CoChat
Sign Up
Cited by 223Neuroprotection in Cerebral IschemiaPhytochemicals and Antioxidant ActivitiesNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage

Wang, Yun, Chang, Chen-Fu, Chou, Jenny, Chen, Hui-Ling, Deng, Xiaolin, Harvey, Brandon K., Cadet, Jean Lud, Bickford, Paula C.·2005·Experimental Neurology
DOI 10.1016/j.expneurol.2004.12.014
Open this paper in CoChat — free account

Abstract

Free radicals are involved in neurodegenerative disorders, such as ischemia and aging. We have previously demonstrated that treatment with diets enriched with blueberry, spinach, or spirulina have been shown to reduce neurodegenerative changes in aged animals. The purpose of this study was to determine if these diets have neuroprotective effects in focal ischemic brain. Adult male Sprague-Dawley rats were fed with equal amounts of diets (blueberry, spinach, and spirulina) or with control diet. After 4 weeks of feeding, all animals were anesthetized with chloral hydrate. The right middle cerebral artery was ligated with a 10-O suture for 60 min. The ligature was later removed to allow reperfusional injury. Animals were sacrificed and brains were removed for caspase-3 enzymatic assays and triphenyltetrazolium chloride staining at 8 and 48 h after the onset of reperfusion. A subgroup of animals was used for locomotor behavior and biochemical assays. We found that animals which received blueberry, spinach, or spirulina enriched diets had a significant reduction in the volume of infarction in the cerebral cortex and an increase in post-stroke locomotor activity. There was no difference in blood biochemistry, blood CO2, and electrolyte levels among all groups, suggesting that the protection was not indirectly mediated through the changes in physiological functions. Animals treated with blueberry, spinach, or spirulina had significantly lower caspase-3 activity in the ischemic hemisphere. In conclusion, our data suggest that chronic treatment with blueberry, spinach, or spirulina reduces ischemia/reperfusion-induced apoptosis and cerebral infarction.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.expneurol.2004.12.014

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 34 references

Cited by

Sorted by citations

See all 223

Related

Metadata

Authors
Wang, Y., Chang, C.-F., Chou, J., Chen, H.-L., Deng, X., Harvey, B. K., Cadet, J. L., & Bickford, P. C.
Affiliations
  • National Institute on Drug Abuse (US)
  • University of South Florida (US)
Corresponding author
Bickford, Paula C.
ORCID
Venue
Experimental Neurology
Publisher
Elsevier BV
Published
2005-05
Volume
193
Issue
1
Pages
75-84
ISSN
0014-4886 (ISSN-L)
DOI
10.1016/j.expneurol.2004.12.014
OpenAlex
W2113563491
Cited by
223
References
34
Citations by year
2026: 2 · 2025: 5 · 2024: 11 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 12 · 2015: 12 · 2014: 21 · 2013: 19 · 2012: 13
FWCI
7.78
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service
  • National Institute on Aging (AG04418, P01AG004418)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
blueberry, spinach, Spirulina, dietary supplementation, cerebral ischemia, ischemia-reperfusion injury, neuroprotection, caspase-3, apoptosis, cerebral infarction, middle cerebral artery occlusion, locomotor recovery, free radicals, neurodegeneration
MeSH terms
Cyanobacteria, Animals, Antioxidants, Bacterial Proteins, Brain Ischemia, Male, Rats, Sprague-Dawley, Spinacia oleracea, Dietary Supplements, Blueberry Plants, Rats, Spirulina

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review