Internalized Antibodies to the Aβ Domain of APP Reduce Neuronal Aβ and Protect against Synaptic Alterations

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · see citing works

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012 · see citing works

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,488 · see citing works

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431 · see citing works

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.040 · Cited by 1,294 · see citing works

Intraneuronal Aβ42 Accumulation in Human Brain

Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., et al. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64700-1 · Cited by 991 · see citing works

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Koo, E. H., & Squazzo, S. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32449-3 · Cited by 989 · see citing works

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

Haass, C., Koo, E., Mellon, A., Hung, A. Y., & Selkoe, D. (1992) · Nature · doi:10.1038/357500a0 · Cited by 901 · see citing works

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., & LaFerla, F. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.003 · Cited by 780 · see citing works

Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease

Höck, C., Konietzko, U., Streffer, J. R., Tracy, J., Signorell, A., Müller-Tillmanns, B., Lemke, U., Henke, K., Moritz, E., Garcia, E., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00294-0 · Cited by 777 · see citing works

Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

Takahashi, R. H., Milner, T. A., Li, F., Nam, E. E., Edgar, M. A., Yamaguchi, H., Beal, M. F., Xu, H., Greengard, P., & Gouras, G. K. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64463-x · Cited by 706 · see citing works

Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

Klyubin, I., Walsh, D. M., Lemere, C. A., Cullen, W. K., Shankar, G. M., Betts, V., Spooner, E. T., Jiang, L., Anwyl, R., Selkoe, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1234 · Cited by 489 · see citing works

Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

Takahashi, R. H., Almeida, C. G., Kearney, P. F., Yu, F., Lin, M. T., Milner, T. A., & Gouras, G. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5167-03.2004 · Cited by 445 · see citing works

Reversible memory loss in a mouse transgenic model of Alzheimer’s disease

Kotilinek, L. A., Bacskai, B., Westerman, M., Kawarabayashi, T., Younkin, L., Hyman, B. T., Younkin, S., & Ashe, K. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06331.2002 · Cited by 420 · see citing works

Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology

Bard, F., Barbour, R., Cannon, C., Carretto, R., Fox, M., Games, D., Guido, T., Hoenow, K., Hu, K., Johnson-Wood, K., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436286100 · Cited by 411 · see citing works

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

Almeida, C. G., Tampellini, D., Takahashi, R. H., Greengard, P., Lin, M. T., Snyder, E. M., & Gouras, G. K. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.02.008 · Cited by 397 · see citing works

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer’s disease

D'Andrea, M. R., Nagele, R. G., Wang, H., Peterson, P. A., & Lee, D. H. S. (2001) · Histopathology · doi:10.1046/j.1365-2559.2001.01082.x · Cited by 390 · see citing works

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

Sheng, J. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00069-x · Cited by 388 · see citing works

Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42

Perez, R. G., Soriano, S., Hayes, J. D., Ostaszewski, B. L., Xia, W., Selkoe, D. J., Chen, X., Stokin, G. B., & Koo, E. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.18851 · Cited by 387 · see citing works

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H., & Yankner, B. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00604-9 · Cited by 387 · see citing works

Aβ vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

Masliah, E., Hansen, L., Adame, A., Crews, L. A., Bard, F., Lee, C., Seubert, P. A., Games, D., Kirby, L., & Schenk, D. (2005) · Neurology · doi:10.1212/01.wnl.0000148590.39911.df · Cited by 355 · see citing works

Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease

Gouras, G. K., Almeida, C. G., & Takahashi, R. H. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.022 · Cited by 338 · see citing works

Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

Wirths, O., Multhaup, G., Czech, C., Blanchard, V., Moussaoui, S., Tremp, G., Pradier, L., Beyreuther, K., & Bayer, T. A. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01876-6 · Cited by 336 · see citing works

Immunology and immunotherapy of Alzheimer's disease

Weiner, H. L., & Frenkel, D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1843 · Cited by 335 · see citing works

The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review

Nixon, R., Cataldo, A., & Mathews, P. (2000) · Neurochemical Research · doi:10.1023/a:1007675508413 · Cited by 332 · see citing works

Non-Fc-Mediated Mechanisms Are Involved in Clearance of Amyloid-β<i>In Vivo</i>by Immunotherapy

Bacskai, B. J., Kajdasz, S. T., McLellan, M. E., Games, D., Seubert, P., Schenk, D., & Hyman, B. T. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07873.2002 · Cited by 323 · see citing works

Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells

Thinakaran, G., Teplow, D. B., Siman, R., Greenberg, B., & Sisodia, S. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9390 · Cited by 317 · see citing works

β-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System

Almeida, C. G., Takahashi, R. H., & Gouras, G. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5078-05.2006 · Cited by 316 · see citing works

A Dynamic Relationship between Intracellular and Extracellular Pools of Aβ

Oddo, S., Caccamo, A., Smith, I. F., Green, K. N., & LaFerla, F. M. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.050593 · Cited by 261 · see citing works

The Arctic Alzheimer mutation facilitates early intraneuronal Aβ aggregation and senile plaque formation in transgenic mice

Lord, A., Kalimo, H., Eckman, C., Zhang, X.-Q., Lannfelt, L., & Nilsson, L. N. G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.12.007 · Cited by 260 · see citing works

Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

Lorenzo, A., Yuan, M., Zhang, Z., Paganetti, P. A., Sturchler-Pierrat, C., Staufenbiel, M., Mautino, J., Vigo, F. S., Sommer, B., & Yankner, B. A. (2000) · Nature Neuroscience · doi:10.1038/74833 · Cited by 258 · see citing works

Intraneuronal Aβ42 accumulation in Down syndrome brain: Original Articles

Mori, C., Spooner, E. T., Wisniewski, K. E., Wisniewski, T. M., Yamaguchi, H., Saido, T. C., Tolan, D. R., Selkoe, D. J., & Lemere, C. A. (2002) · Amyloid · doi:10.3109/13506120208995241 · Cited by 255 · see citing works

Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: Implications for cancer immunotherapy

Friedman, L. M., Rinon, A., Schechter, B., Lyass, L., Lavi, S., Bacus, S. S., Sela, M., & Yarden, Y. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409610102 · Cited by 252 · see citing works

Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

Gyure, K. A., Durham, R., Stewart, W. F., Smialek, J. E., & Troncoso, J. C. (2001) · Archives of Pathology &amp; Laboratory Medicine · doi:10.5858/2001-125-0489-iaapdo · Cited by 248 · see citing works

Inhibition of Intracellular Cholesterol Transport Alters Presenilin Localization and Amyloid Precursor Protein Processing in Neuronal Cells

Runz, H., Rietdorf, J., Tomic, I., de Bernard, M., Beyreuther, K. T., Pepperkok, R., & Hartmann, T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01679.2002 · Cited by 242 · see citing works

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

Wilcock, D. M., DiCarlo, G., Henderson, D., Jackson, J., Clarke, K., Ugen, K. E., Gordon, M. N., & Morgan, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03745.2003 · Cited by 232 · see citing works

Spatial Segregation of γ-Secretase and Substrates in DistinctMembraneDomains

Vetrivel, K. S., Cheng, H., Kim, S.-H., Chen, Y., Barnes, N. Y., Parent, A., Sisodia, S. S., & Thinakaran, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503570200 · Cited by 220 · see citing works

Amyloid-β Immunization Effectively Reduces Amyloid Deposition in FcRγ-/-Knock-Out Mice

Das, P., HOWARD, V. G., Loosbrock, N., Dickson, D. W., Murphy, M. P., & Golde, T. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08532.2003 · Cited by 212 · see citing works

Anti-A 42- and anti-A 40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

Levites, Y. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25410 · Cited by 207 · see citing works

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

Caporaso, G. L., Gandy, S., Buxbaum, J. D., & Greengard, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2252 · Cited by 204 · see citing works

Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration

Wilcock, D. M., Munireddy, S. K., Rosenthal, A., Ugen, K. E., Gordon, M. N., & Morgan, D. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.09.015 · Cited by 202 · see citing works

Trafficking of cell-surface amyloid β-protein precursor: I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

Koo, E. H., Squazzo, S. L., Selkoe, D. J., & Koo, C. H. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.5.991 · Cited by 201 · see citing works

Gleevec inhibits β-amyloid production but not Notch cleavage

Netzer, W. J., Dou, F., Cai, D., Veach, D. R., Jean, S., Li, Y., Bornmann, W. G., Clarkson, B., Xu, H., & Greengard, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1534745100 · Cited by 192 · see citing works

Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice

Saura, C. A., Chen, G., Malkani, S., Choi, S.-Y., Takahashi, R. H., Zhang, D., Gouras, G. K., Kirkwood, A., Morris, R. G. M., & Shen, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1247-05.2005 · Cited by 157 · see citing works

Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice

Lemere, C. A. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00044-5 · Cited by 138 · see citing works

Microtubules and Src homology 3 domains stimulate the dynamin GTPase via its C-terminal domain.

Herskovits, J. S., Shpetner, H. S., Burgess, C. C., & Vallee, R. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11468 · Cited by 136 · see citing works

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein

Carey, R. M., Balcz, B. A., G.‐Coviella, I. L., & Slack, B. E. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-30 · Cited by 135 · see citing works

Trafficking of cell-surface amyloid β-protein precursor: II. Endocytosis, recycling, and lysosomal targeting detected by immunolocalization

Yamazaki, T., Koo, E. H., & Selkoe, D. J. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.5.999 · Cited by 135 · see citing works

Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597–624)

Shaked, G. M., Kummer, M. P., Lu, D. C., Galvan, V., Bredesen, D. E., Koo, E. H., Shaked, G. M., Kummer, M. P., Lu, D. C., Galvan, V., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5032fje · Cited by 132 · see citing works

Intracellular Accumulation of Insoluble, Newly Synthesized Aβn-42 in Amyloid Precursor Protein-transfected Cells That Have Been Treated with Aβ1–42

Yang, A. J., Chandswangbhuvana, D., Shu, T., Henschen, A., & Glabe, C. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20650 · Cited by 108 · see citing works

β-site specific intrabodies to decrease and prevent generation of Alzheimer's Aβ peptide

Paganetti, P., Calanca, V., Galli, C., Stefani, M., & Molinari, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200410047 · Cited by 101 · see citing works

Early intraneuronal Aβ deposition in the hippocampus of APP transgenic mice

Shie, F., LeBoeur, R. C., & Jin, L. (2003) · Neuroreport · doi:10.1097/00001756-200301200-00023 · Cited by 83 · see citing works

Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid‐β Peptides

Goldsbury, C., Mocanu, M., Thies, E., Kaether, C., Haass, C., Keller, P., Biernat, J., Mandelkow, E., & Mandelkow, E. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00434.x · Cited by 82 · see citing works

Inhibition of amyloid precursor protein processing by β-secretase through site-directed antibodies

Arbel, M., Yacoby, I., & Solomon, B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502427102 · Cited by 76 · see citing works

Aβ immunization and anti-Aβ antibodies: potential therapies for the prevention and treatment of Alzheimer’s disease

Holtzman, D. M., Bales, K. R., Paul, S. M., & Demattos, R. B. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00158-8 · Cited by 64 · see citing works

Significance of intracellular A beta 42 accumulation in Alzheimer s disease

Tabira, T. (2002) · Frontiers in bioscience · doi:10.2741/tabira · Cited by 60 · see citing works

Alzheimers Disease and Immunotherapy

Solomon, B. (2004) · Current Alzheimer Research · doi:10.2174/1567205043332126 · Cited by 35 · see citing works

Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements

Asuni, A. A., Boutajangout, A., Quartermain, D., & Sigurdsson, E. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2361-07.2007 · Cited by 506 · see citing works

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

Gouras, G. K., Tampellini, D., Takahashi, R. H., & Capetillo-Zarate, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0679-9 · Cited by 372 · see citing works

Can Alzheimer disease be prevented by amyloid-β immunotherapy?

Lemere, C. A., & Masliah, E. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.219 · Cited by 351 · see citing works

β-amyloid Peptides and Amyloid Plaques in Alzheimer's Disease

Gouras, G. K., Olsson, T. T., & Hansson, O. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0313-y · Cited by 331 · see citing works

Passive immunization targeting pathological phospho‐tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

Boutajangout, A., Ingadottir, J., Davies, P., & Sigurdsson, E. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07337.x · Cited by 306 · see citing works

Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model

Boutajangout, A., Quartermain, D., & Sigurdsson, E. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4363-10.2010 · Cited by 272 · see citing works

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

Ricobaraza, A., Cuadrado‐Tejedor, M., Marco, S., Pérez‐Otaño, I., & García‐Osta, A. (2012) · Hippocampus · doi:10.1002/hipo.20883 · Cited by 239 · see citing works

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils

Habicht, G., Haupt, C., Friedrich, R. P., Hortschansky, P., Sachse, C., Meinhardt, J., Wieligmann, K., Gellermann, G. P., Brodhun, M., Götz, J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703793104 · Cited by 216 · see citing works

Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance

Congdon, E. E., Gu, J., Sait, H. B. R., & Sigurdsson, E. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.491001 · Cited by 195 · see citing works

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice

Boimel, M., Grigoriadis, N., Lourbopoulos, A., Haber, E., Abramsky, O., & Rosenmann, H. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.05.010 · Cited by 174 · see citing works

Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology

Gu, J., Congdon, E. E., & Sigurdsson, E. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.494922 · Cited by 163 · see citing works

Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study

Lewczuk, P., Kamrowski‐Kruck, H., Peters, O., Heuser, I., Jessen, F., Popp, J., Bürger, K., Hampel, H. J., Frölich, L., Wolf, S., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.84 · Cited by 161 · see citing works

An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

Lord, A., Gumucio, A., Englund, H., Sehlin, D., Sundquist, V. S., Söderberg, L., Möller, C., Gellerfors, P., Lannfelt, L., Pettersson, F. E., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.08.007 · Cited by 157 · see citing works

Amyloid‐ß‐directed immunotherapy for Alzheimer's disease

Lannfelt, L., Relkin, N. R., & Siemers, E. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12168 · Cited by 157 · see citing works

HSV-1 and Alzheimer’s disease: more than a hypothesis

Piacentini, R., De Chiara, G., Li Puma, D. D., Ripoli, C., Marcocci, M. E., Garaci, E., Palamara, A. T., & Grassi, C. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00097 · Cited by 130 · see citing works

A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease

Savioz, A., Leuba, G., & Vallet, P. G. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.09.004 · Cited by 127 · see citing works

Synaptic Activity Reduces Intraneuronal Aβ, Promotes APP Transport to Synapses, and Protects against Aβ-Related Synaptic Alterations

Tampellini, D., Rahman, N., Gallo, E. F., Huang, Z., Dumont, M., Capetillo-Zarate, E., Ma, T., Zheng, R., Lu, B., Nanus, D. M., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2292-09.2009 · Cited by 127 · see citing works

Immunotherapy for Alzheimer‘s Disease: From Anti-β-Amyloid to Tau-Based Immunization Strategies

Panza, F., Frisardi, V., Solfrizzi, V., Imbimbo, B. P., Logroscino, G., Santamato, A., Greco, A., Seripa, D., & Pilotto, A. (2012) · Immunotherapy · doi:10.2217/imt.11.170 · Cited by 125 · see citing works

Intracerebroventricular amyloid-β antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

Thakker, D. R., Weatherspoon, M. R., Harrison, J., Keene, T. E., Lane, D. S., Kaemmerer, W. F., Stewart, G. R., & Shafer, L. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813404106 · Cited by 124 · see citing works

Assembly, Maturation, and Trafficking of the γ-Secretase Complex in Alzheimers Disease

Dries, D. R., & Yu, G. (2008) · Current Alzheimer Research · doi:10.2174/156720508783954695 · Cited by 120 · see citing works

Intracellular Accumulation of Amyloid- (A ) Protein Plays a Major Role in A -Induced Alterations of Glutamatergic Synaptic Transmission and Plasticity

Ripoli, C., Cocco, S., Puma, D. D. L., Piacentini, R., Mastrodonato, A., Scala, F., Puzzo, D., D’Ascenzo, M., & Grassi, C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1201-14.2014 · Cited by 122 · see citing works

Aβ Immunotherapy: Intracerebral Sequestration of Aβ by an Anti-Aβ Monoclonal Antibody 266 with High Affinity to Soluble Aβ

Yamada, K., Yabuki, C., Seubert, P., Schenk, D., Hori, Y., Ohtsuki, S., Terasaki, T., Hashimoto, T., & Iwatsubo, T. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2021-09.2009 · Cited by 117 · see citing works

Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies

Sigurdsson, E. M. (2008) · Journal of Alzheimer's Disease · doi:10.3233/jad-2008-15202 · Cited by 116 · see citing works

β-Amyloid Modulation of Synaptic Transmission and Plasticity

Venkitaramani, D. V., Chin, J., Netzer, W. J., Gouras, G. K., Lesné, S., Malinow, R., & Lombroso, P. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3478-07.2007 · Cited by 115 · see citing works

Early-onset network hyperexcitability in presymptomatic Alzheimer’s disease transgenic mice is suppressed by passive immunization with anti-human APP/Aβ antibody and by mGluR5 blockade

Kazim, S. F., Chuang, S.-C., Zhao, W., Wong, R. K. S., Bianchi, R., & Iqbal, K. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00071 · Cited by 109 · see citing works

Intravenous Immunoglobulins as a Treatment for Alzheimerʼs Disease

Dodel, R. C., Neff, F., Noelker, C., Pul, R., Du, Y., Bacher, M., & Oertel, W. H. (2010) · Drugs · doi:10.2165/11533070-000000000-00000 · Cited by 110 · see citing works

Synaptic activity and Alzheimer's disease: a critical update

Tampellini, D. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00423 · Cited by 105 · see citing works

Tau-Based Therapeutics for Alzheimer’s Disease: Active and Passive Immunotherapy

Panza, F., Solfrizzi, V., Seripa, D., Imbimbo, B. P., Lozupone, M., Santamato, A., Tortelli, R., Galizia, I., Prete, C., Daniele, A., et al. (2016) · Immunotherapy · doi:10.2217/imt-2016-0019 · Cited by 105 · see citing works

Long-term electromagnetic field treatment enhances brain mitochondrial function of both Alzheimer's transgenic mice and normal mice: a mechanism for electromagnetic field-induced cognitive benefit?

Dragicevic, N., Bradshaw, P. C., Mamcarz, M. B., Lin, X., Wang, L., Cao, C., & Arendash, G. W. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.012 · Cited by 104 · see citing works

Tau as a Therapeutic Target for Alzheimers Disease

Boutajangout, A., Sigurdsson, E. M., & Krishnamurthy, P. K. (2011) · Current Alzheimer Research · doi:10.2174/156720511796717195 · Cited by 97 · see citing works

Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation

Piacentini, R., Puma, D. D. L., Ripoli, C., Marcocci, M. E., Chiara, G. D., Garaci, E., Palamara, A. T., & Grassi, C. (2015) · Scientific Reports · doi:10.1038/srep15444 · Cited by 97 · see citing works

RAGE–TXNIP axis is required for S100B-promoted Schwann cell migration, fibronectin expression and cytokine secretion

Sbai, O., Devi, T. S., Melone, M. A. B., Feron, F. P., Khrestchatisky, M., Singh, L. P., & Perrone, L. (2010) · Journal of Cell Science · doi:10.1242/jcs.074674 · Cited by 97 · see citing works

Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K+ current inhibition mediated by activation of caspases and GSK-3

Scala, F., Fusco, S., Ripoli, C., Piacentini, R., Puma, D. D. L., Spinelli, M., Laezza, F., Grassi, C., & D’Ascenzo, M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.10.034 · Cited by 96 · see citing works

Dendritic Spine Instability Leads to Progressive Neocortical Spine Loss in a Mouse Model of Huntington's Disease

Murmu, R. P., Li, W., Holtmaat, A., & Li, J.-Y. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5284-12.2013 · Cited by 95 · see citing works

MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease

Yao, J., Hennessey, T., Flynt, A. S., Lai, E. C., Beal, M. F., & Lin, M. T. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015546 · Cited by 92 · see citing works

Aβ Internalization by Neurons and Glia

Mohamed, A., & Chaves, E. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/127984 · Cited by 91 · see citing works

Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration

Kuszczyk, M. A., Sanchez, S., Pankiewicz, J., Kim, J., Duszczyk, M., Guridi, M., Asuni, A. A., Sullivan, P. M., Holtzman, D. M., & Sadowski, M. J. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.01.034 · Cited by 89 · see citing works

Antibody-Mediated Clearance of Brain Amyloid-β: Mechanisms of Action, Effects of Natural and Monoclonal Anti-Aβ Antibodies, and Downstream Effects

Loeffler, D. A. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230025 · Cited by 86 · see citing works

Murine models of Alzheimer's disease and their use in developing immunotherapies

Wısnıewskı, T., & Sigurdsson, E. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.05.004 · Cited by 80 · see citing works

Dopamine Transporter Endocytic Trafficking in Striatal Dopaminergic Neurons: Differential Dependence on Dynamin and the Actin Cytoskeleton

Gabriel, L. R., Wu, S., Kearney, P. J., Bellve, K. D., Standley, C., Fogarty, K. E., & Melikian, H. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3284-13.2013 · Cited by 79 · see citing works

Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells

Pihlaja, R., Helin, J. S., Eskola, O., Vasara, J., Lopez‐Picon, F. R., Haaparanta‐Solin, M., & Rinne, J. O. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0305-9 · Cited by 79 · see citing works

Herpes Simplex Virus Type-1 Infection Impairs Adult Hippocampal Neurogenesis via Amyloid-β Protein Accumulation

Puma, D. D. L., Piacentini, R., Leone, L., Gironi, K., Marcocci, M. E., Chiara, G. D., Palamara, A. T., & Grassi, C. (2019) · Stem Cells · doi:10.1002/stem.3072 · Cited by 74 · see citing works

Potential of the Antibody Against cis–Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury

Lu, K. P., Kondo, A., Albayram, Ö., Herbert, M. K., Liu, H., & Zhou, X. Z. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2027 · Cited by 74 · see citing works

Endogenous Aβ causes cell death via early tau hyperphosphorylation

Amadoro, G., Corsetti, V., Ciotti, M. T., Florenzano, F., Capsoni, S., Amato, G., & Calissano, P. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.06.005 · Cited by 73 · see citing works

Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model

Krishnamurthy, P., Deng, Y., & Sigurdsson, E. M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00059 · Cited by 71 · see citing works

Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells

Näsström, T., Gonçalves, S. A., Sahlin, C., Nordström, E. K. L., Sundquist, V. S., Lannfelt, L., Bergström, J. J. E., Outeiro, T. F., & Ingelsson, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027230 · Cited by 69 · see citing works

RAGE recycles at the plasma membrane in S100B secretory vesicles and promotes Schwann cells morphological changes

Perrone, L., Peluso, G., & Melone, M. A. B. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21474 · Cited by 66 · see citing works

Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation

Akwa, Y., Gondard, E., Mann, A., Capetillo‐Zarate, E., Alberdi, E. M., Matute, C., Marty, S., Vaccari, T., Lozano, A. M., Baulieu, E. E., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.142 · Cited by 62 · see citing works

Mutant Presenilin 1 Increases the Expression and Activity of BACE1

Giliberto, L., Borghi, R., Piccini, A., Mangerini, R., Sorbi, S., Cirmena, G., Garuti, A., Ghetti, B. F., Tagliavini, F., Mughal, M. R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805685200 · Cited by 56 · see citing works

Synapses, synaptic activity and intraneuronal Aβ in Alzheimer’s disease

Tampellini, D. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00013 · Cited by 54 · see citing works

Aβ1–42 reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: A quantitative analysis

Evans, N. A., Facci, L., OWEN, D. E., Soden, P. E., Burbidge, S. A., Prinjha, R. K., Richardson, J. C., & Skaper, S. D. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.08.001 · Cited by 53 · see citing works

Vaccination as a Therapeutic Approach to Alzheimer's Disease

Wısnıewskı, T., & Boutajangout, A. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20156 · Cited by 51 · see citing works

Soluble Beta-Amyloid Precursor Protein Is Related to Disease Progression in Amyotrophic Lateral Sclerosis

Steinacker, P., Fang, L., Kühle, J., Petzold, A., Tumani, H., Ludolph, A. C., Otto, M., & Brettschneider, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023600 · Cited by 45 · see citing works

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

Zampagni, M., Evangelisti, E., Cascella, R., Liguri, G., Becatti, M., Pensalfini, A., Uberti, D. L., Cenini, G., Memo, M., Bagnoli, S., et al. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0603-8 · Cited by 44 · see citing works

What is the role of amyloid precursor protein dimerization?

Khalifa, N. B., Hees, J. V., Tasiaux, B., Huysseune, S., Smith, S. O., Constantinescu, S. N., Octave, J., & Kienlen‐Campard, P. (2010) · Cell Adhesion & Migration · doi:10.4161/cam.4.2.11476 · Cited by 42 · see citing works

Does Impairment of Adult Neurogenesis Contribute to Pathophysiology of Alzheimer's Disease? A Still Open Question

Puma, D. D. L., Piacentini, R., & Grassi, C. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.578211 · Cited by 45 · see citing works

Intracellular Amyloid β-Protein As a Therapeutic Target for Treating Alzheimers Disease

Ohyagi, Y. (2008) · Current Alzheimer Research · doi:10.2174/156720508786898514 · Cited by 40 · see citing works

Immunotherapeutic approaches for Alzheimer’s disease in transgenic mouse models

Wısnıewskı, T., & Boutajangout, A. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0236-2 · Cited by 39 · see citing works

Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease

Kayed, R. (2010) · Human Vaccines · doi:10.4161/hv.6.11.12689 · Cited by 38 · see citing works

Antibodies to cell surface proteins redirect intracellular trafficking pathways

Pierre, C. A. S., Leonard, D. M., Corvera, S., Kurt‐Jones, E. A., & Finberg, R. W. (2011) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2011.05.011 · Cited by 38 · see citing works

Advances on the Understanding of the Origins of Synaptic Pathology in AD

Lacor, P. N. (2007) · Current Genomics · doi:10.2174/138920207783769530 · Cited by 38 · see citing works

Resistance is futile: antineuronal autoimmunity in multiple sclerosis.

Huizinga, R., Linington, C., & Amor, S. (2008) · Trends in immunology · doi:10.1016/j.it.2007.11.002 · Cited by 43 · see citing works

Naturally Occurring Autoantibodies Against β-Amyloid

Bach, J., & Dodel, R. C. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-3461-0_7 · Cited by 34 · see citing works

Immunotherapy for Tauopathies

Gu, J., & Sigurdsson, E. M. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9576-5 · Cited by 34 · see citing works

Concentrations of beta-amyloid precursor protein processing products in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration

Steinacker, P., Hendrich, C., Sperfeld, A., Jesse, S., Lehnert, S., Pabst, A., Arnim, C. A. F. V., Mottaghy, F. M., Uttner, I., Tumani, H., et al. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0271-4 · Cited by 32 · see citing works

Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging

Wu, Q., Lin, Y., Gu, J., & Sigurdsson, E. M. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.08.041 · Cited by 29 · see citing works

Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-modifying Drugs

Froestl, W., Pfeifer, A., & Muhs, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121729 · Cited by 27 · see citing works

Tau Immunotherapies for Alzheimer’s Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies

Sigurdsson, E. M. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231238 · Cited by 27 · see citing works

A relevant in vitro human model for the study of Zika virus antibody-dependent enhancement

Londono-Renteria, B. L., Troupin, A., Cardenas, J. C., Hall, A., Perez, O., Cardenas, L. D., Hartstone‐Rose, A., Halstead, S. B., & Colpitts, T. M. (2017) · Journal of General Virology · doi:10.1099/jgv.0.000833 · Cited by 23 · see citing works

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer’s disease

George, S., Rönnbäck, A., Gouras, G. K., Petit, G. H., Grueninger, F., Winblad, B., Graff, C., & Brundin, P. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-17 · Cited by 23 · see citing works

Protein Conformational Pathology in Alzheimers and Other Neurodegenerative Diseases; New Targets for Therapy

Žerovnik, E. (2010) · Current Alzheimer Research · doi:10.2174/156720510790274437 · Cited by 23 · see citing works

Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design

Singh, S. S., & Jois, S. D. S. (2017) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2017.08.003 · Cited by 23 · see citing works

Non-invasive characterization of β-amyloid1-40 vasoactivity by functional magnetic resonance imaging in mice

Luo, F., Seifert, T. R., Edalji, R. P., Loebbert, R. W., Hradil, V. P., Harlan, J. E., Schmidt, M. U., Nimmrich, V., Cox, B. F., & Fox, G. B. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.021 · Cited by 23 · see citing works

Amyloid-β Peptide-specific DARPins as a Novel Class of Potential Therapeutics for Alzheimer Disease

Hanenberg, M., McAfoose, J., Kulic, L., Welt, T., Wirth, F., Parizek, P., Strobel, L., Cattepoel, S., Späni, C. B., Derungs, R., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.564013 · Cited by 21 · see citing works

Harnessing the Immune System for Treatment and Detection of Tau Pathology

Congdon, E. E., Krishnaswamy, S., & Sigurdsson, E. M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132435 · Cited by 20 · see citing works

Reciprocal regulation of cholesterol and beta amyloid at the subcellular level in Alzheimer’s disease

Chaves, E. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-076 · Cited by 18 · see citing works

Neurofilament light as an immune target for pathogenic antibodies

Puentes, F., van der Star, B. J., Boomkamp, S. D., Kipp, M., Boon, L., Boscá, I., Raffel, J., Gnanapavan, S., van der Valk, P., Stephenson, J., et al. (2017) · Immunology · doi:10.1111/imm.12797 · Cited by 17 · see citing works

Recombinant GST-I-Aβ28-induced efficient serum antibody against Aβ42

Huang, X., Wang, J., Cui, L., Zou, X., & Zhang, Y. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.10.026 · Cited by 17 · see citing works

Immunotherapy for Alzheimer's disease: attacking amyloid-β from the inside

Arbel, M., & Solomon, B. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.09.005 · Cited by 16 · see citing works

Structures of Aβ-Related Peptide−Monoclonal Antibody Complexes,

Gardberg, A. S., Dice, L. T., Pridgen, K., Ko, J., Patterson, P. H., Ou, S. K.-H., Wetzel, R. B., & Dealwis, C. G. (2009) · Biochemistry · doi:10.1021/bi9001216 · Cited by 16 · see citing works

Prophylactic active immunization with a novel epitope vaccine improves cognitive ability by decreasing amyloid plaques and neuroinflammation in APP/PS1 transgenic mice

Ding, L., Meng, Y., Zhang, H., Yin, W., Yan, Y., & Cao, Y. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.01.003 · Cited by 15 · see citing works

The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice

Upadhaya, A. R., Scheibe, F., Kosterin, I., Abramowski, D., Gerth, J., Kumar, S., Liebau, S., Yamaguchi, H., Walter, J., Staufenbiel, M., et al. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-77 · Cited by 14 · see citing works

Disease Modifying Therapies for Alzheimer's Disease Targeting AβOligomers: Implications for Therapeutic Mechanisms

Matsubara, E., Takamura, A., Okamoto, Y., Oono, H., Nakata, T., Wakasaya, Y., Kawarabayashi, T., & Shoji, M. (2013) · BioMed Research International · doi:10.1155/2013/984041 · Cited by 12 · see citing works

A light at the end of the tunnel – from mutation identification to a potential treatment for Alzheimer’s disease

Lannfelt, L. (2023) · Upsala Journal of Medical Sciences · doi:10.48101/ujms.v128.10316 · Cited by 11 · see citing works

An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature

Cascella, R., Banchelli, M., Ghadami, S. A., Ami, D., Gagliani, M. C., Bigi, A., Staderini, T., Tampellini, D., Cortese, K., Cecchi, C., et al. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2148734 · Cited by 10 · see citing works

Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Aβ peptides

Houacine, J., Bolmont, T., Aeschbach, L., Oulad‐Abdelghani, M., & Fraering, P. C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.033 · Cited by 10 · see citing works

Conformation‐specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen

Bonito-Oliva, A., Schedin‐Weiss, S., Younesi, S. S., Tiiman, A., Adura, C., Paknejad, N., Brendel, M., Romin, Y., Parchem, R. J., Graff, C., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14119 · Cited by 10 · see citing works

Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology

Laversenne, V., Nazeeruddin, S., Källstig, E., Colin, P., Voize, C., & Schneider, B. L. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01069-3 · Cited by 10 · see citing works

Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance

Thomas, R. S., Liddell, J. E., & Kidd, E. J. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07942.x · Cited by 10 · see citing works

Immunotherapies for Parkinson’s Disease: Progression of Clinical Development

Teng, J. S., Ooi, Y. Y., Chye, S. M., Ling, A. P. K., & Koh, R. Y. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210526160926 · Cited by 10 · see citing works

Specific serum antibody binding to phosphorylated and non-phosphorylated tau in non-cognitively impaired, mildly cognitively impaired, and Alzheimer’s disease subjects: an exploratory study

Klaver, A. C., Coffey, M. P., Bennett, D. A., & Loeffler, D. A. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0100-x · Cited by 9 · see citing works

Therapeutic applications of antibodies in non-infectious neurodegenerative diseases

Krishnamurthy, P., & Sigurdsson, E. M. (2011) · New Biotechnology · doi:10.1016/j.nbt.2011.03.020 · Cited by 8 · see citing works

Endocytic mechanisms and drug discovery in neurodegenerative diseases

Zhang, M. (2008) · Frontiers in bioscience · doi:10.2741/3140 · Cited by 8 · see citing works

Multiple Antigenic Peptide System Coupled with Amyloid Beta Protein Epitopes As An Immunization Approach to Treat Alzheimer’s Disease

Sun, D., Qiao, Y., Jiang, X., Li, P., Kuai, Z., Gong, X., Liu, D., Fu, Q., Sun, L., He, L., et al. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00020 · Cited by 7 · see citing works

The toxicity of β-amyloid is attenuated by interaction with its specific human scFv E3 in vitro

Yue, S., Li, Y., Wang, X., Bai, H., Xia, J., Jiang, L., Ji, Y. I., Fan, L., He, Z.-G., & Chen, Q. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.04.009 · Cited by 7 · see citing works

Analysis of Vesicular Trafficking in Primary Neurons by Live Imaging

Tampellini, D., & Gouras, G. K. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-328-8_22 · Cited by 4 · see citing works

Developing injectable immunoglobulins to treat cognitive impairment in Alzheimer's disease

Steinitz, M. O. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.5.633 · Cited by 4 · see citing works

Tau Immunotherapy

Sigurdsson, E. M. (2016) · Methods in pharmacology and toxicology · doi:10.1007/978-1-4939-3560-4_8 · Cited by 3 · see citing works

Nutrient signaling pathways regulate amyloid clearance and synaptic loss in Alzheimer’s diseasePreprint

Mondal, M., Bali, J., Tzioras, M., Paolicelli, R. C., Jawaid, A., Malnar, M., Dominko, K., Udayar, V., Halima, S. B., Vadodaria, K. C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.13.381186 · Cited by 3 · see citing works

Aβ antibodies target not only amyloid plaques but also distinct brain cells and vessels

Wen, G., Lindblom, N., Zhan, X., Garcia, M. G., Deierborg, T., Kobro‐Flatmoen, A., & Gouras, G. K. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71121 · Cited by 2 · see citing works

O4–06–08: Internalized antibodies to the Aβ domain of APP reduce intraneuronal Aβ and protect against synaptic alterations

Tampellini, D., Magrané, J., Takahashi, R. H., Li, F., Almeida, C. G., & Gouras, G. K. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.343

Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

Klyubin, I., Walsh, D. M., Lemere, C. A., Cullen, W. K., Shankar, G. M., Betts, V., Spooner, E. T., Jiang, L., Anwyl, R., Selkoe, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1234 · Cited by 489 · see citing works

Immunotherapy for Alzheimer's disease: attacking amyloid-β from the inside

Arbel, M., & Solomon, B. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.09.005 · Cited by 16 · see citing works

The role of intracellular amyloid β in Alzheimer's disease

Li, M. C., Chen, L., Lee, D. H. S., Yu, L., & Zhang, Y. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.08.002 · Cited by 116 · see citing works

β-Amyloid Immunotherapy Prevents Synaptic Degeneration in a Mouse Model of Alzheimer's Disease

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