Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
Open accessAbstract
Tau aggregation occurs in neurodegenerative diseases including Alzheimer's disease and many other disorders collectively termed tauopathies. trans-cellular propagation of tau pathology, mediated by extracellular tau aggregates, may underlie pathogenesis of these conditions. P301S tau transgenic mice express mutant human tau protein and develop progressive tau pathology. Using a cell-based biosensor assay, we screened anti-tau monoclonal antibodies for their ability to block seeding activity present in P301S brain lysates. We infused three effective antibodies or controls into the lateral ventricle of P301S mice for 3 months. The antibodies markedly reduced hyperphosphorylated, aggregated, and insoluble tau. They also blocked development of tau seeding activity detected in brain lysates using the biosensor assay, reduced microglial activation, and improved cognitive deficits. These data imply a central role for extracellular tau aggregates in the development of pathology. They also suggest that immunotherapy specifically designed to block trans-cellular aggregate propagation will be a productive treatment strategy.
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Immunotherapies targeting extracellular tau reduce pathology in mice.
“Finally, immunotherapies targeting extracellular tau reduce pathology in mice (Yanamandra et al., 2013).”
From Spontaneous pathology in PS19 tauopathy mice progresses via brain networks (2025) · cites this paper as Yanamandra et al., 2013
Human tau expression was consistently present across brain sections spanning the rostrocaudal extent of the hippocampus at 3, 6, 9 and 12 months of age in PS19 mice.
“Staining for human tau (with HJ8.5 antibody (Yanamandra et al., 2013, Holmes et al., 2014)) showed consistent expression of human tau across brain sections spanning the rostrocaudal extent of the hippocampus at 3, 6, 9 and 12 months of age (Fig. 3).”
From Spontaneous pathology in PS19 tauopathy mice progresses via brain networks (2025) · cites this paper as Yanamandra et al., 2013
Antibodies that block tau seeding activity can prevent the formation of tangles and brain atrophy in mice.
“Alternatively, it has been shown that antibodies that block tau seeding activity can prevent the formation of tangles and brain atrophy in mice [183].”
From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [183]
HJ8.5 in PS19 mice reduced tau seeding, hyperphosphorylation, thioflavin S staining, detergent-insoluble tau, brain atrophy, and cognitive deficits when given before significant tau pathology, whether intraventricularly or peripherally.
“In preclinical studies, mouse anti-human tau monoclonal antibody HJ8.5 demonstrated reduced tau seeding, hyperphosphorylation and thioflavin S staining, reduced levels of detergent insoluble tau, and reduced brain atrophy and cognitive deficits in PS19 (P301S) mice, whether administered via intraventricular infusion (Yanamandra et al., 2013) or peripherally (Yanamandra et al., 2015) when administ”
From Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) · cites this paper as Yanamandra et al., 2013
Monoclonal antibodies against the amino-terminal or repeat domain (306-320) region, oligomeric tau, misfolded tau, pSer202, pThr231, pSer409, pSer413 and pSer422 have proved to be efficacious in tauopathy models.
“In addition, monoclonal antibodies against the amino-terminal or repeat domain (306–320) region209–215, oligomeric tau216,217, misfolded tau201,218,219, pSer202220,221, pThr231208 pSer409222, pSer413223 and pSer422224 have proved to be efficacious in tauopathy models.”
From Tau-targeting therapies for Alzheimer disease (2018) · cites this paper as [213]
No adverse immune reactions were seen; in fact, microglial activation was reduced in the treated animals.
“No adverse immune reactions were seen; in fact, microglial activation was reduced in the treated animals213,239.”
From Tau-targeting therapies for Alzheimer disease (2018) · cites this paper as [213]
Infusion of this antibody into the brain in a transgenic mouse model of tauopathy reduced the levels of aggregated and hyperphosphorylated tau, and also improved cognition.
“Infusion of this antibody into the brain in a transgenic mouse model of tauopathy reduced the levels of aggregated and hyperphosphorylated tau, and also improved cognition213.”
From Tau-targeting therapies for Alzheimer disease (2018) · cites this paper as [213]
Previous reports show that on SDD-AGE, low-molecular-weight tau accumulates at the bottom of the gel and high-molecular-weight tau oligomers appear as smears at the top.
“Previous reports of HMW and LMW tau run on SDD-AGE show an accumulation of LMW tau at the bottom of the gel with smears of HMW tau oligomers at the top (7, 63–65).”
From Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy (2017) · cites this paper as [7]
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Self-citation
- Authors
- Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T. E., Ma, S., Maloney, S. E., Wozniak, D. F., Diamond, M. I., & Holtzman, D. M.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Diamond, Marc I.
- Holtzman, David M.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 80
- Issue
- 2
- Pages
- 402-414
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3924573
- OpenAlex
- W2059809766
- Cited by
- 574
- References
- 58
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 43 · 2023: 31 · 2022: 40 · 2021: 37 · 2020: 54 · 2019: 56 · 2018: 69 · 2017: 63 · 2016: 41 · 2015: 41 · 2014: 57 · 2013: 5
- FWCI
- 33.42
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-12-18)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS071835)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- anti-tau antibodies, tau aggregation, tau seeding, P301S tau transgenic mice, tauopathy, Alzheimer's disease, immunotherapy, microglial activation, cognitive impairment, hyperphosphorylated tau
- MeSH terms
- Animals, Antibodies, Monoclonal, Brain, Cells, Cultured, Cognition Disorders, Humans, Mice, Transgenic, tau Proteins, Microglia, Tauopathies, Mice, Infusions, Intraventricular
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