Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases

Glutamate neurotoxicity and diseases of the nervous system

Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378 · see citing works

2013 Alzheimer's disease facts and figures

Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,331 · see citing works

n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases

Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525 · see citing works

Bioactive compounds in seaweed: functional food applications and legislation

Holdt, S. L., & Kraan, S. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9632-5 · Cited by 2,135 · see citing works

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

Ambati, R., Phang, S. M., Ravi, S., & Ravishankar, G. A. (2014) · Marine Drugs · doi:10.3390/md12010128 · Cited by 1,993 · see citing works

Alzheimer’s Dementia

Melnick, V. L., & Dubler, N. N. (1985) · Contemporary Issues in Biomedicine, Ethics, and Society · doi:10.1007/978-1-4612-5174-3 · Cited by 1,986 · see citing works

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

Chaudhuri, К. R., & Schapira, A. H. V. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70068-7 · Cited by 1,739 · see citing works

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

in 't Veld, B. A., Ruitenberg, A., Hofman, A., Launer, L. J., van Duijn, C. M., Stijnen, T., Breteler, M. M. B., & Stricker, B. H. C. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010178 · Cited by 1,196 · see citing works

Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses

Moreau, R. A., Whitaker, B. D., & Hicks, K. B. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(02)00006-1 · Cited by 1,162 · see citing works

The Cholinergic Hypothesis of Age and Alzheimer’s Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development

Terry, A. V., & Buccafusco, J. J. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.041616 · Cited by 1,159 · see citing works

Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135 · see citing works

Microglial Activation and Chronic Neurodegeneration

Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · see citing works

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

Tansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045 · see citing works

A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds

Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026 · see citing works

Fucoxanthin, a Marine Carotenoid Present in Brown Seaweeds and Diatoms: Metabolism and Bioactivities Relevant to Human Health

Peng, J., Yuan, J.-P., Wu, C.-F., & Wang, J.-H. (2011) · Marine Drugs · doi:10.3390/md9101806 · Cited by 820 · see citing works

Medicinal and pharmaceutical uses of seaweed natural products: A review

Smit, A. J. (2004) · Journal of Applied Phycology · doi:10.1023/b:japh.0000047783.36600.ef · Cited by 806 · see citing works

Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review

Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786 · see citing works

Inflammatory processes in Alzheimer's disease

Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works

Marine Bioactives as Functional Food Ingredients: Potential to Reduce the Incidence of Chronic Diseases

Lordan, S., Ross, R. P., & Stanton, C. (2011) · Marine Drugs · doi:10.3390/md9061056 · Cited by 754 · see citing works

Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402531101 · Cited by 753 · cited 4× · see citing works

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

Greig, N. H., Utsuki, T., Ingram, D. K., Wang, Y., Pepeu, G., Scali, C., Yu, Q.-S., Mamczarz, J., Holloway, H. W., Giordano, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508575102 · Cited by 745 · see citing works

C-Phycocyanin: A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects

Romay, C., Gonzalez, R., Ledón, N., Remírez, D., & Rimbau, V. (2003) · Current Protein and Peptide Science · doi:10.2174/1389203033487216 · Cited by 718 · see citing works

Natural Products

Ramawat, K. G., & Mérillon, J. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6 · Cited by 652 · see citing works

Anti-inflammatory activity of natural dietary flavonoids

Pan, M., Lai, C., & Ho, C. (2010) · Food & Function · doi:10.1039/c0fo00103a · Cited by 612 · see citing works

Bioactive potential and possible health effects of edible brown seaweeds

Gupta, S., & Abu-Ghannam, N. (2011) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2011.03.011 · Cited by 608 · see citing works

Biological activities and health benefit effects of natural pigments derived from marine algae

Pangestuti, R., & Kim, S. (2011) · Journal of Functional Foods · doi:10.1016/j.jff.2011.07.001 · Cited by 577 · see citing works

The cholinergic system and Parkinson disease

Bohnen, N. I., & Albin, R. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.048 · Cited by 576 · see citing works

Application of Novel Extraction Technologies for Bioactives from Marine Algae

Kadam, S. U., Tiwari, B. K., & O’Donnell, C. P. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400819p · Cited by 547 · see citing works

The role of neuronal growth factors in neurodegenerative disorders of the human brain

Connor, B. J., & Dragunow, M. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00004-6 · Cited by 534 · see citing works

Seaweeds: A sustainable functional food for complementary and alternative therapy

Mohamed, S., Hashim, S. N., & Rahman, H. A. (2011) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2011.09.001 · Cited by 529 · see citing works

Digestion, absorption, and cancer preventative activity of dietary chlorophyll derivatives

Ferruzzi, M. G., & Blakeslee, J. J. (2007) · Nutrition Research · doi:10.1016/j.nutres.2006.12.003 · Cited by 529 · see citing works

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

Srikanth, V., Maczurek, A., Phan, T., Steele, M., Westcott, B., Juskiw, D., & Münch, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.016 · Cited by 524 · cited 1× · see citing works

Essential fatty acids and the brain: possible health implications

Youdim, K. A., Martin, A., & Joseph, J. A. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00013-7 · Cited by 517 · see citing works

Radical Scavenging and Singlet Oxygen Quenching Activity of Marine Carotenoid Fucoxanthin and Its Metabolites

Sachindra, N. M., Sato, E., Maeda, H., Hosokawa, M., Niwano, Y., Kohno, M., & Miyashita, K. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071848a · Cited by 516 · see citing works

C-Phycocyanin: A potent peroxyl radical scavenger in Vivo and in Vitro

Bhat, V. B., & Madyastha, K. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3270 · Cited by 477 · see citing works

Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival

Akbar, M. D., Calderón, F. H., Wen, Z., & Kim, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502903102 · Cited by 466 · see citing works

Phenolic compounds and antioxidant activities of selected species of seaweeds from Danish coast

Farvin, K. H. S., & Jacobsen, C. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.10.078 · Cited by 465 · see citing works

Antioxidant activity of different fractions of Spirulina platensis protean extract

Piñero Estrada, J. (2001) · Il Farmaco · doi:10.1016/s0014-827x(01)01084-9 · Cited by 447 · see citing works

Untitled work

Bergmann (1951) · doi:10.1021/jo01146a023 · Cited by 403 · see citing works

Functional ingredients from algae for foods and nutraceuticals

Domínguez, H. (2013) · doi:10.1533/9780857098689 · Cited by 387 · see citing works

Polyunsaturated Fatty Acids of Marine Macroalgae: Potential for Nutritional and Pharmaceutical Applications

Pereira, H., Barreira, L. A., Figueiredo, F., Custódio, L. M. B., Vizetto‐Duarte, C., Polo, C., Rešek, E., Engelen, A. H., & Varela, J. C. S. (2012) · Marine Drugs · doi:10.3390/md10091920 · Cited by 356 · see citing works

Functional properties of carotenoids originating from algae

Christaki, E., Bonos, E., Giannenas, I., & Florou‐Paneri, P. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5902 · Cited by 346 · see citing works

Tropical marine macroalgae as potential sources of nutritionally important PUFAs

Kumari, P., Kumar, M., Gupta, V., Reddy, C. R. K., & Jha, B. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2009.11.006 · Cited by 328 · see citing works

Immunomodulation and antitumor activity of κ-carrageenan oligosaccharides

YUAN, H., SONG, J., LI, X., LI, N., & DAI, J. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.11.032 · Cited by 324 · see citing works

Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells

Park, H. Y., Han, M. H., Park, C., Jin, C., Kim, G., Choi, I., Kim, N. D., Nam, T., Kwon, T. K., & Choi, Y. H. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.04.020 · Cited by 321 · see citing works

Extraction and Characterization of Bioactive Compounds with Health Benefits from Marine Resources: Macro and Micro Algae, Cyanobacteria, and Invertebrates

Ibáñez, E., Herrero, M., Mendiola, J. A., & Castro‐Puyana, M. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1247-2_2 · Cited by 319 · see citing works

Nova Science Publishers

Artopoulos, A., Coward, T. J., Jan, D., & Jan, B. (2013) · Cited by 301 · see citing works

Trends in the Discovery of New Marine Natural Products from Invertebrates over the Last Two Decades – Where and What Are We Bioprospecting?

Leal, M. C., Puga, J., Serôdio, J., Gomes, N. C. M., & Calado, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030580 · Cited by 297 · see citing works

Potential pharmacological applications of polyphenolic derivatives from marine brown algae

Thomas, N. V., & Kim, S.-K. (2011) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2011.09.004 · Cited by 269 · see citing works

Anti-diabetic effects of brown algae derived phlorotannins, marine polyphenols through diverse mechanisms

Lee, S., & Jeon, Y. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.02.013 · Cited by 260 · see citing works

Dietary fatty acids and the risk of Parkinson disease

de Lau, L. M. L., Bornebroek, M., Witteman, J. C. M., Albert Hofman, D., Koudstaal, P. J., & Breteler, M. M. B. (2005) · Neurology · doi:10.1212/01.wnl.0000166038.67153.9f · Cited by 260 · see citing works

Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation

Xu, P., Wang, S.-W., Yu, X., Su, Y., Wang, T., Zhou, W., Zhang, H., Wang, Y., & Liu, R. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.002 · Cited by 245 · see citing works

Neuroprotective Effects of Marine Algae

Pangestuti, R., & Kim, S. (2011) · Marine Drugs · doi:10.3390/md9050803 · Cited by 245 · see citing works

Isoprenoid biosynthesis in eukaryotic phototrophs: A spotlight on algae

Lohr, M., Schwender, J., & Polle, J. E. W. (2011) · Plant Science · doi:10.1016/j.plantsci.2011.07.018 · Cited by 244 · see citing works

Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

Weinreb, O., Amit, T., Mandel, S. A., & Youdim, M. B. H. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0143-4 · Cited by 244 · see citing works

Can Phlorotannins Purified Extracts Constitute a Novel Pharmacological Alternative for Microbial Infections with Associated Inflammatory Conditions?

Lopes, G., Sousa, C., Silva, L. R., Pinto, E., Andrade, P. B., Bernardo, J., Mouga, T., & Valentão, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031145 · Cited by 227 · see citing works

Antimicrobial effect of phlorotannins from marine brown algae

Eom, S., Kim, Y., & Kim, S. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.06.028 · Cited by 227 · see citing works

Alkaloids in Marine Algae

Güven, K. C., Percot, A., & Sezik, E. (2010) · Marine Drugs · doi:10.3390/md8020269 · Cited by 225 · see citing works

Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro

Lee, D.-H., Kim, C., & Lee, Y. J. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.10.029 · Cited by 214 · see citing works

Cytoprotective effect of fucoxanthin isolated from brown algae Sargassum siliquastrum against H2O2-induced cell damage

Heo, S., Ko, S., Kang, S., Kang, H., Kim, J.-P., Kim, S.-H., Lee, K.-W., Cho, M.-G., & Jeon, Y. (2008) · European Food Research and Technology · doi:10.1007/s00217-008-0918-7 · Cited by 210 · see citing works

LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells

Murthy, S., Born, E. J., Mathur, S. N., & Field, F. J. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m100358-jlr200 · Cited by 210 · see citing works

Phycobiliprotein C-Phycocyanin from <i>Spirulina platensis</i> Is Powerfully Responsible for Reducing Oxidative Stress and NADPH Oxidase Expression Induced by an Atherogenic Diet in Hamsters

Riss, J., Décordé, K., Sutra, T., Delage, M., Baccou, J.-C., Jouy, N., Brune, J.-P., Oréal, H., Cristol, J.-P., & Rouanet, J.-M. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070529g · Cited by 208 · see citing works

Iron-chelating ability and antioxidant properties of phycocyanin isolated from a protean extract of Spirulinaplatensis

Bermejo‐Bescós, P., Piñero, E., & Villar, Á. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.02.021 · Cited by 204 · see citing works

H2o2 and 4-hydroxynonenal mediate amyloid β-induced neuronal apoptosis by activating jnks and p38mapk

Tamagno, E., Robino, G., Obbili, A., Bardini, P., Aragno, M., Parola, M., & Danni, O. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(02)00059-6 · Cited by 201 · see citing works

Terpenoids As Therapeutic Drugs and Pharmaceutical Agents

Wang, G., Tang, W., & Bidigare, R. R. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-976-9_9 · Cited by 192 · see citing works

Protective effects of astaxanthin on 6‐hydroxydopamine‐induced apoptosis in human neuroblastoma SH‐SY5Y cells

Ikeda, Y., Tsuji, S., Satoh, A., Ishikura, M., Shirasawa, T., & Shimizu, T. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05743.x · Cited by 190 · see citing works

Valuable compounds in macroalgae extracts

Andrade, P. B., Barbosa, M., Matos, R. P., Lopes, G., Vinholes, J., Mouga, T., & Valentão, P. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2012.11.081 · Cited by 188 · see citing works

Therapeutic approaches to inflammation in neurodegenerative disease

Klegeris, A., McGeer, E. G., & McGeer, P. L. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3280adc943 · Cited by 186 · see citing works

Anticancer and Antitumor Potential of Fucoidan and Fucoxanthin, Two Main Metabolites Isolated from Brown Algae

Moghadamtousi, S. Z., Karimian, H., Khanabdali, R., Razavi, M., Firoozinia, M., Zandi, K., & Kadir, H. A. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/768323 · Cited by 182 · see citing works

Fatty acid contents and profiles of 16 macroalgae collected from the Irish Coast at two seasons

Schmid, M., Guihéneuf, F., & Stengel, D. B. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-013-0132-2 · Cited by 178 · see citing works

Acetyl- and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera

Yoon, N. Y., Chung, H. Y., Kim, H. R., & Choi, J. S. (2008) · Fisheries Science · doi:10.1111/j.1444-2906.2007.01511.x · Cited by 173 · see citing works

The Antinociceptive and Anti-Inflammatory Activities of Caulerpin, a Bisindole Alkaloid Isolated from Seaweeds of the Genus Caulerpa

de Souza, É. T., de Lira, D. P., de Queiroz, A. C., da Silva, D. J. C., de Aquino, A. B., Mella, E. A. C., Lorenzo, V. P., de Miranda, G. E. C., de Araújo‐Júnior, J. X., Chaves, M. C. D. O., et al. (2009) · Marine Drugs · doi:10.3390/md7040689 · Cited by 173 · see citing works

Molecular Basis of the Anti-Inflammatory Effects of Terpenoids

Heras, B. D. L., & Hortelano, S. (2009) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152809787582534 · Cited by 171 · see citing works

Marine Tannins: The Importance of a Mechanistic Framework for Predicting Ecological Roles

Arnold, T. M., & Targett, N. M. (2002) · Journal of Chemical Ecology · doi:10.1023/a:1020737609151 · Cited by 165 · see citing works

Algal lipids, fatty acids and sterols

Kumari, P., Kumar, M., Reddy, C. R. K., & Jha, B. (2013) · Functional Ingredients from Algae for Foods and Nutraceuticals · doi:10.1533/9780857098689.1.87 · Cited by 163 · see citing works

Unesterified docosahexaenoic acid is protective in neuroinflammation

Orr, S. K., Palumbo, S., Bosetti, F., Mount, H. T. J., Kang, J. X., Greenwood, C. E., David, W. L., Serhan, C. N., & Bazinet, R. P. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12392 · Cited by 162 · see citing works

Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats

Upasani, C. D., & Balaraman, R. (2003) · Phytotherapy Research · doi:10.1002/ptr.1135 · Cited by 158 · see citing works

Marine Bioactives: Pharmacological Properties and Potential Applications against Inflammatory Diseases

D’Orazio, N., Gammone, M. A., Gemello, E., Girolamo, M. D., Cusenza, S., & Riccioni, G. (2012) · Marine Drugs · doi:10.3390/md10040812 · Cited by 154 · see citing works

Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model

Kang, M., Wijesinghe, W. A. J. P., Lee, S., Kang, S., Ko, S., Yang, X., Kang, N., Jeon, B.-T., Kim, J., Lee, D.-H., et al. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.12.012 · Cited by 151 · see citing works

Antioxidant properties of phlorotannins from brown seaweed Cystoseira trinodis (Forsskål) C. Agardh

Sathya, R., Kanaga, N., Sankar, P., & Jeeva, S. (2013) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2013.09.039 · Cited by 149 · see citing works

Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease

Ikonomović, M. D., Abrahamson, E. E., Uz, T., Manev, H., & DeKosky, S. T. (2008) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2008.951855 · Cited by 147 · see citing works

Terpenoids from Marine Organisms: Unique Structures and their Pharmacological Potential

Gross, H., & König, G. M. (2006) · Phytochemistry Reviews · doi:10.1007/s11101-005-5464-3 · Cited by 144 · see citing works

Fucoidan protects against dopaminergic neuron death in vivo and in vitro

Luo, D., Zhang, Q., Wang, H., Cui, Y., Sun, Z., Yang, J., Zheng, Y., Jia, J., Yu, F., Wang, X., et al. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.06.015 · Cited by 141 · see citing works

Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase

Bazelyansky, M., Robey, E. A., & Kirsch, J. F. (1986) · Biochemistry · doi:10.1021/bi00349a019 · Cited by 138 · see citing works

Inhibitory Effects and Molecular Mechanism of Dieckol Isolated from Marine Brown Alga on COX-2 and iNOS in Microglial Cells

Jung, W., Heo, S., Jeon, Y., Lee, C., Park, Y., Byun, H., Choi, Y. H., Park, S.-G., & Choi, I. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9003913 · Cited by 137 · see citing works

Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells

Bermejo-Bescós, P., Piñero-Estrada, E., & Villar del Fresno, Á. M. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.05.004 · Cited by 134 · see citing works

Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2- C -methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids

Schwender, J., Gemünden, C., & Lichtenthaler, H. K. (2001) · Planta · doi:10.1007/s004250000409 · Cited by 130 · see citing works

Neuroprotective effect of astaxanthin on H2O2-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo

Lu, Y., Liu, S., Sun, H., Wu, X., Li, J.-J., & Zhu, L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.016 · Cited by 128 · see citing works

Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells.

Choi, S. K., Park, Y. S., Choi, D., & Chang, H. I. (2008) · PubMed · Cited by 127 · see citing works

Terpenes: Chemistry, Biological Role, and Therapeutic Applications

Brahmkshatriya, P. P., & Brahmkshatriya, P. S. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_120 · Cited by 126 · see citing works

Effect of Undaria pinnatifida (Wakame) on the development of cerebrovascular diseases in stroke‐prone spontaneously hypertensive rats

Ikeda, K., Kitamura, A., Machida, H., Watanabe, M., Negishi, H., Hiraoka, J., & Nakano, T. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03786.x · Cited by 126 · see citing works

N-Docosahexaenoylethanolamide promotes development of hippocampal neurons

Kim, H., Moon, H., Cao, D., Lee, J., Kevala, K., Jun, S. B., Lovinger, D. M., Akbar, M. D., & Huang, B. X. (2011) · Biochemical Journal · doi:10.1042/bj20102118 · Cited by 123 · see citing works

Lipid Replacement Therapy: A natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function

Nicolson, G. L., & Ash, M. E. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.11.010 · Cited by 113 · see citing works

Marine Bioactive Compounds: Sources, Characterization and Applications

(2012) · doi:10.1007/978-1-4614-1247-2 · Cited by 111 · see citing works

Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-κB pathways

Jung, W., Ahn, Y.-W., Lee, S., Choi, Y. H., Kim, S., Yea, S. S., Choi, I., Park, S.-G., Seo, S., Lee, S.-W., et al. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.11.041 · Cited by 110 · see citing works

Improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: Possible involvement of the inhibition of acetylcholinesterase

Myung, C., Shin, H., Bao, H. Y., Yeo, S. J., Lee, B. H., & Kang, J. S. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02969360 · Cited by 109 · see citing works

Plasmalogens, Phospholipase A2, and Docosahexaenoic Acid Turnover in Brain Tissue

Farooqui, A. A., & Horrocks, L. A. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:263 · Cited by 108 · see citing works

Fucoidan inhibits cellular and neurotoxic effects of β‐amyloid (Aβ) in rat cholinergic basal forebrain neurons

Jhamandas, J. H., Wie, M., Harris, K. H., MacTavish, D., & Kar, S. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04111.x · Cited by 108 · see citing works

Structural studies on κ-carrageenan derived oligosaccharides

Yu, G., Guan, H., Ioanoviciu, A. S., Sikkander, S. A., Thanawiroon, C., Tobacman, J. K., Toida, T., & Linhardt, R. J. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00009-5 · Cited by 108 · see citing works

Marine Macroalgae as Sources of Polyunsaturated Fatty Acids

COLOMBO, M. L., Risé, P., Giavarini, F., Angelis, L. D., Galli, C. L., & Bolis, C. L. (2006) · Plant Foods for Human Nutrition · doi:10.1007/s11130-006-0015-7 · Cited by 107 · see citing works

Seaweed micropropagation techniques and their potentials: an overview

Reddy, C. R. K., Jha, B., Fujita, Y., & Ohno, M. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-007-9205-4 · Cited by 107 · see citing works

Phlorotannins from Brown Algae (Fucus vesiculosus) Inhibited the Formation of Advanced Glycation Endproducts by Scavenging Reactive Carbonyls

Liu, H., & Gu, L. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204112f · Cited by 105 · see citing works

CONTRIBUTIONS TO THE STUDY OF MARINE PRODUCTS

Bergmann, W. (1937) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)74505-5 · Cited by 102 · see citing works

Fucoxanthin Ameliorates Inflammation and Oxidative Reponses in Microglia

Pangestuti, R., Vo, T., Ngo, D., & Kim, S. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400015k · Cited by 99 · see citing works

Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study

Chen, C. T., Liu, Z., & Bazinet, R. P. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07116.x · Cited by 97 · see citing works

Acetylcholinesterase inhibitory activity of phlorotannins isolated from the brown alga, Ecklonia maxima (Osbeck) Papenfuss

Rengasamy, K. R. R., Aderogba, M. A., Ndhlala, A. R., Stirk, W. A., & Staden, J. V. (2012) · Food Research International · doi:10.1016/j.foodres.2012.11.017 · Cited by 97 · see citing works

STEROL PROFILES IN 18 MACROALGAE OF THE PORTUGUESE COAST1

Lopes, G., Sousa, C., Bernardo, J., Andrade, P. B., Valentão, P., Ferreres, F., & Mouga, T. (2011) · Journal of Phycology · doi:10.1111/j.1529-8817.2011.01028.x · Cited by 97 · see citing works

Nerve Growth Factor, Neural Stem Cells and Alzheimer’s Disease

Heese, K., Low, J. W., & Inoue, N. (2006) · Neurosignals · doi:10.1159/000094383 · Cited by 96 · see citing works

Cognitive profiling of Parkinson disease patients with mild cognitive impairment and dementia

Biundo, R., Weis, L., Facchini, S., Formento‐Dojot, P., Vallelunga, A., Pilleri, M., & Antonini, A. (2014) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2014.01.009 · Cited by 96 · see citing works

Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells

Kang, S., Cha, S., Ko, J.-Y., Kang, M., Kim, D., Heo, S., Kim, J., Heu, M. S., Kim, Y.-T., Jung, W., et al. (2012) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2012.03.006 · Cited by 94 · see citing works

Anticholinesterase activity of plastoquinones from Sargassum sagamianum: lead compounds for alzheimer's disease therapy

Choi, B. W., Ryu, G., Park, S. H., Kim, E. S., Shin, J., Roh, S. S., Shin, H., & Lee, B. H. (2007) · Phytotherapy Research · doi:10.1002/ptr.2090 · Cited by 94 · see citing works

Antioxidant activity and phenolic content of pressurised liquid and solid–liquid extracts from four Irish origin macroalgae

Heffernan, N., Smyth, T. J., FitzGerald, R. J., Soler‐Vila, A., & Brunton, N. (2014) · International Journal of Food Science &amp; Technology · doi:10.1111/ijfs.12512 · Cited by 93 · see citing works

Neuroprotective Effects of Astaxanthin in Oxygen-Glucose Deprivation in SH-SY5Y Cells and Global Cerebral Ischemia in Rat

Lee, D., Lee, Y. J., & Kwon, K. H. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.10-29 · Cited by 93 · see citing works

Differential effects of n-3 fatty acid deficiency on phospholipid molecular species composition in the rat hippocampus

Murthy, M., Hamilton, J., Greiner, R. S., Moriguchi, T., Salem, N., & Kim, H. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31491-7 · Cited by 93 · see citing works

Phlorotannins from Ishige okamurae and their acetyl- and butyrylcholinesterase inhibitory effects

Yoon, N. Y., Lee, S., Yongli, & Kim, S. (2009) · Journal of Functional Foods · doi:10.1016/j.jff.2009.07.002 · Cited by 92 · see citing works

Degradation and antioxidant activity of κ-Carrageenans

Sun, T., Tao, H., Xie, J., Zhang, S., & Xu, X. (2010) · Journal of Applied Polymer Science · doi:10.1002/app.31955 · Cited by 91 · see citing works

Fucoidan Protects against Lipopolysaccharide‐Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia

Cui, Y., Jia, Y., Zhang, T., Zhang, Q., & Wang, X. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00372.x · Cited by 91 · see citing works

Cancer Preventive Efficacy of Marine Carotenoid Fucoxanthin: Cell Cycle Arrest and Apoptosis

Rengarajan, T., Rajendran, P., Nandakumar, N., Balasubramanian, M. P., & Nishigaki, I. (2013) · Nutrients · doi:10.3390/nu5124978 · Cited by 91 · see citing works

C-Phycocyanin is neuroprotective against global cerebral ischemia/reperfusion injury in gerbils

Pentón‐Rol, G., Marín‐Prida, J., Andreu, G. L. P., Martı́nez-Sánchez, G., Acosta-Medina, E. F., Valdivia, A., Lagumersindez-Denis, N., Jiménez, E. R., Llopiz, A., López-Saura, P. A., et al. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.05.016 · Cited by 91 · see citing works

Down-regulation of IL-6 production by astaxanthin via ERK-, MSK-, and NF-κB-mediated signals in activated microglia

Kim, Y. H., Koh, H.-K., & Kim, D. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.09.007 · Cited by 88 · see citing works

The Use of Flavonoids in Central Nervous System Disorders

Grosso, C., Valentão, P., Ferreres, F., & Andrade, P. B. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990155 · Cited by 87 · see citing works

Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata

Suganthy, N., Pandian, S. K., & Devi, K. P. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.001 · Cited by 86 · see citing works

Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa

Liu, D.-Q., Mao, S., Zhang, H., Yu, X., Feng, M.-T., Wang, B., Feng, L., & Guo, Y. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.08.014 · Cited by 86 · see citing works

Bioactive Compounds from Marine Foods

(2013) · Wiley eBooks · doi:10.1002/9781118412893 · Cited by 84 · see citing works

Pheophytin a, a low molecular weight compound found in the marine brown alga Sargassum fulvellum, promotes the differentiation of PC12 cells

Ina, A., Hayashi, K., Nozaki, H., & Kamei, Y. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2006.09.323 · Cited by 83 · see citing works

Fucoidans as Potential Inhibitors of HIV-1

Prokofjeva, M. M., Imbs, T. I., Shevchenko, N., Spirin, P., Horn, S., Fehse, B., Николаевна, З. Т., & Prassolov, V. (2013) · Marine Drugs · doi:10.3390/md11083000 · Cited by 82 · see citing works

Utilization of seaweed derived ingredients as potential antioxidants and functional ingredients in the food industry: An overview

Li, Y.-X., & Kim, S. (2011) · Food Science and Biotechnology · doi:10.1007/s10068-011-0202-7 · Cited by 82 · see citing works

Neuroprotective Effect of Fucoidan on H2O2-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway

Gao, Y., Dong, C., Yin, J., Shen, J., Tian, J., & Li, C. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9792-0 · Cited by 81 · see citing works

Quantitative structure−activity relationship (QSAR) for neuroprotective activity of terpenoids

Chang, H., Kim, H. J., & Chun, H. S. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.11.009 · Cited by 81 · see citing works

Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide‐activated primary microglia

Cui, Y., Zhang, L., Zhang, T., Luo, D., Jia, Y., Guo, Z., Zhang, Q., Wang, X., & Wang, X. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05314.x · Cited by 81 · see citing works

Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia

Kim, M., Li, Y.-X., Dewapriya, P., Ryu, B., & Kim, S. (2013) · BMB Reports · doi:10.5483/bmbrep.2013.46.8.237 · Cited by 75 · see citing works

Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells

Ahn, B. R., Moon, H. E., Kim, H. R., Jung, H. A., & Choi, J. S. (2012) · Archives of Pharmacal Research · doi:10.1007/s12272-012-1116-5 · Cited by 75 · see citing works

Sargachromenol, a novel nerve growth factor-potentiating substance isolated from Sargassum macrocarpum, promotes neurite outgrowth and survival via distinct signaling pathways in PC12D cells

Tsang, C. K., Ina, A., Goto, T., & Kamei, Y. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.028 · Cited by 75 · see citing works

Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death

Kang, I., Jeon, Y. E., Yin, X. F., Nam, J., You, S. G., Hong, M. S., Jang, B. G., & Kim, M.-J. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.06.023 · Cited by 68 · see citing works

New Therapeutic Strategy for Parkinsons and Alzheimers Disease

Esposito, E., & Cuzzocrea, S. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791859324 · Cited by 67 · see citing works

Cyclooxygenases and 5-lipoxygenase in Alzheimer's disease

Manev, H., Chen, H., Dzitoyeva, S., & Manev, R. M. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.032 · Cited by 66 · see citing works

Astaxanthin Suppresses MPP+-Induced Oxidative Damage in PC12 Cells through a Sp1/NR1 Signaling Pathway

Ye, Q., Zhang, X., Huang, B., Zhu, Y., & Chen, X. (2013) · Marine Drugs · doi:10.3390/md11041019 · Cited by 64 · see citing works

Sterols in Algae and Health

Lopes, G., Sousa, C., Valentão, P., & Andrade, P. B. (2013) · doi:10.1002/9781118412893.ch9 · Cited by 63 · see citing works

Exposure to the Saturated Free Fatty Acid Palmitate Alters BV-2 Microglia Inflammatory Response

Tracy, L. M., Bergqvist, F., Ivanova, E. V., Jacobsen, K. T., & Iverfeldt, K. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0068-7 · Cited by 63 · see citing works

Neuroprotective Effect of Phlorotannin Isolated from Ishige okamurae Against H2O2-Induced Oxidative Stress in Murine Hippocampal Neuronal Cells, HT22

Heo, S., Cha, S., Kim, K., Lee, S., Ahn, G., Kang, D.-H., Oh, C., Choi, Y., Affan, A., Kim, D., et al. (2012) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-012-9545-7 · Cited by 59 · see citing works

Lipid Replacement and Antioxidant Nutritional Therapy for Restoring Mitochondrial Function and Reducing Fatigue in Chronic Fatigue Syndrome and Other Fatiguing Illnesses

Nicolson, G. L., & Ellithorpe, R. R. (2006) · Journal of Chronic Fatigue Syndrome · doi:10.1300/j092v13n01_06 · Cited by 59 · see citing works

Sargaquinoic acid supports the survival of neuronal PC12D cells in a nerve growth factor-independent manner

Tsang, C. K., & Kamei, Y. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.01.033 · Cited by 58 · see citing works

Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro

Khodosevich, K. V., & Monyer, H. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-18 · Cited by 58 · see citing works

Distinct fatty acid profile of ten brown macroalgae

Silva, G., Pereira, R. B., Valentão, P., Andrade, P. B., & Sousa, C. (2013) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2013005000048 · Cited by 57 · see citing works

Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical

Smid, S. D., Mååg, J. L. V., & Musgrave, I. (2012) · Food & Function · doi:10.1039/c2fo30075c · Cited by 57 · see citing works

Cholinesterase inhibitory activity of two farnesylacetone derivatives from the brown algaSargassum sagamianum

Ryu, G., Park, S. H., Kim, E.-S., Choi, B. W., Ryu, S. Y., & Lee, B. H. (2003) · Archives of Pharmacal Research · doi:10.1007/bf02980022 · Cited by 54 · see citing works

The anti-inflammatory effects of phlorotannins from Eisenia arborea on mouse ear edema by inflammatory inducers

Sugiura, Y., Tanaka, R., Katsuzaki, H., Imai, K., & Matsushita, T. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.08.010 · Cited by 53 · see citing works

Anti-inflammatory activity of halogenated secondary metabolites of Laurencia snackeyi (Weber-van Bosse) Masuda in LPS-stimulated RAW 264.7 macrophages

Vairappan, C. S., Kamada, T., Lee, W., & Jeon, Y. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-0023-6 · Cited by 51 · see citing works

Relevant activities of extracts and constituents of animals used in traditional Chinese medicine for central nervous system effects associated with Alzheimer's disease

Ren, Y., Houghton, P. J., & Hider, R. C. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.7.0015 · Cited by 51 · see citing works

The immune regulation of κ-carrageenan oligosaccharide and its desulfated derivatives on LPS-activated microglial cells

Xu, L., Yao, Z., Wu, H., Wang, F., & Zhang, S. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.06.019 · Cited by 50 · see citing works

Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses

Nobre, M. E. P., Correia, A. O., Borges, M. D. B., Sampaio, T. M. A., Chakraborty, S. A., Gonçalves, D. D. O., Brito, G. A. D. C., Leal, L. K. A. M., Felipe, C. F. B., Lucetti, D. L., et al. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.02.011 · Cited by 49 · see citing works

Use of cholinesterase inhibitors in dementia

Holden, M., & KELLY, C. A. (2002) · Advances in Psychiatric Treatment · doi:10.1192/apt.8.2.89 · Cited by 49 · see citing works

Sargaquinoic acid promotes neurite outgrowth via protein kinase A and MAP kinases-mediated signaling pathways in PC12D cells

Kamei, Y., & Tsang, C. K. (2003) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(03)00068-6 · Cited by 47 · see citing works

Immunomodulatory Function of κ-Carrageenan Oligosaccharides Acting on LPS-Activated Microglial Cells

Yao, Z., Xu, L., & Wu, H. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1228-4 · Cited by 46 · see citing works

The inhibitory effects of components from a brown alga, Eisenia arborea, on degranulation of mast cells and eicosanoid synthesis

Sugiura, Y., Matsuda, K., Okamoto, T., Yamada, Y., Imai, K., Ito, Y., Kakinuma, M., & Amano, H. (2009) · Journal of Functional Foods · doi:10.1016/j.jff.2009.08.002 · Cited by 41 · see citing works

Assessment of Anticholinesterase Activity ofGelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease

Syad, A. N., Pandian, S. K., & Kasi, P. D. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/497242 · Cited by 41 · see citing works

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity

Kang, I., Jang, B. G., In, S., Choi, B., Kim, M., & Kim, M.-J. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.09.013 · Cited by 39 · see citing works

Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases

Grosso, C., Valentão, P., Ferreres, F., & Andrade, P. B. (2014) · Marine Drugs · doi:10.3390/md12052539 · Cited by 39 · see citing works

Cabergoline protects SH-SY5Y neuronal cells in an in vitro model of ischemia

Miglio, G., Varsaldi, F., Francioli, E., Battaglia, A., Canonico, P. L., & Lombardi, G. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.03.006 · Cited by 34 · see citing works

In vitro antibacterial activity of alkaloid extracts from green, red and brown macroalgae from western coast of Libya

Alghazeer, R. O., Whida, F., Abduelrhman, E., Gammoudi, F., & Naili, M. B. (2013) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb2013.13223 · Cited by 34 · see citing works

Pharmacotherapeutic Approaches of Parkinson’s Disease

Ansari, J. A., Siraj, A., & Inamdar, N. N. (2010) · International Journal of Pharmacology · doi:10.3923/ijp.2010.584.590 · Cited by 34 · see citing works

The Sesquiterpene Caulerpenyne from Caulerpa spp. is a Lipoxygenase Inhibitor

Cengiz, S., Çavaş, L., Yurdakoç, K., & Pohnert, G. (2010) · Marine Biotechnology · doi:10.1007/s10126-010-9303-1 · Cited by 30 · see citing works

Lipid Replacement as an Adjunct to Therapy for Chronic Fatigue, Anti-Aging and Restoration of Mitochondrial Function

Nicolson, G. L. (2003) · Cited by 30 · see citing works

Caulerchlorin, a Novel Chlorinated Bisindole Alkaloid with Antifungal Activity from the Chinese Green Alga Caulerpa racemosa

Mao, S., Liu, D.-Q., Yu, X., Feng, L., & Lai, X.-P. (2011) · Heterocycles · doi:10.3987/com-11-12408 · Cited by 29 · see citing works

Chronic-Fatigue-Syndrom

Hausotter, W. (2013) · Elsevier eBooks · doi:10.1016/b978-3-437-31606-7.00009-5 · Cited by 26 · see citing works

Lipoxygenase inhibitors derived from marine macroalgae

Kurihara, H., Kagawa, Y., Konno, R., Kim, S. M., & Takahashi, K. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.01.046 · Cited by 21 · see citing works

Phlorofucofuroeckol-A, a potent inhibitor of aldo-keto reductase family 1 member B10, from the edible brown alga Eisenia bicyclis

Lee, J. Y., Kim, S. M., Jung, W., Song, D., Um, B., Son, J.-K., & Pan, C. (2012) · Journal of the Korean Society for Applied Biological Chemistry · doi:10.1007/s13765-012-2169-3 · Cited by 19 · see citing works

Seaweed micropropagation techniques and their potentials: an overview

Reddy, C. R. K., Jha, B., Fujita, Y., & Ohno, M. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9619-8_21 · Cited by 18 · see citing works

Seaweeds from the Portuguese coast: chemistry, antimicrobial and antiinflammatory capacity

Lopes, G. L. L. (2014) · Open Repository of the University of Porto (University of Porto) · doi:10.34626/68na-8c58 · Cited by 13 · see citing works

Synthesis and characterization of α‐butyl‐omega‐{3‐[2‐hydroxy‐3‐(N‐methyl‐N‐hydroxy‐ ethylamino)propoxy]propyl}polydimethylsiloxane

Sun, H., Zhang, Q., Zhang, M., Yu, Y., & Zong, J. (2010) · Journal of Applied Polymer Science · doi:10.1002/app.31339 · Cited by 11 · see citing works

Alkaloids of Marine Macroalgae

Güven, K. C., Çoban, B., Sezik, E., Erduğan, H., & Kaleağasıoğlu, F. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_179 · Cited by 7 · see citing works

Pharmacology of Macroalgae Alkaloids

Kaleağasıoğlu, F., Güven, K. C., Sezik, E., Erduğan, H., & Çoban, B. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_3 · Cited by 6 · see citing works

Neuropharmacological Properties of Marine Plants

Kim, S. (2012) · Cited by 4 · see citing works

Antimicrobial Action of Compounds from Marine Seaweed

Pérez, M. J., Falqué, E., & Domı́nguez, H. (2016) · Marine Drugs · doi:10.3390/md14030052 · Cited by 663 · see citing works

Seaweeds as a Functional Ingredient for a Healthy Diet

Peñalver, R., Lorenzo, J. M., Ros, G., Amarowicz, R., Pateiro, M., & Nieto, G. (2020) · Marine Drugs · doi:10.3390/md18060301 · Cited by 518 · see citing works

Macroalgae—A Sustainable Source of Chemical Compounds with Biological Activities

BIRIȘ-DORHOI, E. S., MICHIU, D., Pop, C. R., Rotar, A. M., Tofană, M., Pop, O. L., Socaci, S., & Fărcaș, A. C. (2020) · Nutrients · doi:10.3390/nu12103085 · Cited by 319 · see citing works

Novel Bioactive Compounds From Marine Sources as a Tool for Functional Food Development

Ghosh, S., Sarkar, T., Pati, S., Kari, Z. A., Edinur, H. A., & Chakraborty, R. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.832957 · Cited by 282 · see citing works

Seaweeds as nutraceuticals for health and nutrition

Shannon, E., & Abu‐Ghannam, N. (2019) · Phycologia · doi:10.1080/00318884.2019.1640533 · Cited by 279 · see citing works

Extraction of Proteins from Two Marine Macroalgae, Ulva Sp. and Gracilaria Sp., for Food Application, and Evaluating Digestibility, Amino Acid Composition and Antioxidant Properties of the Protein Concentrates

Kazir, M., Abuhassira, Y., Robin, A., Nahor, O., Luo, J., Israel, A., Golberg, A., & Livney, Y. D. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.07.047 · Cited by 269 · see citing works

The Evolution Road of Seaweed Aquaculture: Cultivation Technologies and the Industry 4.0

García‐Poza, S., Leandro, A., Cotas, C., Cotas, J., Marques, J. C., Pereira, L., & Gonçalves, A. M. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17186528 · Cited by 252 · see citing works

Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?

Menaa, F., Wijesinghe, U., Thiripuranathar, G., Althobaiti, N. A., Albalawi, A. E., Khan, B. A., & Menaa, B. (2021) · Marine Drugs · doi:10.3390/md19090484 · Cited by 247 · see citing works

A review on bioenergy and bioactive compounds from microalgae and macroalgae-sustainable energy perspective

Sudhakar, M. P., Kumar, B., Mathimani, T., & Arunkumar, K. (2019) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2019.04.287 · Cited by 238 · see citing works

Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae

Cikoš, A.-M., Jokić, S., Šubarić, D., & Jerković, I. (2018) · Marine Drugs · doi:10.3390/md16100348 · Cited by 225 · see citing works

Ecosystem Services Provided by Seaweeds

Cotas, J., Gomes, L., Pacheco, D., & Pereira, L. (2023) · Hydrobiology · doi:10.3390/hydrobiology2010006 · Cited by 176 · see citing works

An Overview to the Health Benefits of Seaweeds Consumption

Lomartire, S., Marques, J. C., & Gonçalves, A. M. M. (2021) · Marine Drugs · doi:10.3390/md19060341 · Cited by 169 · see citing works

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Hannan, M. A., Dash, R., Haque, M. N., Mohibbullah, M., Sohag, A. A. M., Rahman, M. A., Uddin, M. J., Alam, M., & Moon, I. S. (2020) · Marine Drugs · doi:10.3390/md18070347 · Cited by 152 · see citing works

Multifunctional role of fucoidan, sulfated polysaccharides in human health and disease: A journey under the sea in pursuit of potent therapeutic agents

Pradhan, B., Patra, S., Nayak, R., Behera, C., Dash, S. R., Nayak, S., Sahu, B. B., Bhutia, S. K., & Jena, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.019 · Cited by 142 · see citing works

Antioxidant and Signal‐Modulating Effects of Brown Seaweed‐Derived Compounds against Oxidative Stress‐Associated Pathology

Begum, R., Saurav, H., Mamun-Or-Rashid, A. N. M., Rafiquzzaman, S. M., Ashraf, G. M., Albadrani, G. M., Sayed, A. A., Peluso, I., Abdel‐Daim, M. M., & Uddin, M. S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9974890 · Cited by 126 · see citing works

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan, P., Ko, H.-M., Kim, I., & Choi, D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s93918 · Cited by 119 · see citing works

Effect of particle size on phytochemical composition and antioxidant properties of Sargassum cristaefolium ethanol extract

Prasedya, E. S., Frediansyah, A., Martyasari, N. W. R., Ilhami, B. K., Abidin, A. S., Padmi, H., Fahrurrozi, Juanssilfero, A. B., Widyastuti, S., & Sunarwidhi, A. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-95769-y · Cited by 118 · see citing works

Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity

Rocha, D. H. A., Seca, A. M. L., & Pinto, D. C. G. A. (2018) · Marine Drugs · doi:10.3390/md16110410 · Cited by 113 · see citing works

Phlorotannins: Towards New Pharmacological Interventions for Diabetes Mellitus Type 2

Lopes, G., Andrade, P. B., & Valentão, P. (2016) · Molecules · doi:10.3390/molecules22010056 · Cited by 98 · see citing works

Seaweed bioactives potential as nutraceuticals and functional ingredients: A review

Matos, J., Cardoso, C. L., Serralheiro, M. L., Bandarra, N. M., & Afonso, C. M. (2024) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2024.106453 · Cited by 95 · see citing works

Phytochemical Analysis and Evaluation of the Antioxidant, Anti-Inflammatory, and Antinociceptive Potential of Phlorotannin-Rich Fractions from Three Mediterranean Brown Seaweeds

Abdelhamid, A., Jouini, M., Amor, H. B. H., Mzoughi, Z., Dridi, M., Said, R. B., & Bouraoui, A. (2018) · Marine Biotechnology · doi:10.1007/s10126-017-9787-z · Cited by 93 · see citing works

Enhanced Antimicrobial and Anticancer Activity of Silver and Gold Nanoparticles Synthesised Using Sargassum incisifolium Aqueous Extracts

Mmola, M., Roes‐Hill, M. L., Durrell, K. A., Bolton, J. J., Sibuyi, N. R. S., Meyer, M., Beukes, D. R., & Antunes, E. M. (2016) · Molecules · doi:10.3390/molecules21121633 · Cited by 90 · see citing works

Antibacterial efficacy of a fucoidan fraction (Fu-F2) extracted from Sargassum polycystum

Palanisamy, S., Vinosha, M., Rajasekar, P., Anjali, R., Sathiyaraj, G., Marudhupandi, T., Selvam, S., Prabhu, N. M., & You, S. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.12.070 · Cited by 89 · see citing works

Consumption of seaweeds and the human brain

Cornish, M. L., Critchley, A. T., & Mouritsen, O. G. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-1049-3 · Cited by 81 · see citing works

Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights

Oliyaei, N., Moosavi‐Nasab, M., Tanideh, N., & Iraji, A. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.11.018 · Cited by 79 · see citing works

The mechanism of neuroprotective action of natural compounds

Wąsik, A., & Antkiewicz‐Michaluk, L. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.03.018 · Cited by 79 · see citing works

Comparison of extraction methods for selected carotenoids from macroalgae and the assessment of their seasonal/spatial variation

Heffernan, N., Smyth, T. J., FitzGerald, R. J., Vila-Soler, A., Mendiola, J., Ibáñez, E., & Brunton, N. P. (2016) · Innovative Food Science &amp; Emerging Technologies · doi:10.1016/j.ifset.2016.06.004 · Cited by 76 · see citing works

Marine Biocompounds for Neuroprotection—A Review

Bălașa, A. F., Chircov, C., & Grumezescu, A. M. (2020) · Marine Drugs · doi:10.3390/md18060290 · Cited by 75 · see citing works

Intranasal delivery of stem cells as therapy for central nervous system disease

Lǐ, Y., Feng, L., Zhang, G., & Ma, C. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.01.016 · Cited by 74 · see citing works

GC/MS spectroscopic approach and antifungal potential of bioactive extracts produced by marine macroalgae

Shobier, A. H., Ghani, S. A. A., & Barakat, K. M. (2016) · The Egyptian Journal of Aquatic Research · doi:10.1016/j.ejar.2016.07.003 · Cited by 72 · see citing works

Neuroprotective Effects of the Cultivated Chondrus crispus in a C. elegans Model of Parkinson’s Disease

Liu, J., BANSKOTA, A. H., Critchley, A. T., Hafting, J. T., & Prithiviraj, B. (2015) · Marine Drugs · doi:10.3390/md13042250 · Cited by 66 · see citing works

Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson’s Disease

Sita, G., Hrelia, P., Tarozzi, A., & Morroni, F. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091454 · Cited by 62 · see citing works

Neuroprotective activities of natural products from marine macroalgae during 1999–2015

Alghazwi, M., Kan, Y. Q., Zhang, W., Gai, W. P., Garson, M. J., & Smid, S. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-016-0908-2 · Cited by 58 · see citing works

Bioprospecting of brown seaweeds for biotechnological applications: Phlorotannin actions in inflammation and allergy network

Barbosa, M., Lopes, G., Andrade, P. B., & Valentão, P. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.02.037 · Cited by 58 · see citing works

TRPM2 in the Brain: Role in Health and Disease

Sita, G., Hrelia, P., Graziosi, A., Ravegnini, G., & Morroni, F. (2018) · Cells · doi:10.3390/cells7070082 · Cited by 57 · see citing works

Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review

Martins, B., Vieira, M., Delerue-Matos, C. M., Grosso, C., & Soares, C. M. D. (2022) · Marine Drugs · doi:10.3390/md20060362 · Cited by 56 · see citing works

Recent advances in biological properties of brown algae-derived compounds for nutraceutical applications

Silva, A., Cassani, L., Grosso, C., Garcia‐Oliveira, P., Morais, S. L., Echave, J., Carpena, M., Xiao, J., Barroso, M. F., Simal‐Gándara, J., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2115004 · Cited by 55 · see citing works

Phlorotannins

Venkatesan, J., Keekan, K. K., Anil, S., Bhatnagar, I., & Kim, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.22360-3 · Cited by 52 · see citing works

Antioxidants from microalgae and their potential impact on human well-being

Pereira, L., Cotas, J., & Valado, A. (2024) · Exploration of Drug Science · doi:10.37349/eds.2024.00048 · Cited by 48 · see citing works

Algal bioactive compounds: A review on their characteristics and medicinal properties

Bouafir, Y., Bouhenna, M. M., Nebbak, A., Belfarhi, L., Aouzal, B., Boufahja, F., Bendıf, H., & Bruno, M. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106591 · Cited by 48 · see citing works

An ACE inhibitory peptide from Isochrysis zhanjiangensis exhibits antihypertensive effect via anti-inflammation and anti-apoptosis in HUVEC and hypertensive rats

Pei, Y., Cai, S., Ryu, B., Zhou, C., Hong, P., & Qian, Z. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105061 · Cited by 45 · see citing works

Recent Advances in Multi-target Anti-Alzheimer Disease Compounds (2013 Up to the Present)

Wang, N., Qiu, P., Cui, W., Yan, X., Zhang, B., & He, S. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867326666181203124102 · Cited by 45 · see citing works

Phytotoxic effects of seaweed mediated copper nanoparticles against the harmful alga: Lyngbya majuscula

El-Kassas, H. Y., & Okbah, M. A. E.-A. (2017) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2017.01.002 · Cited by 41 · see citing works

Marine macroalgae and their associated microbiomes as a source of antimicrobial chemical diversity

Busetti, A., Maggs, C. A., & Gilmore, B. (2017) · European Journal of Phycology · doi:10.1080/09670262.2017.1376709 · Cited by 41 · see citing works

Agar Extraction By-Products from Gelidium sesquipedale as a Source of Glycerol-Galactosides

Lebbar, S., Fanuel, M., Gall, S. L., Falourd, X., Ropartz, D., Bressollier, P., Gloaguen, V., & Faugeron-Girard, C. (2018) · Molecules · doi:10.3390/molecules23123364 · Cited by 41 · see citing works

Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea

Montalvão, S. I. G. H. M., Demirel, Z., Devi, P., Lombardi, V., Hongisto, V., Perälä, M., Hattara, J., İmamoğlu, E., Tilvi, S., Turan, G., et al. (2016) · New Biotechnology · doi:10.1016/j.nbt.2016.02.002 · Cited by 38 · see citing works

Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation

Jiang, C., Ge, Y.-X., Cheng, Z., Song, J.-L., Wang, Y., Zhu, K., & Zhang, H. (2019) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-019-00202-2 · Cited by 37 · see citing works

Fatty acid composition, TLC screening, ATR-FTIR analysis, anti-cholinesterase activity, and in vitro cytotoxicity to A549 tumor cell line of extracts of 3 macroalgae collected in Madeira

Nunes, N., Rosa, G. P., Ferraz, S., Barreto, M. D. C., & de Carvalho, M. Â. A. P. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-019-01884-9 · Cited by 37 · see citing works

Marine-derived protein kinase inhibitors for neuroinflammatory diseases

Ning, C., Wang, H., Gao, R., Chang, Y., Hu, F., Meng, X., & Huang, S. (2018) · BioMedical Engineering OnLine · doi:10.1186/s12938-018-0477-5 · Cited by 36 · see citing works

Enteromorpha prolifera Extract Improves Memory in Scopolamine-Treated Mice via Downregulating Amyloid-β Expression and Upregulating BDNF/TrkB Pathway

Baek, S. Y., Li, F. Y., Kim, D. H., Kim, S. J., & Kim, M. R. (2020) · Antioxidants · doi:10.3390/antiox9070620 · Cited by 36 · see citing works

Polyphenols from Brown Seaweeds (Ochrophyta, Phaeophyceae): Phlorotannins in the Pursuit of Natural Alternatives to Tackle Neurodegeneration

Barbosa, M., Valentão, P., & Andrade, P. B. (2020) · Marine Drugs · doi:10.3390/md18120654 · Cited by 36 · see citing works

Investigation of antioxidant and anticancer potential of fucoidan (in-vitro & in-silico) from brown seaweed Padina boergesenii

Ragunath, C., & Ramasubramanian, V. (2024) · Algal Research · doi:10.1016/j.algal.2024.103442 · Cited by 35 · see citing works

Cascade valorization process of brown alga seaweed Laminaria hyperborea by isolation of polyphenols and alginate

Cajnko, M. M., Novak, U., & Likozar, B. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-019-01901-x · Cited by 35 · see citing works

Compressed CO2 Technologies for the Recovery of Carotenoid-Enriched Extracts from Dunaliella salina with Potential Neuroprotective Activity

Bueno, M., Vitali, C., Sánchez-Martínez, J. D., Mendiola, J. A., Cifuentes, A., Ibáñez, E., & Herrero, M. (2020) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.0c03991 · Cited by 35 · see citing works

Nutraceuticals to promote neuronal plasticity in response to corticosterone-induced stress in human neuroblastoma cells

Gite, S., Ross, R. P., Kirke, D. A., Guihéneuf, F., Aussant, J., Stengel, D. B., Dinan, T. G., Cryan, J. F., & Stanton, C. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1418728 · Cited by 35 · see citing works

In silico evaluation of bioactive peptides from the green algae Caulerpa

Ağırbaşlı, Z., & Çavaş, L. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-1045-7 · Cited by 29 · see citing works

Sustainable Resource Production for Manufacturing Bioactives from Micro- and Macroalgae: Examples from Harvesting and Cultivation in the Nordic Region

Chauton, M. S., Forbord, S., Mäkinen, S., Sarno, A., Slizyte, R., Mozuraityte, R., Standal, I. B., & Skjermo, J. (2021) · Physiologia Plantarum · doi:10.1111/ppl.13391 · Cited by 28 · see citing works

Enhancing the bioactivity of Dunaliella salina extracts through ultra-high pressure supercritical fluid extraction (UHP-SFE)

Luna, V. M. A., Herrero, M., Domínguez‐Rodríguez, G., Ibáñez, E., & Montero, L. (2024) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2024.103697 · Cited by 28 · see citing works

Marine Organisms as Alkaloid Biosynthesizers of Potential Anti-Alzheimer Agents

Lima, E., & Medeiros, J. (2022) · Marine Drugs · doi:10.3390/md20010075 · Cited by 28 · see citing works

In vitro and in silico evaluation of fucosterol from Sargassum horridum as potential human acetylcholinesterase inhibitor

Castro-Silva, E. S., Bello, M., Rodríguez, M. H., Correa‐Basurto, J., Murillo-Álvarez, J. I., Rosales‐Hernández, M. C., & Muñoz‐Ochoa, M. (2018) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2018.1505551 · Cited by 28 · see citing works

Bioactive Compounds from Seaweed with Anti-Leukemic Activity: A Mini-Review on Carotenoids and Phlorotannins

Almeida, T., Ramos, A. A., Ferreira, J. S. P. D. M., Azqueta, A., & Rocha, E. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666190311095655 · Cited by 28 · see citing works

Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer’s Disease: A Review

Jy, L., Wong, C.-Y., Koh, R. Y., Lim, C. L., Kok, Y.-Y., & Chye, S. M. (2024) · The Yale Journal of Biology and Medicine · doi:10.59249/jnkb9714 · Cited by 26 · see citing works

Total Synthesis of Pulmonarin B and Design of Brominated Phenylacetic Acid/Tacrine Hybrids: Marine Pharmacophore Inspired Discovery of New ChE and Aβ Aggregation Inhibitors

Cheng, Z., Song, J.-L., Zhu, K., Zhang, J., Jiang, C., & Zhang, H. (2018) · Marine Drugs · doi:10.3390/md16090293 · Cited by 26 · see citing works

Phytochemical Profiling of the Ethanolic Extract of Zaleya pentandra L. Jaffery and Its Biological Activities by In-Vitro Assays and In-Silico Molecular Docking

Shahid, A., Khan, K.-U.-R., Rao, H., Aati, H. Y., Sherif, A. E., Khan, D. A., Basit, A., Umair, M., Mueed, A., Esatbeyoglu, T., et al. (2022) · Applied Sciences · doi:10.3390/app13010584 · Cited by 25 · see citing works

Chemical profiling of edible seaweed (Ochrophyta) extracts and assessment of their in vitro effects on cell-free enzyme systems and on the viability of glutamate-injured SH-SY5Y cells

Fernandes, F., Barbosa, M., Pereira, D. M., Sousa‐Pinto, I., Valentão, P., Azevedo, I. C., & Andrade, P. B. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.04.033 · Cited by 25 · see citing works

The Effect of Fucoidan on Cellular Oxidative Stress and the CatD-Bax Signaling Axis in MN9D Cells Damaged by 1-Methyl-4-Phenypyridinium

Liang, Z., Liu, Z., Sun, X., Tao, M., Xiao, X., Yu, G., & Wang, X. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00429 · Cited by 25 · see citing works

Neuroprotective effects of some seaweeds against Zn – induced neuronal damage in HT-22 cells via modulation of redox imbalance, inhibition of apoptosis and acetylcholinesterase activity

Olasehinde, T. A., Olaniran, A. O., & Okoh, A. I. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00469-2 · Cited by 24 · see citing works

Antioxidant activity of Ulva lactuca L. from different coastal locations of Lombok Island, Indonesia

Prasedya, E. S., Martyasari, N. W. R., Apriani, R., Mayshara, S., Fanani, R. A., & Sunarpi, H. (2019) · AIP conference proceedings · doi:10.1063/1.5141281 · Cited by 24 · see citing works

Insecticidal activity of forty-seven marine algae species from the Mediterranean, Aegean, and Sea of Marmara in connection with their cholinesterase and tyrosinase inhibitory activity

Kılıç, M., Orhan, İ. E., Eren, G., Okudan, E. Ş., Estep, A. S., Bencel, J. J., & Tabanca, N. (2021) · South African Journal of Botany · doi:10.1016/j.sajb.2021.06.038 · Cited by 23 · see citing works

Potential Application of Marine Algae and Their Bioactive Metabolites in Brain Disease Treatment: Pharmacognosy and Pharmacology Insights for Therapeutic Advances

Khairinisa, M. A., Latarissa, I. R., Athaya, N. S., Charlie, V., Musyaffa, H. A., Prasedya, E. S., & Puspitasari, I. M. (2023) · Brain Sciences · doi:10.3390/brainsci13121686 · Cited by 22 · see citing works

Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review

Yow, Y., Goh, T.-K., Nyiew, K.-Y., Lim, L. W., Phang, S., Lim, S., Ratnayeke, S., & Wong, K.-H. (2021) · Cells · doi:10.3390/cells10092194 · Cited by 21 · see citing works

Towards environmental sustainability: further evidences from decarbonization projects in Kenya’s Blue Economy

Rasowo, J., Nyonje, B., Olendi, R., Orina, P., & Odongo, S. (2024) · Frontiers in Marine Science · doi:10.3389/fmars.2024.1239862 · Cited by 20 · see citing works

Investigation of the Potential Phlorotannins and Mechanism of Six Brown Algae in Treating Type II Diabetes Mellitus Based on Biological Activity, UPLC-QE-MS/MS, and Network Pharmacology

Chen, J., Zhou, Z., Li, P., Ye, S., Li, W., Li, M., Zhu, L., & Ding, Y. (2023) · Foods · doi:10.3390/foods12163000 · Cited by 19 · see citing works

Uji Stabilitas Fisik Sediaan Masker Gel dari Ekstrak Alga Merah (Poryphyra sp)

Numberi, A. M. (2020) · Majalah Farmasetika · doi:10.24198/mfarmasetika.v5i1.24066 · Cited by 19 · see citing works

mRNA Expression and Biomarker Responses in Perch at a Biomonitoring Site in the Baltic Sea – Possible Influence of Natural Brominated Chemicals

Förlin, L., Asker, N., Töpel, M., Österlund, T., Kristiansson, E., Parkkonen, J., Haglund, P. S., Faxneld, S., & Sturve, J. (2019) · Frontiers in Marine Science · doi:10.3389/fmars.2019.00316 · Cited by 18 · see citing works

Improved growth of bait microalgae Isochrysis and aquacultural wastewater treatment with mixotrophic culture

Chu, R., Ma, J., Zhou, C., Liu, D., Wang, G., Ruan, R. R., Lu, Y., Yan, X., & Cheng, P. (2022) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-021-02681-w · Cited by 18 · see citing works

Antibacterial activity of red algae(Gracilaria verrucosa)extract againstEscherichia coliandSalmonella typhimurium

Dayuti, S. (2018) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/137/1/012074 · Cited by 18 · see citing works

Total Phenolic Content, Antioxidant and Antibacterial Activities of Sargassum polycystum of Ethanol Extract from Waters of Kabung Island

Safitri, I., Warsidah, W., Sofiana, M. S. J., Kushadiwijayanto, A. A., & Sumarni, T. N. (2021) · BERKALA SAINSTEK · doi:10.19184/bst.v9i3.27199 · Cited by 17 · see citing works

The Protective Effect of the Polysaccharide Precursor, D-Isofloridoside, from Laurencia undulata on Alcohol-Induced Hepatotoxicity in HepG2 Cells

Yang, S., Chen, M., Ryu, B., Chen, J., Xiao, Z., Hong, P., Sun, S., Wang, D., Qian, Z., & Zhou, C. (2020) · Molecules · doi:10.3390/molecules25051024 · Cited by 16 · see citing works

Phycocolloids from Sargassum microcystum: Immunomodulatory and antioxidant activities of alginic acid and fucoidan

Muthu, S., Altemimi, A. B., Lakshmikanthan, M., Krishnan, K., ALKaisy, Q. H., Awlqadr, F. H., & Hesarinejad, M. A. (2025) · Food Hydrocolloids for Health · doi:10.1016/j.fhfh.2025.100209 · Cited by 15 · see citing works

Role of macroalgal blue carbon ecosystems in climate change mitigation

Chandrani, S., Dey, D., Vaishnavi, G., Gunaseelan, S., Ashokkumar, B., Bharathi, K. S. U., Chew, K. W., & Varalakshmi, P. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.177751 · Cited by 15 · see citing works

Algae as Source of Pharmaceuticals

Dmytryk, A., Tuhy, Ł., & Chojnacka, K. (2017) · Springer eBooks · doi:10.1007/978-981-10-1950-0_11 · Cited by 15 · see citing works

Fucosterol from Sargassum horridum as an amyloid-beta (Aβ1-42) aggregation inhibitor: in vitro and in silico studies

Castro-Silva, E. S., Bello, M., Rosales‐Hernández, M. C., Correa‐Basurto, J., Rodríguez, M. H., Villalobos-Acosta, D. M. Á., Méndez‐Méndez, J. V., Estrada-Pérez, A. R., Murillo-Álvarez, J. I., & Muñoz‐Ochoa, M. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1729863 · Cited by 15 · see citing works

Seaweeds’ neuroprotective potential set in vitro on a human cellular stress model

Silva, J., Alves, C., Pintéus, S., Mendes, S., & Pedrosa, R. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03824-5 · Cited by 15 · see citing works

Apoptosis-like cell death upon kinetoplastid induction by compounds isolated from the brown algae Dictyota spiralis

Chiboub, O., Sifaoui, I., Abderrabba, M., Mejri, M., Fernández, J. J., Díaz‐Marrero, A. R., Lorenzo‐Morales, J., & Piñero, J. E. (2021) · Parasites & Vectors · doi:10.1186/s13071-021-04693-7 · Cited by 15 · see citing works

Antifouling Properties of Bacteria Associated with Marine Oyster Crassostrea Sp.

Viju, N., Punitha, S. M. J., & Satheesh, S. (2018) · Thalassas An International Journal of Marine Sciences · doi:10.1007/s41208-018-0095-9 · Cited by 14 · see citing works

Bio‐Inspired Molecules Extracted from Marine Macroalgae: A New Generation of Active Ingredients for Cosmetics and Human Health

Stiger‐Pouvreau, V., & Guérard, F. (2018) · Blue Biotechnology · doi:10.1002/9783527801718.ch22 · Cited by 14 · see citing works

Seaweed phenolic compounds: Relationship with antioxidant activity and application in different food products

Golmakani, M.-T., Alavi, S. N., Sarvestani, F. S., Shaabani, S., & Ibáñez, E. (2025) · Food Chemistry X · doi:10.1016/j.fochx.2025.103242 · Cited by 13 · see citing works

Dimethylsulfoniopropionate Promotes Process Outgrowth in Neural Cells and Exerts Protective Effects against Tropodithietic Acid

Wichmann, H., Brinkhoff, T., Simon, M., & Richter‐Landsberg, C. (2016) · Marine Drugs · doi:10.3390/md14050089 · Cited by 13 · see citing works

Alzheimer’s Disease and Toxins Produced by Marine Dinoflagellates: An Issue to Explore

Botelho, M. J., Milinović, J., Bandarra, N. M., & Vale, C. (2022) · Marine Drugs · doi:10.3390/md20040253 · Cited by 13 · see citing works

BChE inhibitors from marine organisms – A review

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