Senescence in aging and disorders of the central nervous system

Exploring the full spectrum of macrophage activation

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Cellular senescence: when bad things happen to good cells

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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

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Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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The role of senescent cells in ageing

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Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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Genomic analysis of reactive astrogliosis

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Cellular senescence in aging and age-related disease: from mechanisms to therapy

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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

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Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

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Amyloid Precursor Protein Processing and Alzheimer's Disease

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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

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Four faces of cellular senescence

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High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

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Oligodendroglia metabolically support axons and contribute to neurodegeneration

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Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury

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The microglial sensome revealed by direct RNA sequencing

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An english translation of alzheimer’s 1907 paper, “über eine eigenartige erkankung der hirnrinde”

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Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding

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Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

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Life and Death of Neurons in the Aging Brain

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Gliotransmitters Travel in Time and Space

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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

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Age-related changes in lymphocyte development and function

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Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

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Metformin as a tool to target aging

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Ageing and neuronal vulnerability

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Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

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The Role of Microglia in the Healthy Brain: Figure 1.

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Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

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Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

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Review: Activation patterns of microglia and their identification in the human brain

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Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

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Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

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Astrocytes Control Synapse Formation, Function, and Elimination

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Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system

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CNS immune privilege: hiding in plain sight

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Mitochondria are required for pro-ageing features of the senescent phenotype

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mTOR inhibition improves immune function in the elderly

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A senescent cell bystander effect: senescence‐induced senescence

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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

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Regenerating CNS myelin — from mechanisms to experimental medicines

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Astrocyte–neuron metabolic relationships: for better and for worse

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Neocortical glial cell numbers in human brains

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Postmitotic neurons develop a p21‐dependent senescence‐like phenotype driven by a DNA damage response

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Tau protein aggregation is associated with cellular senescence in the brain

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Fulminant Jejuno-Ileitis following Ablation of Enteric Glia in Adult Transgenic Mice

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Astrocyte Senescence as a Component of Alzheimer’s Disease

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Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

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High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease

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Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

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ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

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Cellular forms and functions of brain microglia

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Hereditary Frontotemporal Dementia Caused by <i>Tau</i> Gene Mutations

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The Nodes of Ranvier: Molecular Assembly and Maintenance

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Tau protein and neurodegeneration

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A Decade of Tau Transgenic Animal Models and Beyond

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Young microglia restore amyloid plaque clearance of aged microglia

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A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

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Toward more predictive genetic mouse models of Alzheimer’s disease

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Leukocyte Invasion of the Brain After Experimental Intracerebral Hemorrhage in Mice

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Peripheral monocytes are functionally altered and invade the CNS in ALS patients

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Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat

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Long-term outcome of paediatric-onset multiple sclerosis: a population-based study

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Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity

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Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

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Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

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Failure of remyelination in areas of demyelination produced in the spinal cord of old rats

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Understanding CNS remyelination: Clues from developmental and regeneration biology

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Transmitting senescence to the cell neighbourhood

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CD200 fusion protein decreases microglial activation in the hippocampus of aged rats

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Alzheimer's Disease: Critical Notes on the History of a Medical Concept

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Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice

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KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages.

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Increased IL-1β in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase

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Aging increases microglial proliferation, delays cell migration, and decreases cortical neurogenesis after focal cerebral ischemia

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Rapamycin and Ageing: When, for How Long, and How Much?

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Senescent cells spread the word: non-cell autonomous propagation of cellular senescence

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Neuronal influence behind the central nervous system regulation of the immune cells

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Cajal, Golgi, Nansen, Schäfer and the Neuron Doctrine

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Identification of complexin II in astrocytes: A possible regulator of glutamate release in these cells

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Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression: A Randomized Controlled Trial

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Alzheimer’s disease as a chronic maladaptive polyamine stress response

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Neuronal Senescence in the Aged Brain

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DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

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The Multifaceted Neurotoxicity of Astrocytes in Ageing and Age-Related Neurodegenerative Diseases: A Translational Perspective

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Residual Disease in Glioma Recurrence: A Dangerous Liaison with Senescence

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Adult hypothalamic neurogenesis and sleep–wake dysfunction in aging

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Circadian regulation in aging: Implications for spaceflight and life on earth

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Age-related Mitochondrial Dysfunction in Parkinson's Disease: New Insights Into the Disease Pathology

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Long-term effects of s-KL treatment in wild-type mice: Enhancing longevity, physical well-being, and neurological resilience

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Pheromone representation in the ant antennal lobe changes with age

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Rethinking neurodegenerative diseases: neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair

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Pharmacological implications of ipriflavone against environmental metal–induced neurodegeneration and dementia in rats

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Identification of a Proteomic Signature of Senescence in Primary Human Mammary Epithelial Cells

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Dynamic Changes of Endogenic or Exogenic β-Carboline Alkaloid Harmine in Different Mammals and Human in vivo at Developmental and Physiological States

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Chronic Bedridden Condition Is Reflected by Substantial Changes in Plasma Inflammatory Profile

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Expressional prerequisites for targeted drug delivery to the pathological brain

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Significant β-carboline Alkaloid Harmine in Different Developmental States of Mammals in Vivo: Endogenic or Exogenic?Preprint

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Human Life History Evolution

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Complexities of Aging and Senescence in Clinical Medicine

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Involvement of Metabolic Paradigm in Progression of Neurodegenerative Diseases

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Epidemiology of falls and fall prevention among older adults in Sri Lanka: a scoping review

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Enhanced glioblastoma immunotherapy via SMAC mimetic dose escalation and TGFβ blockade

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Gut–brain Axis Modulation by Probiotics: Insights into Natural Remedies for Neurodegeneration

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The role of cellular senescence in carcinogenesis and aging of the brain

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CELLULAR SENESCENCE: A NOVEL CONTRIBUTOR TO BRAIN AGING AND NEURODEGENERATIVE DISEASE

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Cellular Senescence in the Aging Brain

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Are there roles for brain cell senescence in aging and neurodegenerative disorders?

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Rethinking Senescence Hallmarks in the Brain: Lessons From Peripheral Tissues and Challenges in Defining Neuronal Senescence

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