Cited by 260Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsGut microbiota and health

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Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Abraham, Dora, Feher, Janos, Scuderi, Gian Luca, Szabo, Dora, Dobolyi, Arpad, Cservenak, Melinda, Juhasz, Janos, Ligeti, Balazs, Pongor, Sandor, Gomez-Cabrera, Mari Carmen, Vina, Jose, Higuchi, Mitsuru, Suzuki, Katsuhiro, Boldogh, Istvan, Radak, Zsolt·2019·Experimental Gerontology

DOI 10.1016/j.exger.2018.12.005

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Abstract

It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1 TG). APP/PS1 TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1 TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.

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Authors: Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., Vina, J., Higuchi, M., Suzuki, K., Boldogh, I., & Radak, Z.
Affiliations: Waseda University (JP)
The University of Texas Medical Branch at Galveston (US)
Corresponding author: Radak, Zsolt
ORCID: Abraham, Dora
Dobolyi, Arpad
Juhasz, Janos
Gomez-Cabrera, Mari Carmen
Higuchi, Mitsuru
Suzuki, Katsuhiro
Boldogh, Istvan
Radak, Zsolt
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2019-01
Volume: 115
Pages: 122-131
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/j.exger.2018.12.005
OpenAlex: W2905037443
Cited by: 260
References: 55
Citations by year: 2026: 17 · 2025: 38 · 2024: 36 · 2023: 45 · 2022: 43 · 2021: 44 · 2020: 27 · 2019: 10
FWCI: 13.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders: OTKA (112810)
National Excellence Program (126823)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: Alzheimer's disease, exercise training, probiotics, gut microbiota, APP/PS1 mice, Bacteroides thetaiotaomicron, amyloid plaques, hippocampus, spatial learning and memory, neuroprotection
MeSH terms: Alzheimer Disease, Animals, Disease Models, Animal, Hippocampus, Male, Mice, Transgenic, Physical Conditioning, Animal, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Probiotics, Mice, Presenilin-1, Plaque, Amyloid, Microbiota

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Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

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