The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease
Open accessAbstract
There is an urgent need to identify non-invasive biomarkers for the detection of sporadic Alzheimer’s disease (AD). We previously studied microRNAs (miRNAs) in AD autopsy brain samples and reported a connection between miR-137, -181c, -9, -29a/b and AD, through the regulation of ceramides. In this study, the potential role of these miRNAs as diagnostic markers for AD was investigated. We identified that these miRNAs were down-regulated in the blood serum of probable AD patients. The levels of these miRNAs were also reduced in the serum of AD risk factor models. Although the ability of these miRNAs to conclusively diagnose for AD is currently unknown, our findings suggest a potential use for circulating miRNAs, along with other markers, as non-invasive and relatively inexpensive biomarkers for the early diagnosis of AD, however, with further research and validation.
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Lugli, G., Cohen, A. M., Bennett, D. A., Shah, R. C., Fields, C. J., Hernandez, A. G., & Smalheiser, N. R. (2015) · PLOS ONE · doi:10.1371/journal.pone.0139233 · Cited by 391
Burgos, K., Malenica, I., Metpally, R., Courtright, A., Rakela, B., Beach, T., Shill, H., Adler, C., Sabbagh, M., Villa, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094839 · Cited by 385
Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders
van den Berg, M. M. J., Krauskopf, J., Ramaekers, J. G., Kleinjans, J. C. S., Prickaerts, J., & Briedé, J. J. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101732 · Cited by 253
Advances in the development of new biomarkers for Alzheimer’s disease
Klyucherev, T. O., Olszewski, P., Shalimova, A. A., Chubarev, V. N., Tarasov, V. V., Attwood, M. M., Syvänen, S., & Schiöth, H. B. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00296-z · Cited by 241
Metadata
- Authors
- Geekiyanage, H., Jicha, G. A., Nelson, P. T., & Chan, C.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 235
- Issue
- 2
- Pages
- 491-496
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2000356500
- Cited by
- 294
- References
- 11
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Geekiyanage, H., Jicha, G. A., Nelson, P. T., & Chan, C. (2012). Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease. Experimental Neurology. https://doi.org/10.1016/j.expneurol.2011.11.026
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