Natural Products from Plants and Algae for Treatment of Alzheimer’s Disease: A Review
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Neurodegenerative disorders including Parkinson’s disease (PD), Huntington’s disease (HD) and the most frequent, Alzheimer’s disease (AD), represent one of the most urgent medical needs worldwide. Despite a significantly developed understanding of disease development and pathology, treatments that stop AD progression are not yet available. The recent approval of sodium oligomannate (GV-971) for AD treatment in China emphasized the potential value of natural products for the treatment of neurodegenerative disorders. Many current clinical studies include the administration of a natural compound as a single and combination treatment. The most prominent mechanisms of action are anti-inflammatory and anti-oxidative activities, thus preserving cellular survival. Here, we review current natural products that are either approved or are in testing for a treatment of neurodegeneration in AD. In addition to the most important compounds of plant origin, we also put special emphasis on compounds from algae, given their neuroprotective activity and their underlying mechanisms of neuroprotection.
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Alkaloids, flavonoids, and phenolic acids are among the essential secondary metabolites of plants that play a significant role in preventing neurodegeneration in Alzheimer's disease.
“Alkaloids, flavonoids, and phenolic acids are among the essential secondary metabolites of plants that play a significant role in preventing neurodegeneration in AD [17,58,59].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [58]
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- Authors
- Klose, J., Griehl, C., Roßner, S., & Schilling, S.
- Affiliations
- Anhalt University of Applied Sciences (DE)
- Leipzig University (DE)
- Corresponding author
- Schilling, Stephan
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2022-05-12
- Volume
- 12
- Issue
- 5
- Pages
- 694
- ISSN
- 2218-273X (ISSN-L)
- PMC
- PMC9139049
- OpenAlex
- W4280630307
- Cited by
- 23
- References
- 190
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 10 · 2022: 4
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomolecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Qucosa (Saxon State and University Library Dresden) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, natural products, phytochemicals, neurodegenerative diseases, neuroprotection, anti-inflammatory activity, antioxidant activity, combination therapy, Parkinson's disease, Huntington's disease
- MeSH terms
- Alzheimer Disease, Biological Products, Humans, Huntington Disease, Parkinson Disease, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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