Cited by 109Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsDiabetes, Cardiovascular Risks, and Lipoproteins

Type 2 diabetes mellitus, dyslipidemia, and Alzheimer’s disease

Open access
Carlsson, Cynthia M.·2010·Journal of Alzheimer s Disease

Abstract

The prevalence of Alzheimer's disease (AD) is increasing rapidly, heightening the importance of finding effective preventive therapies for this devastating disease. Midlife vascular risk factors, including type 2 diabetes mellitus (T2DM), have been associated with increased risk of AD decades later and may serve as targets for AD prevention. Studies to date suggest that T2DM and hyperinsulinemia increase risk for AD, possibly through their effects on amyloid-beta metabolism and cerebrovascular dysfunction - two early findings in preclinical AD pathology. This paper reviews the evidence supporting a relationship between T2DM, hyperinsulinemia, and diabetic dyslipidemia on the development of AD, discusses DM treatment trials and their preliminary results on cognitive function, and proposes some strategies for optimizing future AD prevention trial design.

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Crossref · 10.3233/jad-2010-100012

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  • Clinical studies have revealed that type 2 diabetes patients are at higher risk of developing AD.

    “In a recent and surprising twist in the Alzheimer field, clinical studies have revealed that type 2 diabetes patients are at higher risk of developing AD (for reviews, see (Carlsson, 2010; Kopf and Frolich, 2009; Riederer et al., 2011)).”

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Authors
Carlsson, C. M.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Carlsson, Cynthia M.
Venue
Journal of Alzheimer s Disease
Published
2010-05-26
Volume
20
Issue
3
Pages
711-722
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1570302318
Cited by
109
References
103
Citations by year
2025: 3 · 2024: 6 · 2023: 7 · 2022: 13 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 3 · 2012: 11
FWCI
5.23
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Geriatric Research Education and Clinical Center
  • National Institute on Aging (K23AG026752, P50AG033514)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 2 diabetes, Alzheimer's disease
MeSH terms
Alzheimer Disease, Animals, Diabetes Mellitus, Type 2, Humans, Risk Factors, Diabetes Complications, Dyslipidemias

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