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Cited by 56Ovarian function and disordersNutritional Studies and DietAntioxidant Activity and Oxidative Stress

Relation between Inflammation, Oxidative Stress, and Macronutrient Intakes in Normal and Excessive Body Weight Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

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Mizgier, Małgorzata, Jarząbek-Bielecka, Grażyna, Wendland, Natalia, Jodłowska-Siewert, Elżbieta, Nowicki, Marcin, Brożek, Alicja, Kędzia, Witold, Formanowicz, Dorota +1 more·2021·Nutrients
DOI 10.3390/nu13030896PMC PMC8001803
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Abstract

The impact of diet on inflammation and oxidative stress (OS) in girls with polycystic ovary syndrome (PCOS) is unknown. Therefore, our study aimed to investigate, in PCOS girls, whether certain macronutrient intakes can be associated with these disturbances. For this purpose, 59 PCOS participants (aged 14–18 years) were recruited to this study and divided into two subgroups: overweight/obese—Ov/Ob group (n = 22) and normal weight—N group (n = 37). Nutrition was assessed using a 3-day food record. The studied markers were total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukins 1 and 6 (IL-1 and IL-6). We found plant protein intake inversely correlated with IL-6 (p = 0.007; r = −0.557), TNF-α (p = 0.006; r = −0.564), MDA (p = 0.01; r = −0.539) in the Ov/Ob group and with TAC (p = 0.021; r = −0.38) in the N group. Inverse correlations in the Ov/Ob group were observed between protein intake and IL-6 (p = 0.031; r = −0.461), TNF- α (p = 0.043; r = −0.435); carbohydrates and IL-6 (p = 0.037; r = −0.448), MDA (p = 0.045; r = −0.431); fiber and IL-6 (p = 0.025; r = −0.475). A positive relationship between cholesterol intake and CRP concentration (p = 0.038; r = 0.342) was also found in the N group. These findings revealed that inflammation and OS are increased in Ov/Ob girls with decreased plant protein intake and low carbohydrates in the diet. Moreover, inflammation may be increased by cholesterol intake in slim PCOS girls. On the other hand, decreased intake of fiber and total protein intake increased inflammation. ClinicalTrials.gov Identifier: NCT04738409.

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  • Plant protein intake in overweight and obese adolescent girls with PCOS is associated with altered levels of inflammation triggers IL-6 and TNF-α, representing possible anti-inflammatory capacity.

    “Inflammation triggers, including IL-6 and TNF-α, can be alternately found in too high levels due to plant protein intake in overweight and obese adolescent girls with PCOS, which represents possible skin anti-inflammatory capacity [119].”

    From Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management (2025) · cites this paper as [119]

    The Abstract and Discussion report that plant protein intake was inversely correlated with IL-6 and TNF-α in overweight or obese adolescent girls with PCOS clinical features. This supports an association consistent with a possible anti-inflammatory effect, but not the citing sentence’s suggestion that plant protein causes high cytokine levels. The paper does not address skin anti-inflammatory capacity. (LLM, conf=0.88)

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Research works printed but not linked: 2

  1. [6]Jarząbek-Bielecka G. Opydo-Szymaczek J. Mizgier M. Bojanowska K. Pisarska-Krawczyk M. Chuchracki M. Kędzia W. Wojtyła A. Zespół policystycznych jajników jako problem w ginekologii i medycynie rodzinnej, z uwzględnieniem pacjentek w wieku rozwojowym (Polycystic ovary syndrome as a problem in gynecology and family medicine, including patients in developmental age) Med. Rodz. 2018 21 335 338 10.25121/MR.2018.21.4.335 · DOI
  2. [7]Małecka-Tendera E. Zespół policystycznych jajników u dziewcząt (Polycystic ovary syndrome in girls) Endokrynol. Ped. 2015 14 51 10.18544/EP-01.14.02.1573 · DOI

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Authors
Mizgier, M., Jarząbek-Bielecka, G., Wendland, N., Jodłowska-Siewert, E., Nowicki, M., Brożek, A., Kędzia, W., Formanowicz, D., & Opydo-Szymaczek, J.
Affiliations
  • Department of Dietetics, Faculty of Physical Culture in Gorzów Wlkp., Poznan University of Physical Education, Estkowskiego 13, 66-400 Gorzów Wielkopolski, Poland
  • Department of Perinatology and Gynecology, Division of Developmental Gynecology and Sexology, Poznan University of Medical Sciences, 60-535 Poznan, Poland
  • Poznan University of Medical Sciences (PL)
Corresponding author
Mizgier, Małgorzata
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2021-03-10
Volume
13
Issue
3
Pages
896
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu13030896
PMC
PMC8001803
OpenAlex
W3136882713
Cited by
56
References
105
Citations by year
2026: 4 · 2025: 11 · 2024: 17 · 2023: 14 · 2022: 7 · 2021: 3
FWCI
8.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Narodowym Centrum Nauki (2019/03/X/NZ7/01068)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
polycystic ovary syndrome, adolescent girls, inflammation, oxidative stress, macronutrient intake, plant proteins, dietary fiber, carbohydrates, cholesterol intake, overweight and obesity, C-reactive protein, TNF-α, interleukin-6, malondialdehyde, total antioxidant capacity, diet and inflammation, diet and obesity
MeSH terms
Adolescent, Antioxidants, C-Reactive Protein, Dietary Fats, Dietary Proteins, Eating, Female, Humans, Inflammation, Malondialdehyde, Obesity, Polycystic Ovary Syndrome, Plant Proteins, Dietary, Diet Records, Body Mass Index, Cytokines, Oxidative Stress, Overweight

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