The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex
Open accessAbstract
The purinergic receptor P2X 7 is part of a complex signaling mechanism participating in a variety of physiological and pathological processes. Depending on the activation scheme, P2X 7 receptors in vivo are non‐selective cation channels or form large pores that can mediate apoptotic cell death. Expression of P2X 7 R in Xenopus oocytes results exclusively in formation of a non‐selective cation channel. However, here we show that co‐expression of P2X 7 R with pannexin1 in oocytes leads to the complex response seen in many mammalian cells, including cell death with prolonged ATP application. While the cation channel activity is resistant to carbenoxolone treatment, this gap junction and hemichannel blocking drug suppressed the currents induced by ATP in pannexin1/P2X 7 R co‐expressing cells. Thus, pannexin1 appears to be the molecular substrate for the permeabilization pore (or death receptor channel) recruited into the P2X 7 R signaling complex.
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Cites
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )
Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
Pelegrin, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,431
Pannexin membrane channels are mechanosensitive conduits for ATP
Bao, L., Locovei, S., & Dahl, G. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.009 · Cited by 802
Self-citationPannexins, a family of gap junction proteins expressed in brain
Bruzzone, R., Hormuzdi, S. G., Barbe, M. T., Herb, A., & Monyer, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233464100 · Cited by 774
A ubiquitous family of putative gap junction molecules
Panchina, Y., Kelmanson, I., Matz, M., Lukyanov, K., Usman, N., & Lukyanov, S. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00576-5 · Cited by 562
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium
Locovei, S., Wang, J., & Dahl, G. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.004 · Cited by 520
Self-citationP2X7Receptors Mediate ATP Release and Amplification of Astrocytic Intercellular Ca2+Signaling
Suadicani, S. O., Brosnan, C. F., & Scemes, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3902-05.2006 · Cited by 512
Self-citationPannexin 1 in erythrocytes: Function without a gap
Locovei, S., Bao, L., & Dahl, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601037103 · Cited by 508
Self-citationThe erythrocyte as a regulator of vascular tone
Ellsworth, M. L., Forrester, T., Ellis, C. G., & Dietrich, H. H. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.6.h2155 · Cited by 502
Cited by
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120
Fernandes-Alnemri, T., Wu, J., Yu, J.-W., Datta, P., Miller, B., Jankowski, W., Rosenberg, S., Zhang, J., & Alnemri, E. S. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402194 · Cited by 1,026
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Lamkanfi, M., Mueller, J. L., Vitari, A. C., Misaghi, S., Fedorova, A., Deshayes, K., Lee, W. P., Hoffman, H. M., & Dixit, V. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903124 · Cited by 820
Acid sphingomyelinase activity triggers microparticle release from glial cells
Bianco, F., Perrotta, C., Novellino, L., Francolini, M., Riganti, L., Menna, E., Saglietti, L., Schuchman, E. H., Furlan, R., Clementi, E., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.45 · Cited by 615
Liaisons dangereuses: P2X7 and the inflammasome
Di Virgilio, F. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.07.002 · Cited by 493
Metadata
- Authors
- Locovei, S., Scemes, E., Qiu, F., Spray, D. C., & Dahl, G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-01-16
- Volume
- 581
- Issue
- 3
- Pages
- 483-488
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2079901569
- Cited by
- 434
- References
- 32
- FWCI
- 17.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Locovei, S., Scemes, E., Qiu, F., Spray, D. C., & Dahl, G. (2007). Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex. FEBS Letters. https://doi.org/10.1016/j.febslet.2006.12.056
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