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Systematic review on herb-induced liver injury in Korea

Lee, Woo-Jin, Kim, Hae-Won, Lee, Hyun-Yong, Son, Chang-Gue·2015·Food and Chemical Toxicology
DOI 10.1016/j.fct.2015.06.004
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Abstract

Herbal drugs are generally regarded as safe due to their extensive clinical use especially in East Asian countries. However, the potential toxicity of herbal drugs has become an important medical issue recently, resulting in numerous reports of drug-induced liver injury (DILI). Here, we performed a systematic review of herbal medicines with the potential to cause hepatotoxicity in Korea. A literature search of six databases, including PubMed and five Korean electronic databases, was performed to identify cases of herb-induced liver injury (HILI) in Korea, yielding 31 unique reports, including 21 single herb and 10 multi-herb preparations. From these reports, we identified 97 cases of HILI (47 males, 49 females, and 1 unknown sex) consisting of 74.7% hepatocellular-type injury, 10.8% cholestatic-type injury, and 14.5% mixed-type injury. Causative agents included 21 unique herbal preparations, including 11 single species and 10 multispecies, with Polygoni Multiflori (39.2%) and Dictamnus dasycarpus (37.1%) as the most frequent agents. These analyses presented a feature of HILI, and produced a comprehensive list of herbs with a higher risk of hepatotoxicity in Korea. Further studies will be necessary to ascertain the mechanisms by which these herbs induce HILI and to determine whether these effects are specific to the Korean population.

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Research works printed but not linked: 58

  1. An, 2010, One case of fulminant hepatic failure related to Dictamnus dasycarpus, Korean J. Med., 78, 490
  2. Andrade, 2005, Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period, Gastroenterology, 129, 512, 10.1016/j.gastro.2005.05.006 · DOI · Paper page
  3. Au, 2011, Review article: drug-induced liver injury its pathophysiology and evolving diagnostic tools, Aliment. Pharmacol. Ther., 34, 11, 10.1111/j.1365-2036.2011.04674.x · DOI
  4. Bae, 2010, Case reports: toxic hepatitis associated with Polygoni Multiflori, Korean J. Hepatol., 16, 182, 10.3350/kjhep.2010.16.2.182 · DOI · Paper page
  5. Barnes, 2008, Complementary and alternative medicine use among adults and children: United States, 2007, Natl. Health Stat. Rep., 12, 1
  6. Cárdenas, 2006, Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum, J. Clin. Gastroenterol., 40, 629, 10.1097/00004836-200608000-00014 · DOI
  7. Chalasani, 2008, Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States, Gastroenterology, 135, 1924, 10.1053/j.gastro.2008.09.011 · DOI · Paper page
  8. Chang, 2002, Cytotoxic terpenoid and immunosuppressive phenolic glycosides from the root bark of Dictamnus dasycarpus, Planta Med., 68, 425, 10.1055/s-2002-32077 · DOI
  9. Cho, 1999, A case of acute hepatitis related to the Chinese medicine Ho-Shou-Wu, Korean J. Med., 56, 753
  10. Choi, 2009, Two cases of toxic hepatitis after Polygonum multiflorum Thunb ingestion, Korean J. Med., 77, 7
  11. Fung, 2015, Developing traditional chinese medicine in the era of evidence-based medicine: current evidences and challenges, Evid. Based Complement. Altern. Med., 2015, 425037, 10.1155/2015/425037 · DOI · Paper page
  12. Gao, 2012, Definitive diagnosis of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids, J. Dig. Dis., 13, 33, 10.1111/j.1751-2980.2011.00552.x · DOI · Paper page
  13. Han, 2003, One case of drug induced hepatitis caused by Dyctamnus dasycarpus, Korean J. Med., 24, 374
  14. Han, 2009, The study of dosages of herbal medicine including Aconiti Lateralis Preparata Radix and Aconiti Tuber on aspartate aminotransferase, alanine aminotransferase, Korea J. Herbol., 24, 87
  15. Huang, 2007, Chinese herb Radix Polygoni Multiflori as a therapeutic drug for liver cirrhosis in mice, J. Ethnopharmacol., 114, 199, 10.1016/j.jep.2007.07.034 · DOI
  16. Jang, 2008, Four cases of toxic liver injury associated with Dictamnus dasycarpus (case reports), Korean J. Hepatol., 14, 206, 10.3350/kjhep.2008.14.2.206 · DOI
  17. Jhun, 2011, Case reports: a case of interstitial pneumonitis with acute liver injury caused by herbal medicine made from golden thread, Tuberc. Respir. Dis., 71, 470, 10.4046/trd.2011.71.6.470 · DOI
  18. Jo, 2014, Case of suspected drug-induced liver injury after intravenous wild ginseng pharmacopuncture, Korean J Orient. Physiol. Pathol., 28, 102
  19. Jung, 2010, Clinical features of 28 acutely toxic hepatitis patients who ingested Dictamnus dasycarpus: a single center clinical experience, Korean J. Med., 78, 457
  20. Jung, 2007, Ten cases of acute hepatitis following ingestion of Polygonum multiflorum Thunb, Korean J. Gastroenterol., 50, 337
  21. Jung, 2011, Drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of Polygonum multiflorum Thunb, Gut Liver, 5, 493, 10.5009/gnl.2011.5.4.493 · DOI · Paper page
  22. Kane, 1995, Hepatitis induced by traditional Chinese herbs: possible toxic components, Gut, 36, 146, 10.1136/gut.36.1.146 · DOI
  23. Kang, 2009, A case of acute cholestatic hepatitis induced by Corydalis speciosa Max, Korean J. Hepatol., 15, 517, 10.3350/kjhep.2009.15.4.517 · DOI · Paper page
  24. Kang, 2008, Clinical characteristics of 159 cases of acute toxic hepatitis, Korean J. Hepatol., 14, 483, 10.3350/kjhep.2008.14.4.483 · DOI · Paper page
  25. Kim, 2010, Case report: a case of acute toxic hepatitis and acute kidney injury after ingestion of Ulmus davidiana var. japonica extracts, Korean J. Nephrol., 29, 136
  26. Kim, 2013, Case reports: a case of acute pancreatitis and acute hepatitis caused by ingestion of Ceramium kondoi, Korean J Gastroentrol., 62, 306, 10.4166/kjg.2013.62.5.306 · DOI
  27. Kim, 2012, A case report for a toxic liver injury caused by voluntary administration of Smilacis Chinae Radix, Korean J. Med., 33, 609
  28. Kim, 2002, One case of hepatotoxic hepatitis after taking Yugmijihwang-won, Korean J. Med., 23, 716
  29. Kim, 2009, Case reports: gastroenterology; a case of acute hepatitis caused by ingesting Dictamnus dasycarpus, Korean J. Med., 76, 476, 10.3904/kjm.2012.82.4.476 · DOI
  30. Kim, 2009, Case reports: two cases of toxic hepatitis caused by arrowroot juice, Korean J. Hepatol., 15, 504, 10.3350/kjhep.2009.15.4.504 · DOI · Paper page
  31. Koh, 2014, Adverse drug reactions after taking the extract of Cudrania tricuspidata, Allergy Asthma Respir. Dis., 2, 387, 10.4168/aard.2014.2.5.387 · DOI
  32. Kwon, 2009, A clinical case of liver injury with administration of Yeoldahanso-tang plus Rheum rhabarbarum, J Sasang Const. Med., 21, 209
  33. Larrey, 2011, Herbal medicine hepatotoxicity: a new step with development of specific biomarkers, J. Hepatol., 54, 599, 10.1016/j.jhep.2010.12.003 · DOI
  34. Lee, 1998, Drug-induced liver disease caused by ingestion of Dyctamnus dasycarpus, Korean J. Gastroenterol., 31, 251
  35. Lee, 2014, Case report: acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review, Korean J. Gastroentrol., 64, 54, 10.4166/kjg.2014.64.1.54 · DOI
  36. Lee, 2011, A psoriasis case report on liver damage related to Scutellaria Radix, Korean J. Med., 32, 149
  37. Lee, 2000, One case of hepatic injury suggested toxic hepatitis (drug induced hepatitis) in the treatment of oriental medicine for cerebral infarction, Korean J. Med., 21, 869
  38. Li, 2007, Evaluation of prognostic markers in severe drug-induced liver disease, World J. Gastroenterol., 13, 628, 10.3748/wjg.v13.i4.628 · DOI
  39. Lucena, 2011, Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis, J. Hepatol., 55, 820, 10.1016/j.jhep.2010.12.041 · DOI · Paper page
  40. Lu, 1998, Toxicological study of food safety of Baishouwu (Cynanchum Auriculatum Royle ex Wright), J. Nanjing Rail Med. Col., 17, 261
  41. Mantani, 2002, Incidence and clinical features of liver injury related to Kampo (Japanese herbal) medicine in 2,496 cases between 1979 and 1999: problems of the lymphocyte transformation test as a diagnostic method, Phytomedicine, 9, 280, 10.1078/0944-7113-00141 · DOI
  42. Nam, 2005, A case of acute cholestatic hepatitis associated with the seeds of Psoralea corylifolia (Boh-Gol-Zhee), Clin. Toxicol. (Phila), 43, 589, 10.1081/CLT-200068863 · DOI
  43. Oh, 2015, Systematic review of the incidence of herbal drug-induced liver injury in Korea, J. Ethnopharmacol., 159, 253, 10.1016/j.jep.2014.11.027 · DOI
  44. Ostapowicz, 2002, Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States, Ann. Intern Med., 137, 947, 10.7326/0003-4819-137-12-200212170-00007 · DOI · Paper page
  45. Shin, 2011, One case of drug-induced liver injury after taking Gamiyukgunja-tang, Korean J. Med., 32, 444
  46. Suh, 2000, A case of acute hepatitis and acute renal failure after ingestion of complementary medication, Chonbuk Univ. Med. J., 24, 197
  47. Suk, 2012, A prospective nationwide study of drug-induced liver injury in Korea, Am. J. Gastroenterol., 107, 1380, 10.1038/ajg.2012.138 · DOI · Paper page
  48. Teschke, 2014, Drug and herb induced liver injury: Council for International Organizations of Medical Sciences scale for causality assessment, World J. Hepatol., 6, 17, 10.4254/wjh.v6.i1.17 · DOI · Paper page
  49. Teschke, 2014, Review article: herbal hepatotoxicity–an update on traditional Chinese medicine preparations, Aliment. Pharmacol. Ther., 40, 32, 10.1111/apt.12798 · DOI · Paper page
  50. Xu, 2009, Traditional Chinese medicine in the Chinese health care system, Health Policy, 90, 133, 10.1016/j.healthpol.2008.09.003 · DOI
  51. Yang, 2001, One case of report of acute cholestatic-hepatitis (drug induced hepatitis) after taking herbal-medicine, Korean J. Med., 22, 251
  52. Ye, 2010, The bright future of Chinese herbal medicine: only after a twisty road, Contemp. Clin. Trials, 31, 508, 10.1016/j.cct.2010.07.007 · DOI
  53. Yoo, 2007, The survey for the actual condition of drug medication and development of health care cost associated with toxic liver injury in Korea: a multicenter study for the detection and the development of nationwide reporting system of toxic liver injury, Korean J. Hepatol., 13, 34
  54. Yoon, 2004, A clinical case of liver injury induced by Chungsim Yeonja-tang, Korean J. Med., 25, 539
  55. Yu, 2011, Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata, J. Ethnopharmacol., 137, 1291, 10.1016/j.jep.2011.07.055 · DOI
  56. Yuen, 2006, Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1-year prospective study, Aliment. Pharmacol. Ther., 24, 1179, 10.1111/j.1365-2036.2006.03111.x · DOI · Paper page
  57. Yun, 2003, Case reports: two cases of acute toxic hepatitis and renal failure after ingestion of the extract of elm bark in lung cancer patients, Korean J. Med., 65, 826
  58. Zhou, 2013, Epidemiology of drug-induced liver injury in China: a systematic analysis of the Chinese literature including 21,789 patients, Eur. J. Gastroenterol. Hepatol., 25, 825, 10.1097/MEG.0b013e32835f6889 · DOI · Paper page

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Metadata

Authors
Lee, W.-J., Kim, H.-W., Lee, H.-Y., & Son, C.-G.
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2015-10
Volume
84
Pages
47-54
ISSN
0278-6915
DOI
10.1016/j.fct.2015.06.004
Cited by
77
References
1
Language
en
Licence
Funders
Ministry of Health & Welfare (HI12C1920-010014)

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