Cited by 23Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Natural Products from Plants and Algae for Treatment of Alzheimer’s Disease: A Review

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Klose, Jana, Griehl, Carola, Roßner, Steffen, Schilling, Stephan·2022·Biomolecules

Abstract

Neurodegenerative disorders including Parkinson’s disease (PD), Huntington’s disease (HD) and the most frequent, Alzheimer’s disease (AD), represent one of the most urgent medical needs worldwide. Despite a significantly developed understanding of disease development and pathology, treatments that stop AD progression are not yet available. The recent approval of sodium oligomannate (GV-971) for AD treatment in China emphasized the potential value of natural products for the treatment of neurodegenerative disorders. Many current clinical studies include the administration of a natural compound as a single and combination treatment. The most prominent mechanisms of action are anti-inflammatory and anti-oxidative activities, thus preserving cellular survival. Here, we review current natural products that are either approved or are in testing for a treatment of neurodegeneration in AD. In addition to the most important compounds of plant origin, we also put special emphasis on compounds from algae, given their neuroprotective activity and their underlying mechanisms of neuroprotection.

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Authors
Klose, J., Griehl, C., Roßner, S., & Schilling, S.
Affiliations
  • Anhalt University of Applied Sciences (DE)
  • Leipzig University (DE)
Corresponding author
Schilling, Stephan
Venue
Biomolecules
Publisher
MDPI AG
Published
2022-05-12
Volume
12
Issue
5
Pages
694
ISSN
2218-273X (ISSN-L)
OpenAlex
W4280630307
Cited by
23
References
190
Citations by year
2026: 4 · 2025: 2 · 2024: 3 · 2023: 10 · 2022: 4
FWCI
1.10
Type
journal article
Language
en
Open access
Locations
  • Biomolecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
  • Qucosa (Saxon State and University Library Dresden) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
Alzheimer's disease, natural products, phytochemicals, neurodegenerative diseases, neuroprotection, anti-inflammatory activity, antioxidant activity, combination therapy, Parkinson's disease, Huntington's disease
MeSH terms
Alzheimer Disease, Biological Products, Humans, Huntington Disease, Parkinson Disease, Neurodegenerative Diseases

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