Plasmodium falciparum adhesion in the placenta

Duffy, Patrick E; Fried, Michal

doi:10.1016/s1369-5274(03)00090-0

Cited by 73Malaria Research and ControlHemoglobinopathies and Related DisordersBlood groups and transfusion

Plasmodium falciparum adhesion in the placenta

Duffy, Patrick E, Fried, Michal·2003·Current Opinion in Microbiology

DOI 10.1016/s1369-5274(03)00090-0

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Abstract

Plasmodium falciparum parasites sequester in the human placenta, and placental malaria is associated with disease and death of both mother and child. Placental isolates of P. falciparum uniformly bind to chondroitin sulfate A on the syncytiotrophoblast. Forms of the variant surface antigen PfEMP1 that bind chondroitin sulfate A in vitro (PfEMP1(varCSA)) are highly conserved in many field isolates. Two related forms of PfEMP1(varCSA) are commonly expressed by placental isolates, but these are also transcribed by most non-placental isolates. PfEMP1(varCSA) gene transcription is not upregulated when parasites are selected to bind chondroitin sulfate A, but other PfEMP1 forms may be upregulated. Young ring-stage parasites derived from chondroitin sulfate A-binding isolates may also bind to the endothelium through a process that does not involve PfEMP1 or chondroitin sulfate A. Adhesins and other surface proteins of placental parasites are targets of naturally occurring antibodies associated with protection and therefore could be used to develop vaccines that prevent malaria in pregnancy.

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The binding of VAR2CSA with chondroitin sulphate A has been implicated in the pathology of falciparum malaria in pregnancy.
“The binding of the variant surface antigen (VAR2CSA) with chondroitin sulphate A has been implicated in the pathology of falciparum malaria in pregnancy.65–68”
From Malaria in pregnancy. (2013) · cites this paper as [68]

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Authors: Duffy, P. E., & Fried, M.
Affiliations: Center for Infectious Disease Research (US)
Corresponding author: Duffy, Patrick E
Fried, Michal
ORCID: Duffy, Patrick E
Fried, Michal
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2003-08
Volume: 6
Issue: 4
Pages: 371-376
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/s1369-5274(03)00090-0
OpenAlex: W2008900005
Cited by: 73
References: 31
Citations by year: 2026: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (AI52059, R01AI043680, AI43680, R01AI052059)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Health Sciences › Medicine › Hematology › Blood groups and transfusion
Keywords: Plasmodium falciparum, placental malaria, parasite sequestration, chondroitin sulfate A, syncytiotrophoblast, PfEMP1, variant surface antigens, adhesion, ring-stage parasites, endothelial binding, naturally acquired antibodies, malaria vaccine development, pregnancy
MeSH terms: Animals, Cell Adhesion, Female, Humans, Placenta, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Infectious, Virulence, Malaria, Falciparum

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Plasmodium falciparum adhesion in the placenta

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