Cited by 50Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsMagnesium in Health and Disease

Telomere Homeostasis: Interplay with Magnesium

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Maguire, Donogh, Neytchev, Ognian, Talwar, Dinesh, McMillan, Donald, Shiels, Paul·2018·International Journal of Molecular Sciences

Abstract

Telomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes that accompany age-related diseases such as cancer. Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is also diminished during cellular senescence and normative physiological ageing. Inherent in the biochemistry of these processes is the role of magnesium, one of the main cellular ions and an essential cofactor in all reactions that use ATP. Magnesium plays an important role in many of the processes involved in regulating telomere structure, integrity and function. This review explores the mechanisms that maintain telomere structure and function, their influence on circadian rhythms and their impact on health and age-related disease. The pervasive role of magnesium in telomere homeostasis is also highlighted.

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  • Magnesium has structural roles in DNA, proteins, and enzymes including telomerases, and promotes DNA replication, transcription, protein synthesis, and mitochondrial functions.

    “Magnesium has structural roles in DNA, proteins and enzymes including telomerases. It promotes DNA replication and transcription, protein synthesis and mitochondrial functions [444,445].”

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  1. [129]Blumenreich M.S. The White Blood Cell and Differential Count Butterworths Boston, MA, USA 1990 040990077X 21250104

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Authors
Maguire, D., Neytchev, O., Talwar, D., McMillan, D., & Shiels, P.
Affiliations
  • Glasgow Royal Infirmary (GB)
  • University of Glasgow (GB)
Corresponding author
Shiels, Paul
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2018-01-05
Volume
19
Issue
1
Pages
157
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2783647833
Cited by
50
References
153
Citations by year
2026: 5 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 2
FWCI
0.66
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Keywords
telomere homeostasis, magnesium, cellular senescence, mitochondrial physiology, cellular metabolism, aging, age-related diseases, circadian rhythm
MeSH terms
Animals, Circadian Rhythm, Humans, Magnesium, Oxidative Stress, Telomere Homeostasis

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