Clinical and biochemical presentations of polycystic ovary syndrome among obese and nonobese women
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Objective To study the differences in clinical and biochemical characteristics between obese and nonobese women with polycystic ovary syndrome (PCOS).Design Retrospective study.Setting University teaching hospital.Patient(s) Four hundred sixty-four Taiwan Chinese women, among whom 295 were diagnosed with PCOS and 169 were non-PCOS controls.Main outcome measure(s) Body mass index, average menstrual interval, modified Ferriman-Gallwey score, acne, total T, and waist-to-hip ratio.Result(s) Obese women with polycystic ovary morphology (PCOM) had a greater risk of developing of PCOS (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.5-10.4) than nonobese women with PCOM. Obese women with PCOM had a higher incidence oligomenorrhea (OR, 2.6; 95% CI, 1.6-4.1) and biochemical hyperandrogenemia (OR, 2.5; 95% CI, 1.6-4.0) than nonobese women with PCOM. Obese subjects with PCOS had a higher risk of developing oligomenorrhea (OR, 2.2; 95% CI, 1.3-3.7) and biochemical hyperandrogenemia (OR, 2.6; 95% CI, 1.6-4.2) than nonobese women with PCOS. Moreover, obese women with PCOS had significantly higher serum total T levels and more prolonged menstrual intervals than nonobese women with PCOS. Notably, the obese women with PCOS presented less acne than the nonobese subjects (OR, 0.5; 95% CI, 0.3-0.9).Conclusion(s) Obese women with PCOS had more severe ovulatory dysfunction and higher serum total T levels than nonobese subjects. Moreover, obese women with PCOS had a significantly lower frequency of acne than nonobese subjects.
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A relationship between serum plasma levels of androgens and obesity has been reported.
“Furthermore, a relationship between serum plasma levels of androgens and obesity has also been reported (Liou et al., 2009).”
From Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention (2021) · cites this paper as Liou et al., 2009
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- Authors
- Liou, T.-H., Yang, J.-H., Hsieh, C.-H., Lee, C.-Y., Hsu, C.-S., & Hsu, M.-I.
- Affiliations
- Wan Fang Hospital (TW)
- Chung Shan Medical University Hospital (TW)
- Corresponding author
- Hsu, Ming-I.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 92
- Issue
- 6
- Pages
- 1960-1965
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1988469475
- Cited by
- 100
- References
- 34
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 1 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 3 · 2012: 9
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, obesity, polycystic ovary morphology, oligomenorrhea, hyperandrogenemia, serum total testosterone, acne, ovulatory dysfunction
- MeSH terms
- Acne Vulgaris, Adolescent, Adult, Female, Follicle Stimulating Hormone, Hirsutism, Humans, Luteinizing Hormone, Menstruation, Obesity, Oligomenorrhea, Polycystic Ovary Syndrome, Prolactin, Risk Factors, Taiwan, Testosterone, Body Mass Index, Incidence, Hyperandrogenism, Young Adult
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