Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice

Lee, Phil; Kim, Jieun; Williams, Rachel; Sandhir, Rajat; Gregory, Eugene; Brooks, William M.; Berman, Nancy E.J.

doi:10.1016/j.expneurol.2011.12.016

Cited by 78Barrier Structure and Function StudiesTraumatic Brain Injury and Neurovascular DisturbancesAcute Ischemic Stroke Management

Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice

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Lee, Phil, Kim, Jieun, Williams, Rachel, Sandhir, Rajat, Gregory, Eugene, Brooks, William M., Berman, Nancy E.J.·2012·Experimental Neurology

DOI 10.1016/j.expneurol.2011.12.016PMC PMC4042317

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Abstract

Aging alters the ability of the brain to respond to injury. One of the major differences between the adult and aged brain is that comparable injuries lead to greater blood brain barrier disruption in the aged brain. The goals of these studies were to quantify the effects of age on BBB permeability using high field strength MRI T1 mapping and to determine whether activation of matrix metalloproteases, their inhibitors, or expression of blood brain barrier structural proteins, occludin, zonnula occludins-1 (ZO-1) and claudin-5 were altered following injury to the aged C57/BL6 mouse brain. T1 mapping studies revealed greater blood brain barrier permeability in the aged (21-24 months old) brain than in the adult (4-6 months old) following controlled cortical impact. The increased blood brain barrier permeability in the pericontusional region was confirmed with IgG immunohistochemistry. MMP-9 activity was increased following controlled cortical impact in the aged brain, and this was accompanied by increased MMP-9 gene expression. MMP-2 activity was higher in the uninjured aged brain than in the adult brain. Occludin and ZO-1 mRNA levels were unchanged following injury in either age group, but claudin-5 mRNA levels were lower in the aged than the adult brain following injury. These results demonstrate quantitative increases in blood brain barrier permeability in the aged brain following injury that are accompanied by increased MMP-9 activation and decreased blood brain barrier repair responses.

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Numerous studies have shown increased BBB permeability in aged mice, facilitating infiltration of peripheral immune cells into CNS.
“Moreover, numerous studies have shown an increased BBB permeability in aged mice, which facilitates the infiltration of peripheral immune cells into the CNS.117,118”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [118]
The Results (Immunohistochemistry; page not provided) show greater BBB leakage in aged than adult mice after controlled cortical impact, but no significant age difference in uninjured mice. The Discussion (Gene expression of MMPs, TIMPs and BBB structural proteins; page not provided) proposes that BBB disruption may allow increased neutrophil infiltration; it does not establish increased peripheral immune-cell infiltration as a measured result. (LLM, conf=0.88)
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Authors: Lee, P., Kim, J., Williams, R., Sandhir, R., Gregory, E., Brooks, W. M., & Berman, N. E. J.
Affiliations: University of Kansas Medical Center (US)
Corresponding author: Berman, Nancy E.J.
ORCID: Lee, Phil
Sandhir, Rajat
Brooks, William M.
Venue: Experimental Neurology
Publisher: Elsevier BV
Published: 2012-03
Volume: 234
Issue: 1
Pages: 50-61
ISSN: 0014-4886 (ISSN-L)
DOI: 10.1016/j.expneurol.2011.12.016
PMC: PMC4042317
OpenAlex: W2089588272
Cited by: 78
References: 73
Citations by year: 2026: 3 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 8 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 4
FWCI: 3.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (R01AG31140, P30 HD02528, P20 RR016475)
Hoglund Family Foundation
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords: aging, blood-brain barrier permeability, matrix metalloproteinases, MMP-9, MMP-2, controlled cortical impact, traumatic brain injury, claudin-5, occludin, zonula occludens-1, BBB repair, T1 mapping, aged mice
MeSH terms: Aging, Animals, Blood-Brain Barrier, Brain Injuries, Brain Mapping, Cerebral Cortex, Disease Models, Animal, Gene Expression Regulation, Magnetic Resonance Imaging, Male, Membrane Proteins, Mice, Inbred C57BL, Permeability, Phosphoproteins, Time Factors, Trauma Severity Indices, Tissue Inhibitor of Metalloproteinases, Gadolinium DTPA, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Mice, Occludin, Zonula Occludens-1 Protein

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Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice

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