The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Plasmodium falciparum: Chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta
Abstract
Plasmodium falciparum parasites that sequester in the placenta bind to the molecule chondroitin sulfate A (CSA). Women become resistant to malaria during pregnancy as they acquire antibodies that inhibit parasite adhesion to CSA, suggesting that a vaccine against placental malaria is feasible. Hyaluronic acid (HA) and non-immune IgG have also been proposed as receptors for P. falciparum adhesion in the placenta, but evidence for their roles is inconclusive. In this study, CSA, HA, and IgG were simultaneously assessed for their relative contributions to placental adhesion. Placental parasites collected in Tanzania uniformly adhered to the molecule CSA, and soluble CSA completely inhibited adhesion of most samples to placental cryosections. Three of 46 placental parasite samples also adhered to immobilized HA, but HA failed to inhibit adhesion of any placental parasites to placental cryosections. Similarly, non-immune IgG and protein A failed to inhibit adhesion of parasite samples to placental cryosection. P. falciparum adhesion in the placenta appears to be a non-redundant process that requires CSA as a receptor. Vaccines that elicit functional antibodies against CSA-binding parasites may confer resistance to pregnancy malaria.
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“Although some studies point to the existence of additional receptors (Beeson et al. , 2000), current evidence suggests that they are less important than CSA (Fried et al. , 2006).”
From Towards a vaccine against pregnancy-associated malaria (2008) · cites this paper as Fried et al., 2006
Citations
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Self-citation
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Malaria in pregnancy: pathogenesis and immunity
Rogerson, S. J., Hviid, L., Duffy, P. E., Leke, R. F., & Taylor, D. W. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70022-1 · Cited by 628
Self-citationInfections at the maternal–fetal interface: an overview of pathogenesis and defence
Megli, C., & Coyne, C. B. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00610-y · Cited by 473
The Role of Animal Models for Research on Severe Malaria
Craig, A. G., Grau, G. E., Janse, C. J., Kazura, J. W., Milner, D. A., Barnwell, J. W., Turner, G. D. H., & Langhorne, J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002401 · Cited by 321
Fried, M., & Duffy, P. E. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025551 · Cited by 202
Self-citationA review of human vaccine research and development: Malaria
Girard, M. P., Reed, Z. H., Friede, M., & Kiény, M. P. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.09.074 · Cited by 152
Metadata
- Authors
- Fried, M., Domingo, G. J., Gowda, C. D., Mutabingwa, T. K., & Duffy, P. E.
- Affiliations
- Center for Infectious Disease Research (US)
- Pennsylvania State University (US)
- Corresponding author
- Fried, Michal
- Venue
- Experimental Parasitology
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 113
- Issue
- 1
- Pages
- 36-42
- ISSN
- 0014-4894 (ISSN-L)
- OpenAlex
- W2084381085
- Cited by
- 107
- References
- 27
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 1 · 2017: 8 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 7
- FWCI
- 15.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bill and Melinda Gates Foundation
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI52059, R01AI052059)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Keywords
- Plasmodium falciparum, chondroitin sulfate A, placental malaria, parasite adhesion, receptor specificity, hyaluronic acid, placental sequestration
- MeSH terms
- Adolescent, Adult, Animals, Cell Adhesion, Chondroitin Sulfates, Erythrocytes, Female, Humans, Hyaluronic Acid, Immunoglobulin G, Middle Aged, Placenta, Plasmodium falciparum, Pregnancy, Tanzania, Malaria Vaccines
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