The nucleosome remodeling and deacetylase complex in development and disease

Basta, Jeannine; Rauchman, Michael

doi:10.1016/j.trsl.2014.05.003

Cited by 192Chromatin Remodeling and CancerGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

The nucleosome remodeling and deacetylase complex in development and disease

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Basta, Jeannine, Rauchman, Michael·2015·Translational Research

DOI 10.1016/j.trsl.2014.05.003PMC PMC4793962

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Abstract

The nucleosome remodeling and deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.

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At the biochemical level, the NuRD complex, with nucleosome remodeling and deacetylase roles, is epigenetically involved in gene regulation, with DNA fixed via binding where damage occurs on multiple loci spots.
“At the biochemical level, the NuRD complex, with nucleosome remodeling and deacetylase roles, is epigenetically involved in gene regulation, with DNA fixed via binding where the damage occurs on multiple loci spots [110].”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [110]
The NuRD Biochemistry section describes NuRD’s nucleosome-remodeling and deacetylase activities and its role in regulating gene expression. The Cancer and Ageing section reports a role in DNA-damage response and describes recruitment to damage sites as a potential mechanism. It does not establish that DNA is repaired through binding at multiple loci, as the citing sentence implies. (LLM, conf=0.86)
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Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis
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New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening
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Regulating the Regulators: The Post‐Translational Code of Class I HDAC1 and HDAC2
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Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: Role in epithelial cancer cell invasion, proliferation and nuclear regulation
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p66α–MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2–NuRD complex
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Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice
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ATM Engages Autodegradation of the E3 Ubiquitin Ligase COP1 After DNA Damage
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The structure of the core NuRD repression complex provides insights into its interaction with chromatin
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A Conserved 12-Amino Acid Motif in Sall1 Recruits the Nucleosome Remodeling and Deacetylase Corepressor Complex
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ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State
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Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences
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SALL4, the missing link between stem cells, development and cancer
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NuRD–ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination
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MTA1, a transcriptional activator of breast cancer amplified sequence 3
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Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications
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MBD3, a Component of the NuRD Complex, Facilitates Chromatin Alteration and Deposition of Epigenetic Marks
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Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression
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Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein
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Chromodomain Helicase DNA-binding Protein 4 (CHD4) Regulates Homologous Recombination DNA Repair, and Its Deficiency Sensitizes Cells to Poly(ADP-ribose) Polymerase (PARP) Inhibitor Treatment
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Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14
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A new non‐catalytic role for ubiquitin ligase RNF8 in unfolding higher‐order chromatin structure
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MBD3 Localizes at Promoters, Gene Bodies and Enhancers of Active Genes
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Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain
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Metastasis-Associated Protein 1/Nucleosome Remodeling and Histone Deacetylase Complex in Cancer
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NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells
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Insights into Association of the NuRD Complex with FOG-1 from the Crystal Structure of an RbAp48·FOG-1 Complex
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Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells
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SALL4 is a new target in endometrial cancer
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Metastasis Tumor Antigen Family Proteins during Breast Cancer Progression and Metastasis in a Reliable Mouse Model for Human Breast Cancer
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Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex
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CHD5 is required for spermiogenesis and chromatin condensation
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CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now
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The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation
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Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor
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The chromatin remodeler Mi-2β is required for establishment of the basal epidermis and normal differentiation of its progeny
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A network of epigenetic regulators guides developmental haematopoiesis in vivo
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Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin
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Role of CHD5 in Human Cancers: 10 Years Later
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E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1
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Identification of Conserved Pathways of DNA-Damage Response and Radiation Protection by Genome-Wide RNAi
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Insight into the Architecture of the NuRD Complex
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The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis
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A Core Chromatin Remodeling Factor Instructs Global Chromatin Signaling through Multivalent Reading of Nucleosome Codes
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The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4
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Methyl binding domain protein 2 mediates γ-globin gene silencing in adult human βYAC transgenic mice
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The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules
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dMec: a novel Mi‐2 chromatin remodelling complex involved in transcriptional repression
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FOG‐1‐mediated recruitment of NuRD is required for cell lineage re‐enforcement during haematopoiesis
Gao, Z., Huang, Z., Olivey, H. E., Gurbuxani, S. K., Crispino, J. D., & Svensson, E. C. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.368 · Cited by 72 · see citing works
A PTBA small molecule enhances recovery and reduces postinjury fibrosis after aristolochic acid-induced kidney injury
Novitskaya, T., McDermott, L. A., Zhang, K. X., Chiba, T., Paueksakon, P., Hukriede, N. A., & de Caestecker, M. P. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00534.2013 · Cited by 72 · see citing works
FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment
Gregory, G. D., Miccio, A., Bersenev, A., Wang, Y., Wei, H., Zhang, Z., Poncz, M., Tong, W., & Blobel, G. A. (2010) · Blood · doi:10.1182/blood-2009-10-251280 · Cited by 70 · see citing works
Structural and Functional Insights into the Human Börjeson-Forssman-Lehmann Syndrome-associated Protein PHF6
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GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila
Willemsen, M. H., Nijhof, B., Fencková, M., Nillesen, W. M., Bongers, E. M. H. F., Castells‐Nobau, A., Asztalos, L., Viràgh, E., van Bon, B. W. M., Tezel, E., et al. (2013) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101490 · Cited by 69 · see citing works
Repression of Six3 by a corepressor regulates rhodopsin expression
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Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex
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HDAC inhibitors in kidney development and disease
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Inactivation of NuRD Component Mta2 Causes Abnormal T Cell Activation and Lupus-like Autoimmune Disease in Mice
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The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose)
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Estrogen Regulates the Tumour Suppressor MiRNA-30c and Its Target Gene, MTA-1, in Endometrial Cancer
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Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathwayPreprint
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Sall1 balances self-renewal and differentiation of renal progenitor cells
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CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex
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SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules
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The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex
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The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex
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Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos
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β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation
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Inhibition of histone binding by supramolecular hosts
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Role of the GATA-1/FOG-1/NuRD Pathway in the Expression of Human β-Like Globin Genes
Miccio, A., & Blobel, G. A. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00001-10 · Cited by 46 · see citing works
SALL1 truncated protein expression in Townes-Brocks syndrome leads to ectopic expression of downstream genes
Kiefer, S. M., Robbins, L., Barina, A. R., Zhang, Z., & Rauchman, M. I. (2008) · Human Mutation · doi:10.1002/humu.20759 · Cited by 45 · see citing works
Self-citation
Fusion of ZMYND8 and RELA Genes in Acute Erythroid Leukemia
Panagopoulos, I., Micci, F., Thorsen, J., Haugom, L., Buechner, J., Kerndrup, G. B., Tierens, A. M., Zeller, B., & Heim, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063663 · Cited by 45 · see citing works
The Caenorhabditis elegans LET ‐418/ M i2 plays a conserved role in lifespan regulation
de Vaux, V., Pfefferli, C., Passannante, M., Belhaj, K., von Essen, A. M. H. J., Sprecher, S. G., Müller, F., & Wicky, C. (2013) · Aging Cell · doi:10.1111/acel.12129 · Cited by 45 · see citing works
Requirement of MTA1 in ATR-mediated DNA Damage Checkpoint Function
Li, D., Ohshiro, K., Khan, M. N., & Kumar, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085258 · Cited by 43 · see citing works
A Phosphomimetic Mutation in the Sall1 Repression Motif Disrupts Recruitment of the Nucleosome Remodeling and Deacetylase Complex and Repression of Gbx2
Lauberth, S. M., Bilyeu, A., Firulli, B. A., Kroll, K. L., & Rauchman, M. I. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703702200 · Cited by 42 · see citing works
Self-citation
Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+ T-Cell Activation
Dubuissez, M., Loison, I., Paget, S., Vorng, H., Yahia, S. A., Rohr, O., Tsicopoulos, A., & Leprince, D. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00062-16 · Cited by 40 · see citing works
Mi-2/NuRD is required in renal progenitor cells during embryonic kidney development
Denner, D. R., & Rauchman, M. I. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.11.018 · Cited by 40 · see citing works
Self-citation
The function of chromatin modifiers in lineage commitment and cell fate specification
Signolet, J., & Hendrich, B. (2015) · The FEBS Journal · doi:10.1111/febs.13132 · Cited by 40 · see citing works
Unique Features of the Anti-parallel, Heterodimeric Coiled-coil Interaction between Methyl-cytosine Binding Domain 2 (MBD2) Homologues and GATA Zinc Finger Domain Containing 2A (GATAD2A/p66α)
Walavalkar, N. M., Gordon, N. C., & Williams, D. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.431346 · Cited by 38 · see citing works
An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation
Wolf, J., Müller‐Decker, K., Flechtenmacher, C., Zhang, F., Shahmoradgoli, M., Mills, G. B., Hoheisel, J. D., & Boettcher, M. (2013) · Oncogene · doi:10.1038/onc.2013.515 · Cited by 38 · see citing works
FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development
Garnatz, A. S., Gao, Z., Broman, M., Martens, S., Earley, J. U., & Svensson, E. C. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.08.030 · Cited by 37 · see citing works
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity
Yang, T., Jian, W., Luo, Y., Fu, X., Noguchi, C., Bungert, J., Huang, S., & Qiu, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.349704 · Cited by 35 · see citing works
Sall3 is required for the terminal maturation of olfactory glomerular interneurons
Harrison, S. J., Parrish, M. E., & Monaghan, A. P. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21650 · Cited by 31 · see citing works
Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumours
Aury‐Landas, J., Bougeard, G., Castel, H., Hernández‐Vargas, H., Drouet, A., Latouche, J., Schouft, M., Férec, C., Leroux, D., Lasset, C., et al. (2013) · European Journal of Human Genetics · doi:10.1038/ejhg.2013.68 · Cited by 31 · see citing works
Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice
Costa, F. C., Fedosyuk, H., Chazelle, A. M., Neades, R. Y., & Peterson, K. R. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003155 · Cited by 30 · see citing works
A role for repressive complexes and H3K9 di-methylation in PRDM5-associated brittle cornea syndrome
Porter, L. F., Galli, G. G., Williamson, S. J. M., Selley, J. N., Knight, D., Elcioglu, N. H., Aydın, A., Elçioğlu, M. N., Venselaar, H., Lund, A. H., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv345 · Cited by 25 · see citing works
A Novel Regulatory Factor Recruits the Nucleosome Remodeling Complex to Wingless Integrated (Wnt) Signaling Gene Promoters in Mouse Embryonic Stem Cells
Kim, J., Khalid, O. S., Vo, S., Sun, H.-H. B., Wong, D. T., & Kim, Y. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.416545 · Cited by 19 · see citing works
Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction
Wang, Y., Meng, R., Hayes, V., Fuentes, R., Yu, X., Abrams, C. S., Heijnen, H. F. G., Blobel, G. A., Marks, M. S., & Poncz, M. (2011) · Blood · doi:10.1182/blood-2011-06-363580 · Cited by 14 · see citing works
Friend of GATA (FOG) Interacts with the Nucleosome Remodeling and Deacetylase Complex (NuRD) to Support Primitive Erythropoiesis in Xenopus laevis
Mimoto, M. S., & Christian, J. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029882 · Cited by 6 · see citing works

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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
Study, T. P., Schumacher, F. R., (APCB), A. P. C. B., Study, T. I., Canary PASS Investigators, Breast and Prostate Cancer Cohort Consortium (BPC3), The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, (CAPS), C. O. T. P. I. S., Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS), The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium, et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0142-8 · Cited by 902 · see citing works
Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability
Milazzo, G., Mercatelli, D., Muzio, G. D., Triboli, L., Rosa, P. D., Perini, G., & Giorgi, F. M. (2020) · Genes · doi:10.3390/genes11050556 · Cited by 431 · see citing works
A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development
Nitarska, J., Smith, J. G., Sherlock, W. T., Hillege, M. M., Nott, A., Barshop, W. D., Vashisht, A. A., Wohlschlegel, J. A., Mitter, R., & Riccio, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.022 · Cited by 170 · see citing works
Chromatin Remodelers: From Function to Dysfunction
Längst, G., & Manelytė, L. (2015) · Genes · doi:10.3390/genes6020299 · Cited by 174 · see citing works
Moonlighting with WDR5: A Cellular Multitasker
Guarnaccia, A. D., & Tansey, W. P. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7020021 · Cited by 151 · see citing works
De Novo Mutations in CHD4 , an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms
Weiss, K., Terhal, P. A., Cohen, L., Bruccoleri, M., Irving, M. D., Martinez, A. F., Rosenfeld, J. A., Machol, K., Yang, Y., Liu, P., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.08.001 · Cited by 140 · see citing works
PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling
van Beek, L., McClay, É., Patel, S., Schimpl, M., Spagnolo, L., & de Oliveira, T. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105112 · Cited by 128 · see citing works
CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language
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Chromatin regulation: How complex does it get?
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ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
Kidiyoor, G. R., Li, Q., Bastianello, G., Bruhn, C., Giovannetti, I., Adhil, M., Beznoussenko, G. V., Mironov, A., Raab, M., Piel, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18580-9 · Cited by 111 · see citing works
O-GlcNAcylation and O-GlcNAc Cycling Regulate Gene Transcription: Emerging Roles in Cancer
Parker, M. P., Peterson, K. R., & Slawson, C. M. (2021) · Cancers · doi:10.3390/cancers13071666 · Cited by 104 · see citing works
HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding
Gruber, J. J., Geller, B. S., Lipchik, A. M., Chen, J., Salahudeen, A. A., Ram, A. N., Ford, J. M., Kuo, C. J., & Snyder, M. P. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.05.034 · Cited by 101 · see citing works
The CHD4-related syndrome: a comprehensive investigation of the clinical spectrum, genotype–phenotype correlations, and molecular basis
Weiss, K., Lazar, H. P., Kurolap, A., Martinez, A. F., Paperna, T., Cohen, L., Smeland, M. F., Whalen, S., Heide, S., Keren, B., et al. (2019) · Genetics in Medicine · doi:10.1038/s41436-019-0612-0 · Cited by 91 · see citing works
KDM1A microenvironment, its oncogenic potential, and therapeutic significance
Ismail, T., Lee, H.-K., Kim, C., Kwon, T., Park, T. J., & Lee, H. (2018) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0203-3 · Cited by 77 · see citing works
TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer developmentPreprint
Cornelissen, L. M., Drenth, A. P., van der Burg, E., de Bruijn, R., Pritchard, C. E. J., Huijbers, I. J., Zwart, W. T., & Jonkers, J. (2019) · Genes & Development · doi:10.1101/gad.331371.119 · Cited by 70 · see citing works
KDM1 class flavin‐dependent protein lysine demethylases
Burg, J. M., Link, J. E., Morgan, B. S., Heller, F. J., Hargrove, A. E., & McCafferty, D. G. (2015) · Biopolymers · doi:10.1002/bip.22643 · Cited by 69 · see citing works
Reprogramming: identifying the mechanisms that safeguard cell identity
Brumbaugh, J., Stefano, B. D., & Hochedlinger, K. (2019) · Development · doi:10.1242/dev.182170 · Cited by 64 · see citing works
Histone deacetylase complexes: Structure, regulation and function
Asmamaw, M. D., He, A., Zhang, L., Liu, H., & Gao, Y. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189150 · Cited by 70 · see citing works
Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines
Guo, T., Luna, A., Rajapakse, V. N., Koh, C. C., Wu, Z., Liu, W., Sun, Y., Gao, H., Menden, M. P., Xu, C., et al. (2019) · iScience · doi:10.1016/j.isci.2019.10.059 · Cited by 65 · see citing works
Molecular networks of the FOXP2 transcription factor in the brain
den Hoed, J., Devaraju, K., & Fisher, S. E. (2021) · EMBO Reports · doi:10.15252/embr.202152803 · Cited by 62 · see citing works
Refinement of the subunit interaction network within the nucleosome remodelling and deacetylase (Nu RD ) complex
Torrado, M., Low, J. K. K., Silva, A. P. G., Schmidberger, J. W., Sana, M., Tabar, M. S., Işılak, M. E., Winning, C. S., Kwong, C., Bedward, M. J., et al. (2017) · FEBS Journal · doi:10.1111/febs.14301 · Cited by 62 · see citing works
NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins
Campbell, A. E., Shadle, S. C., Jagannathan, S., Lim, J.-W., Resnick, R., Tawil, R., van der Maarel, S. M., & Tapscott, S. J. (2018) · eLife · doi:10.7554/elife.31023 · Cited by 62 · see citing works
PAX3-FOXO1: Zooming in on an “undruggable” target
Wachtel, M., & Schäfer, B. W. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.006 · Cited by 59 · see citing works
Foxp1 regulation of neonatal vocalizations via cortical developmentPreprint
Usui, N., Araujo, D. J., Kulkarni, A., Co, M., Ellegood, J., Harper, M. J., Toriumi, K., Lerch, J. P., & Konopka, G. (2017) · Genes & Development · doi:10.1101/gad.305037.117 · Cited by 56 · see citing works
The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1
Elsen, G. E., Bedogni, F., Hodge, R. D., Bammler, T. K., MacDonald, J. W., Lindtner, S., Rubenstein, J. L. R., & Hevner, R. F. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00571 · Cited by 56 · see citing works
Role of Natural Products in Modulating Histone Deacetylases in Cancer
Mérarchi, M., Sethi, G., Shanmugam, M. K., Fan, L., Arfuso, F., & Ahn, K. S. (2019) · Molecules · doi:10.3390/molecules24061047 · Cited by 55 · see citing works
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state
Nodelman, I. M., Das, S., Faustino, A. M., Fried, S. D., Bowman, G. D., & Armache, J. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-021-00719-x · Cited by 53 · see citing works
Targeting HDAC Complexes in Asthma and COPD
Zwinderman, M. R. H., de Weerd, S., & Dekker, F. J. (2019) · Epigenomes · doi:10.3390/epigenomes3030019 · Cited by 53 · see citing works
Human Hepatocyte Nuclear Factor 4-α Encodes Isoforms with Distinct Transcriptional Functions
Lambert, É., Babeu, J., Simoneau, J., Raisch, J., Lavergne, L., Lévesque, D., Jolibois, É., Avino, M., Scott, M. S., Boudreau, F., et al. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra119.001909 · Cited by 48 · see citing works
Characterization of two distinct Nucleosome Remodeling and Deacetylase (NuRD) complex assemblies in embryonic stem cells
Bode, D., Yu, L., Tate, P., Pardo, M., & Choudhary, J. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.053207 · Cited by 50 · see citing works
New Insights on the Nuclear Functions and Targeting of FAK in Cancer
Pomella, S., Cassandri, M., Braghini, M. R., Marampon, F., Alisi, A., & Rota, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041998 · Cited by 46 · see citing works
The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer
Hasan, N. M., & Ahuja, N. (2019) · Cancers · doi:10.3390/cancers11121859 · Cited by 46 · see citing works
Regulating the Regulators: The Role of Histone Deacetylase 1 (HDAC1) in Erythropoiesis
Kim, M. Y., Yan, B., Huang, S., & Qiu, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228460 · Cited by 44 · see citing works
Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors
Pittol, J. M. R., Oruba, A., Mittler, G., Saccani, S., & van Essen, D. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2004526 · Cited by 43 · see citing works
Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex
Ivanochko, D., Halabelian, L., Henderson, E., Savitsky, P. A., Jain, H., Marcon, E., Duan, S., Hutchinson, A., Seitova, A., Baršytė-Lovejoy, D., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1192 · Cited by 43 · see citing works
CHD4-mediated loss of E-cadherin determines metastatic ability in triple-negative breast cancer cells
Luo, C., Wu, C., Chang, S., Chang, T., Chen, T.-Y., Chai, C., Chang, C., Hou, M., & Pan, M. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.12.032 · Cited by 41 · see citing works
Altered primary chromatin structures and their implications in cancer development
Ferraro, A. (2016) · Cellular Oncology · doi:10.1007/s13402-016-0276-6 · Cited by 39 · see citing works
Epigenetic Regulation of Aging and its Rejuvenation
An, Y., Wang, Q., Gao, K., Zhang, C., Ouyang, Y., Li, R., Zhou, M., Wu, T., Zhou, L., Xie, Z., et al. (2025) · MedComm · doi:10.1002/mco2.70369 · Cited by 44 · see citing works
The NuRD complex and macrocephaly associated neurodevelopmental disorders
Pierson, T. M., Otero, M. G., Grand, K., Choi, A., Graham, J. M., Young, J. I., & Mackay, J. P. (2019) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31752 · Cited by 39 · see citing works
PHF6 Mutations in Hematologic Malignancies
Kurzer, J. H., & Weinberg, O. K. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.704471 · Cited by 39 · see citing works
m6A is required for resolving progenitor identity during planarian stem cell differentiation
Dagan, Y., Yesharim, Y., Bonneau, A. R., Frankovits, T., Schwartz, S., Reddien, P. W., & Wurtzel, O. (2022) · The EMBO Journal · doi:10.15252/embj.2021109895 · Cited by 37 · see citing works
SALL Proteins; Common and Antagonistic Roles in Cancer
Álvarez, C., Quiroz, A., Benítez-Riquelme, D., Riffo, E., Castro, A. F., & Pincheira, R. (2021) · Cancers · doi:10.3390/cancers13246292 · Cited by 37 · see citing works
The transcriptional repressors VAL1 and VAL2 mediate genome-wide recruitment of the CHD3 chromatin remodeler PICKLE in Arabidopsis
Liang, Z., Yuan, L., Xiong, X., Hao, Y., Song, X., Zhu, T., Yu, Y., Fu, W., Lei, Y., Xu, J., et al. (2022) · The Plant Cell · doi:10.1093/plcell/koac217 · Cited by 36 · see citing works
Tagging Methyl-CpG-Binding Domain Proteins Reveals Different Spatiotemporal Expression and Supports Distinct Functions
Wood, K. H., Johnson, B. S., Welsh, S. A., Lee, J. Y., Cui, Y., Krizman, E. N., Brodkin, E. S., Blendy, J. A., Robinson, M. B., Bartolomei, M. S., et al. (2016) · Epigenomics · doi:10.2217/epi-2015-0004 · Cited by 35 · see citing works
Highly Parallel Quantification and Compartment Localization of Transcription Factors and Nuclear Proteins
Alexander Joel Federation, Nandakumar, V., Searle, B. C., Stergachis, A. B., Wang, H., Pino, L. K., Merrihew, G. E., Ting, Y. S., Howard, N., Kutyavin, T. V., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.096 · Cited by 35 · see citing works
GATAD2B-associatedneurodevelopmental disorder (GAND): clinical and molecular insights into a NuRD-relateddisorder
Shieh, C., Jones, N., Vanle, B., Au, M., Huang, A. Y.-W., Silva, A. P. G., Lee, H., Douine, E. D., Otero, M. G., Choi, A., et al. (2020) · Genetics in Medicine · doi:10.1038/s41436-019-0747-z · Cited by 34 · see citing works
BRMS1: a multifunctional signaling molecule in metastasis
Zimmermann, R. C., & Welch, D. R. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09871-0 · Cited by 33 · see citing works
Current and future therapeutic strategies for high-grade gliomas leveraging the interplay between epigenetic regulators and kinase signaling networks
Stitzlein, L. M., Adams, J. T., Stitzlein, E., Dudley, R. W., & Chandra, J. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02923-7 · Cited by 32 · see citing works
Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins
Ali, I., Ruiz, D. G., Ni, Z., Johnson, J. R., Zhang, H., Li, P.-C., Khalid, M. M., Conrad, R. J., Guo, X., Min, J., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.04.008 · Cited by 32 · see citing works
DNA Methylation-Governed Gene Expression in Autoimmune Arthritis
Brandt, B., Rashidiani, S., Bán, Á., & Rauch, T. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225646 · Cited by 33 · see citing works
Chromatin remodeling in plants: Complex composition, mechanistic diversity, and biological functions
Huang, Y., Guo, J., He, X., & Li, C. (2025) · Molecular Plant · doi:10.1016/j.molp.2025.08.004 · Cited by 31 · see citing works
The Epstein-Barr Virus BMRF1 Protein Activates Transcription and Inhibits the DNA Damage Response by Binding NuRD
Salamun, S. G., Sitz, J., de la Cruz-Herrera, C. F., Yockteng-Melgar, J., Marcon, E., Greenblatt, J. F., Fradet‐Turcotte, A., & Frappier, L. (2019) · Journal of Virology · doi:10.1128/jvi.01070-19 · Cited by 29 · see citing works
MTA1 expression in human cancers – Clinical and pharmacological significance
Malisetty, V. L., Penugurti, V., Panta, P., Chitta, S. K., & Manavathi, B. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.09.025 · Cited by 30 · see citing works
The gene repressor complex NuRD interacts with the histone variant H3.3 at promoters of active genesPreprint
Kraushaar, D. C., Chen, Z., Tang, Q., Cui, K., Zhang, J., & Zhao, K. (2018) · Genome Research · doi:10.1101/gr.236224.118 · Cited by 31 · see citing works
Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV
Naik, N. G., Nguyen, T. H., Roberts, L., Fischer, L. T., Glickman, K., Golas, G., Papp, B., & Tóth, Z. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008268 · Cited by 30 · see citing works
EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes
Kreher, J., Kovač, K., Bouazoune, K., Mačinković, I., Ernst, A. L., Engelen, E., Pahl, R., Finkernagel, F., Murawska, M., Ullah, I., et al. (2017) · Nature Communications · doi:10.1038/ncomms14806 · Cited by 28 · see citing works
Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associationsPreprint
Ramaker, R. C., Hardigan, A. A., Goh, S.-T., Partridge, E. C., Wold, B. J., Cooper, S. J., & Myers, R. (2020) · Genome Research · doi:10.1101/gr.260463.119 · Cited by 30 · see citing works
Properties and clinical relevance of MTA1 protein in human cancer
Toh, Y., & Nicolson, G. L. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9516-2 · Cited by 29 · see citing works
CHD4 mutations promote endometrial cancer stemness by activating TGF-beta signaling.
Li, Y., Liu, Q., McGrail, D. J., Dai, H., Li, K., & Lin, S. (2018) · Europe PMC (PubMed Central) · Cited by 29 · see citing works
Emerging Role of Epigenetic Modifiers in Breast Cancer Pathogenesis and Therapeutic Response
Lee, R. S., Sad, K., Fawwal, D. V., & Spangle, J. M. (2023) · Cancers · doi:10.3390/cancers15154005 · Cited by 28 · see citing works
Aging mechanisms—A perspective mostly from Drosophila
Tsurumi, A., & Li, W. X. (2020) · Advanced Genetics · doi:10.1002/ggn2.10026 · Cited by 29 · see citing works
IKZF1 Alterations and Therapeutic Targeting in B-Cell Acute Lymphoblastic Leukemia
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Authors: Basta, J., & Rauchman, M.
Affiliations: John Cochran VA Medical Center (US)
Corresponding author: Rauchman, Michael
ORCID: Basta, Jeannine
Rauchman, Michael
Venue: Translational Research
Publisher: Elsevier BV
Published: 2015-01
Volume: 165
Issue: 1
Pages: 36-47
ISSN: 1878-1810 (ISSN-L)
1931-5244
DOI: 10.1016/j.trsl.2014.05.003
PMC: PMC4793962
OpenAlex: W1973871665
Cited by: 191
References: 170
Citations by year: 2026: 14 · 2025: 26 · 2024: 26 · 2023: 20 · 2022: 11 · 2021: 14 · 2020: 20 · 2019: 19 · 2018: 17 · 2017: 11 · 2016: 8 · 2015: 3 · 2014: 2
FWCI: 0.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Translational research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases
American Heart Association
March of Dimes
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: NuRD complex, chromatin remodeling, histone deacetylase, transcriptional regulation, genome stability, cell cycle progression, developmental defects, carcinogenesis, aging, congenital malformations, cancer therapy
MeSH terms: Aging, Animals, Female, Humans, Neoplasms, Pregnancy, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Embryonic Development, Embryonic Stem Cells, Mi-2 Nucleosome Remodeling and Deacetylase Complex, Translational Research, Biomedical

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