Telomere Homeostasis: Interplay with Magnesium
Open accessAbstract
Telomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes that accompany age-related diseases such as cancer. Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is also diminished during cellular senescence and normative physiological ageing. Inherent in the biochemistry of these processes is the role of magnesium, one of the main cellular ions and an essential cofactor in all reactions that use ATP. Magnesium plays an important role in many of the processes involved in regulating telomere structure, integrity and function. This review explores the mechanisms that maintain telomere structure and function, their influence on circadian rhythms and their impact on health and age-related disease. The pervasive role of magnesium in telomere homeostasis is also highlighted.
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Magnesium has structural roles in DNA, proteins, and enzymes including telomerases, and promotes DNA replication, transcription, protein synthesis, and mitochondrial functions.
“Magnesium has structural roles in DNA, proteins and enzymes including telomerases. It promotes DNA replication and transcription, protein synthesis and mitochondrial functions [444,445].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [445]
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- Authors
- Maguire, D., Neytchev, O., Talwar, D., McMillan, D., & Shiels, P.
- Affiliations
- Glasgow Royal Infirmary (GB)
- University of Glasgow (GB)
- Corresponding author
- Shiels, Paul
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-01-05
- Volume
- 19
- Issue
- 1
- Pages
- 157
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5796106
- OpenAlex
- W2783647833
- Cited by
- 50
- References
- 153
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 2
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Keywords
- telomere homeostasis, magnesium, cellular senescence, mitochondrial physiology, cellular metabolism, aging, age-related diseases, circadian rhythm
- MeSH terms
- Animals, Circadian Rhythm, Humans, Magnesium, Oxidative Stress, Telomere Homeostasis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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