Cited by 380Stress Responses and CortisolNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

The role of corticotropin-releasing factor–norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress

Francis, Darlene D, Caldji, Christian, Champagne, Frances, Plotsky, Paul M, Meaney, Michael J·1999·Biological Psychiatry

Abstract

Naturally occurring variations in maternal care in early postnatal life are associated with the development of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the rat. These effects appear to be mediated by the influence of maternal licking and grooming on the development of central corticotropin-releasing factor (CRF) systems, which regulate the expression of behavioral, endocrine, and autonomic responses to stress through activation of forebrain noradrenergic systems. These findings provide a neurobiologic basis for the observed relationship between early life events and health in adulthood. In more recent studies, we explored the behavioral transmission of individual differences in stress reactivity, and thus, vulnerability to stress-induced illness, across generations.

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Registry

Crossref · 10.1016/s0006-3223(99)00237-1

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107 of 107 references verified0 citation errors · 0 not checkable

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  • The relationship between quality of early social environment and adult health appears partly mediated by development of individual differences in neural systems underlying behavioral and endocrine stress responses.

    “The relationship between the quality of the early social environment and health in adulthood appears to be, in part, mediated by the development of individual differences in neural systems that underlie the expression of behavioral and endocrine responses to stress.26-30”

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Authors
Francis, D. D., Caldji, C., Champagne, F., Plotsky, P. M., & Meaney, M. J.
Affiliations
  • Douglas Mental Health University Institute (CA)
  • Emory University (US)
Corresponding author
Meaney, Michael J
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1999-11
Volume
46
Issue
9
Pages
1153-1166
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2047908047
Cited by
380
References
110
Citations by year
2026: 17 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 14 · 2021: 6 · 2020: 6 · 2019: 13 · 2018: 7 · 2017: 4 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 14 · 2012: 15
FWCI
1.32
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
corticotropin-releasing factor, noradrenergic system, maternal care, early life experience, stress reactivity, hypothalamic-pituitary-adrenal axis, individual differences, intergenerational transmission
MeSH terms
Animals, Corticotropin-Releasing Hormone, Disease Susceptibility, Female, Handling, Psychological, Hypothalamo-Hypophyseal System, Male, Maternal Behavior, Norepinephrine, Pituitary-Adrenal System, Stress, Psychological, Genetic Predisposition to Disease, Rats

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