The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study
Open accessAbstract
In the present NONA immune longitudinal study, we investigate the previously identified Immune Risk Profile (IRP), defined by an inverted CD4/CD8 ratio and associated with persistent cytomegalovirus infection and increased numbers of CD8+CD28- cells, relative 6-year survival and age in NONA individuals. These subjects have now reached age 92, 96, and for the first time in this study, 100 years at follow-up. A 55 year old middle-aged group was used for comparison. Immunological monitoring included the analysis of numbers of lymphocytes and neutrophils, the T-cell subsets CD3+CD4+, CD3+CD8+, CD8+CD28+, CD8+CD28-, and the CD4/CD8 ratio. Longitudinal data were analysed by multivariate analyses of variance (MANOVA) from four measurement occasions at 2-year inter-intervals. One-way ANOVA was used for cross-sectional comparisons at baseline and the 6-year follow-up. The results confirmed the importance of the IRP as a major predictor of mortality in this population of very old. Moreover, the results suggested that survival to the age of 100 years is associated with selection of individuals with an "inverted" IRP that was stable across time, i.e., maintenance of a high CD4/CD8 ratio and low numbers of CD8+CD28- cells. The results underlines the importance of a longitudinal study design in dissecting immune parameters predictive of survival and show for the first time that centenarian status is associated with avoidance of the IRP over at least the previous 6 years and probably throughout life.
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Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474
Self-citationHadrup, S. R., Strindhall, J., Køllgaard, T., Seremet, T., Johansson, B. E. A., Pawelec, G., Straten, P. T., & Wikby, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2645 · Cited by 471
Self-citationWikby, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00212-1 · Cited by 414
Self-citationWikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407
Self-citationHuman immunosenescence: is it infectious?
Pawelec, G., Akbar, A., Caruso, C., Solana, R., Grubeck‐Loebenstein, B., & Wikby, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00271.x · Cited by 405
Self-citationWikby, A., Maxson, P., Olsson, J., Johansson, B. E. A., & Ferguson, F. G. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00151-6 · Cited by 381
Self-citationFerguson, F. G., Wikby, A., Maxson, P., Olsson, J., & Johansson, B. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.6.b378 · Cited by 378
Self-citationEffros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90073-6 · Cited by 377 · cited 1×
“The association between the number of CD8+CD28- cells and CD4/CD8 ratio, as presented for the very old individuals in figure 1, conform with previous findings (Effros et al., 1994).”
ResultSolana, R., Pawelec, G., & Tarazona, R. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.003 · Cited by 313
Self-citationCell-Mediated Immunity as a Predictor of Morbidity and Mortality in Subjects Over 60
Wayne, S. J., Rhyne, R. L., Garry, P. J., & Goodwin, J. S. (1990) · Journal of Gerontology · doi:10.1093/geronj/45.2.m45 · Cited by 303 · cited 1×
“There is considerable evidence of age-associated changes in immune capabilities resulting in increased morbidity and mortality due to altered function of the adaptive immune system (Wayne et al., 1990).”
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Fahy, G. M., Brooke, R. T., Watson, J. P., Good, Z., Vasanawala, S. S., Maecker, H., Leipold, M. D., Lin, D. T. S., Kobor, M. S., & Horvath, S. (2019) · Aging Cell · doi:10.1111/acel.13028 · Cited by 477
Metadata
- Authors
- Strindhall, J., Nilsson, B.-O., Löfgren, S., Ernerudh, J., Pawelec, G., Johansson, B., & Wikby, A.
- Affiliations
- Jönköping University (SE)
- Ryhov Hospital Jönköping (SE)
- Linköping University (SE)
- University of Tübingen (DE)
- University of Gothenburg (SE)
- Corresponding author
- Wikby, Anders
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 42
- Issue
- 8
- Pages
- 753-761
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2077977710
- Cited by
- 209
- References
- 20
- Citations by year
- 2026: 4 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 13 · 2018: 12 · 2017: 18 · 2016: 10 · 2015: 15 · 2014: 12 · 2013: 20 · 2012: 17
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- centenarians, cytomegalovirus infection, T cell subsets, mortality prediction, immunosenescence, oldest old
- MeSH terms
- Aged, Aged, 80 and over, Aging, Carrier State, Cross-Sectional Studies, Cytomegalovirus Infections, Female, Humans, Longevity, Longitudinal Studies, Lymphocytes, Male, Middle Aged, Mortality, Neutrophils, Risk Factors, Sweden, T-Lymphocyte Subsets, CD4-CD8 Ratio
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