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Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome
Abstract
It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1 TG). APP/PS1 TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1 TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.
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“It was concluded that regular physical exercise and probiotic supplementation prevent further progression of AD and alleviates its symptoms [128].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [128]
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Metadata
- Authors
- Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., Vina, J., Higuchi, M., Suzuki, K., Boldogh, I., & Radak, Z.
- Affiliations
- Waseda University (JP)
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Radak, Zsolt
- ORCID
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 115
- Pages
- 122-131
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2905037443
- Cited by
- 260
- References
- 55
- Citations by year
- 2026: 17 · 2025: 38 · 2024: 36 · 2023: 45 · 2022: 43 · 2021: 44 · 2020: 27 · 2019: 10
- FWCI
- 13.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- OTKA (112810)
- National Excellence Program (126823)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Alzheimer's disease, exercise training, probiotics, gut microbiota, APP/PS1 mice, Bacteroides thetaiotaomicron, amyloid plaques, hippocampus, spatial learning and memory, neuroprotection
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Hippocampus, Male, Mice, Transgenic, Physical Conditioning, Animal, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Probiotics, Mice, Presenilin-1, Plaque, Amyloid, Microbiota
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