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Telomerase, mitochondria and oxidative stress
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The rates of stem cell replenishment are unlikely to completely account for the telomere length differences observed.
“Although the rates of stem cell replenishment are unlike to completely account for the telomere length differences observed, we cannot discard other roles of telomerase such as the rescue of telomere shortening through stress protection (Saretzki, 2009) or the recently association to mitochondrial protection in post mitotic tissues (Sahin et al, 2011).”
From Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer (2012) · cites this paper as Saretzki, 2009
Saretzki is cited for telomerase’s possible role in protecting against stress, not for the preceding statement about stem-cell replenishment. The indexed Abstract (page unavailable) discusses stress resistance and telomere maintenance, but does not say that stress protection rescues telomere shortening. (LLM, conf=0.78)
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Cites
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
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Self-citationMitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
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“…animal models showed inconsistent results and therefore, the exact relationship between oxidative metabolism and ROS as determinants of ageing and longevity are far from clear and the subject of a controverse debate (Lapointe and Hekimi 2008, Jang and van Remmen, 2009, Trifunovic et al., 2004).”
BackgroundTelomerase modulates expression of growth-controlling genes and enhances cell proliferation
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Conditional telomerase induction causes proliferation of hair follicle stem cells
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The longest telomeres: a general signature of adult stem cell compartments
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Monoubiquitylation promotes mitochondrial p53 translocation
Marchenko, N. D., Wolff, S., Erster, S., Becker, K., & Moll, U. M. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601560 · Cited by 286
Serra, V., von Zglinicki, T., Lorenz, M., & Saretzki, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207939200 · Cited by 278
Self-citationSaretzki, G., Murphy, M. P., & Von Zglinicki, T. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00040.x · Cited by 203
Self-citationThe Catalytic Subunit of Telomerase Protects Neurons Against Amyloid β‐Peptide‐Induced Apoptosis
Zhu, H., Fu, W., & Mattson, M. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750117.x · Cited by 175 · cited 1×
“Telomerase suppression in embryonic neurons promoted apoptosis upon ABP treatment whereas over-expression of TERT in PC12 cells counteracted ABP induced apoptosis and cytotoxicity (Zhu et al., 2000).”
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Self-citationTERT promotes cellular and organismal survival independently of telomerase activity
Lee, J., Sung, Y. H., Cheong, C., Choi, Y. S., Jeon, H. K., Sun, W., Hahn, W. C., Ishikawa, F., & Lee, H.-W. (2008) · Oncogene · doi:10.1038/sj.onc.1211037 · Cited by 145
hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway
Massard, C., Zermati, Y., Pauleau, A.-L., Larochette, N., Métivier, D., Sabatier, L., Kroemer, G., & Soria, J.-C. (2006) · Oncogene · doi:10.1038/sj.onc.1209487 · Cited by 144
Yang, C., Przyborski, S., Cooke, M. J., Zhang, X., Stewart, R., Anyfantis, G., Atkinson, S. P., Saretzki, G., Armstrong, L., & Lako, M. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0677 · Cited by 136
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Metadata
- Authors
- Saretzki, G.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 44
- Issue
- 8
- Pages
- 485-492
- ISSN
- 0531-5565
- Cited by
- 128
- References
- 23
- Language
- en
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