Type 2 diabetes mellitus, dyslipidemia, and Alzheimer’s disease
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The prevalence of Alzheimer's disease (AD) is increasing rapidly, heightening the importance of finding effective preventive therapies for this devastating disease. Midlife vascular risk factors, including type 2 diabetes mellitus (T2DM), have been associated with increased risk of AD decades later and may serve as targets for AD prevention. Studies to date suggest that T2DM and hyperinsulinemia increase risk for AD, possibly through their effects on amyloid-beta metabolism and cerebrovascular dysfunction - two early findings in preclinical AD pathology. This paper reviews the evidence supporting a relationship between T2DM, hyperinsulinemia, and diabetic dyslipidemia on the development of AD, discusses DM treatment trials and their preliminary results on cognitive function, and proposes some strategies for optimizing future AD prevention trial design.
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Clinical studies have revealed that type 2 diabetes patients are at higher risk of developing AD.
“In a recent and surprising twist in the Alzheimer field, clinical studies have revealed that type 2 diabetes patients are at higher risk of developing AD (for reviews, see (Carlsson, 2010; Kopf and Frolich, 2009; Riederer et al., 2011)).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Carlsson, 2010
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- Authors
- Carlsson, C. M.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Carlsson, Cynthia M.
- ORCID
- Carlsson, Cynthia M.
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2010-05-26
- Volume
- 20
- Issue
- 3
- Pages
- 711-722
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC4235787
- OpenAlex
- W1570302318
- Cited by
- 109
- References
- 103
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 7 · 2022: 13 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 3 · 2012: 11
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Geriatric Research Education and Clinical Center
- National Institute on Aging (K23AG026752, P50AG033514)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Diabetes Mellitus, Type 2, Humans, Risk Factors, Diabetes Complications, Dyslipidemias
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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