Cited by 209T-cell and B-cell ImmunologyCytomegalovirus and herpesvirus researchGenetics, Aging, and Longevity in Model Organisms

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study

Open access

Strindhall, Jan, Nilsson, Bengt-Olof, Löfgren, Sture, Ernerudh, Jan, Pawelec, Graham, Johansson, Boo, Wikby, Anders·2007·Experimental Gerontology

DOI 10.1016/j.exger.2007.05.001

Open this paper in CoChat — free account

Abstract

In the present NONA immune longitudinal study, we investigate the previously identified Immune Risk Profile (IRP), defined by an inverted CD4/CD8 ratio and associated with persistent cytomegalovirus infection and increased numbers of CD8+CD28- cells, relative 6-year survival and age in NONA individuals. These subjects have now reached age 92, 96, and for the first time in this study, 100 years at follow-up. A 55 year old middle-aged group was used for comparison. Immunological monitoring included the analysis of numbers of lymphocytes and neutrophils, the T-cell subsets CD3+CD4+, CD3+CD8+, CD8+CD28+, CD8+CD28-, and the CD4/CD8 ratio. Longitudinal data were analysed by multivariate analyses of variance (MANOVA) from four measurement occasions at 2-year inter-intervals. One-way ANOVA was used for cross-sectional comparisons at baseline and the 6-year follow-up. The results confirmed the importance of the IRP as a major predictor of mortality in this population of very old. Moreover, the results suggested that survival to the age of 100 years is associated with selection of individuals with an "inverted" IRP that was stable across time, i.e., maintenance of a high CD4/CD8 ratio and low numbers of CD8+CD28- cells. The results underlines the importance of a longitudinal study design in dissecting immune parameters predictive of survival and show for the first time that centenarian status is associated with avoidance of the IRP over at least the previous 6 years and probably throughout life.

Integrity signals

Registry

Crossref · 10.1016/j.exger.2007.05.001

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study
Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474
Self-citation
Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly
Hadrup, S. R., Strindhall, J., Køllgaard, T., Seremet, T., Johansson, B. E. A., Pawelec, G., Straten, P. T., & Wikby, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2645 · Cited by 471
Self-citation
Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
Wikby, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00212-1 · Cited by 414
Self-citation
An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans
Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407
Self-citation
Human immunosenescence: is it infectious?
Pawelec, G., Akbar, A., Caruso, C., Solana, R., Grubeck‐Loebenstein, B., & Wikby, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00271.x · Cited by 405
Self-citation
Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study
Wikby, A., Maxson, P., Olsson, J., Johansson, B. E. A., & Ferguson, F. G. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00151-6 · Cited by 381
Self-citation
Immune Parameters in a Longitudinal Study of a Very Old Population of Swedish People: A Comparison Between Survivors and Nonsurvivors
Ferguson, F. G., Wikby, A., Maxson, P., Olsson, J., & Johansson, B. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.6.b378 · Cited by 378
Self-citation
Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence
Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377 · cited 1×
“The association between the number of CD8+CD28- cells and CD4/CD8 ratio, as presented for the very old individuals in figure 1, conform with previous findings (Effros et al., 1994).”
Result
Aging and Innate Immunity
Solana, R., Pawelec, G., & Tarazona, R. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.003 · Cited by 313
Self-citation
Cell-Mediated Immunity as a Predictor of Morbidity and Mortality in Subjects Over 60
Wayne, S. J., Rhyne, R. L., Garry, P. J., & Goodwin, J. S. (1990) · Journal of Gerontology · doi:10.1093/geronj/45.2.m45 · Cited by 303 · cited 1×
“There is considerable evidence of age-associated changes in immune capabilities resulting in increased morbidity and mortality due to altered function of the adaptive immune system (Wayne et al., 1990).”
Background

Show all 20 references

Sorted by citations

Items 101–200 of 209

DAMPs and influenza virus infection in ageing
Samy, R. P., & Lim, L. H. K. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.07.005 · Cited by 23
Immune signatures associated with mortality differ in elderly populations from different birth cohorts and countries even within northern Europe
Pawelec, G. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.04.005 · Cited by 20
Self-citation
Dietary supplementation of chitosan affects milk performance, markers of inflammatory response and antioxidant status in dairy cows
Zheng, Y.-G., Zhang, B. Q., Qi, J., Zhao, Y., Guo, X., Shi, B., & Yan, S. (2021) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2021.114952 · Cited by 21
Systems Biology and immune aging
O’Connor, J., Herrera, G., Martínez‐Romero, A., de Oyanguren, F. S., Díaz, L., Carvalho‐Gomes, Â., Balaguer, S., & Callaghan, R. C. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.09.009 · Cited by 24
Heart Disease and Ageing: The Roles of Senescence, Mitochondria, and Telomerase in Cardiovascular Disease
Booth, L. K., Redgrave, R. E., Tual‐Chalot, S., Spyridopoulos, I., Phillips, H. M., & Richardson, G. D. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_4 · Cited by 20
An Enhanced Immune Response of Mclk1+/− Mutant Mice Is Associated with Partial Protection from Fibrosis, Cancer and the Development of Biomarkers of Aging
Wang, D., Wang, Y., Argyriou, C., Carrière, A., Malo, D., & Hekimi, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049606 · Cited by 18
Inverted CD4:CD8 ratio is not associated with three-year mortality in a sample of community-dwelling oldest old: The octabaix immune study
Formiga, F., Ferrer, A., Padrós, G., Contra, A., & Pujol, R. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0403-2 · Cited by 19
Dynamic study of oral Candida infection and immune status in HIV infected patients during HAART
Du, X., Xiong, H., Yang, Y., Yan, J., Zhu, S., & Chen, F. (2020) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2020.104741 · Cited by 17
Killer Immunoglobulin-like Receptors (KIR) haplogroups A and B track with Natural Killer Cells and Cytokine Profile in Aged Subjects: Observations from Octo/Nonagenarians in the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)
Rea, I. M., Maxwell, L. D., McNerlan, S., Alexander, H. D., Curran, M. D., Middleton, D., & Ross, O. A. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-35 · Cited by 16
Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study
Granic, A., Martin-Ruiz, C. M., Dodds, R. M., Robinson, L. A., Spyridopoulos, I., Kirkwood, T. B. L., von Zglinicki, T., & Sayer, A. A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111321 · Cited by 16
Immunoactivation at the Crossroads of Human Disease
Margolis, L. B. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.12.026 · Cited by 16
The long-lived immune system of centenarians
Plaza‐Florido, A., Carrera‐Bastos, P., Pérez‐Prieto, I., Fiuza‐Luces, C., Radom‐Aizik, S., Cruz, B. D. P., Franceschi, C., López‐Soto, A., López-Otı́n, C., & Lucía, A. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01291-5 · Cited by 13
Differences according to gender and health status in CD4:CD8 ratio in a sample of community-dwelling oldest old. The OCTABAIX immune study
Formiga, F., Ferrer, A., Padrós, G., López‐Soto, A., Sarro, M., & Pujol, R. (2011) · Aging Clinical and Experimental Research · doi:10.1007/bf03324966 · Cited by 13
Successful ageing of nonagenarians is related to the sensitivity of NK cells to activation.
Kaszubowska, L., Dettlaff‐Pokora, A., Hak, Ł., Szaryńska, M., Ryba, M., Myśliwska, J. M., & Myśliwski, A. (2008) · PubMed · Cited by 12
IL-7 concentration is increased in nonagenarians but is not associated with markers of T cell immunosenescence
Marttila, S., Jylhävä, J., Pesu, M., Hämäläinen, S., Jylhä, M. K., Hervonen, A., & Hurme, M. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.09.004 · Cited by 12
L’immunosénescence
Lang, P.-O., Govind, S., & Aspinall, R. (2012) · NPG. Neurologie, psychiatrie, gériatrie/NPG · doi:10.1016/j.npg.2012.04.005 · Cited by 12
BELFAST nonagenarians: nature or nurture? Immunological, cardiovascular and genetic factors
Rea, I. M. (2010) · Immunity & Ageing · doi:10.1186/1742-4933-7-6 · Cited by 12
Role of Chronic Cytomegalovirus Infection in T‐Cell Immunosenescence and Frailty: More Questions than Answers
Leng, S. X. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03815.x · Cited by 12
Trajectories of peripheral white blood cells count around the menopause: a prospective cohort study
Dai, Q., Zhang, Y., Zhao, X., Yang, X., Sun, H., Wu, S., Chen, S., Wang, J., Cao, Z., & Ma, X. (2024) · BMC Women s Health · doi:10.1186/s12905-024-03344-0 · Cited by 11
Role of Normalized T-Cell Subsets in Predicting Comorbidities in a Large Cohort of Geriatric HIV-Infected Patients
Calcagno, A., Piconi, S., Focà, E., Nozza, S., Carli, F., Montrucchio, C., Cattelan, A. M., Orofino, G., Celesia, B. M., Morena, V., et al. (2017) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001496 · Cited by 11
Immunosenescence and inflammatory markers in Cuban centenarians: implications for survival
Ledón, N., Añé-Kourí, A. L., Ramos, M. B., Lorenzo-Luaces, P., Silva, A., Pereira, K., Lage, A., & Saavedra, D. (2023) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02567-9 · Cited by 10
Potential relationship between cytomegalovirus and immunosenescence: Evidence from observational studies
Gadoth, A., Ourfalian, K., Basnet, S., Kunzweiler, C. P., Bohn, R. L., Fülöp, T., & Diaz-Decaro, J. D. (2024) · Reviews in Medical Virology · doi:10.1002/rmv.2560 · Cited by 10
Sex and age as determinants of rat T-cell phenotypic characteristics: influence of peripubertal gonadectomy
Arsenović-Ranin, N., Kosec, D. J., Pilipović, I., Nacka-Aleksić, M., Bufan, B., Stojić-Vukanić, Z., & Leposavić, G. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-2989-x · Cited by 10
Melatonin in Healthy Aging and Longevity
Hardeland, R. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-63001-4_10 · Cited by 10
Cytomegalovirus Immunity, Inflammation and Cognitive Abilities in the Elderly
Hesson, J., Fudge, N. J., & Grant, M. D. (2021) · Viruses · doi:10.3390/v13112321 · Cited by 9
Multidimensional Clusters of CD4+ T Cell Dysfunction Are Primarily Associated with the CD4/CD8 Ratio in Chronic HIV Infection
Frederiksen, J., Buggert, M., Noyan, K., Nowak, P., Sönnerborg, A. B., Lund, O., & Karlsson, A. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137635 · Cited by 9
Onchocerciasis Fingerprints in the Geriatric Population: Does Host Immunity Play a Role?
Shintouo, C. M., Shey, R. A., Mets, T. F., Vanhamme, L., Souopgui, J., Ghogomu, S. M., & Njemini, R. (2021) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed6030153 · Cited by 9
The ageing immune system and its clinical implications
Wordsworth, D., & Dunn‐Walters, D. K. (2010) · Reviews in Clinical Gerontology · doi:10.1017/s0959259810000407 · Cited by 9
Immunseneszenz
Peters, T. (2011) · Der Hautarzt · doi:10.1007/s00105-011-2134-9 · Cited by 10
The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies
Wikby, A., Strindhall, J., & Johansson, B. E. A. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_1 · Cited by 8
Self-citation
A systematic investigation on animal models of cyclosporine A combined with Escherichia coli to simulate the immunosuppressive status of sepsis patients before onset
Kong, X., Zhang, J., Huo, J., Wang, L., Guo, L., Liu, Y., He, T., Sun, Z., Chen, X., Hou, Z.-J., et al. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.05.031 · Cited by 8
Assessing the differential impact of chronic CMV and treated HIV infection on CD8+ T-cell differentiation in a matched cohort study: is CMV the key?
Mueller, M. C., Kern, W. V., Usadel, S., Pauly, M.-C., Cathomen, T., & Salzer, U. (2021) · AIDS Research and Therapy · doi:10.1186/s12981-021-00361-z · Cited by 8
Active immunization against gonadotropin-releasing hormone affects thymic T cell production, migration, and colonization in male rat lymphoid tissue
Li, D., Yao, H., Han, X., Cao, X., Du, X., Meng, F., Bu, G., Kong, F., Song, T., & Zeng, X. (2023) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2023.104132 · Cited by 7
Immunotherapy of Immunosenesence; Who, How and When?
Govind, S. (2012) · Open Longevity Science · doi:10.2174/1876326x01206010056 · Cited by 7
Age-related Changes in Subpopulations of Peripheral Blood Lymphocytes in Healthy Japanese Population
Utsuyama, M., Kikuchi, Y., Kitagawa, M., & Hirokawa, K. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_11 · Cited by 7
Baseline Immune Phenotypes and CD4+ T Lymphocyte Responses to Antiretroviral Therapy in Younger versus Older HIV-infected Individuals
Hoffman, R. M., Jamieson, B. D., Bosch, R. J., Currier, J. S., Ramirez, C. M., Schmid, I., Zhu, Y., Bennett, K. K., & Mitsuyasu, R. T. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9550-6 · Cited by 7
Vaccination choices for older people, looking beyond age specific approaches
Aspinall, R., & Lang, P. O. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2018.1411197 · Cited by 7
Immunological parameters in elderly women: Correlations with aerobic power, muscle strength and mood state
Raso, V., Natale, V. M., Duarte, A. J. D. S., Greve, J. M. D., & Shephard, R. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.01.012 · Cited by 7
Immunological and nutritional factors in elderly people in low-level care and their association with mortality
Woods, J., Iuliano-Burns, S., & Walker, K. Z. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-32 · Cited by 7
Combined Plasma Elevation of CRP, Intestinal-Type Fatty Acid-Binding Protein (I-FABP), and sCD14 Identify Older Patients at High Risk for Health Care-Associated Infections
Paillaud, É., Bastuji‐Garin, S., Plonquet, A., Foucat, E., Fournier, B., Boutin, E., Thuaut, A. L., Lévy, Y., & Hüe, S. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx106 · Cited by 8
Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans
Li, C., Mo, D., Li, M., Zheng, Y., Li, Q., Ou, S., & Zhang, Z. (2018) · Genes & Genetic Systems · doi:10.1266/ggs.17-00052 · Cited by 6
Thymic function and survival at advance ages in nursing home residents from Southern Italy
Paparazzo, E., Geracitano, S., Lagani, V., Citrigno, L., Bartolomeo, D., Aceto, M. A., Bruno, F., Maletta, R., Passarino, G., & Montesanto, A. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00340-0 · Cited by 7
Why Influenza Viruses Continue to Pose a Significant Threat to Aging and Aged Populations Worldwide
Lang, P. O. (2013) · Current Geriatrics Reports · doi:10.1007/s13670-013-0070-5 · Cited by 6
Introduction to Ageing of the Adaptive Immune System
Müller, L., & Pawelec, G. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4776-4_2 · Cited by 6
Self-citation
Challenges and Promise for the Development of Human Immune Monitoring
Shen-Orr, S. S. (2012) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10090 · Cited by 5
Possibilities of using T-cell biophysical biomarkers of ageing
González‐Bermúdez, B., Abarca‐Ortega, A., González-Sánchez, M., la Fuente, M. D., & Plaza, G. R. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.29 · Cited by 4
The immune system during ageing
Müller, L., Pawelec, G., & Derhovanessian, E. (2013) · Elsevier eBooks · doi:10.1533/9780857095749.4.631 · Cited by 5
Self-citation
Immunosenescence, Inflammaging, and Their Implications for Cancer and Anemia
Paudel, S., Sharma, P., & Puri, N. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_14 · Cited by 6
Cytomegalovirus
Griffiths, P. D., Emery, V. C., & Milne, R. S. B. (2009) · Wiley eBooks · doi:10.1128/9781555815981.ch22 · Cited by 5
Healthy aging: when periodontal health matters
Rengo, C., Valletta, A., Liccardo, D., Spagnuolo, G., Corbi, G., Luca, F. D., Lauria, M. R., Perrotta, A., Rengo, G., Ferrara, N., et al. (2023) · Journal of Gerontology and Geriatrics · doi:10.36150/2499-6564-n580 · Cited by 5
CMV Driven Immunosenescence and Alzheimer’s Disease
Dow, C. T. (2015) · Journal of Neuroinfectious Diseases · doi:10.4172/2314-7326.1000195 · Cited by 4
Immunseneszenz. Bestandsaufnahme und molekulare Grundlagen
Peters, T. (2011) · Der Hautarzt · Cited by 4
Melatonin and neurodegeneration: From neurotoxic environment to cell resilience
Ramos, E., Gil‐Martín, E., & Romero, A. (2019) · Advances in molecular toxicology · doi:10.1016/b978-0-444-64293-6.00003-8 · Cited by 4
Age, T-cell Homeostasis, and T-cell Diversity in Humans
Lamar, D. L., Weyand, C. M., & Goronzy, J. J. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_9 · Cited by 4
Somatische Veränderungen im Alter
Langsenlehner, U., Muchar, H., & Schippinger, W. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1581-7_4 · Cited by 4
In-depth human immune cellular profiling from newborn to frail
Li, W., Liu, H., Gao, L., Hu, Y., Zhang, A., Li, W., Liu, G., Bai, W., Xu, Y., Xiao, C., et al. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae046 · Cited by 3
Changes in hematological indices and lymphocyte subsets in response to whole blood donation in healthy male donors
Borai, A., Livingstone, C., Alsobhi, E. M., Alsofyani, A. A., Balgoon, D., Anwar, F., Almohammadi, M., Al-Amri, A., Bahijri, S., Alrowaili, D. G., et al. (2017) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2017.1286520 · Cited by 3
Association between C-reactive protein, neutrophils, lymphocytes, cognition, and functional capacity in an oldest old population
Aguiar, M. B., Barros, G. H. H., Colleoni, G. W. B., Cendoroglo, M. S., & Filho, C. D. M. A. (2023) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2023.100067 · Cited by 3
Aging and the Effect of Calorie Restriction in Rhesus Monkeys
Messaoudi, I., Young, J. E., Colman, R. J., Handy, A. M., Roth, G. S., Ingram, D. K., & Mattison, J. A. (2010) · Springer eBooks · doi:10.1007/978-90-481-8556-6_4 · Cited by 3
Targeting Senescent Cells to Improve Human Health
Wijshake, T., & van Deursen, J. M. A. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-26239-0_16 · Cited by 3
Chronic Viral Infections and Immunosenescence, with a Focus on CMV
Tatum, A. M. (2012) · Open Longevity Science · doi:10.2174/1876326x01206010033 · Cited by 2
Environmental Influences on the Immune System: The Aging Immune System
Mälzer, J. N., Schulz, A. R., & Thiel, A. (2016) · Springer eBooks · doi:10.1007/978-3-7091-1890-0_3 · Cited by 2
Frailty in Old Age Is Associated with Altered Cytokine Production in Response to TLR Ligation
Compté, N., Pepersack, T., & Goriely, S. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_152 · Cited by 2
Immunosenescence
Rink, L., & Weßels, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818731-9.00072-0 · Cited by 2
Immune Ageing Clocks: A Methods-Oriented Review of Tasks, Modalities, Models, and Recalibration
Yu, G., Shao, Z., Zhuo, J., & Chen, Z. (2026) · Cells · doi:10.3390/cells15050421 · Cited by 1
Cytomégalovirus humain et cancers.
Lepiller, Q., Fafi‐Kremer, S., Stoll‐Keller, F., & Herbein, G. (2012) · PubMed · doi:10.1684/vir.2012.0462 · Cited by 1
Cytomegalovirus and ageing of the immune system: a controversial cause of ageing
van Zuijlen, W. (2013) · Microbiology Australia · doi:10.1071/ma13052 · Cited by 1
CMV Subversion of the Immune System in Later Life
Powell, F., & Kern, F. (2011) · Springer eBooks · doi:10.1007/978-3-0346-0219-8_6 · Cited by 1
Role of Immunosenescence in Coronary Artery Disease
Boag, S. E., Andreano, E., Martin-Ruiz, C. M., & Spyridopoulos, I. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_129 · Cited by 1
Cytomegalovirus
Griffiths, P. D., & Reeves, M. B. (2016) · ASM Press eBooks · doi:10.1128/9781555819439.ch23 · Cited by 1
A case of vitiligo after COVID-19 vaccination: a possible role of thymic dysfunction
Kuznetsov, D., Kalyuzhin, O. V., Миронов, А. Ф., Несчисляев, В. А., & Kuznetsova, A. (2023) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2300025 · Cited by 1
Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS)
Patel, R. A., Cosentino, S., Zheng, E. Z., Schupf, N., Barral, S., Feitosa, M. F., Andersen, S. L., Paola Sebastiani, B., Ukraintseva, S. V., Christensen, K., et al. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100746 · Cited by 1
T Cell-Mediated Immunity in the Immunosenescence Process
Lang, P. O. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_10 · Cited by 1
WITHDRAWN: Systems Biology and Immune Aging
O’Connor, J., Herrera, G., Martínez‐Romero, A., de Oyanguren, F. S., Díaz, L., Carvalho‐Gomes, Â., Balaguer, S., & Callaghan, R. C. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.09.008 · Cited by 1
La terza età della terapia antiretrovirale di combinazione
Facciolà, A., D’Aleo, F., Ceccarelli, M., & Pellicanò, G. F. (2018) · JHA - Journal of HIV and Ageing · doi:10.19198/jha31449 · Cited by 1
Aging of immune system
Pinti, M., Biasi, S. D., Gibellini, L., Tartaro, D. L., Gaetano, A. D., Mattioli, M., Fidanza, L., Nasi, M., & Cossarizza, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822569-1.00008-1 · Cited by 1
Age-Related Changes in Subpopulations of Peripheral Blood Lymphocytes in Healthy Japanese Population
Utsuyama, M., Yoshida-Kikuchi, Y., Kitagawa, M., & Hirokawa, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_11-1 · Cited by 1
Quelle valeur accorder a l'elevation du ratio lymphocytaire T CD4/CD8 dans le phenotypage lymphocytaire du sang : analyse d'une etude preliminaire et retrospective au CHU de Bordeaux
Guy, A. (2015) · HAL · Cited by 1
Immune Predictors of Clinical Outcomes in Elderly Nursing Home Residents
Johnstone, J. (2014) · MacSphere (McMaster University) · doi:10.71548/9512 · Cited by 1
Alterações fenotipicas e transcricionais em linfócitos T de uma população idosa em risco imune no sul do Brasil
Ornaghi, A. P. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Impact of Aging on T Cell Repertoire and Immunity
Blackman, M. A., & Woodland, D. L. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_9
Mechanisms underlying innate immunesenescence
Hazeldine, J. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)
Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer
Balasubramanian, P., & Longo, V. D. (2013) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2013010596
IMMUNOSENESCENCE AND ITS IMPACT ON MEDICAL PRACTICE. A NEW LOOK AT AN OLD PROBLEM.
Lorencetti, P. G., van der Geest, K. S. M., Wang, Q., Brouwer, E., & Boots, A. M. H. (2014) · Revista Médica da UFPR · doi:10.5380/rmu.v1i4.40693
Análise de parâmetros psiconeuroimunológicos em longevos saudáveis
de Oliveira, Á. S. (2014)
Chronic cytomegalovirus infection drives the accumulation of memory T cells with low functional avidity during ageing
Griffiths, S. (2011) · UCL Discovery (University College London)
Système immunitaire et infections nosocomiales
Fagon, J.-Y., & Gisselbrecht, M. (2012) · Références en réanimation · doi:10.1007/978-2-8178-0287-9_22
The aging immune system and nutritional interventions
van Beek, A. A. (2017) · doi:10.18174/392235
Cytomegalovirus IgG in HIV+ persons on anti-retroviral therapy: characterisation and association with insulin resistance
Brunt, S. J. (2016) · UWA Profiles and Research Repository (University of Western Australia)
Role of Immunosenescence in Coronary Artery Disease
Boag, S. E., Andreano, E., Martin-Ruiz, C. M., & Spyridopoulos, I. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_129-1
Frailty in Old Age is Associated with Altered Cytokine Production in Response to TLR Ligation
Compté, N., Pepersack, T., & Goriely, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_152-1
Models of Immune Aging
O’Connor, J., Herrera, G., Jávega, B., & Martínez‐Romero, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00058-0
B Cells in Centenarians and Their Offspring
Bulati, M., Caruso, C., & Colonna‐Romano, G. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_88-1
Circulating levels and assessment of clinical laboratory analytes, in >80-year-old, apparently healthy, moderately healthy, and frail individuals
Edvardsson, M. (2019) · Linköping University medical dissertations · doi:10.3384/diss.diva-160148
Immune Parameters Associated with Mortality in Longitudinal Studies of Very Old People Can Be Markedly Dissimilar Even in Apparently Similar Populations
Pawelec, G., & Goldeck, D. (2019) · Healthy ageing and longevity · doi:10.1007/978-3-030-24970-0_16
Self-citation
Better satisfaction with life is associated with normal immune profile (CD4/CD8 ratio) – and dependent on the successful aging status – in older Brazilian individuals
Chaves1, 2. J. R. G. D. C. M. L. F. (2019) · International Journal of Aging Research · doi:10.28933/ijoar-2019-09-1205
Potential of Interleukin 7 and CD4/CD8 Ratio as Markers of Immune Reconstitution in HIV Patients on Antiretroviral Therapy in Yaoundé, Cameroon
Mbakam, C. H., Assoumou, M. C. O., Jacobs, G. B., Agueguia, F. S. A., Mesembe, M. T., Lyonga, E., Tagny, C. T., & Ikomey, G. M. (2020) · HEALTH SCIENCES AND DISEASE
Efeitos do uso de globulina antitimócito e de everolimo nas subpopulações de linfócitos T e B do sangue periférico em receptores idosos de transplante renal
de Freitas, G. R. R. (2020) · doi:10.11606/t.5.2020.tde-31012020-115923
Awareness, Health Seeking Behaviors and Preventive Measures towards COVID-19 among Najran University StudentsPreprint
Alshahrani, M. S., Aedh, A. I., Elfaki, N., & Alwadei, H. S. A. (2020) · doi:10.22541/au.159646066.66986070
B Cells in Centenarians and Their Offspring
Bulati, M., Caruso, C., & Colonna‐Romano, G. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_88

Authors: Strindhall, J., Nilsson, B.-O., Löfgren, S., Ernerudh, J., Pawelec, G., Johansson, B., & Wikby, A.
Affiliations: Jönköping University (SE)
Ryhov Hospital Jönköping (SE)
Linköping University (SE)
University of Tübingen (DE)
University of Gothenburg (SE)
Corresponding author: Wikby, Anders
ORCID: Ernerudh, Jan
Pawelec, Graham
Johansson, Boo
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2007-08
Volume: 42
Issue: 8
Pages: 753-761
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/j.exger.2007.05.001
OpenAlex: W2077977710
Cited by: 209
References: 20
Citations by year: 2026: 4 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 13 · 2018: 12 · 2017: 18 · 2016: 10 · 2015: 15 · 2014: 12 · 2013: 20 · 2012: 17
FWCI: 3.94
Type: journal article
Language: en
Open access: green
hal.science
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: centenarians, cytomegalovirus infection, T cell subsets, mortality prediction, immunosenescence, oldest old
MeSH terms: Aged, Aged, 80 and over, Aging, Carrier State, Cross-Sectional Studies, Cytomegalovirus Infections, Female, Humans, Longevity, Longitudinal Studies, Lymphocytes, Male, Middle Aged, Mortality, Neutrophils, Risk Factors, Sweden, T-Lymphocyte Subsets, CD4-CD8 Ratio

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks