Cited by 169Seaweed-derived Bioactive CompoundsDrug-Induced Hepatotoxicity and ProtectionFungal Biology and Applications

Anti-peroxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on d-galactosamine induced hepatitis in rats

Sathivel, Arumugam, Raghavendran, Hanumantha Rao Balaji, Srinivasan, Periasamy, Devaki, Thiruvengadam·2008·Food and Chemical Toxicology

Abstract

To find whether pretreatment of Ulva lactuca polysaccharide (ULP) extract could be effective against D-Galactosamine (500 mg/kg body weight, i.p.) induced anomaly in rat. Serum total cholesterol (TC), triglycerides (TG), free fatty acid (FFA), phospholipids (PL), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), tissue lipoperoxides (LPO), hepatic protein thiols, non-enzymatic anti-oxidants glutathione (GSH) and vitamins (E and C) were examined using spectrophotometer. The ultra structural changes of liver during D-Galactosamine and protection offered by ULP were examined by electron microscopy. Seaweed histology and chemical composition of polysaccharides in seaweed were examined. Alcian blue staining showed the presence of sulphated polysaccharide with total sugar (65.4%), sulphate (17.4%), and uronic acid (17.2%) content. D-Galactosamine intoxicated rats showed significant (p<0.01) liver damage with acute aberration in serum lipid profile, hepatic protein thiols and tissue non-enzymatic anti-oxidants. Assorted deposits of lipid droplets and abnormal appearance of mitochondria was observed in electron microscopy study. Rats pretreated with ULP (30 mg/kg body weight/day/for 21 days) showed a significant inhibition (p<0.05) against abnormality induced by d-Galactosamine. U.lactuca exhibit anti-peroxidative and anti-hyperlipidemic property.

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Crossref · 10.1016/j.fct.2008.07.016

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Authors
Sathivel, A., Raghavendran, H. R. B., Srinivasan, P., & Devaki, T.
Affiliations
  • Saveetha University (IN)
  • Korea Atomic Energy Research Institute (KR)
  • University of Madras (IN)
Corresponding author
Raghavendran, Hanumantha Rao Balaji
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2008-10
Volume
46
Issue
10
Pages
3262-3267
ISSN
0278-6915 (ISSN-L)
OpenAlex
W2041247294
Cited by
169
References
33
Citations by year
2026: 5 · 2025: 5 · 2024: 9 · 2023: 15 · 2022: 29 · 2021: 3 · 2020: 10 · 2019: 12 · 2018: 6 · 2017: 14 · 2016: 11 · 2015: 13 · 2014: 5 · 2013: 9 · 2012: 10
FWCI
6.51
Type
journal article
Language
en
Open access
closed
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
Keywords
Ulva lactuca, seaweed polysaccharides, hepatotoxicity, hypolipidemic activity, lipid profile, hepatic lipid peroxidation, non-enzymatic antioxidants, glutathione, sulfated polysaccharides, liver ultrastructure, lipid droplets, mitochondrial abnormalities
MeSH terms
Animals, Drug Administration Schedule, Galactosamine, Hyperlipidemias, Liver, Male, Polysaccharides, Lipid Peroxidation, Rats, Wistar, Ulva, Rats, Chemical and Drug Induced Liver Injury

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