Expression of Variant Surface Antigens by Plasmodium falciparum Parasites in the Peripheral Blood of Clinically Immune Pregnant Women Indicates Ongoing Placental Infection
Open accessAbstract
Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA(PAM)) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research.
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The binding of VAR2CSA with chondroitin sulphate A has been implicated in the pathology of falciparum malaria in pregnancy.
“The binding of the variant surface antigen (VAR2CSA) with chondroitin sulphate A has been implicated in the pathology of falciparum malaria in pregnancy.65–68”
From Malaria in pregnancy. (2013) · cites this paper as [67]
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- Authors
- Ofori, M. F., Staalsoe, T., Bam, V., Lundquist, M., David, K. P., Browne, E. N. L., Akanmori, B. D., & Hviid, L.
- Affiliations
- University of Copenhagen (DK)
- Centre for Medical Parasitology, Department of Infectious Diseases, Department of Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
- Kwame Nkrumah University of Science and Technology (GH)
- University of Ghana (GH)
- Corresponding author
- Hviid, Lars
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2003-03
- Volume
- 71
- Issue
- 3
- Pages
- 1584-1586
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC148875
- OpenAlex
- W2112884272
- Cited by
- 37
- References
- 21
- Citations by year
- 2023: 1 · 2018: 1 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- Plasmodium falciparum, variant surface antigens, malaria in pregnancy, placental malaria
- MeSH terms
- Animals, Antibodies, Protozoan, Antigens, Protozoan, Antigens, Surface, Female, Humans, Immunoglobulin G, Placenta, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Malaria, Falciparum
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