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The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

Marion, Rosa M., Strati, Katerina, Li, Han, Tejera, Agueda, Schoeftner, Stefan, Ortega, Sagrario, Serrano, Manuel, Blasco, Maria A.·2009·Cell Stem Cell
DOI 10.1016/j.stem.2008.12.010
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Abstract

Telomere shortening is associated with organismal aging. iPS cells have been recently derived from old patients; however, it is not known whether telomere chromatin acquires the same characteristics as in ES cells. We show here that telomeres are elongated in iPS cells compared to the parental differentiated cells both when using four (Oct3/4, Sox2, Klf4, cMyc) or three (Oct3/4, Sox2, Klf4) reprogramming factors and both from young and aged individuals. We demonstrate genetically that, during reprogramming, telomere elongation is usually mediated by telomerase and that iPS telomeres acquire the epigenetic marks of ES cells, including a low density of trimethylated histones H3K9 and H4K20 and increased abundance of telomere transcripts. Finally, reprogramming efficiency of cells derived from increasing generations of telomerase-deficient mice shows a dramatic decrease in iPS cell efficiency, a defect that is restored by telomerase reintroduction. Together, these results highlight the importance of telomere biology for iPS cell generation and functionality.

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Crossref · 10.1016/j.stem.2008.12.010

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18 of 18 references verified0 citation errors · 0 not checkable

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  • Full reprogramming implies cellular rejuvenation, characterized by aging features reset to the embryonic state, as indicated by p16 reduction, extension of telomeres and resetting of the DNA methylation clock.

    “Full reprogramming not only implies a change of cellular identity but also cellular rejuvenation, characterized by a number of aging features that are reset to the embryonic state, as indicated by p16 reduction 210 , extension of telomeres 211 and resetting of the DNA methylation clock 212 .”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [211]

  • Our reprogramming system did not induce telomere elongation until the SP.

    “Consistent with previous studies (Marion et al., 2009), our reprogramming system did not induce telomere elongation until the SP”

    From Multi-omic rejuvenation of human cells by maturation phase transient reprogramming (2022) · cites this paper as Marion et al., 2009

  • Early reports using cells derived from old donors to generate iPS cells demonstrated beneficial effects on senescence phenotypes and telomere length.

    “Early reports using cells derived from old donors to generate iPS cells demonstrated beneficial effects on senescence phenotypes and telomere length [26][27][28] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [27]

Citations

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Flagged first, then by citations

Research works printed but not linked: 36

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Metadata

Authors
Marion, R. M., Strati, K., Li, H., Tejera, A., Schoeftner, S., Ortega, S., Serrano, M., & Blasco, M. A.
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2009-02
Volume
4
Issue
2
Pages
141-154
ISSN
1934-5909
DOI
10.1016/j.stem.2008.12.010
Cited by
461
References
18
Language
en
Licence

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