L., & Sullivan, R. M. (2010) · Developmental Psychobiology · doi:10.1002/dev.20482 · Cited by 119 · see citing works
Prenatal maternal stress and early caregiving experiences: implications for childhood asthma risk
Wright, R. J. (2007) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2007.00879.x · Cited by 120 · see citing works
Graziano, P. A., Keane, S. P., & Calkins, S. D. (2010) · Infant and Child Development · doi:10.1002/icd.670 · Cited by 116 · see citing works
González‐Mariscal, G., & Poindron, P. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50005-6 · Cited by 115 · see citing works
Real-world stress resilience is associated with the responsivity of the locus coeruleus
Grueschow, M., Stenz, N., Thörn, H., Ehlert, U., Breckwoldt, J., Brodmann Maeder, M., Exadaktylos, A. K., Bingisser, R., Ruff, C. C., & Kleim, B. (2021) · Nature Communications · doi:10.1038/s41467-021-22509-1 · Cited by 116 · see citing works
Perinatal stress and early life programming of lung structure and function
Wright, R. J. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.01.007 · Cited by 114 · see citing works
Wang, X., Cen, X., & Lü, L. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01487-x · Cited by 112 · see citing works
Emotion regulation and touch in infants: the role of cholecystokinin and opioids
Weller, A., & Feldman, R. (2003) · Peptides · doi:10.1016/s0196-9781(03)00118-9 · Cited by 110 · see citing works
Genest, S., Gulemetova, R., Laforest, S., Drolet, G., & Kinkead, R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.052894 · Cited by 108 · see citing works
Brotman, L. M., Gouley, K. K., Huang, K., Kamboukos, D. M., Fratto, C. M., & Pine, D. S. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.10.1172 · Cited by 107 · see citing works
The Contribution of an Animal Model Toward Uncovering Biological Risk Factors for PTSD
Cohen, H., Matar, M. A., Richter‐Levin, G., & Zohar, J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.026 · Cited by 104 · see citing works
Parfitt, D. B., Levin, J. K., Saltstein, K. P., Klayman, A. S., Greer, L. M., & Helmreich, D. L. (2004) · Brain Research · doi:10.1016/j.brainres.2004.04.077 · Cited by 103 · see citing works
The central corticotropin releasing factor system during development and adulthood
Korosi, A., & Baram, T. Z. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.066 · Cited by 102 · see citing works
Vazquez, V., Penit-Soria, J., Durand, C., Besson, M. J., Giros, B., & Daugé, V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4807-04.2005 · Cited by 101 · see citing works
Biology, Genes, and Resilience
Bowes, L., & Jaffee, S. R. (2013) · Trauma Violence & Abuse · doi:10.1177/1524838013487807 · Cited by 99 · see citing works
Early Experience Modifies the Postnatal Assembly of Autonomic Emotional Motor Circuits in Rats
Card, J. P., Levitt, P. R., Gluhovsky, M. Y., & Rinaman, L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2345-05.2005 · Cited by 97 · see citing works
MacQueen, G. M., Ramakrishnan, K., Ratnasingan, R., Chen, B., & Young, L. T. (2003) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703003729 · Cited by 96 · see citing works
Neonatal social isolation alters both maternal and pup behaviors in rats
Zimmerberg, B., Rosenthal, A. J., & Stark, A. C. (2002) · Developmental Psychobiology · doi:10.1002/dev.10086 · Cited by 95 · see citing works
Epigenetic Risk Factors in PTSD and Depression
Raabe, F. J., & Spengler, D. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00080 · Cited by 94 · see citing works
Marmendal, M., Roman, E., Eriksson, C. J. P., Nylander, I., & Fahlke, C. (2004) · Developmental Psychobiology · doi:10.1002/dev.20027 · Cited by 95 · see citing works
Neonatal handling: An overview of the positive and negative effects
Raineki, C., Lucion, A. B., & Weinberg, J. (2014) · Developmental Psychobiology · doi:10.1002/dev.21241 · Cited by 90 · see citing works
Ana, E. J. S., Saladin, M. E., Back, S. E., Waldrop, A. E., Spratt, E. G., McRae‐Clark, A. L., LaRowe, S. D., Timmerman, M. A., Upadhyaya, H. P., & Brady, K. T. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.11.009 · Cited by 88 · see citing works
Bazak, N., Kozlovsky, N., Kaplan, Z., Matar, M. A., Golan, H. M., Zohar, J., Richter‐Levin, G., & Cohen, H. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.12.018 · Cited by 87 · see citing works
Impact of Prenatal Stress on Neuroendocrine Programming
Viltart, O., & Vanbesien-Mailliot, C. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.204 · Cited by 86 · see citing works
In Utero Life and Epigenetic Predisposition for Disease
Thornburg, K. L. R., Shannon, J., Thuillier, P., & Turker, M. S. (2010) · Advances in genetics · doi:10.1016/b978-0-12-380864-6.00003-1 · Cited by 85 · see citing works
Cohen, H., Kaplan, Z., Matar, M. A., Loewenthal, U., Zohar, J., & Richter-Levin, G. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.11.003 · Cited by 84 · see citing works
Pohl, T. T., Young, L. J., & Bosch, O. J. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.12.011 · Cited by 83 · see citing works
- Authors
- Francis, D. D., Caldji, C., Champagne, F., Plotsky, P. M., & Meaney, M. J.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Emory University (US)
- Corresponding author
- Meaney, Michael J
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 46
- Issue
- 9
- Pages
- 1153-1166
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2047908047
- Cited by
- 380
- References
- 110
- Citations by year
- 2026: 17 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 14 · 2021: 6 · 2020: 6 · 2019: 13 · 2018: 7 · 2017: 4 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 14 · 2012: 15
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- corticotropin-releasing factor, noradrenergic system, maternal care, early life experience, stress reactivity, hypothalamic-pituitary-adrenal axis, individual differences, intergenerational transmission
- MeSH terms
- Animals, Corticotropin-Releasing Hormone, Disease Susceptibility, Female, Handling, Psychological, Hypothalamo-Hypophyseal System, Male, Maternal Behavior, Norepinephrine, Pituitary-Adrenal System, Stress, Psychological, Genetic Predisposition to Disease, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review