Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R. W., Bullock, R., Love, S., Neal, J. W., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61075-2 · Cited by 1,416

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397

Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

Orgogozo, J.-M., Gilman, S., Dartigues, J.-F., Laurent, B., Puel, M., Kirby, L. C., Jouanny, P., Dubois, B., Eisner, L., Flitman, S., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000073623.84147.a8 · Cited by 1,356

Classification and basic pathology of Alzheimer disease

Duyckaerts, C., Delatour, B., & Potier, M.-C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0532-1 · Cited by 1,031

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., & LaFerla, F. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.003 · Cited by 780

Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., & LaFerla, F. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2868-05.2005 · Cited by 697

Rapamycin alleviates toxicity of different aggregate-prone proteins

Berger, Z., Ravikumar, B., Menzies, F. M., Oroz, L. G., Underwood, B. R., Pangalos, M. N., Schmitt, I., Wullner, U., Evert, B. O., O'Kane, C. J., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi458 · Cited by 657

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E.-M., Cuervo, A. M., & Mandelkow, E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp367 · Cited by 617

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

Goedert, M., Jakes, R., & Vanmechelen, E. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11484-e · Cited by 608

Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway

Li, Y., Liu, L., Barger, S. W., & Griffin, W. S. T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01605.2003 · Cited by 563

Effects of α-Synuclein Immunization in a Mouse Model of Parkinson’s Disease

Masliah, E., Rockenstein, E., Adame, A., Alford, M., Crews, L., Hashimoto, M., Seubert, P., Lee, M., Goldstein, J., Chilcote, T., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.010 · Cited by 542

Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements

Asuni, A. A., Boutajangout, A., Quartermain, D., & Sigurdsson, E. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2361-07.2007 · Cited by 506

Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease

Ferrer, I., Rovira, M. B., Guerra, M. L. S., Rey, M. J., & Costa‐Jussá, F. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00493.x · Cited by 479

Silver staining of Alzheimer's neurofibrillary changes by means of physical development.

Gallyas, F. (1971) · PubMed · Cited by 411

Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes

Mercken, M. H., Vandermeeren, M., Lübke, U., Six, J., Boons, J., VOORDE, A. V. D., Martin, J., & Gheuens, J. (1992) · Acta Neuropathologica · doi:10.1007/bf00227819 · Cited by 356

Aβ vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

Masliah, E., Hansen, L., Adame, A., Crews, L. A., Bard, F., Lee, C., Seubert, P. A., Games, D., Kirby, L., & Schenk, D. (2005) · Neurology · doi:10.1212/01.wnl.0000148590.39911.df · Cited by 355

Sequential phosphorylation of Tau by glycogen synthase kinase‐3β and protein kinase A at Thr212 and Ser214 generates the Alzheimer‐specific epitope of antibody AT100 and requires a paired‐helical‐filament‐like conformation

Zheng‐Fischhöfer, Q., Biernat, J., Mandelkow, E., Illenberger, S., Godemann, R., & Mandelkow�, E. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2520542.x · Cited by 322

Detection of the anti‐Hu antibody in specific regions of the nervous system and tumor from patients with paraneoplastic encephalomyelitis/sensory neuronopathy

Dalmau, J. O., Furneaux, H., Rosenblum, M. K., Graus, F., & Posner, J. B. (1991) · Neurology · doi:10.1212/wnl.41.11.1757 · Cited by 219

Microglial Activation parallels System Degeneration in progressive Supranuclear palsy and Corticobasal Degeneration

Ishizawa, K., & Dickson, D. W. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.6.647 · Cited by 209

Degradation of Tau by Lysosomal Enzyme Cathepsin D: Implication for Alzheimer Neurofibrillary Degeneration

Kenessey, Á., Nacharaju, P., Ko, L., & Yen, S.-H. C. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052026.x · Cited by 191

Tauopathy-like Abnormalities and Neurologic Deficits in Mice Immunized With Neuronal Tau Protein

Rosenmann, H., Grigoriadis, N., Karussis, D., Boimel, M., Touloumi, O., Ovadia, H., & Abramsky, O. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1459 · Cited by 178

Aβ-induced meningoencephalitis is IFN-γ-dependent and is associated with T cell-dependent clearance of Aβ in a mouse model of Alzheimer's disease

Monsonego, A., Imitola, J., Petrovic, S., Zota, V. E., Nemirovsky, A., Baron, R., Fisher, Y., Owens, T., & Weiner, H. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506209103 · Cited by 165

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

Wong, E. S. P., Tan, J. M. M., Soong, W.-E., Hussein, K., Nukina, N., Dawson, V. L., Dawson, T. M., Cuervo, A. M., & Lim, K. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn157 · Cited by 162

Brain‐derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI‐3Kinase signalling mechanism

Elliott, E., Atlas, R., Lange, A. A., & Ginzburg, I. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04290.x · Cited by 142

Neuronal and microglial cathepsins in aging and age-related diseases

Nakanishi, H. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00027-8 · Cited by 128

Internalized Antibodies to the Aβ Domain of APP Reduce Neuronal Aβ and Protect against Synaptic Alterations

Tampellini, D., Magrané, J., Takahashi, R. H., Li, F., Lin, M. T., Almeida, C. G., & Gouras, G. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700373200 · Cited by 118

Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice

Furlan, R. (2003) · Brain · doi:10.1093/brain/awg031 · Cited by 116

Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury

Shein, N. A., Grigoriadis, N., Alexandrovich, A. G., Simeonidou, C., Lourbopoulos, A. I., Polyzoidou, E., Trembovler, V., Mascagni, P., Dinarello, C. A., & Shohami, E. (2009) · The FASEB Journal · doi:10.1096/fj.09-134700 · Cited by 98

Intraneuronal IgG in the central nervous system

Fabian, R. H., & Petroff, G. (1987) · Neurology · doi:10.1212/wnl.37.11.1780 · Cited by 97

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics

Rosenmann, H., Grigoriadis, N., Eldar-Levy, H., Avital, A., Rozenstein‐Tsalkovich, L., Touloumi, O., Behar, L., Ben‐Hur, T., Avraham, Y., Berry, E., et al. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.03.007 · Cited by 93

Statins reduce the neurofibrillary tangle burden in a mouse model of tauopathy

Boimel, M., Grigoriadis, N., Lourbopoulos, A., Touloumi, O., Rosenmann, D., Abramsky, O., & Rosenmann, H. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31819ac3cb · Cited by 86

Ramification of microglia, monocytes and macrophages in vitro: influences of various epithelial and mesenchymal cells and their conditioned media *

Wilms, H., Hartmann, D., & Sievers, J. (1997) · Cell and Tissue Research · doi:10.1007/s004410050769 · Cited by 86

Detection of circulating antibodies against tau protein in its unphosphorylated and in its neurofibrillary tangles-related phosphorylated state in Alzheimer's disease and healthy subjects

Rosenmann, H., Meiner, Z., Geylis, V., Abramsky, O., & Steinitz, M. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.01.072 · Cited by 77

The central nervous sytem-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS)

Kaye, J. F., de Rosbo, N. K., Mendel, I., Flechter, S., Hoffman, M. A., Yust, I., & Ben‐Nun, A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00168-x · Cited by 72

Are the Extracelluar Pathways a Conduit for the Delivery of Therapeutics to the Brain?

Banks, W. A. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384862 · Cited by 58

Amelioration of autoimmune neuroinflammation by recombinant human alpha-fetoprotein

Irony-Tur-Sinai, M., Grigoriadis, N., Lourbopoulos, A. I., Pinto-Maaravi, F., Abramsky, O., & Brenner, T. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.11.012 · Cited by 47

Phosphorylation of Tau Alters Its Association with the Plasma Membrane

Ekinci, F. J., & Shea, T. B. (2000) · Cellular and Molecular Neurobiology · doi:10.1023/a:1007075115574 · Cited by 45

Uptake of antineuronal IgM by CNS neurons

Fabian, R. H. (1990) · Neurology · doi:10.1212/wnl.40.3_part_1.419 · Cited by 38

Inhibition of Autophagy Causes Tau Proteolysis by Activating Calpain in Rat Brain

Zhang, J. Y., Peng, C., Shi, H., Wang, S., Wang, Q., & Wang, J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0908 · Cited by 34

Tau pathology and neurodegeneration

Spillantini, M. G., & Goedert, M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70090-5 · Cited by 1,133

Tau-targeting therapies for Alzheimer disease

Congdon, E. E., & Sigurdsson, E. M. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0013-z · Cited by 1,113

The many faces of tau

Morris, M., Maeda, S., Vossel, K., & Mucke, L. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.009 · Cited by 899

Therapeutics of Alzheimer's disease: Past, present and future

Anand, R., Gill, K. D., & Mahdi, A. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.004 · Cited by 765

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T. E., Ma, S., Maloney, S. E., Wozniak, D. F., Diamond, M. I., & Holtzman, D. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.046 · Cited by 574

S4‐04‐08: Immunotherapy Targeting Pathologically Phosphorylated Tau in a Tauopathy Mouse Model

Boimel, M., Grigoriadis, N., Lourbopoulos, A. I., Haber, E., Abramsky, O., & Rosenmann, H. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.07.135

Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation

Rozenstein-Tsalkovich, L., Grigoriadis, N., Lourbopoulos, A., Nousiopoulou, E., Kassis, I., Abramsky, O., Karussis, D., & Rosenmann, H. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.07.006 · Cited by 66

Immunotherapy for Targeting Tau Pathology in Alzheimer’s Disease and Tauopathies

Rosenmann, H. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310030001 · Cited by 52

P2‐387: Phospho‐tau–specific vaccine for the treatment of tau pathology

Adolfsson, O., Gafner, V., Theunis, C., Pihlgren, M., Crespo‐Biel, N., Papin, S., López-Deber, M. P., Borghgraef, P., Piorkowska, K., Devijver, H., et al. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.1097

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model

Theunis, C., Crespo‐Biel, N., Pihlgren, M., Reis, P., Hickman, D. T., Adolfsson, O., Chuard, N., Ndao, D. M., Borghgraef, P., Devijver, H., et al. (2013)