Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress
Abstract
Hyperlipidemia is associated with increased risk of coronary artery disease and stroke, both of which, in turn, are risk factors of old-age depression. Statins are extensively used for decreasing cholesterol levels. Clinical investigations revealed that long-term use of statins appeared to be associated with a lower risk of anxiety and depression. However, the antidepressant property of statins has not been well examined. This study aimed at examining the antidepressant-like effects of statins in rats exposed to chronic mild stress (CMS). We found that animals exposed to CMS for 4 weeks developed depressive-like state, shown by forced swim test and sucrose preference test. However, these CMS-induced behavioral changes were reversed by simvastatin (5 or 10mg/kg/day) for 14 days, comparable to imipramine (10mg/kg/day) treatment. Locomotor activity and anxiety-like behaviors were not altered by CMS or these treatments. These results demonstrated antidepressant-like effects of statin in CMS model of rats and suggested the potential that statins could be used to facilitate antidepressant treatment in clinical setting.
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Preclinical studies indicate that simvastatin may have anxiolytic and antidepressant-like effects in stress-related murine models.
“Preclinical studies indicate that simvastatin may have anxiolytic and antidepressant-like effects in stress-related murine models [167, 168].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [167]
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- Authors
- Lin, P.-Y., Chang, A. Y. W., & Lin, T.-K.
- Affiliations
- Chang Gung University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Corresponding author
- Lin, Pao-Yen
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 124
- Pages
- 174-179
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2055443049
- Cited by
- 43
- References
- 39
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 1
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kaohsiung Chang Gung Memorial Hospital (CMRPG891651, CMRPG8A0811)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- simvastatin, statins, antidepressant-like effects, chronic mild stress, depression, imipramine, forced swim test, sucrose preference, anxiety-like behavior, locomotor activity, hyperlipidemia
- MeSH terms
- Animals, Behavior, Animal, Corticosterone, Depression, Male, Stress, Psychological, Rats, Sprague-Dawley, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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