Outreach and support in South-London (OASIS) 2001—2020: Twenty years of early detection, prognosis and preventive care for young people at risk of psychosis
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This study aims to describe twenty years of early detection, prognosis and preventive care in the Outreach and Support In South-London (OASIS) mental health service for individuals at Clinical High risk of psychosis (CHR-P). The study presents a comprehensive analysis of the 2001- 2020 activity of the OASIS team encompassing core domains: (i) service characteristics, (ii) detection, (iii) prognosis, (iv) treatment and (v) clinical research. The analyses employed descriptive statistics, population-level data, the epidemiological incidence of psychosis, Kaplan Meier failure functions and Greenwood 95% CIs and Electronic Health Records. OASIS is part of the South London and Maudsley (SLaM) NHS trust, the largest European mental health provider, serving a total urban population of 1,358,646 individuals (population aged 16-35: 454,525). Incidence of psychosis in OASIS's catchment area ranges from 58.3 to 71.9 cases per 100,000 person-years, and it is higher than the national average of 41.5 cases per 100,000 person-year. OASIS is a standalone, NHS-funded, multidisciplinary (team leader, consultant and junior psychiatrists, clinical psychologists, mental health professionals), transitional (for those aged 14-35 years) community mental health service with a yearly caseload of 140 CHR-P individuals. OASIS regularly delivers a comprehensive service promotion outreach to several local community organisations. Referrals to OASIS (2366) are made by numerous agencies; about one-third of the referrals eventually met CHR-P criteria. Overall, 600 CHR-P individuals (55.33% males, mean age 22.63 years, white ethnicity 46.44%) have been under the care of the OASIS service: 80.43% met attenuated psychotic symptoms, 18.06% brief and limited intermittent psychotic symptoms and 1.51% genetic risk and deterioration CHR-P criteria. All CHR-P individuals were offered cognitive behavioural therapy and psychosocial support; medications were used depending on individual needs. The cumulative risk of psychosis at ten years was 0.365 (95%CI 0.302-0.437). At six years follow-up, across two-third of individuals non-transitioning to psychosis, 79.24% still displayed some mental health problem, and only 20.75% achieved a complete clinical remission. Research conducted at OASIS encompassed clinical, prognostic, neurobiological and interventional studies and leveraged local, national and international infrastructures; over the past ten years, OASIS-related research attracted about £ 50 million of grant income, with 5,922 citations in the international databases. Future developments may include broadening OASIS to prevent other serious mental disorders beyond psychosis and fostering translational risk prediction and interventional research. With a twenty-years activity, OASIS' cutting-edge quality of preventive care, combined with translational research innovations, consolidated the service as a leading reference model for evidence-based prevention of psychosis worldwide.
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CHR-P services represent a successful global template for transitional mental health services and applied clinical research that fully integrate between adolescence and young adulthood.
“CHR-P services also represent a successful global template for transitional mental health services and applied clinical research 232 that fully integrate between adolescence and young adulthood 67”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [232]
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Self-citationLivingston, N. R., Micheli, A. D., McCutcheon, R. A., Butler, E., Hamdan, M., Grace, A. A., McGuire, P. K., Egerton, A., Fusar‐Poli, P., & Modinos, G. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae036 · Cited by 8 · see citing works
Self-citationColizzi, M., Basaldella, M., Candolo, A., Garzitto, M., Palermo, A., Scipioni, C., Tavian, G., Balestrieri, M., Bortoletto, R., & Comacchio, C. (2024) · Early Intervention in Psychiatry · doi:10.1111/eip.13604 · Cited by 6 · see citing works
Inns, M., Gill, M., Arribas, M., Logeswaran, Y., Minichino, A., Reilly, T. J., Micheli, A. D., Shah, J. L., McGuire, P. K., Fusar‐Poli, P., et al. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaf201 · Cited by 6 · see citing works
Self-citationOliver, D., Davies, C., Zelaya, F. O., Selvaggi, P., Micheli, A. D., Catalán, A., Baldwin, H., Arribas, M., Modinos, G., Crossley, N. A., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1092213 · Cited by 6 · see citing works
Self-citationArribas, M., Solmi, M., Thompson, T., Oliver, D., & Fusar‐Poli, P. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.976035 · Cited by 6 · see citing works
Self-citationHippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk
Davies, C., Bossong, M. G., Martins, D., Wilson, R. P., Appiah‐Kusi, E., Blest‐Hopley, G., Allen, P., Zelaya, F. O., Lythgoe, D. J., Brammer, M. J., et al. (2023) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgad022 · Cited by 6 · see citing works
Self-citationAronica, R., Ostinelli, E. G., Austin, C., Oliver, D., McGuire, P. K., Brambilla, P., Torous, J. B., & Cipriani, A. (2025) · BMJ Mental Health · doi:10.1136/bmjment-2024-301337 · Cited by 7 · see citing works
Self-citationPercudani, M., Iardino, R., Porcellana, M., Lisoni, J., Brogonzoli, L., Barlati, S., & Vita, A. (2023) · Brain Sciences · doi:10.3390/brainsci13050822 · Cited by 5 · see citing works
Piccolo, M. C. D., Valmaggia, L., Henderson, C., Spencer, T. J., Lewis, D., Fitzell, S., Edwards, S. A., Evans, C., & Tognin, S. (2023) · Psychiatric Rehabilitation Journal · doi:10.1037/prj0000585 · Cited by 5 · see citing works
Self-citationLogeswaran, Y., Micheli, A. D., Toniol, I., Chen, T., Melillo, A., Arribas, M., Livingston, N. R., Krakowski, K., Oliver, D., Stahl, D. R., et al. (2026) · World Psychiatry · doi:10.1002/wps.70063 · Cited by 4 · see citing works
Self-citationLukow, P. B., Schubert, J. J., Severino, M., Knight, S., Kiemes, A., Livingston, N. R., Davies, J., Micheli, A. D., Spencer, T. J., Fusar‐Poli, P., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03204-9 · Cited by 4 · see citing works
Self-citationOffspring studies: Predicting conversion to psychosis
Sugranyes, G., & de la Serna, E. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.05.016 · Cited by 4 · see citing works
Haussler, S. M., Zahid, U., Day, F., Ciufolini, S., Petros, N., Gifford, G., Alameda, L., Quattrone, D., Dazzan, P., Pariante, C. M., et al. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107283 · Cited by 3 · see citing works
Self-citationVita, A., Barlati, S., Porcellana, M., Sala, E., Lisoni, J., Brogonzoli, L., Percudani, M., & Iardino, R. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1382326 · Cited by 2 · see citing works
Electronic Health Records to Detect Psychosis Risk
Oliver, D., & Fusar‐Poli, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-10698-9_12
Self-citationDigital behavioural tests as diagnostic aid for psychosisPreprint
Słowiński, P., White, A., Lison, S., Sullivan, S. A., Emmens, T., Self, P., Wileman, J., Karl, A., & Tsaneva-Atanasova, K. T. (2023) · medRxiv · doi:10.1101/2023.01.14.23284551
Esordi psicotici in adolescenza e giovane età adulta: prospettive teoriche e di trattamento
Paterlini, F. (2022) · RIVISTA SPERIMENTALE DI FRENIATRIA · doi:10.3280/rsf2022-003003
Tarbox, S. I., Walsh, B. C., Pogue‐Geile, M. F., & Woods, S. W. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad001 · Cited by 1 · see citing works
Substance Abuse, Personality Disorders, and Severe Mental Illness
Emmelkamp, P. M. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-34078-9_9
The potential of digital behavioural tests as a diagnostic aid for psychosis
Słowiński, P., White, A., Lison, S., Sullivan, S. A., Emmens, T., Self, P., Wileman, J., Karl, A., & Tsaneva-Atanasova, K. T. (2023) · PLOS Digital Health · doi:10.1371/journal.pdig.0000339
A co-produced community engagement workshop in South London to reduce psychosis related stigmaPreprint
Cai, S., N’Danga-Koroma, J., Graham, C., McKay, M., Bray, C., Colgan, L., Lynch, S. B., Fitzell, S., Akande, I., & Spencer, T. J. (2024) · medRxiv · doi:10.1101/2024.02.21.24303172
Self-citationLukow, P. B., Schubert, J. J., Severino, M., Knight, S., Kiemes, A., Livingston, N. R., Davies, J., Micheli, A. D., Spencer, T. J., Fusar‐Poli, P., et al. (2025) · medRxiv · doi:10.1101/2025.02.27.25322861
Self-citationMultimodal Prediction of Psychosis in the Prospective MoBa Birth CohortPreprint
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Self-citationHardiyati, H., Yosep, I., Dhamayanti, M., Pandia, V., & Hikmat, R. (2025) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2503301
Dargan, P. (2025) · The Child & Family Clinical Psychology Review · doi:10.53841/bpscypf.2025.10.1.17
Diazepam modulates anterior cingulate glutamate levels in people at clinical high-risk for psychosis
Kiemes, A., Livingston, N. R., Lukow, P. B., Knight, S., Jelen, L. A., Reilly, T. J., Dima, A., Nettis, M. A., Lythgoe, D. J., Casetta, C., et al. (2025) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaf078
Self-citationPetersen, T., Martini, J., Bauer, M., Bechdolf, A., Bermpohl, F., Berndt, C., Bröckel, K. L., Sperling, T., Correll, C. U., Dannlowski, U., et al. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121419
Self-citationGee, A. L., Livingston, N. R., Kiemes, A., Knight, S., Lukow, P. B., Lythgoe, D. J., Vorontsova, N., Donocik, J. G., Davies, J., Rabiner, E. A., et al. (2026) · medRxiv · doi:10.64898/2026.04.08.26350385
Self-citationMelillo, A., Micheli, A. D., Nandha, S., Gadelrab, R., Jauhar, S., Young, A. H., Azis, M., Manchia, M., Pfennig, A., Mucci, A., et al. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1773189
Self-citationGenetic evidence for the psychosis continuum: polygenic score analysis.
Haussler, S., Prata, D., Kempton, M., Bhavsar, V., Arathimos, R., Coleman, J. R. I., Valmaggia, L., Tognin, S., Modinos, G., Fusar-Poli, P., et al. (2026) · The British journal of psychiatry : the journal of mental science · doi:10.1192/bjp.2026.10795
Self-citation
- Authors
- Fusar-Poli, P., Spencer, T., De Micheli, A., Curzi, V., Nandha, S., & McGuire, P.
- Affiliations
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 39
- Pages
- 111-122
- ISSN
- 0924-977X (ISSN-L)
- PMC
- PMC7540251
- OpenAlex
- W3085900994
- Cited by
- 57
- References
- 47
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 10 · 2023: 18 · 2022: 5 · 2021: 8
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Neuropsychopharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- clinical high risk for psychosis, early detection of psychosis, psychosis prevention, service evaluation, psychosis incidence, attenuated psychotic symptoms, cognitive behavioral therapy, psychosocial support, antipsychotic drugs
- MeSH terms
- Adolescent, Adult, Female, Humans, London, Male, Preventive Medicine, Prognosis, Psychotic Disorders, Referral and Consultation, Risk Factors, Time Factors, Early Diagnosis, Young Adult
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