Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis
Open accessAbstract
Objective To test the hypothesis that the expression of the different isoforms of the estrogen receptor alpha (ER-α) and beta (ER-β) and the progesterone receptor A (PR-A) and B (PR-B) would be differentially modulated in uteri with adenomyosis compared with controls and that modulation would be related to the menstrual cycle.Design Case control, blinded comparison.Setting University department.Patient(s) 54 premenopausal women with and 35 without uterine adenomyosis as the sole pathology.Intervention(s) Multiple samples studied using immunohistochemistry for estrogen and progesterone receptors.Main outcome measure(s) Histomorphometric analysis of receptor expression.Result(s) The ER-α expression in the adenomyotic endometrium was different from that of the normal endometrium and the foci in the midsecretory phase of the cycle, but expression of ER-α in the inner and outer myometrium was not statistically significantly different. The ER-β expression was statistically significantly elevated in the adenomyotic functionalis gland during the proliferative phase and throughout the myometrium across the entire menstrual cycle. Expression of PR-A was similar to that of PR-B, with reduced expression in the basalis stroma, and inner and outer myometrium in the adenomyotic samples. The pattern of ER-β, PR-A, and PR-B expression was similar in the endometrial basalis and adenomyotic foci.Conclusion(s) These data suggest ER-β expression and the lack of PR expression are related to the development and/or progression of adenomyosis and might explain the poor response of adenomyosis-associated menstrual symptoms to progestational agents.
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The finding of reduced ERα expression agrees with previous reports.
“Our finding of reduced ERα expression agrees with previous reports (Brandenberger et al., 1999; Mehasseb et al., 2011).”
From Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium (2025) · cites this paper as Mehasseb et al., 2011
The endometrium of endometriosis patients displays aberrant molecular expression patterns that give it the ability to implant, invade, and develop into endometriotic foci.
“which have demonstrated that the endometrium of endometriosis patients displays aberrant molecular expression patterns that give it the ability to implant, invade, and develop into endometriotic foci (27)(28)(29)(30).”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [29]
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- Authors
- Mehasseb, M. K., Panchal, R., Taylor, A. H., Brown, L., Bell, S. C., & Habiba, M.
- Affiliations
- University of Leicester (GB)
- Leicester Royal Infirmary (GB)
- Corresponding author
- Mehasseb, Mohamed Khairy
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 95
- Issue
- 7
- Pages
- 2228-2235.e1
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2013657815
- Cited by
- 165
- References
- 57
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 13 · 2023: 11 · 2022: 17 · 2021: 18 · 2020: 20 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 7
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- uterine adenomyosis, estrogen receptor alpha, estrogen receptor beta, progesterone receptor A, progesterone receptor B, menstrual cycle, endometrium, myometrium, endometrial stroma, proliferative phase, luteal phase
- MeSH terms
- Adult, Endometriosis, England, Female, Hospitals, University, Humans, Immunohistochemistry, Menstrual Cycle, Receptors, Progesterone, Uterine Diseases, Uterus, Case-Control Studies, Estrogen Receptor alpha, Estrogen Receptor beta
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