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Cited by 50

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

A different path: Revealing the function of staphylococcal proteins in biofilm formation

Atkin, Kate E., MacDonald, Sandy J., Brentnall, Andrew S., Potts, Jennifer R., Thomas, Gavin H.·2014·FEBS Letters
DOI 10.1016/j.febslet.2014.04.002
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Abstract

Staphylococcus aureus and Staphylococcus epidermidis cause dangerous and difficult to treat medical device‐related infections through their ability to form biofilms. Extracellular poly‐N‐acetylglucosamine (PNAG) facilitates biofilm formation and is a vaccination target, yet details of its biosynthesis by the icaADBC gene products is limited. IcaC is the proposed transporter for PNAG export, however a comparison of the Ica proteins to homologous exo‐polysaccharide synthases suggests that the common IcaAD protein components both synthesise and transport the PNAG. The limited distribution of icaC to the Staphylococcaceae and its membership of a family of membrane‐bound acyltransferases, leads us to suggest that IcaC is responsible for the known O‐succinylation of PNAG that occurs in staphylococci, identifying a potentially new therapeutic target specific for these bacteria.

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Metadata

Authors
Atkin, K. E., MacDonald, S. J., Brentnall, A. S., Potts, J. R., & Thomas, G. H.
Venue
FEBS Letters
Publisher
Wiley
Published
2014-04-13
Volume
588
Issue
10
Pages
1869-1872
ISSN
  • 0014-5793
  • 1873-3468
DOI
10.1016/j.febslet.2014.04.002
Cited by
50
References
1
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • Centre for Chronic Diseases and Disorders
  • Institutional Strategic Support Fund

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CoChat. (2026). Citation check: A different path: Revealing the function of staphylococcal proteins in biofilm formation. https://app.cochat.ai/papers/10.1016/j.febslet.2014.04.002
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Atkin, K. E., MacDonald, S. J., Brentnall, A. S., Potts, J. R., & Thomas, G. H. (2014). A different path: Revealing the function of staphylococcal proteins in biofilm formation. FEBS Letters. https://doi.org/10.1016/j.febslet.2014.04.002

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.