Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria

Beeson, James G.; Rogerson, Stephen J.; Cooke, Brian M.; Reeder, John C.; Chai, Wengang; Lawson, Alexander M.; Molyneux, Malcolm E.; Brown, Graham V.

doi:10.1038/71582

Cited by 310Malaria Research and ControlPregnancy and preeclampsia studiesHemoglobinopathies and Related Disorders

Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria

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Beeson, James G., Rogerson, Stephen J., Cooke, Brian M., Reeder, John C., Chai, Wengang, Lawson, Alexander M., Molyneux, Malcolm E., Brown, Graham V.·2000·Nature Medicine

DOI 10.1038/71582PMC PMC2613479

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Abstract

Infection with Plasmodium falciparum during pregnancy leads to the accumulation of parasite-infected erythrocytes in the placenta, and is associated with excess perinatal mortality, premature delivery and intrauterine growth retardation in the infant, as well as increased maternal mortality and morbidity. P. falciparum can adhere to specific receptors on host cells, an important virulence factor enabling parasites to accumulate in various organs. We report here that most P. falciparum isolates from infected placentae can bind to hyaluronic acid, a newly discovered receptor for parasite adhesion that is present on the placental lining. In laboratory isolates selected for specific high-level adhesion, binding to hyaluronic acid could be inhibited by dodecamer or larger oligosaccharide fragments or polysaccharides, treatment of immobilized receptor with hyaluronidase, or treatment of infected erythrocytes with trypsin. In vitro flow-based assays demonstrated that high levels of adhesion occurred at low wall shear stress, conditions thought to prevail in the placenta. Our findings indicate that adhesion to hyaluronic acid is involved in mediating placental parasite accumulation, thus changing the present understanding of the mechanisms of placental infection, with implications for the development of therapeutic and preventative interventions.

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Detectable placental infections are often associated with undetectable peripheral infections.
“This could be because parasitized erythrocytes sequester in the placenta [20]; thus detectable placental infections are often associated with undetectable peripheral infections.”
From Diagnosis of placental malaria in poorly fixed and processed placental tissue (2016) · cites this paper as [20]
Parasitized erythrocytes sequester in the placenta.
“This could be because parasitized erythrocytes sequester in the placenta [20]; thus detectable placental infections are often associated with undetectable peripheral infections.”
From Diagnosis of placental malaria in poorly fixed and processed placental tissue (2016) · cites this paper as [20]

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Authors: Beeson, J. G., Rogerson, S. J., Cooke, B. M., Reeder, J. C., Chai, W., Lawson, A. M., Molyneux, M. E., & Brown, G. V.
Affiliations: Walter and Eliza Hall Institute of Medical Research (AU)
University of Liverpool (GB)
Monash University (AU)
Northwick Park Hospital (GB)
The University of Melbourne (AU)
Corresponding author: Beeson, James G.
ORCID: Beeson, James G.
Rogerson, Stephen J.
Reeder, John C.
Chai, Wengang
Molyneux, Malcolm E.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2000-01
Volume: 6
Issue: 1
Pages: 86-90
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/71582
PMC: PMC2613479
OpenAlex: W1948679507
Cited by: 310
References: 25
Citations by year: 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 7 · 2020: 1 · 2019: 6 · 2018: 8 · 2017: 9 · 2016: 10 · 2015: 5 · 2014: 9 · 2013: 10 · 2012: 10
FWCI: 30.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust (063215)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Keywords: Plasmodium falciparum, placental malaria, parasite adhesion, hyaluronic acid, infected erythrocytes, host cell receptors, oligosaccharide fragments, hyaluronidase, wall shear stress, pregnancy complications, parasite virulence
MeSH terms: Animals, Cattle, Cell Adhesion, Erythrocytes, Female, Cricetinae, Hyaluronic Acid, Oligosaccharides, Placenta, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, CHO Cells, Malaria, Falciparum

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Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria

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