The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells
Open accessAbstract
Fucoidan, a sulfated polysaccharide extracted from brown seaweed, displays a wide variety of internal biological activities; however, the cellular and molecular mechanisms underlying fucoidan's anti-inflammatory activity remain poorly understood. In this study, we investigated the inhibitory effects of fucoidan on production of lipopolysaccharide (LPS)-induced pro-inflammatory mediators in BV2 microglia. Our data indicated that fucoidan treatment significantly inhibited excessive production of nitric oxide (NO) and prostaglandin E₂ (PGE₂) in LPS-stimulated BV2 microglia. It also attenuated expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, monocyte chemoattractant protein-1 (MCP-1), and pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor (TNF)-α. Moreover, fucoidan exhibited anti-inflammatory properties by suppression of nuclear factor-kappa B (NF-κB) activation and down-regulation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and AKT pathways. These finding suggest that fucoidan may offer substantial therapeutic potential for treatment of neurodegenerative diseases that are accompanied by microglial activation.
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Metadata
- Authors
- Park, H. Y., Han, M. H., Park, C., Jin, C.-Y., Kim, G.-Y., Choi, I.-W., Kim, N. D., Nam, T.-J., Kwon, T. K., & Choi, Y. H.
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 49
- Issue
- 8
- Pages
- 1745-1752
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2086790402
- Cited by
- 321
- References
- 3
- FWCI
- 19.02
- Type
- journal article
- Language
- en
- Open access
- green
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