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Cited by 434

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

Regulation of virulence determinants in Staphylococcus aureus: complexity and applications

Open access
Bronner, Stéphane, Monteil, Henri, Prévost, Gilles·2004·FEMS Microbiology Reviews
DOI 10.1016/j.femsre.2003.09.003
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Abstract

The virulence of Staphylococcus aureus is essentially determined by cell wall associated proteins and secreted toxins that are regulated and expressed according to growth phases and/or growth conditions. Gene expression is regulated by specific and sensitive mechanisms, most of which act at the transcriptional level. Regulatory factors constitute numerous complex networks, driving specific interactions with target gene promoters. These factors are largely regulated by two-component regulatory systems, such as the agr, saeRS, srrAB, arlSR and lytRS systems. These systems are sensitive to environmental signals and consist of a sensor histidine kinase and a response regulator protein. DNA-binding proteins, such as SarA and the recently identified SarA homologues (SarR, Rot, SarS, SarT, SarU), also regulate virulence factor expression. These homologues might be intermediates in the regulatory networks. The multiple pathways generated by these factors allow the bacterium to adapt to environmental conditions rapidly and specifically, and to develop infection. Precise knowledge of these regulatory mechanisms and how they control virulence factor expression would open up new perspectives for antimicrobial chemotherapy using key inhibitors of these systems.

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Metadata

Authors
Bronner, S., Monteil, H., & Prévost, G.
Venue
FEMS Microbiology Reviews
Publisher
Oxford University Press (OUP)
Published
2004-05
Volume
28
Issue
2
Pages
183-200
ISSN
  • 0168-6445 (ISSN-L)
  • 1574-6976
DOI
10.1016/j.femsre.2003.09.003
OpenAlex
W2005056854
Cited by
434
References
101
FWCI
7.75
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. https://app.cochat.ai/papers/10.1016/j.femsre.2003.09.003
The paper
Bronner, S., Monteil, H., & Prévost, G. (2004). Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. FEMS Microbiology Reviews. https://doi.org/10.1016/j.femsre.2003.09.003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.